JP2005524719A5 - - Google Patents

Info

Publication number

JP2005524719A5

JP2005524719A5 JP2004503957A JP2004503957A JP2005524719A5 JP 2005524719 A5 JP2005524719 A5 JP 2005524719A5 JP 2004503957 A JP2004503957 A JP 2004503957A JP 2004503957 A JP2004503957 A JP 2004503957A JP 2005524719 A5 JP2005524719 A5 JP 2005524719A5

Authority

JP

Japan

Prior art keywords

composition

amino acids

polypeptide

group

cell

Prior art date

2002-10-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000203 mixture Substances 0.000 claims 36
• 210000004027 cell Anatomy 0.000 claims 17
• 229920001184 polypeptide Polymers 0.000 claims 17
• 102000004196 processed proteins & peptides Human genes 0.000 claims 17
• 108090000765 processed proteins & peptides Proteins 0.000 claims 17
• 150000001413 amino acids Chemical class 0.000 claims 12
• 239000000427 antigen Substances 0.000 claims 9
• 102000036639 antigens Human genes 0.000 claims 9
• 108091007433 antigens Proteins 0.000 claims 9
• 206010028980 Neoplasm Diseases 0.000 claims 7
• 210000004881 tumor cell Anatomy 0.000 claims 6
• 201000011510 cancer Diseases 0.000 claims 5
• 239000003937 drug carrier Substances 0.000 claims 5
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 239000012634 fragment Substances 0.000 claims 4
• 230000028993 immune response Effects 0.000 claims 4
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
• 150000007523 nucleic acids Chemical group 0.000 claims 3
• 206010033128 Ovarian cancer Diseases 0.000 claims 2
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
• 230000000735 allogeneic effect Effects 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• ULUOXCRNSRVJPE-MJRHPTFMSA-N 2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[2-[[(2S,3S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-methylpentanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]propanoyl]amino]propanoyl]amino]acetic acid Chemical compound C([C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(O)=O)C1=CN=CN1 ULUOXCRNSRVJPE-MJRHPTFMSA-N 0.000 claims 1
• 206010003571 Astrocytoma Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 208000032612 Glial tumor Diseases 0.000 claims 1
• 206010018338 Glioma Diseases 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
• 210000004958 brain cell Anatomy 0.000 claims 1
• 239000008121 dextrose Substances 0.000 claims 1
• 208000005017 glioblastoma Diseases 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 208000029974 neurofibrosarcoma Diseases 0.000 claims 1
• 239000003921 oil Substances 0.000 claims 1
• 239000011780 sodium chloride Substances 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 238000013268 sustained release Methods 0.000 claims 1
• 239000012730 sustained-release form Substances 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1