JP2005524421A5 - - Google Patents
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- Publication number
- JP2005524421A5 JP2005524421A5 JP2003565426A JP2003565426A JP2005524421A5 JP 2005524421 A5 JP2005524421 A5 JP 2005524421A5 JP 2003565426 A JP2003565426 A JP 2003565426A JP 2003565426 A JP2003565426 A JP 2003565426A JP 2005524421 A5 JP2005524421 A5 JP 2005524421A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- microparticle
- bmp
- composition
- bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011859 microparticle Substances 0.000 claims 27
- 239000000243 solution Substances 0.000 claims 24
- 102000008143 Bone Morphogenetic Protein 2 Human genes 0.000 claims 20
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 20
- 238000000034 method Methods 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 12
- 210000000988 bone and bone Anatomy 0.000 claims 5
- 230000000975 bioactive effect Effects 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 3
- 208000010392 Bone Fractures Diseases 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000007900 aqueous suspension Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 claims 1
- 239000004677 Nylon Substances 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000013011 aqueous formulation Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000045896 human BMP2 Human genes 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000012931 lyophilized formulation Substances 0.000 claims 1
- 229920001778 nylon Polymers 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 239000002745 poly(ortho ester) Substances 0.000 claims 1
- -1 polyethylene vinyl acetate Polymers 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 210000002303 tibia Anatomy 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35513502P | 2002-02-08 | 2002-02-08 | |
| PCT/US2003/003809 WO2003066000A2 (en) | 2002-02-08 | 2003-02-10 | Formulation comprising bioactive agents and method of using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009284564A Division JP2010059211A (ja) | 2002-02-08 | 2009-12-15 | 生体活性因子を含有する処方物およびそれを使用する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005524421A JP2005524421A (ja) | 2005-08-18 |
| JP2005524421A5 true JP2005524421A5 (https=) | 2006-03-16 |
| JP4614661B2 JP4614661B2 (ja) | 2011-01-19 |
Family
ID=27734467
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003565426A Expired - Fee Related JP4614661B2 (ja) | 2002-02-08 | 2003-02-10 | 生体活性因子を含有する処方物およびそれを使用する方法 |
| JP2009284564A Pending JP2010059211A (ja) | 2002-02-08 | 2009-12-15 | 生体活性因子を含有する処方物およびそれを使用する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009284564A Pending JP2010059211A (ja) | 2002-02-08 | 2009-12-15 | 生体活性因子を含有する処方物およびそれを使用する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7897174B2 (https=) |
| EP (1) | EP1578348A4 (https=) |
| JP (2) | JP4614661B2 (https=) |
| AU (2) | AU2003209071B2 (https=) |
| CA (1) | CA2474919A1 (https=) |
| WO (1) | WO2003066000A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4614661B2 (ja) * | 2002-02-08 | 2011-01-19 | ワイス | 生体活性因子を含有する処方物およびそれを使用する方法 |
| US7454785B2 (en) * | 2002-12-19 | 2008-11-18 | Avocent Huntsville Corporation | Proxy method and system for secure wireless administration of managed entities |
| US8398611B2 (en) | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
| US8524662B2 (en) | 2010-12-28 | 2013-09-03 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| US8623839B2 (en) | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
| US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
| DE202017101042U1 (de) | 2017-02-24 | 2017-03-24 | Manitowoc Crane Group France Sas | Verbolzungseinheit |
| US10675330B2 (en) | 2018-03-21 | 2020-06-09 | Warsaw Orthopedic, Inc. | Injectable bone morphogenetic protein |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4563489A (en) * | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
| US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US6559119B1 (en) * | 1990-11-27 | 2003-05-06 | Loyola University Of Chicago | Method of preparing a tissue sealant-treated biomedical material |
| US7056882B2 (en) * | 1991-03-11 | 2006-06-06 | Curis, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| WO1993000050A1 (en) * | 1991-06-21 | 1993-01-07 | Genetics Institute, Inc. | Pharmaceutical formulations of osteogenic proteins |
| US5171579A (en) * | 1991-10-11 | 1992-12-15 | Genetics Institute, Inc. | Formulations of blood clot-polymer matrix for delivery of osteogenic proteins |
| ATE238417T1 (de) * | 1991-11-04 | 2003-05-15 | Inst Genetics Llc | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
| US5385887A (en) * | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
| WO1996039169A1 (en) * | 1995-06-05 | 1996-12-12 | Genetics Institute, Inc. | Methods and compositions for healing and repair of connective tissue attachment |
| US5674292A (en) * | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
| CA2223583A1 (en) * | 1995-06-07 | 1996-12-19 | Alkermes Controlled Therapeutics Inc. | Device for releasing aggregation-stabilized, biologically active agent |
| US6048964A (en) * | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
| ZA9711580B (en) * | 1996-12-25 | 1999-09-23 | Hoechst Marion Roussel Ltd | Process for the production of purified dimeric bone morphogenetic factors. |
| CA2334075A1 (en) * | 1998-07-15 | 2000-01-27 | Human Genome Sciences, Inc. | Bone morphogenic protein |
| US6287588B1 (en) * | 1999-04-29 | 2001-09-11 | Macromed, Inc. | Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof |
| US6696410B1 (en) * | 1999-09-27 | 2004-02-24 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins, hormones and hormone receptors |
| US6743446B2 (en) * | 1999-12-15 | 2004-06-01 | The Ohio State University Research Foundation | Methods for stabilizing biologically active agents encapsulated in biodegradable controlled-release polymers |
| WO2001070288A2 (en) * | 2000-03-23 | 2001-09-27 | Genetics Institute, Inc. | Thermoreversible polymers for delivery and retention of osteoinductive proteins |
| TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| US7381426B2 (en) * | 2002-01-24 | 2008-06-03 | Southwest Research Institute | Targeted delivery of bioactive factors to the systemic skeleton |
| JP4614661B2 (ja) * | 2002-02-08 | 2011-01-19 | ワイス | 生体活性因子を含有する処方物およびそれを使用する方法 |
| US7270813B2 (en) * | 2002-10-08 | 2007-09-18 | Osteotech, Inc. | Coupling agents for orthopedic biomaterials |
| EP1462126A1 (en) * | 2003-03-28 | 2004-09-29 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Improved Osteoinductive Materials |
| US7671012B2 (en) * | 2004-02-10 | 2010-03-02 | Biosurface Engineering Technologies, Inc. | Formulations and methods for delivery of growth factor analogs |
| US8372419B2 (en) * | 2004-03-10 | 2013-02-12 | Scil Technology Gmbh | Coated implants, their manufacturing and use thereof |
| ATE520711T1 (de) * | 2005-05-27 | 2011-09-15 | Bbs Bioactive Bone Substitutes Oy | Knochenmorphogenetisches protein 4 und osteogene vorrichtungen und pharmazeutische produkte, die dieses enthalten |
| CA2627907C (en) * | 2005-11-01 | 2014-06-17 | Osteotech, Inc. | Osteoinductive composition comprising osteoinductive factors recovered from mineralized bone and a carrier |
| CA2690457C (en) * | 2007-06-15 | 2018-02-20 | Osteotech, Inc. | Bone matrix compositions and methods |
| US8524253B2 (en) * | 2008-11-25 | 2013-09-03 | Warsaw Orthopedic, Inc. | Bone regeneration device |
-
2003
- 2003-02-10 JP JP2003565426A patent/JP4614661B2/ja not_active Expired - Fee Related
- 2003-02-10 CA CA002474919A patent/CA2474919A1/en not_active Abandoned
- 2003-02-10 EP EP03707799A patent/EP1578348A4/en not_active Withdrawn
- 2003-02-10 WO PCT/US2003/003809 patent/WO2003066000A2/en not_active Ceased
- 2003-02-10 AU AU2003209071A patent/AU2003209071B2/en not_active Ceased
- 2003-02-10 US US10/361,263 patent/US7897174B2/en not_active Expired - Fee Related
-
2008
- 2008-11-06 AU AU2008243150A patent/AU2008243150B2/en not_active Ceased
-
2009
- 2009-12-15 JP JP2009284564A patent/JP2010059211A/ja active Pending
-
2011
- 2011-01-26 US US13/014,365 patent/US20120004170A1/en not_active Abandoned
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