JP2005524399A - Ａｌｃａｍおよびａｌｃａｍ調節因子 - Google Patents

Ａｌｃａｍおよびａｌｃａｍ調節因子 Download PDF

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Publication number
JP2005524399A
JP2005524399A JP2004501579A JP2004501579A JP2005524399A JP 2005524399 A JP2005524399 A JP 2005524399A JP 2004501579 A JP2004501579 A JP 2004501579A JP 2004501579 A JP2004501579 A JP 2004501579A JP 2005524399 A JP2005524399 A JP 2005524399A
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Prior art keywords
alcam
antibody
cancer cells
cell
cells
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JP2004501579A
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English (en)
Japanese (ja)
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JP2005524399A5 (https=
Inventor
ジェニー ピー． マサー，
ロン ハオ リー，
マリー シー． ツァオ，
デリク ティー． ルー，
Original Assignee
レイヴェン バイオテクノロジーズ， インコーポレイテッド
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Application filed by レイヴェン バイオテクノロジーズ， インコーポレイテッド filed Critical レイヴェン バイオテクノロジーズ， インコーポレイテッド
Publication of JP2005524399A publication Critical patent/JP2005524399A/ja
Publication of JP2005524399A5 publication Critical patent/JP2005524399A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2004501579A 2002-05-03 2003-05-02 Ａｌｃａｍおよびａｌｃａｍ調節因子 Withdrawn JP2005524399A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37747902P 2002-05-03 2002-05-03
PCT/US2003/014025 WO2003093443A2 (en) 2002-05-03 2003-05-02 Alcam and alcam modulators

Publications (2)

Publication Number Publication Date
JP2005524399A true JP2005524399A (ja) 2005-08-18
JP2005524399A5 JP2005524399A5 (https=) 2006-03-16

Family

ID=29401505

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004501579A Withdrawn JP2005524399A (ja) 2002-05-03 2003-05-02 Ａｌｃａｍおよびａｌｃａｍ調節因子

Country Status (7)

Country Link
US (1) US20040048319A1 (https=)
EP (1) EP1501544A4 (https=)
JP (1) JP2005524399A (https=)
CN (1) CN1662254A (https=)
AU (1) AU2003225294A1 (https=)
CA (1) CA2483912A1 (https=)
WO (1) WO2003093443A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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KR101213445B1 (ko) 2011-01-13 2012-12-18 강원대학교산학협력단 백혈구의 혈관외유출 억제 활성 및 암세포의 전이 억제 활성을 갖는 펩타이드를 포함하는 약학 조성물

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WO2005111623A1 (en) * 2004-05-17 2005-11-24 Crucell Holland B.V. Methods for diagnosis of acute myeloid leukemia
WO2006084075A2 (en) * 2005-02-02 2006-08-10 Raven Biotechnologies, Inc. Adam-9 modulators
WO2008063479A2 (en) * 2006-11-17 2008-05-29 Fred Hutchinson Cancer Research Center Pancreatic cancer biomarkers
GB0705775D0 (en) * 2007-03-26 2007-05-02 Affitech As Product
US20100216652A1 (en) * 2007-04-25 2010-08-26 The Trustees Of The Universit Of Pennsylvania Low Level Fluorescence Detection at the Light Microscopic Level
EP2065399A1 (en) * 2007-11-30 2009-06-03 Siemens Healthcare Diagnostics GmbH The present invention relates to methods for prediction of the therapeutic success of breast cancer therapy
US20110151580A1 (en) * 2007-11-06 2011-06-23 University Health Network Method for the detection of breast cancer by determining alcam and/or bcam levels in a patient
EP2215251A2 (en) 2007-11-30 2010-08-11 Siemens Healthcare Diagnostics GmbH Method for predicting therapy responsiveness in basal like tumors
DK2786762T3 (da) 2008-12-19 2019-05-06 Macrogenics Inc Kovalente diabodies og anvendelser deraf
SG168430A1 (en) * 2009-07-22 2011-02-28 Agency Science Tech & Res Molecular signature of human lung cancer initiating cells
EP2542256B1 (en) 2010-03-04 2019-05-22 MacroGenics, Inc. Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
AU2011286024B2 (en) 2010-08-02 2014-08-07 Macrogenics, Inc. Covalent diabodies and uses thereof
BR112013029892A2 (pt) 2011-05-21 2016-12-20 Macrogenics Inc polipeptídeo, molécula de ligação a antígeno, diacorpo e uso de uma porção polipeptídica de uma proteína de ligação a soro desimunizada
WO2013033734A1 (en) 2011-09-02 2013-03-07 The Trustees Of Columbia University In The City Of New York Diagnosis and Treatment of Cancer Expressing ILT3 or ILT3 Ligand
WO2014059372A1 (en) * 2012-10-11 2014-04-17 Vanderbilt University Characterization of cancer using detection of activated leukocyte cell adhesion molecule (alcam) shedding
US10451628B2 (en) 2014-05-07 2019-10-22 University Of Utah Research Foundation Biomarkers and methods for diagnosis of early stage pancreatic ductal adenocarcinoma
EA035419B9 (ru) 2014-05-29 2020-08-07 Мэкроудженикс, Инк. Триспецифичные связывающие молекулы и способы их применения
IL292798A (en) 2015-05-04 2022-07-01 Cytomx Therapeutics Inc Anti-cd166 antibodies, activatable anti-cd166 antibodies, preparations containing them and their uses
WO2017015227A1 (en) * 2015-07-17 2017-01-26 The Trustees Of Columbia University In The City Of New York Methods of treating cd166-expressing cancer
HUE068868T2 (hu) 2015-07-30 2025-02-28 Macrogenics Inc PD-1-hez kötõdõ molekulák és alkalmazásukra szolgáló eljárások
IL260021B (en) 2015-12-14 2022-09-01 Macrogenics Inc Bispecific molecules that are immunoreactive for pd1 and ctla4 and methods for using them
AU2018224094B2 (en) 2017-02-24 2025-04-17 Macrogenics, Inc. Bispecific binding molecules that are capable of binding CD137 and tumor antigens, and uses thereof
CN111133006A (zh) 2017-07-14 2020-05-08 西托姆克斯治疗公司 抗cd166抗体及其用途
KR20200098590A (ko) 2017-12-12 2020-08-20 마크로제닉스, 인크. 이중특이적 cd16-결합 분자 및 질환 치료에서의 그것의 용도
JP7337079B2 (ja) 2018-02-15 2023-09-01 マクロジェニクス，インコーポレーテッド 変異型ｃｄ３結合ドメイン、及び疾患の治療のための併用療法におけるその使用
WO2020072761A1 (en) * 2018-10-05 2020-04-09 The Regents Of The University Of Michigan Compositions and methods for treating cancer

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101213445B1 (ko) 2011-01-13 2012-12-18 강원대학교산학협력단 백혈구의 혈관외유출 억제 활성 및 암세포의 전이 억제 활성을 갖는 펩타이드를 포함하는 약학 조성물

Also Published As

Publication number Publication date
AU2003225294A1 (en) 2003-11-17
WO2003093443A2 (en) 2003-11-13
WO2003093443A3 (en) 2004-11-18
EP1501544A4 (en) 2006-06-21
CA2483912A1 (en) 2003-11-13
EP1501544A2 (en) 2005-02-02
CN1662254A (zh) 2005-08-31
US20040048319A1 (en) 2004-03-11

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