JP2005521489A - 連結電極による循環系反射制御用デバイスおよび方法 - Google Patents
連結電極による循環系反射制御用デバイスおよび方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
- A61N1/0556—Cuff electrodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36114—Cardiac control, e.g. by vagal stimulation
- A61N1/36117—Cardiac control, e.g. by vagal stimulation for treating hypertension
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37205—Microstimulators, e.g. implantable through a cannula
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
- A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
- A61N1/37223—Circuits for electromagnetic coupling
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Abstract
Description
本発明は全体として、循環障害および腎臓障害の治療および/または管理に使用される医療用デバイスおよび方法に関する。具体的には、本発明は、循環障害、腎臓障害、それらの基礎原因および病態の治療および/または管理のために、圧反射系を制御するためのデバイスおよび方法に関する。
高血圧、心不全、および、それらと関連する循環系・神経系障害に対処するために、本発明は、圧受容器を活性化することによって、血圧、神経系活動および神経ホルモン活動を選択的制御的に調整することを可能とする、いくつかのデバイス、システム、および、方法を提供する。圧受容器を選択的制御的に活性化することによって、本発明は、過度の血圧、交感神経系の活性化および神経ホルモンの活性化を下げ、それによって心臓、血管系およびその他の器官・組織に対するそれらの有害作用を極小のものとする。
下記の詳細な説明は、図面を参照しながら読むべきである。様々な図面で類似の要素は同じ番号が付されている。図面は必ずしも原寸大ではなく、例示の実施形態を描くものであって、本発明の範囲を限定することを意図するものではない。
Claims (27)
- 患者の圧反射系に変化を起こす圧受容器信号を誘発するシステムであって、該システムは、
圧受容器活性化デバイスであって、該圧受容器活性化デバイスの活性化によって圧受容器信号が誘発されるよう圧受容器近傍に設置することが可能な圧受容器活性化デバイス、および、
前記圧受容器活性化デバイスに結合され、プロセッサーとメモリーとを含む制御装置であって、メモリーは活性化を定義するソフトウェアを含み、制御装置は、刺激処方の関数として制御信号を発生し、圧受容器活性化デバイスと制御装置との間の結合は、該デバイスと該制御装置の間の少なくとも1個の無線結合を含むことを特徴とする制御装置、
を含むシステム。 - 前記活性化デバイスは、圧受容器近傍の血管腔に埋設が可能な電極を含むことを特徴とする、請求項1のシステム。
- 前記制御装置は、血管内の圧受容器部位に近接する静脈に埋設可能な送信アンテナを含み、前記アンテナは、電極構造体と無線でつながれる信号を送信し、その構造体の中に電流を生じることを特徴とする、請求項2のシステム。
- 血管受容器を活性化するシステムであって、該システムは、
血管外送信器、および、
血管腔内に埋設可能な電極構造体であって、血管外送信器から送信される信号を受信し、かつ、前記血管受容器を活性化する電流を発生するようになっている電極構造体、
を含むシステム。 - 前記血管外送信器は誘導コイルを含むことを特徴とする、請求項4のシステム。
- 前記血管外送信器は電磁送信器を含むことを特徴とする、請求項4のシステム。
- 前記血管外送信器はマイクロウェーブ送信器を含むことを特徴とする、請求項4のシステム。
- 前記血管外送信器は患者の体の中に埋め込まれるようになっている、請求項4のシステム。
- 前記送信器は、血管中の標的受容器に近接する血管腔内に埋設されるようになっていることを特徴とする、請求項8のシステム。
- 前記送信器はアンテナおよびケーブルを含み、ケーブルは静脈の腔内に配置されるようになっている、請求項9のシステム。
- 血管外送信器につながれる制御信号を発生する駆動手段を有する制御装置をさらに含むことを特徴とする、請求項4のシステム。
- 前記制御装置が埋設可能であることを特徴とする、請求項11のシステム。
- 制御装置を血管外送信器に接続するケーブルをさらに含むことを特徴とする、請求項12のシステム。
- 前記送信器は、前記埋設可能な制御装置に組み込まれることを特徴とする、請求項12のシステム。
- 前記血管外送信器は、電極構造体が埋設された動脈部位に近接する静脈に埋設されるよう適応しており、前記ケーブルは、制御装置と送信器間の静脈腔内に設置されるよう適応していることを特徴とする、請求項14のシステム。
- 前記電極構造体は、血管内を潰れた状態で配送され、かつ、拡張されて標的受容器近傍の血管内に埋設されることが可能なステント様構造体を含むことを特徴とする、請求項4のシステム。
- 前記電極構造体は、送信器からのEM送信によって励起が可能な導電性金属を含むことを特徴とする、請求項4のシステム。
- 前記導電性金属は絶縁されていることを特徴とする、請求項17のシステム。
- 前記電極構造体は受信コイルを含むことを特徴とする、請求項4のシステム。
- 前記電極構造体は、受信コイルに接続される複数の電極パッドを含むことを特徴とする、請求項19のシステム。
- 頚動脈内の圧受容器を活性化するためのシステムであって、該システムは、
圧受容器に近接する頚動脈内に埋め込みが可能な電極構造体、および、
前記頚動脈に近接する頚静脈内に埋め込みが可能な送信器
を含むことを特徴とするシステム。 - 前記電極構造体は受信コイルを含み、前記送信器は送信コイルを含むことを特徴とする、請求項21のシステム。
- 前記システムはEM制御信号を発生する制御装置およびリードをさらに含み、前記制御装置は埋設可能であり、前記リードは、静脈を通じて遠隔進入部位を介して、送信器を制御装置に接続するようになっていることを特徴とする、請求項22のシステム。
- 血管受容器を活性化する方法であって、該方法は、
血管外位置から制御信号を送信することを含み、
制御信号は、血管受容器に向けて血管中に、または、血管上に埋設された電極構造体によって受信され、それによって、制御信号が、電極構造体の中に、受容器を活性化する電流を誘発することになることを特徴とする、方法。 - 前記制御信号は、血管受容器近傍の静脈から送信されることを特徴とする、請求項24の方法。
- 前記制御信号は、動脈受容器から離れて埋め込まれた制御装置によって生成され、制御装置は、静脈腔を通じて、前記動脈受容器近傍の静脈中の送信器に対して結線されていることを特徴とする、請求項25の方法。
- 動脈中に電極構造体を埋設する方法であって、
動脈構造体を動脈の標的位置に血管内において設置すること、
動脈中の電極構造体の近傍位置に、静脈腔を通じて少なくとも1本の電気リードを進めること、および、
前記少なくとも1本の電気的リードを、動脈壁と静脈壁とを貫いて電極構造体に接続すること、
を含むことを特徴とする方法。
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US36822202P | 2002-03-27 | 2002-03-27 | |
PCT/US2003/009764 WO2003082403A2 (en) | 2002-03-27 | 2003-03-27 | Devices and methods for cardiovascular reflex control via coupled electrodes |
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JP2005521489A true JP2005521489A (ja) | 2005-07-21 |
JP2005521489A5 JP2005521489A5 (ja) | 2006-05-18 |
JP4413626B2 JP4413626B2 (ja) | 2010-02-10 |
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JP2003579933A Expired - Lifetime JP4413626B2 (ja) | 2002-03-27 | 2003-03-27 | 連結電極による循環系反射制御用デバイスおよび方法 |
JP2003579629A Expired - Lifetime JP4295627B2 (ja) | 2002-03-27 | 2003-03-27 | 電極構造体および循環系反射の制御におけるその使用方法 |
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JP2007514482A (ja) * | 2003-12-12 | 2007-06-07 | シネコー・エルエルシー | 前置移植外骨格を有する移植可能な医療デバイス |
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Publication number | Publication date |
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JP4295627B2 (ja) | 2009-07-15 |
AU2003220599A8 (en) | 2003-10-13 |
AU2003220574A8 (en) | 2003-10-13 |
EP1487535A4 (en) | 2009-12-02 |
WO2003082403A3 (en) | 2004-01-08 |
EP1487535A2 (en) | 2004-12-22 |
WO2003082080A3 (en) | 2004-02-05 |
JP2005521448A (ja) | 2005-07-21 |
AU2003220599A1 (en) | 2003-10-13 |
EP1487535B1 (en) | 2012-06-20 |
WO2003082403A2 (en) | 2003-10-09 |
EP1487536A4 (en) | 2009-12-02 |
AU2003220574A1 (en) | 2003-10-13 |
WO2003082080A2 (en) | 2003-10-09 |
JP4413626B2 (ja) | 2010-02-10 |
EP1487536A2 (en) | 2004-12-22 |
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