JP2005520780A - Ｄ−ｔｈｒｅｏメチルフェニデートを用いる認識および閉経期の障害の治療方法 - Google Patents
Ｄ−ｔｈｒｅｏメチルフェニデートを用いる認識および閉経期の障害の治療方法 Download PDFInfo
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Classifications
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Analytical Chemistry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/903,803 US6486177B2 (en) | 1995-12-04 | 2001-07-12 | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
| PCT/US2002/022039 WO2003005962A2 (en) | 2001-07-12 | 2002-07-11 | Methods for treatment of cognitive and menopausal disorders with d-threo methylphenidate |
Publications (2)
| Publication Number | Publication Date |
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| JP2005520780A true JP2005520780A (ja) | 2005-07-14 |
| JP2005520780A5 JP2005520780A5 (enExample) | 2006-01-05 |
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Country Status (10)
| Country | Link |
|---|---|
| US (7) | US6486177B2 (enExample) |
| EP (1) | EP1411943A4 (enExample) |
| JP (1) | JP2005520780A (enExample) |
| KR (1) | KR20040029360A (enExample) |
| AU (1) | AU2002318302B2 (enExample) |
| CA (1) | CA2453510C (enExample) |
| IL (1) | IL159313A0 (enExample) |
| MX (1) | MXPA04000249A (enExample) |
| NZ (2) | NZ565754A (enExample) |
| WO (1) | WO2003005962A2 (enExample) |
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| CA2222713C (en) | 1995-07-14 | 2003-04-22 | Andrew John Mcglashan Richards | Composition comprising d-threo-methylphenidate and another drug |
| US6486177B2 (en) * | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
| US5837284A (en) * | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| US5922736A (en) * | 1995-12-04 | 1999-07-13 | Celegene Corporation | Chronic, bolus administration of D-threo methylphenidate |
| US6962997B1 (en) * | 1997-05-22 | 2005-11-08 | Celgene Corporation | Process and intermediates for resolving piperidyl acetamide steroisomers |
| US20020035139A1 (en) * | 2000-06-20 | 2002-03-21 | Herbst Arthur L. | COX-2 inhibitors and the prevention of the side effects of radiation therapy |
| FR2823975B1 (fr) * | 2001-04-27 | 2003-05-30 | Sanofi Synthelabo | Nouvelle utilisation de pyridoindolone |
| EP1680144B1 (en) * | 2003-10-08 | 2011-10-05 | Mallinckrodt LLC | Methylphenidate solution and associated methods of administration and production |
| US20050239830A1 (en) * | 2004-04-26 | 2005-10-27 | Vikram Khetani | Methods of diminishing co-abuse potential |
| JP2008507552A (ja) * | 2004-07-22 | 2008-03-13 | ワイス | 神経系障害および状態の治療方法 |
| JP2008507550A (ja) * | 2004-07-22 | 2008-03-13 | ワイス | 神経系障害及び状態の処置方法 |
| KR20070045278A (ko) * | 2004-07-22 | 2007-05-02 | 와이어쓰 | 신경계 질환 및 장애의 치료 방법 |
| EP1812390A2 (en) * | 2004-10-22 | 2007-08-01 | Mark Froimowitz | Methylphenidate analogs and methods of use thereof |
| US20060127421A1 (en) * | 2004-12-09 | 2006-06-15 | Celgene Corporation | Treatment using D-threo methylphenidate |
| KR101318806B1 (ko) * | 2005-01-20 | 2013-10-16 | 인스티튜트 포 몰리큘러 메디신, 인코포레이티드 | 메틸페니데이트 유도체 및 그 용도 |
| US20060183773A1 (en) * | 2005-01-20 | 2006-08-17 | David Bar-Or | Uses of methylphenidate derivatives |
| US20070021488A1 (en) * | 2005-07-21 | 2007-01-25 | Wyeth | Method for treating nervous system disorders and conditions |
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| WO2009146320A1 (en) | 2008-05-27 | 2009-12-03 | Dmi Life Sciences, Inc. | Therapeutic methods and compounds |
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| US20120238590A1 (en) * | 2010-09-13 | 2012-09-20 | Tenera Therapeutics, LLC Delaware | Compositions for treating cancer-related fatigue and methods of screening thereof |
| US8287903B2 (en) | 2011-02-15 | 2012-10-16 | Tris Pharma Inc | Orally effective methylphenidate extended release powder and aqueous suspension product |
| DK2755498T3 (en) * | 2011-09-15 | 2018-05-22 | Friulchem Spa | COMPOSITION FOR ORAL ADMINISTRATION FOR ANIMALS AND PROCEDURE FOR OBTAINING |
| KR101312286B1 (ko) * | 2012-11-26 | 2013-09-27 | (주)비씨월드제약 | 즉시방출 및 조절방출 특성을 갖고 d-트레오-메틸페니데이트를 포함하는 약학 조성물 |
| US11590228B1 (en) | 2015-09-08 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine compositions |
| US11590081B1 (en) | 2017-09-24 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine tablets |
| US12458592B1 (en) | 2017-09-24 | 2025-11-04 | Tris Pharma, Inc. | Extended release amphetamine tablets |
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| US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| US5908850A (en) | 1995-12-04 | 1999-06-01 | Celgene Corporation | Method of treating attention deficit disorders with d-threo methylphenidate |
| US5733756A (en) | 1996-01-05 | 1998-03-31 | Celgene Corporation | Lactams and processes for stereoselective enrichment of lactams, amides, and esters |
| US6242464B1 (en) * | 1996-01-22 | 2001-06-05 | Chiroscience Limited | Single isomer methylphenidate and resolution process |
| MX9805870A (enExample) | 1996-01-22 | 1999-01-31 | ||
| HUP9901658A3 (en) | 1996-02-02 | 1999-12-28 | Medeva Europ Ltd | Process for the preparation of d-threo-(r,r)-methyl phenidate and recycling of undesired enantiomers by epimerisation |
| GB9604943D0 (en) * | 1996-03-08 | 1996-05-08 | Chiroscience Ltd | Resolution |
| CA2243542C (en) | 1996-03-08 | 2003-02-18 | Medeva Europe Limited | Resolution of threo-methylphenidate |
| GB9606417D0 (en) * | 1996-03-27 | 1996-06-05 | Chiroscience Ltd | Asymmetric cyclisation |
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| ATE252903T1 (de) | 1999-12-17 | 2003-11-15 | Celltech Pharma Europ Ltd | Arzneimittel zur behandlung konvulsivischer zustände |
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| US6359139B1 (en) * | 2000-11-07 | 2002-03-19 | Celgene Corporation | Methods for production of piperidyl acetamide stereoisomers |
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2001
- 2001-07-12 US US09/903,803 patent/US6486177B2/en not_active Expired - Fee Related
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2002
- 2002-07-11 JP JP2003511771A patent/JP2005520780A/ja active Pending
- 2002-07-11 KR KR10-2004-7000312A patent/KR20040029360A/ko not_active Ceased
- 2002-07-11 NZ NZ565754A patent/NZ565754A/en not_active IP Right Cessation
- 2002-07-11 AU AU2002318302A patent/AU2002318302B2/en not_active Ceased
- 2002-07-11 CA CA2453510A patent/CA2453510C/en not_active Expired - Fee Related
- 2002-07-11 MX MXPA04000249A patent/MXPA04000249A/es active IP Right Grant
- 2002-07-11 IL IL15931302A patent/IL159313A0/xx unknown
- 2002-07-11 WO PCT/US2002/022039 patent/WO2003005962A2/en not_active Ceased
- 2002-07-11 NZ NZ530211A patent/NZ530211A/en not_active IP Right Cessation
- 2002-07-11 EP EP02748129A patent/EP1411943A4/en not_active Withdrawn
- 2002-07-16 US US10/195,974 patent/US7115631B2/en not_active Expired - Fee Related
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2004
- 2004-04-08 US US10/820,397 patent/US20040204456A1/en not_active Abandoned
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2006
- 2006-04-11 US US11/402,385 patent/US20060183774A1/en not_active Abandoned
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2009
- 2009-12-17 US US12/640,734 patent/US20100093797A1/en not_active Abandoned
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2011
- 2011-06-30 US US13/172,977 patent/US20110257227A1/en not_active Abandoned
-
2012
- 2012-10-26 US US13/661,472 patent/US20130053414A1/en not_active Abandoned
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|---|---|
| MXPA04000249A (es) | 2004-05-04 |
| US20060183774A1 (en) | 2006-08-17 |
| US20110257227A1 (en) | 2011-10-20 |
| US20100093797A1 (en) | 2010-04-15 |
| WO2003005962A2 (en) | 2003-01-23 |
| CA2453510C (en) | 2012-03-20 |
| CA2453510A1 (en) | 2003-01-23 |
| US20130053414A1 (en) | 2013-02-28 |
| NZ565754A (en) | 2009-05-31 |
| NZ530211A (en) | 2008-04-30 |
| US20020022640A1 (en) | 2002-02-21 |
| IL159313A0 (en) | 2004-06-01 |
| AU2002318302B2 (en) | 2007-03-15 |
| US6486177B2 (en) | 2002-11-26 |
| US20020198234A1 (en) | 2002-12-26 |
| EP1411943A4 (en) | 2005-09-28 |
| WO2003005962A3 (en) | 2003-06-12 |
| US7115631B2 (en) | 2006-10-03 |
| KR20040029360A (ko) | 2004-04-06 |
| EP1411943A2 (en) | 2004-04-28 |
| AU2002318302C1 (en) | 2003-01-29 |
| US20040204456A1 (en) | 2004-10-14 |
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