JP2005519590A5 - - Google Patents

Info

Publication number

JP2005519590A5

JP2005519590A5 JP2003556018A JP2003556018A JP2005519590A5 JP 2005519590 A5 JP2005519590 A5 JP 2005519590A5 JP 2003556018 A JP2003556018 A JP 2003556018A JP 2003556018 A JP2003556018 A JP 2003556018A JP 2005519590 A5 JP2005519590 A5 JP 2005519590A5

Authority

JP

Japan

Prior art keywords

amino acid

acid sequence

polypeptide

seq

antibody

Prior art date

2002-07-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000003275 alpha amino acid group Chemical group 0.000 claims 36
• 229920001184 polypeptide Polymers 0.000 claims 25
• 108090000765 processed proteins & peptides Proteins 0.000 claims 25
• 102000004196 processed proteins & peptides Human genes 0.000 claims 25
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 18
• 239000003814 drug Substances 0.000 claims 15
• 210000004027 cell Anatomy 0.000 claims 11
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
• 238000000034 method Methods 0.000 claims 9
• 150000001875 compounds Chemical class 0.000 claims 8
• 201000010099 disease Diseases 0.000 claims 8
• 241000124008 Mammalia Species 0.000 claims 7
• 239000005557 antagonist Substances 0.000 claims 7
• 239000000523 sample Substances 0.000 claims 7
• 210000001744 T-lymphocyte Anatomy 0.000 claims 6
• 239000000556 agonist Substances 0.000 claims 6
• 238000004519 manufacturing process Methods 0.000 claims 5
• 230000004936 stimulating effect Effects 0.000 claims 5
• 102100037850 Interferon gamma Human genes 0.000 claims 4
• 108010074328 Interferon-gamma Proteins 0.000 claims 4
• 229940079593 drug Drugs 0.000 claims 4
• 230000028993 immune response Effects 0.000 claims 4
• 230000002757 inflammatory effect Effects 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 230000006052 T cell proliferation Effects 0.000 claims 3
• 230000002401 inhibitory effect Effects 0.000 claims 3
• 206010036105 Polyneuropathy Diseases 0.000 claims 2
• 208000026935 allergic disease Diseases 0.000 claims 2
• 239000013068 control sample Substances 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 230000001404 mediated effect Effects 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 230000007824 polyneuropathy Effects 0.000 claims 2
• 230000009257 reactivity Effects 0.000 claims 2
• 208000027930 type IV hypersensitivity disease Diseases 0.000 claims 2
• 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
• 206010050245 Autoimmune thrombocytopenia Diseases 0.000 claims 1
• 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
• 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
• 206010008609 Cholangitis sclerosing Diseases 0.000 claims 1
• 208000016192 Demyelinating disease Diseases 0.000 claims 1
• 206010012438 Dermatitis atopic Diseases 0.000 claims 1
• 206010012442 Dermatitis contact Diseases 0.000 claims 1
• 206010015218 Erythema multiforme Diseases 0.000 claims 1
• 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
• 206010016946 Food allergy Diseases 0.000 claims 1
• 108010068370 Glutens Proteins 0.000 claims 1
• 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
• 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 1
• 208000037319 Hepatitis infectious Diseases 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
• 201000005505 Measles Diseases 0.000 claims 1
• 206010049567 Miller Fisher syndrome Diseases 0.000 claims 1
• 201000002481 Myositis Diseases 0.000 claims 1
• 206010035664 Pneumonia Diseases 0.000 claims 1
• 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
• 208000012287 Prolapse Diseases 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 206010039085 Rhinitis allergic Diseases 0.000 claims 1
• 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
• 208000006045 Spondylarthropathies Diseases 0.000 claims 1
• 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
• 208000004732 Systemic Vasculitis Diseases 0.000 claims 1
• 206010042953 Systemic sclerosis Diseases 0.000 claims 1
• 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 1
• 206010047115 Vasculitis Diseases 0.000 claims 1
• 208000027207 Whipple disease Diseases 0.000 claims 1
• 238000001467 acupuncture Methods 0.000 claims 1
• 201000010105 allergic rhinitis Diseases 0.000 claims 1
• 230000000692 anti-sense effect Effects 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 201000008937 atopic dermatitis Diseases 0.000 claims 1
• 230000001363 autoimmune Effects 0.000 claims 1
• 230000005784 autoimmunity Effects 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 208000019748 bullous skin disease Diseases 0.000 claims 1
• 210000003169 central nervous system Anatomy 0.000 claims 1
• 208000037976 chronic inflammation Diseases 0.000 claims 1
• 230000006020 chronic inflammation Effects 0.000 claims 1
• 230000009918 complex formation Effects 0.000 claims 1
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• 208000010643 digestive system disease Diseases 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 201000009580 eosinophilic pneumonia Diseases 0.000 claims 1
• 235000021312 gluten Nutrition 0.000 claims 1
• 208000024908 graft versus host disease Diseases 0.000 claims 1
• 201000007192 granulomatous hepatitis Diseases 0.000 claims 1
• 208000007475 hemolytic anemia Diseases 0.000 claims 1
• 208000005252 hepatitis A Diseases 0.000 claims 1
• 208000024557 hepatobiliary disease Diseases 0.000 claims 1
• 230000009610 hypersensitivity Effects 0.000 claims 1
• 208000013643 idiopathic inflammatory myopathy Diseases 0.000 claims 1
• 208000026278 immune system disease Diseases 0.000 claims 1
• 230000002458 infectious effect Effects 0.000 claims 1
• 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
• 208000017169 kidney disease Diseases 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 210000001428 peripheral nervous system Anatomy 0.000 claims 1
• 239000008177 pharmaceutical agent Substances 0.000 claims 1
• 230000035755 proliferation Effects 0.000 claims 1
• 230000002685 pulmonary effect Effects 0.000 claims 1
• 201000009732 pulmonary eosinophilia Diseases 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 201000000306 sarcoidosis Diseases 0.000 claims 1
• 208000010157 sclerosing cholangitis Diseases 0.000 claims 1
• 208000017520 skin disease Diseases 0.000 claims 1
• 201000005671 spondyloarthropathy Diseases 0.000 claims 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
• 206010043778 thyroiditis Diseases 0.000 claims 1
• 238000002054 transplantation Methods 0.000 claims 1