JP2005518332A - 細胞表面のプロテアーゼにより活性化される結合体およびその治療的使用 - Google Patents

細胞表面のプロテアーゼにより活性化される結合体およびその治療的使用 Download PDF

Info

Publication number
JP2005518332A
JP2005518332A JP2002592470A JP2002592470A JP2005518332A JP 2005518332 A JP2005518332 A JP 2005518332A JP 2002592470 A JP2002592470 A JP 2002592470A JP 2002592470 A JP2002592470 A JP 2002592470A JP 2005518332 A JP2005518332 A JP 2005518332A
Authority
JP
Japan
Prior art keywords
seq
arg
ser
therapeutic
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2002592470A
Other languages
English (en)
Japanese (ja)
Inventor
エドウィン・エル・マディソン
ジョゼフ・エドワード・センプル
ジョージ・ピー・ブラスク
スコット・ジェフリー・ケンプ
マラレディ・コマンドラ
ダニエル・バナ・シーブ
Original Assignee
デンドレオン コーポレイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by デンドレオン コーポレイション filed Critical デンドレオン コーポレイション
Publication of JP2005518332A publication Critical patent/JP2005518332A/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2002592470A 2001-05-23 2002-05-23 細胞表面のプロテアーゼにより活性化される結合体およびその治療的使用 Withdrawn JP2005518332A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29326701P 2001-05-23 2001-05-23
PCT/US2002/016819 WO2002095007A2 (en) 2001-05-23 2002-05-23 Conjugates activated by cell surface proteases and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
JP2005518332A true JP2005518332A (ja) 2005-06-23

Family

ID=23128397

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002592470A Withdrawn JP2005518332A (ja) 2001-05-23 2002-05-23 細胞表面のプロテアーゼにより活性化される結合体およびその治療的使用

Country Status (5)

Country Link
EP (1) EP1545572A4 (de)
JP (1) JP2005518332A (de)
KR (1) KR20040004642A (de)
CA (1) CA2447023A1 (de)
WO (1) WO2002095007A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012023476A1 (ja) 2010-08-18 2012-02-23 独立行政法人産業技術総合研究所 有機半導体薄膜及び単結晶性有機半導体薄膜の製造方法

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7037667B1 (en) 1998-06-01 2006-05-02 Agensys, Inc. Tumor antigen useful in diagnosis and therapy of prostate and colon cancer
EP1544304A4 (de) * 2002-07-31 2006-05-10 Astellas Pharma Inc Neue serinprotease
WO2005020897A2 (en) 2003-08-22 2005-03-10 Dendreon Corporation Compositions and methods for the treatment of disease associated with trp-p8 expression
US7947436B2 (en) 2004-12-13 2011-05-24 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in the process of bone remodeling
WO2007047995A2 (en) 2005-10-21 2007-04-26 Catalyst Biosciences, Inc. Modified proteases that inhibit complement activation
DK1986622T3 (da) 2006-02-15 2014-01-13 Dendreon Corp Små-molekyle-modulatorer af Trp-p8-aktivitet
US7772266B2 (en) 2006-02-15 2010-08-10 Dendreon Corporation Small-molecule modulators of TRP-P8 activity
KR100906145B1 (ko) * 2006-05-30 2009-07-03 한국생명공학연구원 Tmprss4 억제제를 유효성분으로 포함하는 항암제
KR20140072201A (ko) 2006-07-05 2014-06-12 카탈리스트 바이오사이언시즈, 인코포레이티드 프로테아제 스크리닝 방법 및 이에 의해 확인된 프로테아제
FR2906724B1 (fr) 2006-10-04 2009-03-20 Sanofi Pasteur Sa Methode d'immunisation contre les 4 serotypes de la dengue.
TWI538916B (zh) 2008-04-11 2016-06-21 介控生化科技公司 經修飾的因子vii多肽和其用途
EP2353609A1 (de) 2010-02-04 2011-08-10 Sanofi Pasteur Immunisierungszusammensetzungen und -verfahren
US9869021B2 (en) 2010-05-25 2018-01-16 Aventa Technologies, Inc. Showerhead apparatus for a linear batch chemical vapor deposition system
AR091310A1 (es) 2012-02-16 2015-01-28 Rqx Pharmaceuticals Inc Antibioticos de peptidos lineales
CN104812408A (zh) 2012-07-24 2015-07-29 赛诺菲巴斯德有限公司 用于防止登革热病毒感染的疫苗组合物
EP3932422A1 (de) 2012-07-24 2022-01-05 Sanofi Pasteur Impfstoffzusammensetzungen zur vorbeugung von dengue-virus-infektionen
JP6363600B2 (ja) 2012-07-25 2018-07-25 カタリスト・バイオサイエンシーズ・インコーポレイテッドCatalyst Biosciences, Inc. 修飾第x因子ポリペプチドおよびその使用
BR112015012515B1 (pt) 2012-11-30 2023-04-11 Sanofi Pasteur Uso de antígenos, construções de ácido nucleico ou vetores virais capazes de expressar uma partícula do tipo vírus (vlp) da dengue e de uma vacina contra sarampo, uma vacina contra caxumba e uma vacina contra rubéola
AU2014249003A1 (en) 2013-03-13 2015-10-15 Forma Therapeutics, Inc. Novel compounds and compositions for inhibition of FASN
RS63143B1 (sr) 2016-06-01 2022-05-31 Athira Pharma Inc Jedinjenja
MX2019015402A (es) 2017-06-22 2020-07-20 Catalyst Biosciences Inc Polipeptidos de serina proteasa 1 de tipo membrana modificada (mtsp-1) y metodos de uso.
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
US10793554B2 (en) 2018-10-29 2020-10-06 Forma Therapeutics, Inc. Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone
WO2021030787A1 (en) 2019-08-15 2021-02-18 Catalyst Biosciences, Inc. Modified factor vii polypeptides for subcutaneous administration and on-demand treatment
EP3932935A1 (de) * 2020-06-29 2022-01-05 Centre National de la Recherche Scientifique Antibakterielle peptide
WO2024150172A1 (en) * 2023-01-11 2024-07-18 Bright Peak Therapeutics Ag Cleavable peptides and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972616A (en) * 1998-02-20 1999-10-26 The Board Of Trustees Of The University Of Arkansas TADG-15: an extracellular serine protease overexpressed in breast and ovarian carcinomas
CA2362670A1 (en) * 1999-03-12 2000-09-14 Georgetown University Matriptase, a serine protease and its applications
AU784746B2 (en) * 1999-11-18 2006-06-08 Dendreon Corporation Nucleic acids encoding endotheliases, endotheliases and uses thereof
MXPA02009019A (es) * 2000-03-15 2003-02-12 Du Pont Pharm Co Farmacos antineoplasticos de objetivo, que se desdoblan por la peptidasa y su uso terapeutico.
WO2003000201A2 (en) * 2001-06-25 2003-01-03 Drug Innovation & Design, Incorporated Exponential pattern recognition based cellular targeting, compositions, methods and anticancer applications
WO2003037326A1 (en) * 2001-10-29 2003-05-08 Corvas International, Inc. Solid phase synthesis of chemical libraries
CN101044154A (zh) * 2002-02-14 2007-09-26 威廉·J·鲁特 治疗宿主中切割的嵌合分子
AU2003269880A1 (en) * 2002-05-21 2003-12-22 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 12, the encoded polypeptides and methods based thereon

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012023476A1 (ja) 2010-08-18 2012-02-23 独立行政法人産業技術総合研究所 有機半導体薄膜及び単結晶性有機半導体薄膜の製造方法
US9059407B2 (en) 2010-08-18 2015-06-16 National Institute Of Advanced Industrial Science And Technology Method for manufacturing organic semiconductor thin film and monocryastalline organic semiconductor thin film

Also Published As

Publication number Publication date
EP1545572A4 (de) 2006-04-12
WO2002095007A2 (en) 2002-11-28
EP1545572A2 (de) 2005-06-29
WO2002095007A3 (en) 2005-05-06
CA2447023A1 (en) 2002-11-28
KR20040004642A (ko) 2004-01-13

Similar Documents

Publication Publication Date Title
JP2005518332A (ja) 細胞表面のプロテアーゼにより活性化される結合体およびその治療的使用
US20040001801A1 (en) Conjugates activated by cell surface proteases and therapeutic uses thereof
JP3481948B2 (ja) 新規ペプチド
US5948750A (en) Conjugates useful in the treatment of prostate cancer
US6391305B1 (en) Conjugates useful in the treatment of prostate cancer
JP3607201B2 (ja) Fap活性化抗腫瘍性化合物
US6177404B1 (en) Conjugates useful in the treatment of benign prostatic hyperplasia
AU726434B2 (en) Conjugates useful in the treatment of prostate cancer
EP1144011B1 (de) Prodrugs und verfahren zu deren herstellung
AU715632B2 (en) Conjugates useful in the treatment of prostate cancer
US20040259768A1 (en) Targeted release
JP2003526683A (ja) ペプチダーゼ切断可能な標的抗新生物薬およびそれらの治療への使用
US5998362A (en) Conjugates useful in the treatment of prostate cancer
US20070021350A1 (en) Conjugates useful in the treatment of prostate cancer
US6174858B1 (en) Conjugates useful in the treatment of prostate cancer
US20030232760A1 (en) Conjugates useful in the treatment of prostate cancer
AU7432196A (en) Conjugates useful in the treatment of benign prostatic hyperplasia
US20070129309A1 (en) Conjugates useful in the treatment of prostate cancer
US20020115596A1 (en) Conjugates useful in the treatment of prostate cancer
US20030133927A1 (en) Conjugates useful in the treatment of prostate cancer
US20050119166A1 (en) Conjugates useful in the treatment of prostate cancer
US20040058857A1 (en) Method of treating cancer
AU2002312119A1 (en) Conjugates activated by cell surface proteases and therapeutic uses thereof
AU714288B2 (en) Novel peptides
US20020173451A1 (en) Method of treating cancer

Legal Events

Date Code Title Description
A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20060302