JP2005516979A5 - - Google Patents
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- Publication number
- JP2005516979A5 JP2005516979A5 JP2003565227A JP2003565227A JP2005516979A5 JP 2005516979 A5 JP2005516979 A5 JP 2005516979A5 JP 2003565227 A JP2003565227 A JP 2003565227A JP 2003565227 A JP2003565227 A JP 2003565227A JP 2005516979 A5 JP2005516979 A5 JP 2005516979A5
- Authority
- JP
- Japan
- Prior art keywords
- halogen
- alkyl
- optionally substituted
- cyano
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 30
- 229910052736 halogen Inorganic materials 0.000 claims 28
- 150000002367 halogens Chemical class 0.000 claims 28
- -1 3,4-methylenedioxyphenyl Chemical group 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000004093 cyano group Chemical group *C#N 0.000 claims 19
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 14
- 125000005843 halogen group Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 150000001204 N-oxides Chemical class 0.000 claims 5
- 125000000842 isoxazolyl group Chemical group 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 5
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 229910052801 chlorine Chemical group 0.000 claims 1
- 239000000460 chlorine Chemical group 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35506202P | 2002-02-08 | 2002-02-08 | |
| US41077502P | 2002-09-12 | 2002-09-12 | |
| PCT/US2003/005782 WO2003065789A2 (en) | 2002-02-08 | 2003-02-04 | N-biphenylmethyl aminocycloalkanecarboxamide derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005516979A JP2005516979A (ja) | 2005-06-09 |
| JP2005516979A5 true JP2005516979A5 (https=) | 2006-03-23 |
| JP4069074B2 JP4069074B2 (ja) | 2008-03-26 |
Family
ID=27737482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003565227A Expired - Fee Related JP4069074B2 (ja) | 2002-02-08 | 2003-02-04 | Ｎ−ビフェニルメチルアミノシクロアルカンカルボキサミド誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7091380B2 (https=) |
| EP (1) | EP1476419B1 (https=) |
| JP (1) | JP4069074B2 (https=) |
| AT (1) | ATE316954T1 (https=) |
| AU (1) | AU2003217728B2 (https=) |
| CA (1) | CA2473778A1 (https=) |
| DE (1) | DE60303441T2 (https=) |
| ES (1) | ES2256727T3 (https=) |
| WO (1) | WO2003065789A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI259079B (en) | 2002-02-08 | 2006-08-01 | Merck & Co Inc | N-biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives |
| WO2004019868A2 (en) * | 2002-08-29 | 2004-03-11 | Merck & Co., Inc. | N-biarylmethyl aminocycloalkanecarboxamide derivatives |
| EP1654232A4 (en) * | 2003-08-07 | 2008-11-12 | Merck & Co Inc | SULPHONYL SUBSTITUTED N- (BIARYLMETHYL) AMINOCYCLOPROPANCARBOXYLIC ACID AMIDE |
| ATE423114T1 (de) * | 2004-03-02 | 2009-03-15 | Merck & Co Inc | Aminocyclopropancarbonsäureamidderivate als bradykininantagonisten |
| EP1741444A1 (en) * | 2005-07-05 | 2007-01-10 | Jerini AG | Kinin antagonists for treating bladder dysfunction |
| EP2520561B1 (en) | 2007-06-08 | 2016-02-10 | MannKind Corporation | IRE-1A Inhibitors |
| AR070750A1 (es) | 2007-08-29 | 2010-05-05 | Boehringer Ingelheim Int | Compuestos b1-antagonistas, sus sales farmaceuticamente compatibles, medicamentos que contienen dichos compuestos, uso de los mismos para preparar medicamentos y procedimientoo de preparacion de un medicamento |
| TWI469971B (zh) | 2007-10-26 | 2015-01-21 | Univ California | 二芳基乙內醯脲類化合物 |
| JP5629274B2 (ja) | 2009-02-26 | 2014-11-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ブラジキニンｂ１アンタゴニストとしての化合物 |
| EA019990B1 (ru) * | 2009-06-02 | 2014-07-30 | Бёрингер Ингельхайм Интернациональ Гмбх | ПРОИЗВОДНЫЕ АМИДОВ 6,7-ДИГИДРО-5H-ИМИДАЗО[1,2-a]ИМИДАЗОЛ-3-КАРБОНОВОЙ КИСЛОТЫ |
| US8937073B2 (en) * | 2010-08-20 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists |
| US8592426B2 (en) * | 2011-01-24 | 2013-11-26 | Hoffmann—La Roche Inc. | Aryl-benzocycloalkyl amide derivatives |
| KR101373705B1 (ko) | 2011-08-05 | 2014-03-14 | 동국대학교 산학협력단 | 신규한 바이페닐 유도체 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 포함하는 염증성 질환 또는 자가면역질환의 예방 또는 치료용 약학적 조성물 |
| EP2742030B1 (de) * | 2011-08-11 | 2016-07-27 | Bayer Intellectual Property GmbH | 1,2,4-triazolyl-substituierte ketoenole zum einsatz im pflanzenschutz |
| TWI854164B (zh) * | 2016-02-01 | 2024-09-01 | 美商百歐克斯製藥公司 | 苯并吡唑化合物及其類似物 |
| US12023319B2 (en) | 2016-12-23 | 2024-07-02 | Bayer Pharma Aktiengesellschaft | Carboxylic acid aromatic amides |
| CA3047812A1 (en) | 2016-12-23 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Tetrazole containing compounds |
| JOP20190156B1 (ar) | 2016-12-23 | 2023-09-17 | Bayer Pharma AG | أميدات عطرية لحمض الكربوكسيليك بصفتها مضادات لمستقبلة البراديكينين b1 |
| WO2019090088A1 (en) * | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| TW202545902A (zh) | 2018-10-11 | 2025-12-01 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之前藥調節劑 |
| PL4038052T3 (pl) * | 2019-10-02 | 2024-08-26 | Domain Therapeutics | Antagoniści receptora ep4 prostaglandyny e2 (pge2) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5270317A (en) * | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
| IL99372A0 (en) * | 1990-09-10 | 1992-08-18 | Ciba Geigy Ag | Azacyclic compounds |
| US5208236A (en) * | 1992-09-23 | 1993-05-04 | Schering Corporation | N-(acylaminomethyl)glutaryl amino acids and use |
| DK0655461T3 (da) | 1993-11-16 | 2000-10-02 | Novartis Ag | Cykliske aminosyrederivater med ACE- og NEP-inhiberende aktivitet |
| WO1997011717A1 (en) | 1995-09-27 | 1997-04-03 | Novartis Ag | Treatment of chronic progressive renal failure |
| FR2743562B1 (fr) * | 1996-01-11 | 1998-04-03 | Sanofi Sa | Derives de n-(arylsulfonyl) aminoacides, leur preparation, les compositions pharmaceutiques en contenant |
| US6433185B1 (en) * | 1996-01-11 | 2002-08-13 | Sanofi-Synthelabo | N-(arylsulphonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them |
| JP4350306B2 (ja) | 1998-04-23 | 2009-10-21 | ノバルティス アクチエンゲゼルシャフト | エンドセリン変換酵素のチオール型阻害剤 |
| EP1080104B1 (en) | 1998-04-23 | 2005-02-09 | Novartis AG | Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme |
| US20020052370A1 (en) | 2000-07-06 | 2002-05-02 | Barber Christopher Gordon | Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase |
| DE10036121A1 (de) * | 2000-07-25 | 2002-02-07 | Merck Patent Gmbh | N-Substituierte-1-amino-1,1-dialkyl-carbonsäurederivate |
| TWI259079B (en) * | 2002-02-08 | 2006-08-01 | Merck & Co Inc | N-biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives |
-
2003
- 2003-02-04 US US10/503,502 patent/US7091380B2/en not_active Expired - Lifetime
- 2003-02-04 CA CA002473778A patent/CA2473778A1/en not_active Abandoned
- 2003-02-04 ES ES03713689T patent/ES2256727T3/es not_active Expired - Lifetime
- 2003-02-04 DE DE60303441T patent/DE60303441T2/de not_active Expired - Lifetime
- 2003-02-04 AT AT03713689T patent/ATE316954T1/de not_active IP Right Cessation
- 2003-02-04 AU AU2003217728A patent/AU2003217728B2/en not_active Ceased
- 2003-02-04 JP JP2003565227A patent/JP4069074B2/ja not_active Expired - Fee Related
- 2003-02-04 EP EP03713689A patent/EP1476419B1/en not_active Expired - Lifetime
- 2003-02-04 WO PCT/US2003/005782 patent/WO2003065789A2/en not_active Ceased