JP2005516955A5 - - Google Patents

Info

Publication number

JP2005516955A5

JP2005516955A5 JP2003554683A JP2003554683A JP2005516955A5 JP 2005516955 A5 JP2005516955 A5 JP 2005516955A5 JP 2003554683 A JP2003554683 A JP 2003554683A JP 2003554683 A JP2003554683 A JP 2003554683A JP 2005516955 A5 JP2005516955 A5 JP 2005516955A5

Authority

JP

Japan

Prior art keywords

alkoxy

substituted

alkyl

group

independently selected

Prior art date

2002-12-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000001424 substituent group Chemical group 0.000 claims 20
• 150000001875 compounds Chemical class 0.000 claims 14
• 229910052736 halogen Inorganic materials 0.000 claims 8
• 150000002367 halogens Chemical class 0.000 claims 8
• -1 cyano, amino Chemical group 0.000 claims 7
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
• 229910052799 carbon Inorganic materials 0.000 claims 5
• 125000004432 carbon atom Chemical group C* 0.000 claims 5
• 229910052739 hydrogen Inorganic materials 0.000 claims 5
• 239000001257 hydrogen Substances 0.000 claims 5
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
• 125000000753 cycloalkyl group Chemical group 0.000 claims 4
• XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 4
• 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 4
• 238000004519 manufacturing process Methods 0.000 claims 4
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
• 230000008578 acute process Effects 0.000 claims 3
• 230000006020 chronic inflammation Effects 0.000 claims 3
• 125000004093 cyano group Chemical group *C#N 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
• GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims 3
• 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 claims 3
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
• 125000003545 alkoxy group Chemical group 0.000 claims 2
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
• 229910052794 bromium Inorganic materials 0.000 claims 2
• 229910052801 chlorine Inorganic materials 0.000 claims 2
• 239000000460 chlorine Chemical group 0.000 claims 2
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
• 229910052731 fluorine Inorganic materials 0.000 claims 2
• 239000011737 fluorine Substances 0.000 claims 2
• 125000001153 fluoro group Chemical group F* 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• 235000019260 propionic acid Nutrition 0.000 claims 2
• IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 2
• 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims 2
• YTLYLLTVENPWFT-UPHRSURJSA-N (Z)-3-aminoacrylic acid Chemical compound N\C=C/C(O)=O YTLYLLTVENPWFT-UPHRSURJSA-N 0.000 claims 1
• WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 claims 1
• 125000006091 1,3-dioxolane group Chemical group 0.000 claims 1
• XOTUAMWIFRDGMZ-UHFFFAOYSA-N 2-chloroprop-2-enoyl chloride Chemical compound ClC(=C)C(Cl)=O XOTUAMWIFRDGMZ-UHFFFAOYSA-N 0.000 claims 1
• 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
• 125000000590 4-methylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
• 241001465754 Metazoa Species 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 125000003282 alkyl amino group Chemical group 0.000 claims 1
• 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 1
• 150000001412 amines Chemical group 0.000 claims 1
• 230000003110 anti-inflammatory effect Effects 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 239000012752 auxiliary agent Substances 0.000 claims 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
• PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims 1
• 239000002552 dosage form Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 125000001072 heteroaryl group Chemical group 0.000 claims 1
• 125000001624 naphthyl group Chemical group 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000008569 process Effects 0.000 claims 1
• YYFIGOPUHPDIBO-UHFFFAOYSA-N propanoic acid;hydrochloride Chemical compound Cl.CCC(O)=O YYFIGOPUHPDIBO-UHFFFAOYSA-N 0.000 claims 1
• 238000001308 synthesis method Methods 0.000 claims 1
• 230000002194 synthesizing effect Effects 0.000 claims 1