JP2005511644A5 - - Google Patents
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- Publication number
- JP2005511644A5 JP2005511644A5 JP2003547414A JP2003547414A JP2005511644A5 JP 2005511644 A5 JP2005511644 A5 JP 2005511644A5 JP 2003547414 A JP2003547414 A JP 2003547414A JP 2003547414 A JP2003547414 A JP 2003547414A JP 2005511644 A5 JP2005511644 A5 JP 2005511644A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- dna sequence
- micrometers
- cationic
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 17
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 11
- 229940126575 aminoglycoside Drugs 0.000 claims 8
- 125000002091 cationic group Chemical group 0.000 claims 8
- 239000002245 particle Substances 0.000 claims 7
- 239000000443 aerosol Substances 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 150000002632 lipids Chemical class 0.000 claims 4
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 229930182566 Gentamicin Natural products 0.000 claims 2
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 2
- 229930193140 Neomycin Natural products 0.000 claims 2
- URWAJWIAIPFPJE-UHFFFAOYSA-N Rickamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)CC1N URWAJWIAIPFPJE-UHFFFAOYSA-N 0.000 claims 2
- 238000012387 aerosolization Methods 0.000 claims 2
- 229960004821 amikacin Drugs 0.000 claims 2
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 claims 2
- 230000005494 condensation Effects 0.000 claims 2
- 238000009833 condensation Methods 0.000 claims 2
- 229960002518 gentamicin Drugs 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 229960004927 neomycin Drugs 0.000 claims 2
- ZBGPYVZLYBDXKO-HILBYHGXSA-N netilmycin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@]([C@H](NC)[C@@H](O)CO1)(C)O)NCC)[C@H]1OC(CN)=CC[C@H]1N ZBGPYVZLYBDXKO-HILBYHGXSA-N 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- URWAJWIAIPFPJE-YFMIWBNJSA-N sisomycin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-YFMIWBNJSA-N 0.000 claims 2
- 229960005322 streptomycin Drugs 0.000 claims 2
- 229960000707 tobramycin Drugs 0.000 claims 2
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 1
- 229930192786 Sisomicin Natural products 0.000 claims 1
- 230000003385 bacteriostatic effect Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000002101 lytic effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960000808 netilmicin Drugs 0.000 claims 1
- 230000030648 nucleus localization Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 229960005456 sisomicin Drugs 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/990,181 US20030096774A1 (en) | 2001-11-21 | 2001-11-21 | Compositions of nucleic acids and cationic aminoglycosides and methods of using and preparing the same |
| PCT/US2002/036529 WO2003045965A2 (en) | 2001-11-21 | 2002-11-15 | Compositions of nucleic acids and cationic aminoglycosides and methods of using and preparing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005511644A JP2005511644A (ja) | 2005-04-28 |
| JP2005511644A5 true JP2005511644A5 (enExample) | 2006-03-23 |
Family
ID=25535873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003547414A Pending JP2005511644A (ja) | 2001-11-21 | 2002-11-15 | 核酸およびカチオン性アミノグリコシドの組成物ならびにそれを使用および調製する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20030096774A1 (enExample) |
| EP (1) | EP1453845A4 (enExample) |
| JP (1) | JP2005511644A (enExample) |
| AU (1) | AU2002363928A1 (enExample) |
| CA (1) | CA2467677A1 (enExample) |
| WO (1) | WO2003045965A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| PT1458360E (pt) * | 2001-12-19 | 2011-07-13 | Novartis Ag | Derivados de indole como agonistas do recetor s1p1 |
| JP2005530704A (ja) * | 2002-03-05 | 2005-10-13 | トランセイブ， インク． | 細胞内感染を予防及び治療するための吸入システム |
| US7879351B2 (en) * | 2002-10-29 | 2011-02-01 | Transave, Inc. | High delivery rates for lipid based drug formulations, and methods of treatment thereof |
| US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
| PT1581236E (pt) * | 2002-10-29 | 2013-12-24 | Insmed Inc | Libertação prolongada de anti-infecciosos |
| WO2005060573A2 (en) * | 2003-12-15 | 2005-07-07 | University Of Medicine And Dentistry Of New Jersey | Pna-neamine conjugates and methods for producing and using the same |
| US20080226605A1 (en) * | 2005-05-19 | 2008-09-18 | Dev Priya Arya | Methods and Compositions Facilitating Entry of Compounds Into Cells |
| EP3067047B1 (en) | 2005-12-08 | 2022-04-20 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections |
| CA2885621C (en) * | 2007-03-30 | 2016-01-05 | Hirofumi Takeuchi | Transpulmonary liposome for controlling drug arrival |
| WO2008137717A1 (en) | 2007-05-04 | 2008-11-13 | Transave, Inc. | Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof |
| US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
| US9789194B2 (en) | 2007-11-27 | 2017-10-17 | Rutgers, The State University Of New Jersey | Graft copolymer polyelectrolyte complexes for drug delivery |
| US9271933B2 (en) * | 2007-11-27 | 2016-03-01 | Rutgers, The State University Of New Jersey | Graft copolymer polyelectrolyte complexes for drug delivery |
| US8979797B2 (en) * | 2010-12-16 | 2015-03-17 | Ams Research Corporation | High pressure delivery system and method for treating pelvic disorder using large molecule therapeutics |
| PL2852391T3 (pl) | 2012-05-21 | 2022-04-11 | Insmed Incorporated | Układy do leczenia infekcji płuc |
| US10124066B2 (en) | 2012-11-29 | 2018-11-13 | Insmed Incorporated | Stabilized vancomycin formulations |
| CN103272238B (zh) * | 2013-06-08 | 2015-04-15 | 北京大学 | 基于dna与氨基糖苷类分子复合物的生物材料 |
| LT3466432T (lt) | 2014-05-15 | 2020-12-28 | Insmed Incorporated | Būdai, skirti plaučių netuberkuliozinėms mikobakterinėms infekcijoms gydyti |
| EP3180364B1 (en) * | 2014-08-12 | 2019-07-17 | The Regents of the University of California | Multifunctional membrane-active aminoglycoside-peptide conjugates |
| EP3773505B1 (en) | 2018-03-30 | 2026-04-29 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
| JP7449275B2 (ja) | 2018-05-02 | 2024-03-13 | インスメッド インコーポレイテッド | リポソーム薬物製剤の製造方法 |
| DE102018113243A1 (de) | 2018-06-04 | 2019-12-05 | BIOCHEM Zusatzstoffe Handels- und Produktionsgesellschaft mbH | Verfahren zur Herstellung einer Zusammensetzung enthaltend zumindest eine Metall-Aminosäure-Verbindung sowie Zusammensetzung erhältlich durch ein derartiges Verfahren |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4400375A (en) * | 1981-11-23 | 1983-08-23 | Eli Lilly And Company | Tobramycin-double stranded RNA complex suitable for inducing interferon |
| US5469854A (en) * | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
| US5756353A (en) * | 1991-12-17 | 1998-05-26 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol-and liposome-based delivery |
| WO1994011384A1 (en) * | 1992-11-13 | 1994-05-26 | Immunex Corporation | Novel cytokine designated elk ligand |
| US6015686A (en) * | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
| US6070575A (en) * | 1998-11-16 | 2000-06-06 | Aradigm Corporation | Aerosol-forming porous membrane with certain pore structure |
-
2001
- 2001-11-21 US US09/990,181 patent/US20030096774A1/en not_active Abandoned
-
2002
- 2002-11-15 JP JP2003547414A patent/JP2005511644A/ja active Pending
- 2002-11-15 AU AU2002363928A patent/AU2002363928A1/en not_active Abandoned
- 2002-11-15 EP EP02798441A patent/EP1453845A4/en not_active Withdrawn
- 2002-11-15 WO PCT/US2002/036529 patent/WO2003045965A2/en not_active Ceased
- 2002-11-15 CA CA002467677A patent/CA2467677A1/en not_active Abandoned
-
2004
- 2004-08-20 US US10/923,404 patent/US20050019926A1/en not_active Abandoned
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