JP2005511629A5 - - Google Patents
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- Publication number
- JP2005511629A5 JP2005511629A5 JP2003545267A JP2003545267A JP2005511629A5 JP 2005511629 A5 JP2005511629 A5 JP 2005511629A5 JP 2003545267 A JP2003545267 A JP 2003545267A JP 2003545267 A JP2003545267 A JP 2003545267A JP 2005511629 A5 JP2005511629 A5 JP 2005511629A5
- Authority
- JP
- Japan
- Prior art keywords
- nanoparticles
- pharmaceutical composition
- spray
- composition according
- bioactive agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002105 nanoparticle Substances 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 239000002245 particle Substances 0.000 claims 9
- 239000012867 bioactive agent Substances 0.000 claims 5
- 239000000654 additive Substances 0.000 claims 3
- 230000000996 additive effect Effects 0.000 claims 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- AEUTYOVWOVBAKS-UWVGGRQHSA-N ethambutol Chemical compound CC[C@@H](CO)NCCN[C@@H](CC)CO AEUTYOVWOVBAKS-UWVGGRQHSA-N 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 229960005309 estradiol Drugs 0.000 claims 1
- 229930182833 estradiol Natural products 0.000 claims 1
- 229960000285 ethambutol Drugs 0.000 claims 1
- -1 fatty acid esters Chemical class 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229960005206 pyrazinamide Drugs 0.000 claims 1
- IPEHBUMCGVEMRF-UHFFFAOYSA-N pyrazinecarboxamide Chemical compound NC(=O)C1=CN=CC=N1 IPEHBUMCGVEMRF-UHFFFAOYSA-N 0.000 claims 1
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims 1
- 229960001225 rifampicin Drugs 0.000 claims 1
- 229960002052 salbutamol Drugs 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33170701P | 2001-11-20 | 2001-11-20 | |
| US36566002P | 2002-03-18 | 2002-03-18 | |
| PCT/US2002/037334 WO2003043586A2 (en) | 2001-11-20 | 2002-11-20 | Compositions for sustained action product delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005511629A JP2005511629A (ja) | 2005-04-28 |
| JP2005511629A5 true JP2005511629A5 (enExample) | 2005-12-22 |
Family
ID=26987876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003545267A Pending JP2005511629A (ja) | 2001-11-20 | 2002-11-20 | 持続作用生成物送達用組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20030166509A1 (enExample) |
| EP (1) | EP1458361A4 (enExample) |
| JP (1) | JP2005511629A (enExample) |
| AU (1) | AU2002364701B8 (enExample) |
| CA (1) | CA2465779A1 (enExample) |
| WO (1) | WO2003043586A2 (enExample) |
Families Citing this family (76)
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| US20060171899A1 (en) * | 1998-12-10 | 2006-08-03 | Akwete Adjei | Water-stabilized aerosol formulation system and method of making |
| WO2003000226A2 (en) * | 2001-06-22 | 2003-01-03 | Pfizer Products Inc. | Pharmaceutical compositions containing polymer and drug assemblies |
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| JP5115951B2 (ja) | 2006-03-17 | 2013-01-09 | 学校法人東京理科大学 | ナノコンポジット粒子 |
| CN101415405A (zh) * | 2006-04-04 | 2009-04-22 | Stc.Unm公司 | 用于药物递送的可溶胀颗粒 |
| HUE068406T2 (hu) | 2006-06-23 | 2024-12-28 | Janssen Sciences Ireland Unlimited Co | A TMC278 vizes szuszpenziója |
| AR065720A1 (es) | 2007-03-14 | 2009-06-24 | Tibotec Pharm Ltd | Polvos para reconstitucion que comprenden rilpivirina dispersos en ciertos polimeros. uso. proceso. |
| WO2008135855A2 (en) | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer |
| WO2008135828A2 (en) | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
| EP2162120B1 (en) | 2007-06-04 | 2016-05-04 | Bend Research, Inc | Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer |
| US9545384B2 (en) | 2007-06-04 | 2017-01-17 | Bend Research, Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate |
| EP2050437A1 (en) * | 2007-10-15 | 2009-04-22 | Laboratoires SMB | Improved pharmaceutical dry powder compositions for inhalation. |
| WO2009073215A1 (en) | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
| EP2240162A4 (en) | 2007-12-06 | 2013-10-09 | Bend Res Inc | NANOTE PARTICLES WITH A NON-IONIZABLE POLYMER AND AN AMIN-FUNCTIONALIZED METHACRYLATE COPOLYMER |
| IL188647A0 (en) * | 2008-01-08 | 2008-11-03 | Orina Gribova | Adaptable structured drug and supplements administration system (for oral and/or transdermal applications) |
| US8697098B2 (en) | 2011-02-25 | 2014-04-15 | South Dakota State University | Polymer conjugated protein micelles |
| EP2411137B1 (en) | 2009-03-27 | 2016-09-07 | Bend Research, Inc. | Spray-drying process |
| WO2011057235A2 (en) * | 2009-11-09 | 2011-05-12 | Virginia Commonwealth University | Improved delivery of submicrometer and nonometer aerosols to the lungs using hygroscopic excipients or dual stream nasal delivery |
| EP2611530B1 (en) | 2010-09-03 | 2019-01-16 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
| US8815294B2 (en) | 2010-09-03 | 2014-08-26 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives and a carrier material |
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| EP2618924A1 (en) | 2010-09-24 | 2013-07-31 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
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| KR101952599B1 (ko) | 2011-02-25 | 2019-05-22 | 사우스다코타주립대학 | 고분자 컨쥬게이트화된 단백질 마이셀 |
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| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| KR20250052503A (ko) | 2012-06-21 | 2025-04-18 | 노쓰웨스턴유니버시티 | 펩티드 접합된 입자 |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| HK1220368A1 (zh) | 2013-03-13 | 2017-05-05 | Cour Pharmaceuticals Development Company | 用於治疗炎症的免疫修饰性颗粒 |
| JP6553033B2 (ja) | 2013-08-13 | 2019-07-31 | ノースウェスタン ユニバーシティ | ペプチドコンジュゲート粒子 |
| JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | 天然の併用ホルモン補充療法剤及び療法 |
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| MA40910A (fr) | 2014-11-07 | 2017-09-12 | Civitas Therapeutics Inc | Poudres de rapamycine pour administration pulmonaire |
| JP2018507916A (ja) * | 2015-03-11 | 2018-03-22 | ベフファル アタ | エクソソーム送達技術 |
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| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
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| BR112018069628A2 (pt) | 2016-04-04 | 2019-02-12 | Crititech, Inc. | métodos para tratamento de tumor sólido |
| SG11201909840TA (en) | 2017-06-09 | 2019-11-28 | Crititech Inc | Treatment of epithelial cysts by intracystic injection of antineoplastic particles |
| KR102303762B1 (ko) | 2017-06-14 | 2021-09-23 | 크리티테크, 인크. | 폐 장애의 치료 방법 |
| WO2019070850A1 (en) | 2017-10-03 | 2019-04-11 | Crititech, Inc. | LOCAL ADMINISTRATION OF ANINEOPLASTIC PARTICLES IN COMBINATION WITH SYSTEMIC DELIVERY OF IMMUNOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER |
| GB201807286D0 (en) | 2018-05-03 | 2018-06-20 | Dalsgaard Carl Johan | New use |
| GB201818164D0 (en) | 2018-11-07 | 2018-12-19 | Vicore Pharma Ab | New composition |
| GB201916130D0 (en) | 2019-11-06 | 2019-12-18 | Vicore Pharma Ab | New compositions |
| GB201916121D0 (en) | 2019-11-06 | 2019-12-18 | Vicore Pharma Ab | New compositions |
| GB201916117D0 (en) | 2019-11-06 | 2019-12-18 | Vicore Pharma Ab | New compositions |
| GB201916122D0 (en) | 2019-11-06 | 2019-12-18 | Nanologica Ab | New compositions |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| WO2021235425A1 (ja) * | 2020-05-20 | 2021-11-25 | 株式会社リコー | 脂質ナノ粒子を含有する粒子及びその製造方法 |
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| US6586008B1 (en) * | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
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| US6579519B2 (en) * | 2000-09-18 | 2003-06-17 | Registrar, University Of Delhi | Sustained release and long residing ophthalmic formulation and the process of preparing the same |
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-
2002
- 2002-11-20 EP EP02803701A patent/EP1458361A4/en not_active Withdrawn
- 2002-11-20 JP JP2003545267A patent/JP2005511629A/ja active Pending
- 2002-11-20 CA CA002465779A patent/CA2465779A1/en not_active Abandoned
- 2002-11-20 WO PCT/US2002/037334 patent/WO2003043586A2/en not_active Ceased
- 2002-11-20 AU AU2002364701A patent/AU2002364701B8/en not_active Ceased
- 2002-11-20 US US10/300,070 patent/US20030166509A1/en not_active Abandoned
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