JP2005508382A5 - - Google Patents
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- Publication number
- JP2005508382A5 JP2005508382A5 JP2003542147A JP2003542147A JP2005508382A5 JP 2005508382 A5 JP2005508382 A5 JP 2005508382A5 JP 2003542147 A JP2003542147 A JP 2003542147A JP 2003542147 A JP2003542147 A JP 2003542147A JP 2005508382 A5 JP2005508382 A5 JP 2005508382A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- acid amide
- anthranilic acid
- tautomer
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical compound NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 claims 24
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 150000001204 N-oxides Chemical class 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 13
- 239000011780 sodium chloride Substances 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000003342 alkenyl group Chemical group 0.000 claims 9
- 125000000304 alkynyl group Chemical group 0.000 claims 9
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 9
- WKBOTKDWSSQWDR-UHFFFAOYSA-N bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 9
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 6
- 229910052740 iodine Inorganic materials 0.000 claims 6
- 239000011630 iodine Substances 0.000 claims 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- -1 perfluoro Chemical group 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 3
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 claims 3
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 claims 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- OAEMTEMEJOQHES-UHFFFAOYSA-N 2-amino-N-[3-(trifluoromethyl)phenyl]benzamide Chemical compound NC1=CC=CC=C1C(=O)NC1=CC=CC(C(F)(F)F)=C1 OAEMTEMEJOQHES-UHFFFAOYSA-N 0.000 claims 1
- UOMBFRPWZLSXSD-PVOKDAACSA-N N-[4-[(Z)-prop-1-enyl]-3-(trifluoromethyl)phenyl]-2-(pyridin-4-ylmethylamino)benzamide;hydrochloride Chemical compound Cl.C1=C(C(F)(F)F)C(\C=C/C)=CC=C1NC(=O)C1=CC=CC=C1NCC1=CC=NC=C1 UOMBFRPWZLSXSD-PVOKDAACSA-N 0.000 claims 1
- IWMFVYFWYIUTES-UHFFFAOYSA-N N-[4-bromo-3-(trifluoromethyl)phenyl]-2-(pyridin-4-ylmethylamino)benzamide Chemical compound C1=C(Br)C(C(F)(F)F)=CC(NC(=O)C=2C(=CC=CC=2)NCC=2C=CN=CC=2)=C1 IWMFVYFWYIUTES-UHFFFAOYSA-N 0.000 claims 1
- ANNJRRWDKJXWBM-UHFFFAOYSA-N N-[4-propyl-3-(trifluoromethyl)phenyl]-2-(pyridin-4-ylmethylamino)benzamide Chemical compound C1=C(C(F)(F)F)C(CCC)=CC=C1NC(=O)C1=CC=CC=C1NCC1=CC=NC=C1 ANNJRRWDKJXWBM-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000001728 carbonyl compounds Chemical class 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 239000003638 reducing agent Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0126901.8A GB0126901D0 (en) | 2001-11-08 | 2001-11-08 | Organic compounds |
| GBGB0212917.9A GB0212917D0 (en) | 2001-11-08 | 2002-06-05 | Organic compounds |
| PCT/EP2002/012445 WO2003040101A1 (en) | 2001-11-08 | 2002-11-07 | Anthranilic acid amides and pharmaceutical use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005508382A JP2005508382A (ja) | 2005-03-31 |
| JP2005508382A5 true JP2005508382A5 (US07585860-20090908-C00112.png) | 2005-11-17 |
| JP4179989B2 JP4179989B2 (ja) | 2008-11-12 |
Family
ID=26246753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003542147A Expired - Fee Related JP4179989B2 (ja) | 2001-11-08 | 2002-11-07 | アントラニル酸アミド類およびその医薬的使用 |
Country Status (25)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7307088B2 (en) * | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
| GB0229022D0 (en) * | 2002-12-12 | 2003-01-15 | Novartis Ag | Organic Compounds |
| UA89035C2 (ru) | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Эфиры гидроксамовых кислот и их фармацевтическое применение |
| DK1714958T3 (en) | 2004-01-28 | 2017-03-20 | Mitsui Chemicals Agro Inc | Amide derivatives, process for their preparation and process for their use as insecticide |
| DE102004009238A1 (de) * | 2004-02-26 | 2005-09-08 | Merck Patent Gmbh | Arylamid-Derivate |
| JPWO2006070878A1 (ja) * | 2004-12-28 | 2008-06-12 | アステラス製薬株式会社 | カルボン酸誘導体またはその塩 |
| EP2145873A1 (fr) * | 2008-06-17 | 2010-01-20 | Commissariat A L'energie Atomique | Nouveaux composés ayant une activité protectrice vis-à-vis de l'action de toxines et de virus au mode d'action intracellulaire |
| ES2445517T3 (es) | 2008-08-27 | 2014-03-03 | Leo Pharma A/S | Derivados de piridina como inhibidores de receptor VEGFR-2 y proteína tirosina cinasa |
| JP2011057661A (ja) * | 2009-08-14 | 2011-03-24 | Bayer Cropscience Ag | 殺虫性カルボキサミド類 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3226394A (en) * | 1964-06-16 | 1965-12-28 | Shulton Inc | Pyridylethylated anthranilamides and derivatives thereof |
| WO1998014449A1 (en) | 1996-10-02 | 1998-04-09 | Novartis Ag | Fused pyrazole derivatives and processes for their preparation |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
-
2001
- 2001-11-08 GB GBGB0126901.8A patent/GB0126901D0/en not_active Ceased
-
2002
- 2002-06-05 GB GBGB0212917.9A patent/GB0212917D0/en not_active Ceased
- 2002-11-06 PE PE2002001081A patent/PE20030540A1/es not_active Application Discontinuation
- 2002-11-06 AR ARP020104236A patent/AR037261A1/es not_active Application Discontinuation
- 2002-11-06 TW TW091132668A patent/TWI260985B/zh active
- 2002-11-07 US US10/494,222 patent/US7067543B2/en not_active Expired - Fee Related
- 2002-11-07 MX MXPA04004390A patent/MXPA04004390A/es active IP Right Grant
- 2002-11-07 JP JP2003542147A patent/JP4179989B2/ja not_active Expired - Fee Related
- 2002-11-07 KR KR1020047007000A patent/KR100633814B1/ko not_active IP Right Cessation
- 2002-11-07 EP EP10180423A patent/EP2269988B1/en not_active Expired - Lifetime
- 2002-11-07 PL PL02368417A patent/PL368417A1/xx not_active Application Discontinuation
- 2002-11-07 NZ NZ532587A patent/NZ532587A/en not_active IP Right Cessation
- 2002-11-07 CA CA2462390A patent/CA2462390C/en not_active Expired - Fee Related
- 2002-11-07 EP EP02779536A patent/EP1446381B1/en not_active Expired - Lifetime
- 2002-11-07 RU RU2004117548/04A patent/RU2315756C2/ru not_active IP Right Cessation
- 2002-11-07 IL IL16116302A patent/IL161163A0/xx unknown
- 2002-11-07 PT PT02779536T patent/PT1446381E/pt unknown
- 2002-11-07 AT AT02779536T patent/ATE494278T1/de active
- 2002-11-07 DE DE60238856T patent/DE60238856D1/de not_active Expired - Lifetime
- 2002-11-07 CN CNB028214307A patent/CN100467450C/zh not_active Expired - Fee Related
- 2002-11-07 AU AU2002342889A patent/AU2002342889B2/en not_active Ceased
- 2002-11-07 BR BR0213939-1A patent/BR0213939A/pt not_active IP Right Cessation
- 2002-11-07 RS YUP-294/04A patent/RS29404A/sr unknown
- 2002-11-07 WO PCT/EP2002/012445 patent/WO2003040101A1/en active IP Right Grant
- 2002-11-07 MY MYPI20024160A patent/MY136322A/en unknown
-
2004
- 2004-05-07 HR HR20040412A patent/HRP20040412A2/hr not_active Application Discontinuation
- 2004-05-25 NO NO20042137A patent/NO326986B1/no not_active IP Right Cessation
