JP2005508282A - 新規な脈管形成抑制剤としてのリポキシン類似物 - Google Patents

新規な脈管形成抑制剤としてのリポキシン類似物 Download PDF

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Publication number
JP2005508282A
JP2005508282A JP2002569237A JP2002569237A JP2005508282A JP 2005508282 A JP2005508282 A JP 2005508282A JP 2002569237 A JP2002569237 A JP 2002569237A JP 2002569237 A JP2002569237 A JP 2002569237A JP 2005508282 A JP2005508282 A JP 2005508282A
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lxb
epi
carbon atoms
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lipoxin
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JP2002569237A
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Japanese (ja)
Inventor
サーハン,チヤールズ・エヌ
フイエロ,イオランダ・エム
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ザ・ブリガム・アンド・ウイメンズ・ホスピタル
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203Retinoic acids ; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2002569237A 2001-03-02 2002-03-01 新規な脈管形成抑制剤としてのリポキシン類似物 Withdrawn JP2005508282A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27293101P 2001-03-02 2001-03-02
PCT/US2002/006404 WO2002070068A2 (en) 2001-03-02 2002-03-01 Lipoxin analogs as novel inhibitors of angiogenesis
US10/086,609 US6627658B2 (en) 2001-03-02 2002-03-01 Lipoxin analogs as novel inhibitors of angiogenesis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009256184A Division JP5302856B2 (ja) 2001-03-02 2009-11-09 新規な脈管形成抑制剤としてのリポキシン類似物

Publications (1)

Publication Number Publication Date
JP2005508282A true JP2005508282A (ja) 2005-03-31

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
JP2002569237A Withdrawn JP2005508282A (ja) 2001-03-02 2002-03-01 新規な脈管形成抑制剤としてのリポキシン類似物
JP2009256184A Expired - Fee Related JP5302856B2 (ja) 2001-03-02 2009-11-09 新規な脈管形成抑制剤としてのリポキシン類似物
JP2012195046A Ceased JP2012255025A (ja) 2001-03-02 2012-09-05 新規な脈管形成抑制剤としてのリポキシン類似物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2009256184A Expired - Fee Related JP5302856B2 (ja) 2001-03-02 2009-11-09 新規な脈管形成抑制剤としてのリポキシン類似物
JP2012195046A Ceased JP2012255025A (ja) 2001-03-02 2012-09-05 新規な脈管形成抑制剤としてのリポキシン類似物

Country Status (11)

Country Link
US (4) US6627658B2 (OSRAM)
EP (2) EP1406698B1 (OSRAM)
JP (3) JP2005508282A (OSRAM)
AT (1) ATE412448T1 (OSRAM)
AU (1) AU2002252175A1 (OSRAM)
CY (1) CY1108670T1 (OSRAM)
DE (1) DE60229640D1 (OSRAM)
DK (1) DK1406698T3 (OSRAM)
ES (1) ES2316553T3 (OSRAM)
PT (1) PT1406698E (OSRAM)
WO (1) WO2002070068A2 (OSRAM)

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* Cited by examiner, † Cited by third party
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CN1202068C (zh) 2000-02-16 2005-05-18 布里格姆及妇女医院股份有限公司 阿司匹林触发的脂质介体
AU2001249329A1 (en) 2000-03-20 2001-10-03 Brigham And Women's Hospital Lipoxin analogs and methods for the treatment of periodontal disease
US8722654B2 (en) 2001-03-02 2014-05-13 The Brigham And Women's Hospital, Inc. Lipoxin analogs as novel inhibitors of angiogenesis
US6627658B2 (en) * 2001-03-02 2003-09-30 The Brigham And Women's Hospital Lipoxin analogs as novel inhibitors of angiogenesis
US8481772B2 (en) 2002-04-01 2013-07-09 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
US7902257B2 (en) * 2002-04-01 2011-03-08 University Of Southern California Trihydroxy polyunsaturated eicosanoid
US7759395B2 (en) * 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
EP3584235A3 (en) * 2002-08-12 2020-04-22 Brigham and Women's Hospital Resolvins: biotemplates for novel therapeutic interventions
WO2004078143A2 (en) * 2003-03-05 2004-09-16 The Brigham And Women's Hospital Inc. Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs
WO2005105025A1 (en) * 2004-04-14 2005-11-10 Boston University Methods and compositions for preventing or treating periodontal diseases
PL1809270T3 (pl) * 2004-11-09 2010-08-31 Alcon Inc Kwas 5,6,7-trihydroksyheptanowy i jego analogi do leczenia chorób oczu i chorób związanych z odpowiedziami hiperproliferacyjnymi i angiogenicznymi
WO2007041440A2 (en) 2005-10-03 2007-04-12 The Brigham And Women's Hospital, Inc. Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers
EP1954291A1 (en) 2005-11-18 2008-08-13 Trustees Of Boston University Treatment and prevention of bone loss using resolvins
CA2650607A1 (en) * 2006-04-28 2007-11-08 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treatment of cardiovascular disease
AU2007275658B2 (en) * 2006-07-19 2011-09-01 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treatment of mucositis
EP2131833A2 (en) * 2006-10-26 2009-12-16 Resolvyx Pharmaceuticals, Inc. Use of resolvins for inhibition of bone loss
US20080161275A1 (en) * 2006-12-05 2008-07-03 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treatment of inflammatory disease
CN101778568A (zh) * 2007-08-08 2010-07-14 巴斯夫欧洲公司 含有有机杀虫剂化合物的含水微乳液
US20090137527A1 (en) * 2007-09-14 2009-05-28 Resolvyx Pharmaceuticals, Inc. Compositions and methods for modulating immune function
US20090118243A1 (en) * 2007-10-12 2009-05-07 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treatment of ophthalmic conditions
CA2712970A1 (en) * 2007-10-29 2009-05-07 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Lipoxin a4 protection for retinal cells
US7601693B2 (en) * 2008-02-05 2009-10-13 National Taiwan University Composition for treating cancer and use thereof
US20100105772A1 (en) * 2008-04-25 2010-04-29 Serhan Charles N Use of novel lipid mediators to inhibit angiogenesis
EP2958561B1 (en) * 2013-02-22 2019-12-11 University Of Southern California Lipoxin analogs for use in the treatment of ophthalmic diseases and disorders
JP2016509863A (ja) * 2013-03-15 2016-04-04 ラーソン、マルクス カーレ、トールレイフLARSSON, Marcus Kare, Torleif 細胞、臍帯血収集のための方法及び装置、並びに細胞の単離のための方法及び装置
EP3020398A1 (en) * 2014-11-17 2016-05-18 Nitto Denko Corporation Compounds and formulations for reducing scarring
JP6906047B2 (ja) 2016-06-03 2021-07-21 テティス・ファーマシューティカルズ・エルエルシー 特異的炎症収束性メディエーターの塩に関連する組成物及び方法
US11542473B2 (en) 2016-10-21 2023-01-03 Amniotics Ab Methods and compositions for generating hematopoietic cells
WO2018144316A1 (en) 2017-01-31 2018-08-09 The Brigham And Women's Hospital, Inc. Alx receptor ligands define a biochemical endotype for inflammation-based diseases
CA3055093A1 (en) * 2017-03-09 2018-09-13 University Health Network Lipoxin and lipoxin analogue mediated neuroprotection and treatments
EP3986358A4 (en) 2019-06-20 2023-06-21 Amniotics AB DEVICE FOR FILTERING FRUIT WATER
EP4234019A3 (en) 2019-10-18 2023-09-13 Amniotics AB Processes and apparatuses for obtaining amniotic mesenchymal stem cells from amniotic fluid and cells derived thereof
US12435308B2 (en) 2020-11-06 2025-10-07 Amniotics Ab Immunomodulation by amniotic fluid mesenchymal stem cells
US20240408229A1 (en) 2022-03-03 2024-12-12 Thetis Pharmaceuticals Llc Cyclodextrin complexes of specialized proresolving mediators

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US4560514A (en) 1984-05-04 1985-12-24 Bengt Samuelsson Inflammatory lipoxin A and anti-anflammatory lipoxin B compounds
US4576758A (en) 1984-06-01 1986-03-18 The Upjohn Company Anti-inflammatory lipoxin B analogs
US4780281A (en) 1985-06-14 1988-10-25 Wayne State University Method for assay of peroxidase enzyme or reducing substrate activity
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CA2747376A1 (en) * 1999-03-18 2000-09-21 Brigham And Women's Hospital Use of lipoxin compounds for inhibiting of tnf-(alpha) initiated neutrophil response
CN1202068C (zh) * 2000-02-16 2005-05-18 布里格姆及妇女医院股份有限公司 阿司匹林触发的脂质介体
AU2001249329A1 (en) 2000-03-20 2001-10-03 Brigham And Women's Hospital Lipoxin analogs and methods for the treatment of periodontal disease
US6627658B2 (en) 2001-03-02 2003-09-30 The Brigham And Women's Hospital Lipoxin analogs as novel inhibitors of angiogenesis

Also Published As

Publication number Publication date
US8008282B2 (en) 2011-08-30
US6627658B2 (en) 2003-09-30
US20080064749A1 (en) 2008-03-13
WO2002070068A2 (en) 2002-09-12
JP2012255025A (ja) 2012-12-27
US20040053998A1 (en) 2004-03-18
JP5302856B2 (ja) 2013-10-02
US20060009521A1 (en) 2006-01-12
JP2010059183A (ja) 2010-03-18
EP1406698A2 (en) 2004-04-14
WO2002070068A3 (en) 2003-12-31
DE60229640D1 (de) 2008-12-11
DK1406698T3 (da) 2009-02-09
PT1406698E (pt) 2009-01-12
US20020193431A1 (en) 2002-12-19
ES2316553T3 (es) 2009-04-16
CY1108670T1 (el) 2014-04-09
AU2002252175A1 (en) 2002-09-19
ATE412448T1 (de) 2008-11-15
EP1406698B1 (en) 2008-10-29
EP2221089A1 (en) 2010-08-25

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