JP2005507001A5 - - Google Patents
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- Publication number
- JP2005507001A5 JP2005507001A5 JP2003537678A JP2003537678A JP2005507001A5 JP 2005507001 A5 JP2005507001 A5 JP 2005507001A5 JP 2003537678 A JP2003537678 A JP 2003537678A JP 2003537678 A JP2003537678 A JP 2003537678A JP 2005507001 A5 JP2005507001 A5 JP 2005507001A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- composition according
- cancer
- chelate
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 201000009030 Carcinoma Diseases 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 239000003446 ligand Substances 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 230000002285 radioactive effect Effects 0.000 claims description 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 229910021645 metal ion Inorganic materials 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 239000013522 chelant Substances 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000010668 complexation reaction Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35559801P | 2001-10-22 | 2001-10-22 | |
| PCT/US2002/033918 WO2003035114A1 (en) | 2001-10-22 | 2002-10-22 | Radiopharmaceutical agent for the treatment of early stage cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005507001A JP2005507001A (ja) | 2005-03-10 |
| JP2005507001A5 true JP2005507001A5 (https=) | 2006-01-05 |
Family
ID=23398047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003537678A Pending JP2005507001A (ja) | 2001-10-22 | 2002-10-22 | 初期癌の治療用放射線医薬薬剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20030133872A1 (https=) |
| EP (1) | EP1438076B1 (https=) |
| JP (1) | JP2005507001A (https=) |
| AT (1) | ATE329623T1 (https=) |
| DE (1) | DE60212424T2 (https=) |
| WO (1) | WO2003035114A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005049096A2 (en) * | 2003-11-14 | 2005-06-02 | Dow Global Technologies Inc. | Protein and polymer conjugates as chelants with enhanced blood retention |
| US20060210479A1 (en) * | 2004-08-10 | 2006-09-21 | Dow Global Technologies Inc. | Targeting chelants and chelates |
| CN107847618B (zh) * | 2015-07-07 | 2021-07-16 | 五一一制药股份有限公司 | Hbed-二膦酸盐/酯、其放射金属轭合物和它们作为治疗诊断剂的用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3994996A (en) * | 1972-02-11 | 1976-11-30 | Fmc Corporation | Polymeric phosphazenes and process for preparation |
| DE3249091C2 (de) * | 1981-10-05 | 1993-02-25 | Sanwa Shutter Corp | Hochziehbare Jalousie |
| US4454106A (en) * | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
| US5362476A (en) * | 1984-10-18 | 1994-11-08 | Board Of Regents, The University Of Texas System | Alkyl phosphonate polyazamacrocyclic cheates for MRI |
| US4779930A (en) * | 1987-09-17 | 1988-10-25 | Rosen Steven B | Infant head support for use with infant retaining devices |
| US5739294A (en) * | 1991-12-10 | 1998-04-14 | The Dow Chemical Company | Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents |
| US5428139A (en) * | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
| US5714604A (en) * | 1993-05-06 | 1998-02-03 | The Dow Chemical Company | Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives |
| CA2251924C (en) * | 1996-04-19 | 2006-05-30 | The Dow Chemical Company | Fluorescent chelates as visual tissue specific imaging agents |
| US6670456B2 (en) * | 2001-02-28 | 2003-12-30 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
| EP1429783A4 (en) * | 2001-09-04 | 2006-08-09 | Univ Texas Tech | VERSATILE CHELTS FOR MULTIMODAL PICTURE SETTING |
-
2002
- 2002-10-22 DE DE60212424T patent/DE60212424T2/de not_active Expired - Fee Related
- 2002-10-22 JP JP2003537678A patent/JP2005507001A/ja active Pending
- 2002-10-22 WO PCT/US2002/033918 patent/WO2003035114A1/en not_active Ceased
- 2002-10-22 US US10/278,558 patent/US20030133872A1/en not_active Abandoned
- 2002-10-22 EP EP02789260A patent/EP1438076B1/en not_active Expired - Lifetime
- 2002-10-22 AT AT02789260T patent/ATE329623T1/de not_active IP Right Cessation
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