JP2005506385A5 - - Google Patents
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- JP2005506385A5 JP2005506385A5 JP2003538370A JP2003538370A JP2005506385A5 JP 2005506385 A5 JP2005506385 A5 JP 2005506385A5 JP 2003538370 A JP2003538370 A JP 2003538370A JP 2003538370 A JP2003538370 A JP 2003538370A JP 2005506385 A5 JP2005506385 A5 JP 2005506385A5
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- JP
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- dsrna
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- medicament
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 claims description 22
- 239000002773 nucleotide Substances 0.000 claims description 16
- 125000003729 nucleotide group Chemical group 0.000 claims description 16
- 108700042226 ras Genes Proteins 0.000 claims description 13
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 12
- 230000000295 complement effect Effects 0.000 claims description 9
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims description 8
- 238000009472 formulation Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 238000001802 infusion Methods 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 4
- 101710113436 GTPase KRas Proteins 0.000 claims description 3
- 230000037406 food intake Effects 0.000 claims description 3
- 230000014509 gene expression Effects 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 108020004705 Codon Proteins 0.000 claims 8
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 4
- 229940009098 aspartate Drugs 0.000 claims 4
- 239000003094 microcapsule Substances 0.000 claims 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 235000009697 arginine Nutrition 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 230000006552 constitutive activation Effects 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 230000009368 gene silencing by RNA Effects 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 239000002088 nanocapsule Substances 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920002477 rna polymer Polymers 0.000 claims 2
- 235000004400 serine Nutrition 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- 235000014393 valine Nutrition 0.000 claims 2
- 241000282472 Canis lupus familiaris Species 0.000 claims 1
- 241000255925 Diptera Species 0.000 claims 1
- 101150040459 RAS gene Proteins 0.000 claims 1
- 108020004566 Transfer RNA Proteins 0.000 claims 1
- 210000000234 capsid Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 230000002601 intratumoral effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10155280 | 2001-10-26 | ||
| DE10158411 | 2001-11-29 | ||
| DE10160151A DE10160151A1 (de) | 2001-01-09 | 2001-12-07 | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
| PCT/EP2002/000151 WO2002055692A2 (de) | 2001-01-09 | 2002-01-09 | Verfahren zur hemmung der expression eines zielgens und medikament zur therapie einer tumorerkrankung |
| PCT/EP2002/000152 WO2002055693A2 (de) | 2001-01-09 | 2002-01-09 | Verfahren zur hemmung der expression eines zielgens |
| DE10230996A DE10230996A1 (de) | 2001-10-26 | 2002-07-09 | Medikament zur Behandlung eines Pankreaskarzinoms |
| PCT/EP2002/011968 WO2003035868A1 (de) | 2001-10-26 | 2002-10-25 | Medikament zur erhöhung der wirksamkeit eines rezeptor-vermittelt apoptose in tumorzellen auslösenden arzeimittels |
| PCT/EP2002/011970 WO2003035870A1 (de) | 2001-10-26 | 2002-10-25 | Medikament zur behandlung eines pankreaskarzinoms |
| PCT/EP2002/011971 WO2003035082A1 (de) | 2001-10-26 | 2002-10-25 | Medikament zur hemmung der expression eines zielgens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005506385A JP2005506385A (ja) | 2005-03-03 |
| JP2005506385A5 true JP2005506385A5 (enExample) | 2006-01-05 |
Family
ID=56290351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003538370A Withdrawn JP2005506385A (ja) | 2001-10-26 | 2002-10-25 | 膵臓癌を処置するための医薬 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2005506385A (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2511370B1 (en) * | 2009-12-07 | 2016-09-07 | ARKRAY, Inc. | PROBE FOR DETECTING POLYMORPHISMS IN THE K-ras GENE, AND USE THEREOF |
-
2002
- 2002-10-25 JP JP2003538370A patent/JP2005506385A/ja not_active Withdrawn
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