JP2005506294A5 - - Google Patents
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- Publication number
- JP2005506294A5 JP2005506294A5 JP2002574974A JP2002574974A JP2005506294A5 JP 2005506294 A5 JP2005506294 A5 JP 2005506294A5 JP 2002574974 A JP2002574974 A JP 2002574974A JP 2002574974 A JP2002574974 A JP 2002574974A JP 2005506294 A5 JP2005506294 A5 JP 2005506294A5
- Authority
- JP
- Japan
- Prior art keywords
- tegafur
- use according
- uracil
- administered
- day
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 8
- DHMYGZIEILLVNR-UHFFFAOYSA-N 5-fluoro-1-(oxolan-2-yl)pyrimidine-2,4-dione;1h-pyrimidine-2,4-dione Chemical compound O=C1C=CNC(=O)N1.O=C1NC(=O)C(F)=CN1C1OCCC1 DHMYGZIEILLVNR-UHFFFAOYSA-N 0.000 claims 6
- KVUAALJSMIVURS-ZEDZUCNESA-L calcium folinate Chemical compound [Ca+2].C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)C=C1 KVUAALJSMIVURS-ZEDZUCNESA-L 0.000 claims 6
- WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 claims 6
- 229960001674 tegafur Drugs 0.000 claims 6
- 229930012538 Paclitaxel Natural products 0.000 claims 5
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 5
- 229960004562 carboplatin Drugs 0.000 claims 5
- 229960001592 paclitaxel Drugs 0.000 claims 5
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 5
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims 4
- MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 claims 4
- 235000008191 folinic acid Nutrition 0.000 claims 4
- 239000011672 folinic acid Substances 0.000 claims 4
- 229960001691 leucovorin Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229940035893 uracil Drugs 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 235000008207 calcium folinate Nutrition 0.000 claims 2
- 239000011687 calcium folinate Substances 0.000 claims 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 206010061968 Gastric neoplasm Diseases 0.000 claims 1
- 210000003236 esophagogastric junction Anatomy 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27357701P | 2001-03-06 | 2001-03-06 | |
| PCT/US2002/006262 WO2002076459A1 (en) | 2001-03-06 | 2002-03-04 | Method and dosage form for treating tumors by the administration of tegafur, uracil, folinic acid, paclitaxel and carboplatin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005506294A JP2005506294A (ja) | 2005-03-03 |
| JP2005506294A5 true JP2005506294A5 (https=) | 2005-12-22 |
Family
ID=23044526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002574974A Pending JP2005506294A (ja) | 2001-03-06 | 2002-03-04 | テガフル、ウラシル、フォリン酸、パクリタキセルおよびカルボプラチンの投与による腫瘍の治療方法および剤形 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6770653B2 (https=) |
| EP (1) | EP1368034A1 (https=) |
| JP (1) | JP2005506294A (https=) |
| KR (1) | KR20030081496A (https=) |
| BR (1) | BR0207443A (https=) |
| CA (1) | CA2439676A1 (https=) |
| CZ (1) | CZ20032266A3 (https=) |
| EE (1) | EE200300429A (https=) |
| HR (1) | HRP20030801A2 (https=) |
| HU (1) | HUP0303466A3 (https=) |
| IL (1) | IL157357A0 (https=) |
| IS (1) | IS6925A (https=) |
| MX (1) | MXPA03007989A (https=) |
| NO (1) | NO20033910L (https=) |
| PL (1) | PL363967A1 (https=) |
| RU (1) | RU2284184C2 (https=) |
| SK (1) | SK10602003A3 (https=) |
| WO (1) | WO2002076459A1 (https=) |
| YU (1) | YU69903A (https=) |
| ZA (1) | ZA200306541B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0115162A (pt) * | 2000-11-06 | 2003-10-21 | Pharma Mar Sa | Tratamentos antitumorais eficazes |
| CN1761665A (zh) | 2003-03-14 | 2006-04-19 | 大鹏药品工业株式会社 | 抗肿瘤效果增强剂和抗肿瘤剂 |
| WO2004087105A1 (en) * | 2003-04-02 | 2004-10-14 | Celator Pharmaceuticals, Inc. | Combination formulations of platinum agents and fluoropyrimidines |
| GB0312407D0 (en) * | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
| GB0326486D0 (en) * | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
| AU2004291037A1 (en) * | 2003-11-14 | 2005-06-02 | Pharma Mar, S.A. | Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer |
| KR20050099311A (ko) * | 2004-04-09 | 2005-10-13 | 에이엔에이치 케어연구소(주) | 주사제용 항암제 조성물 |
| EP1827500B1 (en) * | 2004-10-26 | 2009-05-06 | Pharma Mar S.A., Sociedad Unipersonal | Pegylated liposomal doxorubicin in combination with ecteinescidin 743 |
| ATE368461T1 (de) | 2004-10-29 | 2007-08-15 | Pharma Mar Sa | Zusammensetzungen enthaltend ecteinascidin und einen disaccharide |
| KR20070114753A (ko) | 2005-02-18 | 2007-12-04 | 아브락시스 바이오사이언스 인크. | 치료제의 조합 및 투여 방식, 및 조합 요법 |
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| GB0522082D0 (en) * | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
| AU2008202078B2 (en) * | 2007-10-10 | 2012-05-31 | Wellkey Holdings Limited | Stability of secondary metabolite mass production through synchronized plant cell cultures |
| US20100267732A1 (en) * | 2007-10-19 | 2010-10-21 | Pharma Mar, S.A. | Prognostic Molecular Markers for ET-743 Treatment |
| EP3141245A1 (en) | 2010-03-29 | 2017-03-15 | Abraxis BioScience, LLC | Methods of treating cancer |
| MX2012011155A (es) | 2010-03-29 | 2012-12-05 | Abraxis Bioscience Llc | Metodos para mejorar suministros de farmacos y efectividad de agentes terapeuticos. |
| MX347225B (es) | 2010-06-04 | 2017-04-19 | Abraxis Bioscience Llc * | Metodos de tratamiento contra el cancer pancreatico. |
| US20180085377A1 (en) * | 2015-04-22 | 2018-03-29 | Syn-Nat Products Enterprise LLC | Co-crystal composition and its pharmaceutical use |
| IL265044B2 (en) | 2016-08-31 | 2025-02-01 | Fujifilm Corp | An antitumor preparation containing the substances nab-paclitaxel and 1-(2-deoxy-2-fluoro-4-thio-D-beta-arabinofurnosyl)cytosine, a kit containing these substances and their uses |
| RU2646450C1 (ru) * | 2017-05-11 | 2018-03-05 | Владимир Михайлович Курусин | Способ лечения предраковых и ранних стадий раковых заболеваний желудка |
| WO2019146130A1 (ja) | 2018-01-29 | 2019-08-01 | 富士フイルム株式会社 | 胆道がん用抗腫瘍剤および胆道がんの処置方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5A (en) * | 1836-08-10 | Thomas Blanchard | Machine for mortising solid wooden shells of ships' tackle-blocks | |
| US4328229A (en) | 1978-03-29 | 1982-05-04 | Taiho Pharmaceutical Company Limited | Anti-cancer composition for delivering 5-fluorouracil to cancer tissues |
| US5534513A (en) | 1991-09-05 | 1996-07-09 | Taiho Pharmaceutical Company, Ltd. | Antitumor potentiator and antitumor composition |
| FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| RU2194541C1 (ru) * | 2001-07-13 | 2002-12-20 | Научно-исследовательский институт онкологии Томского научного центра СО РАН | Способ комбинированного лечения больных местнораспространенным раком желудка |
-
2002
- 2002-03-04 MX MXPA03007989A patent/MXPA03007989A/es unknown
- 2002-03-04 HR HR20030801A patent/HRP20030801A2/hr not_active Application Discontinuation
- 2002-03-04 CA CA002439676A patent/CA2439676A1/en not_active Abandoned
- 2002-03-04 WO PCT/US2002/006262 patent/WO2002076459A1/en not_active Ceased
- 2002-03-04 RU RU2003129527/14A patent/RU2284184C2/ru not_active IP Right Cessation
- 2002-03-04 EP EP02713715A patent/EP1368034A1/en not_active Withdrawn
- 2002-03-04 EE EEP200300429A patent/EE200300429A/xx unknown
- 2002-03-04 JP JP2002574974A patent/JP2005506294A/ja active Pending
- 2002-03-04 BR BR0207443-5A patent/BR0207443A/pt not_active IP Right Cessation
- 2002-03-04 KR KR10-2003-7011636A patent/KR20030081496A/ko not_active Withdrawn
- 2002-03-04 CZ CZ20032266A patent/CZ20032266A3/cs unknown
- 2002-03-04 US US10/090,354 patent/US6770653B2/en not_active Expired - Fee Related
- 2002-03-04 PL PL02363967A patent/PL363967A1/xx not_active Application Discontinuation
- 2002-03-04 HU HU0303466A patent/HUP0303466A3/hu unknown
- 2002-03-04 IL IL15735702A patent/IL157357A0/xx unknown
- 2002-03-04 SK SK10602003A patent/SK10602003A3/sk not_active Application Discontinuation
- 2002-03-04 YU YU69903A patent/YU69903A/sh unknown
-
2003
- 2003-08-21 ZA ZA200306541A patent/ZA200306541B/xx unknown
- 2003-08-22 IS IS6925A patent/IS6925A/is unknown
- 2003-09-04 NO NO20033910A patent/NO20033910L/no not_active Application Discontinuation
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