ZA200306541B - Method and dosage form for treating tumors by the administration of tegafur, uracil, folinic acid, paclitaxel and carboplatin. - Google Patents
Method and dosage form for treating tumors by the administration of tegafur, uracil, folinic acid, paclitaxel and carboplatin.Info
- Publication number
- ZA200306541B ZA200306541B ZA200306541A ZA200306541A ZA200306541B ZA 200306541 B ZA200306541 B ZA 200306541B ZA 200306541 A ZA200306541 A ZA 200306541A ZA 200306541 A ZA200306541 A ZA 200306541A ZA 200306541 B ZA200306541 B ZA 200306541B
- Authority
- ZA
- South Africa
- Prior art keywords
- tegafur
- carboplatin
- paclitaxel
- uracil
- administration
- Prior art date
Links
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 title 2
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 title 1
- MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 229930012538 Paclitaxel Natural products 0.000 title 1
- 190000008236 carboplatin Chemical compound 0.000 title 1
- 229960004562 carboplatin Drugs 0.000 title 1
- 239000002552 dosage form Substances 0.000 title 1
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 title 1
- 235000008191 folinic acid Nutrition 0.000 title 1
- 239000011672 folinic acid Substances 0.000 title 1
- 229960001691 leucovorin Drugs 0.000 title 1
- 229960001592 paclitaxel Drugs 0.000 title 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title 1
- WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 title 1
- 229960001674 tegafur Drugs 0.000 title 1
- 229940035893 uracil Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27357701P | 2001-03-06 | 2001-03-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200306541B true ZA200306541B (en) | 2004-11-22 |
Family
ID=23044526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200306541A ZA200306541B (en) | 2001-03-06 | 2003-08-21 | Method and dosage form for treating tumors by the administration of tegafur, uracil, folinic acid, paclitaxel and carboplatin. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6770653B2 (https=) |
| EP (1) | EP1368034A1 (https=) |
| JP (1) | JP2005506294A (https=) |
| KR (1) | KR20030081496A (https=) |
| BR (1) | BR0207443A (https=) |
| CA (1) | CA2439676A1 (https=) |
| CZ (1) | CZ20032266A3 (https=) |
| EE (1) | EE200300429A (https=) |
| HR (1) | HRP20030801A2 (https=) |
| HU (1) | HUP0303466A3 (https=) |
| IL (1) | IL157357A0 (https=) |
| IS (1) | IS6925A (https=) |
| MX (1) | MXPA03007989A (https=) |
| NO (1) | NO20033910L (https=) |
| PL (1) | PL363967A1 (https=) |
| RU (1) | RU2284184C2 (https=) |
| SK (1) | SK10602003A3 (https=) |
| WO (1) | WO2002076459A1 (https=) |
| YU (1) | YU69903A (https=) |
| ZA (1) | ZA200306541B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0115162A (pt) * | 2000-11-06 | 2003-10-21 | Pharma Mar Sa | Tratamentos antitumorais eficazes |
| CN1761665A (zh) | 2003-03-14 | 2006-04-19 | 大鹏药品工业株式会社 | 抗肿瘤效果增强剂和抗肿瘤剂 |
| WO2004087105A1 (en) * | 2003-04-02 | 2004-10-14 | Celator Pharmaceuticals, Inc. | Combination formulations of platinum agents and fluoropyrimidines |
| GB0312407D0 (en) * | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
| GB0326486D0 (en) * | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
| AU2004291037A1 (en) * | 2003-11-14 | 2005-06-02 | Pharma Mar, S.A. | Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer |
| KR20050099311A (ko) * | 2004-04-09 | 2005-10-13 | 에이엔에이치 케어연구소(주) | 주사제용 항암제 조성물 |
| EP1827500B1 (en) * | 2004-10-26 | 2009-05-06 | Pharma Mar S.A., Sociedad Unipersonal | Pegylated liposomal doxorubicin in combination with ecteinescidin 743 |
| ATE368461T1 (de) | 2004-10-29 | 2007-08-15 | Pharma Mar Sa | Zusammensetzungen enthaltend ecteinascidin und einen disaccharide |
| KR20070114753A (ko) | 2005-02-18 | 2007-12-04 | 아브락시스 바이오사이언스 인크. | 치료제의 조합 및 투여 방식, 및 조합 요법 |
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| GB0522082D0 (en) * | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
| AU2008202078B2 (en) * | 2007-10-10 | 2012-05-31 | Wellkey Holdings Limited | Stability of secondary metabolite mass production through synchronized plant cell cultures |
| US20100267732A1 (en) * | 2007-10-19 | 2010-10-21 | Pharma Mar, S.A. | Prognostic Molecular Markers for ET-743 Treatment |
| EP3141245A1 (en) | 2010-03-29 | 2017-03-15 | Abraxis BioScience, LLC | Methods of treating cancer |
| MX2012011155A (es) | 2010-03-29 | 2012-12-05 | Abraxis Bioscience Llc | Metodos para mejorar suministros de farmacos y efectividad de agentes terapeuticos. |
| MX347225B (es) | 2010-06-04 | 2017-04-19 | Abraxis Bioscience Llc * | Metodos de tratamiento contra el cancer pancreatico. |
| US20180085377A1 (en) * | 2015-04-22 | 2018-03-29 | Syn-Nat Products Enterprise LLC | Co-crystal composition and its pharmaceutical use |
| IL265044B2 (en) | 2016-08-31 | 2025-02-01 | Fujifilm Corp | An antitumor preparation containing the substances nab-paclitaxel and 1-(2-deoxy-2-fluoro-4-thio-D-beta-arabinofurnosyl)cytosine, a kit containing these substances and their uses |
| RU2646450C1 (ru) * | 2017-05-11 | 2018-03-05 | Владимир Михайлович Курусин | Способ лечения предраковых и ранних стадий раковых заболеваний желудка |
| WO2019146130A1 (ja) | 2018-01-29 | 2019-08-01 | 富士フイルム株式会社 | 胆道がん用抗腫瘍剤および胆道がんの処置方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5A (en) * | 1836-08-10 | Thomas Blanchard | Machine for mortising solid wooden shells of ships' tackle-blocks | |
| US4328229A (en) | 1978-03-29 | 1982-05-04 | Taiho Pharmaceutical Company Limited | Anti-cancer composition for delivering 5-fluorouracil to cancer tissues |
| US5534513A (en) | 1991-09-05 | 1996-07-09 | Taiho Pharmaceutical Company, Ltd. | Antitumor potentiator and antitumor composition |
| FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| RU2194541C1 (ru) * | 2001-07-13 | 2002-12-20 | Научно-исследовательский институт онкологии Томского научного центра СО РАН | Способ комбинированного лечения больных местнораспространенным раком желудка |
-
2002
- 2002-03-04 MX MXPA03007989A patent/MXPA03007989A/es unknown
- 2002-03-04 HR HR20030801A patent/HRP20030801A2/hr not_active Application Discontinuation
- 2002-03-04 CA CA002439676A patent/CA2439676A1/en not_active Abandoned
- 2002-03-04 WO PCT/US2002/006262 patent/WO2002076459A1/en not_active Ceased
- 2002-03-04 RU RU2003129527/14A patent/RU2284184C2/ru not_active IP Right Cessation
- 2002-03-04 EP EP02713715A patent/EP1368034A1/en not_active Withdrawn
- 2002-03-04 EE EEP200300429A patent/EE200300429A/xx unknown
- 2002-03-04 JP JP2002574974A patent/JP2005506294A/ja active Pending
- 2002-03-04 BR BR0207443-5A patent/BR0207443A/pt not_active IP Right Cessation
- 2002-03-04 KR KR10-2003-7011636A patent/KR20030081496A/ko not_active Withdrawn
- 2002-03-04 CZ CZ20032266A patent/CZ20032266A3/cs unknown
- 2002-03-04 US US10/090,354 patent/US6770653B2/en not_active Expired - Fee Related
- 2002-03-04 PL PL02363967A patent/PL363967A1/xx not_active Application Discontinuation
- 2002-03-04 HU HU0303466A patent/HUP0303466A3/hu unknown
- 2002-03-04 IL IL15735702A patent/IL157357A0/xx unknown
- 2002-03-04 SK SK10602003A patent/SK10602003A3/sk not_active Application Discontinuation
- 2002-03-04 YU YU69903A patent/YU69903A/sh unknown
-
2003
- 2003-08-21 ZA ZA200306541A patent/ZA200306541B/xx unknown
- 2003-08-22 IS IS6925A patent/IS6925A/is unknown
- 2003-09-04 NO NO20033910A patent/NO20033910L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005506294A (ja) | 2005-03-03 |
| EP1368034A1 (en) | 2003-12-10 |
| HUP0303466A2 (hu) | 2004-01-28 |
| SK10602003A3 (en) | 2004-10-05 |
| WO2002076459A1 (en) | 2002-10-03 |
| CZ20032266A3 (cs) | 2004-02-18 |
| YU69903A (sh) | 2006-08-17 |
| RU2284184C2 (ru) | 2006-09-27 |
| HUP0303466A3 (en) | 2005-02-28 |
| HRP20030801A2 (en) | 2004-08-31 |
| RU2003129527A (ru) | 2005-03-10 |
| IL157357A0 (en) | 2004-02-19 |
| IS6925A (is) | 2003-08-22 |
| EE200300429A (et) | 2003-12-15 |
| PL363967A1 (en) | 2004-11-29 |
| NO20033910L (no) | 2003-10-23 |
| US6770653B2 (en) | 2004-08-03 |
| KR20030081496A (ko) | 2003-10-17 |
| CA2439676A1 (en) | 2002-10-03 |
| BR0207443A (pt) | 2004-04-06 |
| NO20033910D0 (no) | 2003-09-04 |
| US20020173482A1 (en) | 2002-11-21 |
| MXPA03007989A (es) | 2003-12-04 |
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