JP2005504847A5 - - Google Patents
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- Publication number
- JP2005504847A5 JP2005504847A5 JP2003534430A JP2003534430A JP2005504847A5 JP 2005504847 A5 JP2005504847 A5 JP 2005504847A5 JP 2003534430 A JP2003534430 A JP 2003534430A JP 2003534430 A JP2003534430 A JP 2003534430A JP 2005504847 A5 JP2005504847 A5 JP 2005504847A5
- Authority
- JP
- Japan
- Prior art keywords
- triazafluoren
- acid
- valeric acid
- methylenedioxybenzylamino
- benzylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LANIKWBTBGWYIB-UHFFFAOYSA-N 4-[4-(1,3-benzodioxol-5-ylmethylamino)-9h-pyrimido[4,5-b]indol-2-yl]cyclohexane-1-carboxylic acid Chemical compound C1CC(C(=O)O)CCC1C1=NC(NCC=2C=C3OCOC3=CC=2)=C2C3=CC=CC=C3NC2=N1 LANIKWBTBGWYIB-UHFFFAOYSA-N 0.000 description 1
- AZJFODDQIOLUJU-UHFFFAOYSA-N 4-[4-(1,3-benzodioxol-5-ylmethylamino)-9h-pyrimido[4,5-b]indol-2-yl]pentanoic acid Chemical compound C1=CC=C2C3=C(NCC=4C=C5OCOC5=CC=4)N=C(C(CCC(O)=O)C)N=C3NC2=C1 AZJFODDQIOLUJU-UHFFFAOYSA-N 0.000 description 1
- ITMBRAVOUSZXBM-UHFFFAOYSA-N 4-[4-(benzylamino)-9H-pyrimido[4,5-b]indol-2-yl]cyclohexane-1-carboxylic acid Chemical compound C1CC(CCC1C2=NC3=C(C4=CC=CC=C4N3)C(=N2)NCC5=CC=CC=C5)C(=O)O ITMBRAVOUSZXBM-UHFFFAOYSA-N 0.000 description 1
- HMTKLCHJPGQONU-UHFFFAOYSA-N 4-[4-(benzylamino)-9H-pyrimido[4,5-b]indol-2-yl]pentanoic acid Chemical compound CC(CCC(=O)O)C1=NC2=C(C3=CC=CC=C3N2)C(=N1)NCC4=CC=CC=C4 HMTKLCHJPGQONU-UHFFFAOYSA-N 0.000 description 1
- CCYNATFERMKCGA-UHFFFAOYSA-N 4-[4-(pyridin-3-ylmethylamino)-9h-pyrimido[4,5-b]indol-2-yl]pentanoic acid Chemical compound N1C2=CC=CC=C2C=2C1=NC(C(CCC(O)=O)C)=NC=2NCC1=CC=CN=C1 CCYNATFERMKCGA-UHFFFAOYSA-N 0.000 description 1
- NHPJZIZPUMXREP-UHFFFAOYSA-N 4-[4-[(3,4-dichlorophenyl)methylamino]-9h-pyrimido[4,5-b]indol-2-yl]pentanoic acid Chemical compound N1C2=CC=CC=C2C=2C1=NC(C(CCC(O)=O)C)=NC=2NCC1=CC=C(Cl)C(Cl)=C1 NHPJZIZPUMXREP-UHFFFAOYSA-N 0.000 description 1
- OBNPNHLUJAPXLU-UHFFFAOYSA-N 4-[4-[(3,4-dimethoxyphenyl)methylamino]-9h-pyrimido[4,5-b]indol-2-yl]pentanoic acid Chemical compound C1=C(OC)C(OC)=CC=C1CNC1=NC(C(C)CCC(O)=O)=NC2=C1C1=CC=CC=C1N2 OBNPNHLUJAPXLU-UHFFFAOYSA-N 0.000 description 1
- WWEZGINWWXUDEU-UHFFFAOYSA-N 4-[4-[(3-chloro-4-methoxyphenyl)methylamino]-9h-pyrimido[4,5-b]indol-2-yl]cyclohexane-1-carboxylic acid Chemical compound C1=C(Cl)C(OC)=CC=C1CNC1=NC(C2CCC(CC2)C(O)=O)=NC2=C1C1=CC=CC=C1N2 WWEZGINWWXUDEU-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10148883.1 | 2001-10-04 | ||
| DE10148883A DE10148883A1 (de) | 2001-10-04 | 2001-10-04 | Pyrimidinderivate |
| PCT/EP2002/009935 WO2003031447A2 (de) | 2001-10-04 | 2002-09-05 | Pyrimidinderivate mit pde-v hemmender wirkung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005504847A JP2005504847A (ja) | 2005-02-17 |
| JP2005504847A5 true JP2005504847A5 (https=) | 2006-01-05 |
| JP4782376B2 JP4782376B2 (ja) | 2011-09-28 |
Family
ID=7701322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003534430A Expired - Fee Related JP4782376B2 (ja) | 2001-10-04 | 2002-09-05 | ピリミジン誘導体 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7312224B2 (https=) |
| EP (1) | EP1432715B1 (https=) |
| JP (1) | JP4782376B2 (https=) |
| KR (1) | KR20040041166A (https=) |
| CN (1) | CN1863803A (https=) |
| AT (1) | ATE389655T1 (https=) |
| AU (1) | AU2002362806B2 (https=) |
| BR (1) | BR0213037A (https=) |
| CA (1) | CA2462799C (https=) |
| DE (2) | DE10148883A1 (https=) |
| ES (1) | ES2303564T3 (https=) |
| HU (1) | HUP0401654A3 (https=) |
| PL (1) | PL369819A1 (https=) |
| RU (1) | RU2004114239A (https=) |
| WO (1) | WO2003031447A2 (https=) |
| ZA (1) | ZA200403334B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005061171A1 (de) * | 2005-12-21 | 2007-07-05 | Bayer Healthcare Ag | Neue, cyclisch substituierte Furopyrimidin-Derivate und ihre Verwendung |
| DE102005061170A1 (de) * | 2005-12-21 | 2007-07-05 | Bayer Healthcare Ag | Neue, acyclisch substituierte Furopyrimidin-Derivate und ihre Verwendung |
| AR062501A1 (es) * | 2006-08-29 | 2008-11-12 | Actelion Pharmaceuticals Ltd | Composiciones terapeuticas |
| WO2008070740A1 (en) * | 2006-12-07 | 2008-06-12 | F.Hoffmann-La Roche Ag | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| DE102007027800A1 (de) * | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung |
| DE102007027799A1 (de) * | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte Furopyrimidine und ihre Verwendung |
| DE102007051762A1 (de) * | 2007-10-30 | 2009-05-07 | Bayer Healthcare Ag | Substituierte Pyrrolotriazine und ihre Verwendung |
| DE102007054786A1 (de) * | 2007-11-16 | 2009-05-20 | Bayer Healthcare Ag | Trisubstituierte Furopyrimidine und ihre Verwendung |
| US20130065936A1 (en) * | 2010-05-14 | 2013-03-14 | The Regents Of The University Of California | Modulation of bioactive epoxy-fatty acid levels by phosphodiesterase inhibitors |
| AU2011281015B2 (en) | 2010-07-23 | 2015-09-24 | President And Fellows Of Harvard College | Tricyclic proteasome activity enhancing compounds |
| CA2861464C (en) | 2012-01-25 | 2018-03-06 | Proteostasis Therapeutics, Inc. | Proteasome activity modulating tricyclic compounds |
| EP3194399B1 (en) | 2014-09-17 | 2019-04-10 | Pécsi Tudományegyetem | New agents for treating neurogenic inflammation and neuropathic hyperalgesia related disorders |
| US10813894B2 (en) | 2015-02-20 | 2020-10-27 | The Regents Of The University Of California | Methods of inhibiting pain |
| CN108137614B (zh) * | 2015-12-02 | 2021-01-05 | 深圳市塔吉瑞生物医药有限公司 | 一种稠合嘧啶化合物及包含该化合物的组合物及其用途 |
| CN105461728A (zh) * | 2015-12-29 | 2016-04-06 | 中山大学 | 一种4-取代胺基-6-甲氧羰基苯并呋喃并[2,3-d]嘧啶类化合物及制备方法 |
| RU2625316C1 (ru) * | 2016-04-13 | 2017-07-13 | Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) | 2-АМИНОЗАМЕЩЕННЫЕ 6-МЕТОКСИ-4-ТРИФТОРМЕТИЛ-9Н-ПИРИМИДО[4,5b]ИНДОЛЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ, ПРИМЕНЕНИЕ И ПРЕДШЕСТВЕННИКИ |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3037980A (en) * | 1955-08-18 | 1962-06-05 | Burroughs Wellcome Co | Pyrrolopyrimidine vasodilators and method of making them |
| GB915303A (en) * | 1958-03-13 | 1963-01-09 | Wellcome Found | Pyrrolo[2,3-d]pyrimidine derivatives and the manufacture thereof |
| JPS5542999B2 (https=) * | 1972-02-14 | 1980-11-04 | ||
| CH592668A5 (https=) | 1973-10-02 | 1977-10-31 | Delalande Sa | |
| ZA815765B (en) * | 1980-08-22 | 1983-04-27 | Du Pont | Herbicidal sulfonamides |
| US4487626A (en) | 1980-08-22 | 1984-12-11 | E. I. Du Pont De Nemours And Company | Herbicidal sulfonamides |
| EP0514540B1 (en) | 1989-09-19 | 1996-07-17 | Teijin Limited | PYRROLO 2,3-d]PYRIMIDINE DERIVATIVE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL PREPARATION COMPRISING THE DERIVATIVE AS ACTIVE INGREDIENT |
| JP2562520B2 (ja) * | 1989-09-19 | 1996-12-11 | 帝人株式会社 | ピロロ〔２，３ーｄ〕ピリミジン誘導体、その製造方法およびそれを有効成分とする医薬製剤 |
| US5869486A (en) | 1995-02-24 | 1999-02-09 | Ono Pharmaceutical Co., Ltd. | Fused pyrimidines and pyriazines as pharmaceutical compounds |
| DE19644228A1 (de) | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
| DE19752952A1 (de) | 1997-11-28 | 1999-06-02 | Merck Patent Gmbh | Thienopyrimidine |
| DE19819023A1 (de) | 1998-04-29 | 1999-11-04 | Merck Patent Gmbh | Thienopyrimidine |
| YU76100A (sh) | 1998-06-02 | 2003-12-31 | Osi Pharmaceuticals Inc. | Pirolo(2,3-d) pirimidin preparati i njihova primena |
| DE19942474A1 (de) | 1999-09-06 | 2001-03-15 | Merck Patent Gmbh | Pyrazolo[4,3-d]pyrimidine |
| DE19944604A1 (de) | 1999-09-17 | 2001-03-22 | Merck Patent Gmbh | Aminderivate |
| KR100840727B1 (ko) | 1999-12-02 | 2008-06-23 | 오에스아이 파마슈티컬스, 인코포레이티드 | 아데노신 ａ1, ａ2ａ 및 ａ3 수용체 특이 화합물 및 그의 사용방법 |
| AP1893A (en) | 2000-12-01 | 2008-09-23 | Osi Pharm Inc | Compounds specific to adenosine A1, A2A and A3 receptor and uses thereof |
-
2001
- 2001-10-04 DE DE10148883A patent/DE10148883A1/de not_active Withdrawn
-
2002
- 2002-09-04 US US10/491,680 patent/US7312224B2/en not_active Expired - Fee Related
- 2002-09-05 ES ES02800556T patent/ES2303564T3/es not_active Expired - Lifetime
- 2002-09-05 WO PCT/EP2002/009935 patent/WO2003031447A2/de not_active Ceased
- 2002-09-05 CN CNA028195817A patent/CN1863803A/zh active Pending
- 2002-09-05 AU AU2002362806A patent/AU2002362806B2/en not_active Ceased
- 2002-09-05 EP EP02800556A patent/EP1432715B1/de not_active Expired - Lifetime
- 2002-09-05 JP JP2003534430A patent/JP4782376B2/ja not_active Expired - Fee Related
- 2002-09-05 PL PL02369819A patent/PL369819A1/xx unknown
- 2002-09-05 HU HU0401654A patent/HUP0401654A3/hu unknown
- 2002-09-05 AT AT02800556T patent/ATE389655T1/de not_active IP Right Cessation
- 2002-09-05 KR KR10-2004-7003997A patent/KR20040041166A/ko not_active Withdrawn
- 2002-09-05 RU RU2004114239/04A patent/RU2004114239A/ru not_active Application Discontinuation
- 2002-09-05 CA CA2462799A patent/CA2462799C/en not_active Expired - Fee Related
- 2002-09-05 BR BR0213037-8A patent/BR0213037A/pt not_active Application Discontinuation
- 2002-09-05 DE DE50211929T patent/DE50211929D1/de not_active Expired - Lifetime
-
2004
- 2004-05-03 ZA ZA200403334A patent/ZA200403334B/en unknown
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