JP2005503809A5 - - Google Patents
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- Publication number
- JP2005503809A5 JP2005503809A5 JP2003530824A JP2003530824A JP2005503809A5 JP 2005503809 A5 JP2005503809 A5 JP 2005503809A5 JP 2003530824 A JP2003530824 A JP 2003530824A JP 2003530824 A JP2003530824 A JP 2003530824A JP 2005503809 A5 JP2005503809 A5 JP 2005503809A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- ramp1
- humanized
- amino acid
- humanized ramp1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101000584583 Homo sapiens Receptor activity-modifying protein 1 Proteins 0.000 claims 26
- 102100030697 Receptor activity-modifying protein 1 Human genes 0.000 claims 20
- 210000004027 cell Anatomy 0.000 claims 13
- 125000000539 amino acid group Chemical group 0.000 claims 12
- 230000009261 transgenic effect Effects 0.000 claims 9
- 239000013604 expression vector Substances 0.000 claims 7
- 102000050292 human RAMP1 Human genes 0.000 claims 6
- 238000011830 transgenic mouse model Methods 0.000 claims 6
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 6
- 108020004414 DNA Proteins 0.000 claims 5
- 239000012528 membrane Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 102100024654 Calcitonin gene-related peptide type 1 receptor Human genes 0.000 claims 4
- 101000760563 Homo sapiens Calcitonin gene-related peptide type 1 receptor Proteins 0.000 claims 4
- 101150026505 Ramp1 gene Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 3
- 238000009395 breeding Methods 0.000 claims 3
- 230000001488 breeding effect Effects 0.000 claims 3
- 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 claims 3
- 210000001082 somatic cell Anatomy 0.000 claims 3
- 102000053602 DNA Human genes 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 210000002308 embryonic cell Anatomy 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32529501P | 2001-09-27 | 2001-09-27 | |
| PCT/US2002/030501 WO2003027252A2 (en) | 2001-09-27 | 2002-09-26 | Isolated dna molecules encoding humanized calcitonin gene-related peptide receptor, related non-human transgenic animals and assay methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005503809A JP2005503809A (ja) | 2005-02-10 |
| JP2005503809A5 true JP2005503809A5 (https=) | 2005-12-22 |
| JP4603261B2 JP4603261B2 (ja) | 2010-12-22 |
Family
ID=23267273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003530824A Expired - Fee Related JP4603261B2 (ja) | 2001-09-27 | 2002-09-26 | ヒト化カルシトニン遺伝子関連ペプチド受容体をコードする単離ｄｎａ分子、関連する非ヒトトランスジェニック動物及びアッセイ方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7193070B2 (https=) |
| EP (1) | EP1438325B1 (https=) |
| JP (1) | JP4603261B2 (https=) |
| AT (1) | ATE453661T1 (https=) |
| CA (1) | CA2461917C (https=) |
| DE (1) | DE60234944D1 (https=) |
| WO (1) | WO2003027252A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2371861B1 (en) | 2002-01-25 | 2017-08-09 | Novo Nordisk A/S | Monoclonal antibodies against extracellular loops of C5aR |
| US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| BRPI0311812B8 (pt) | 2002-06-05 | 2021-05-25 | Bristol Myers Squibb Co | antagonistas de receptor de peptídeo relacionado com o gene de calcitonina, composição farmacêutica e seu uso |
| US7842808B2 (en) | 2002-06-05 | 2010-11-30 | Bristol-Myers Squibb Company | Anti-migraine spirocycles |
| WO2004097421A2 (en) * | 2003-04-29 | 2004-11-11 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with calcitonin receptor-like receptor (calcrl) |
| US7569578B2 (en) | 2003-12-05 | 2009-08-04 | Bristol-Meyers Squibb Company | Heterocyclic anti-migraine agents |
| CA2549330A1 (en) | 2003-12-05 | 2005-07-21 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| WO2005060739A1 (en) * | 2003-12-24 | 2005-07-07 | G2 Inflammation Pty Ltd | Transgenic non-human mammal comprising a polynucleotide encoding human or humanized c5ar |
| TW200533398A (en) | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
| US7384930B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7384931B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7449586B2 (en) | 2004-12-03 | 2008-11-11 | Bristol-Myers Squibb Company | Processes for the preparation of CGRP-receptor antagonists and intermediates thereof |
| FR2882628B1 (fr) * | 2005-03-04 | 2011-03-18 | Centre Nat Rech Scient | Souris transgeniques et leurs applications comme modele experimental |
| US7834007B2 (en) | 2005-08-25 | 2010-11-16 | Bristol-Myers Squibb Company | CGRP antagonists |
| MY153249A (en) | 2005-11-14 | 2015-01-29 | Rinat Neuroscience Corp | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| JP2009201355A (ja) * | 2006-06-02 | 2009-09-10 | Osaka Univ | 高血圧モデル非ヒト動物 |
| MX2009001914A (es) | 2006-08-22 | 2009-03-31 | G2 Inflammation Pty Ltd | Anticuerpos anti-c5ar con propiedades mejoradas. |
| JP2010536326A (ja) * | 2007-04-26 | 2010-12-02 | アキリオン ファーマシューティカルズ，インコーポレーテッド | Ｈｃｖのキメラｎｓ４ａタンパク質を発現する細胞およびアッセイ法におけるその使用 |
| EP2254911B1 (en) | 2008-02-20 | 2015-11-25 | Novo Nordisk A/S | Humanized anti-c5ar antibodies |
| CA2716424C (en) | 2008-03-04 | 2015-04-28 | Pfizer Limited | Methods of treating chronic pain |
| JO3382B1 (ar) | 2008-12-23 | 2019-03-13 | Amgen Inc | أجسام مضادة ترتبط مع مستقبل cgrp بشري |
| KR101519192B1 (ko) | 2009-08-28 | 2015-05-11 | 리나트 뉴로사이언스 코프. | 칼시토닌 유전자-관련된 펩티드에 대해 지시된 길항제 항체의 투여에 의한 내장 통증의 치료 방법 |
| PL2718322T3 (pl) | 2011-06-06 | 2019-07-31 | Novo Nordisk A/S | Lecznicze przeciwciała |
| JP6267986B2 (ja) * | 2014-02-13 | 2018-01-24 | 株式会社特殊免疫研究所 | ヒトの特定分子と結合する分子標的物質のｉｎｖｉｖｏ評価法 |
| PE20161439A1 (es) | 2014-03-21 | 2017-01-26 | Teva Pharmaceuticals Int Gmbh | Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| WO2016044224A1 (en) | 2014-09-15 | 2016-03-24 | Amgen Inc. | Bi-specific anti-cgrp receptor/pac1 receptor antigen binding proteins and uses thereof |
| TWI799849B (zh) | 2015-04-24 | 2023-04-21 | 美商安美基公司 | 治療或預防偏頭痛之方法 |
| WO2018055574A1 (en) | 2016-09-23 | 2018-03-29 | Teva Pharmaceuticals International Gmbh | Treating refractory migraine |
| AU2019246983B2 (en) | 2018-04-02 | 2025-12-18 | Amgen Inc. | Erenumab compositions and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4882609A (en) * | 1984-11-19 | 1989-11-21 | Max-Planck Gesellschaft Zur Forderung Der Wissenschafter E.V. | Semiconductor devices with at least one monoatomic layer of doping atoms |
| US4908678A (en) * | 1986-10-08 | 1990-03-13 | Semiconductor Energy Laboratory Co., Ltd. | FET with a super lattice channel |
| US5081513A (en) * | 1991-02-28 | 1992-01-14 | Xerox Corporation | Electronic device with recovery layer proximate to active layer |
| US5606177A (en) * | 1993-10-29 | 1997-02-25 | Texas Instruments Incorporated | Silicon oxide resonant tunneling diode structure |
| US6255150B1 (en) * | 1997-10-23 | 2001-07-03 | Texas Instruments Incorporated | Use of crystalline SiOx barriers for Si-based resonant tunneling diodes |
-
2002
- 2002-09-26 AT AT02763731T patent/ATE453661T1/de not_active IP Right Cessation
- 2002-09-26 EP EP02763731A patent/EP1438325B1/en not_active Expired - Lifetime
- 2002-09-26 DE DE60234944T patent/DE60234944D1/de not_active Expired - Lifetime
- 2002-09-26 US US10/490,594 patent/US7193070B2/en not_active Expired - Fee Related
- 2002-09-26 JP JP2003530824A patent/JP4603261B2/ja not_active Expired - Fee Related
- 2002-09-26 CA CA2461917A patent/CA2461917C/en not_active Expired - Fee Related
- 2002-09-26 WO PCT/US2002/030501 patent/WO2003027252A2/en not_active Ceased
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