JP2005503141A - アシル化ポリペプチドを作出するための方法 - Google Patents

アシル化ポリペプチドを作出するための方法 Download PDF

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Publication number
JP2005503141A
JP2005503141A JP2003515544A JP2003515544A JP2005503141A JP 2005503141 A JP2005503141 A JP 2005503141A JP 2003515544 A JP2003515544 A JP 2003515544A JP 2003515544 A JP2003515544 A JP 2003515544A JP 2005503141 A JP2005503141 A JP 2005503141A
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JP
Japan
Prior art keywords
glu
arg
polypeptide
ala
seq
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JP2003515544A
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English (en)
Japanese (ja)
Inventor
バルシュミット、パー
ディエル、イバン
エゲル−ミタニ、ミチ
マルクッセン、ジャン
ホエグ−ジェンセン、トーマス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
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Novo Nordisk AS
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Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of JP2005503141A publication Critical patent/JP2005503141A/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2003515544A 2001-07-24 2002-07-18 アシル化ポリペプチドを作出するための方法 Withdrawn JP2005503141A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101140 2001-07-24
PCT/DK2002/000501 WO2003010185A2 (fr) 2001-07-24 2002-07-18 Procede pour produire des polypeptides acyles

Publications (1)

Publication Number Publication Date
JP2005503141A true JP2005503141A (ja) 2005-02-03

Family

ID=8160636

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003515544A Withdrawn JP2005503141A (ja) 2001-07-24 2002-07-18 アシル化ポリペプチドを作出するための方法

Country Status (4)

Country Link
EP (1) EP1421102A2 (fr)
JP (1) JP2005503141A (fr)
AU (1) AU2002355160A1 (fr)
WO (1) WO2003010185A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011509077A (ja) * 2007-12-28 2011-03-24 ノボ・ノルデイスク・エー／エス Ｇｌｐ−１アナログの半組換え調製

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1877424A4 (fr) 2005-04-11 2010-09-29 Pharmagap Inc Inhibiteurs de protéines kinases et leurs utilisations
US20100041597A1 (en) * 2005-08-05 2010-02-18 Jenny Phipps Peptides targeted to protein kinase c isoforms and uses thereof
EP1872790A1 (fr) 2006-06-26 2008-01-02 DeveloGen Aktiengesellschaft Nouvelle formulation pour augmenter la biodisponibilité de neurturine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011007A (en) * 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
ZA954983B (en) * 1994-06-17 1996-02-14 Novo Nordisk As N-terminally extended proteins expressed in yeast
US5646242A (en) * 1994-11-17 1997-07-08 Eli Lilly And Company Selective acylation of epsilon-amino groups
US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
IL144989A0 (en) * 1999-03-17 2002-06-30 Novo Nordisk As Method for acylating peptides and novel acylating agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011509077A (ja) * 2007-12-28 2011-03-24 ノボ・ノルデイスク・エー／エス Ｇｌｐ−１アナログの半組換え調製
US9732137B2 (en) 2007-12-28 2017-08-15 Novo Nordisk A/S Semi-recombinant preparation of GLP-1 analogues

Also Published As

Publication number Publication date
WO2003010185A3 (fr) 2004-03-25
WO2003010185A2 (fr) 2003-02-06
EP1421102A2 (fr) 2004-05-26
AU2002355160A1 (en) 2003-02-17

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