JP2005501544A5 - - Google Patents
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- Publication number
- JP2005501544A5 JP2005501544A5 JP2003525023A JP2003525023A JP2005501544A5 JP 2005501544 A5 JP2005501544 A5 JP 2005501544A5 JP 2003525023 A JP2003525023 A JP 2003525023A JP 2003525023 A JP2003525023 A JP 2003525023A JP 2005501544 A5 JP2005501544 A5 JP 2005501544A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- compound according
- sequence
- analog
- mimetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 10
- 150000001413 amino acids Chemical group 0.000 claims 9
- 229940024606 amino acid Drugs 0.000 claims 7
- 235000001014 amino acid Nutrition 0.000 claims 7
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 2
- 150000008575 L-amino acids Chemical class 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- 229960005261 aspartic acid Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 229960004799 tryptophan Drugs 0.000 claims 2
- 229960004295 valine Drugs 0.000 claims 2
- NNERWURVSCBMJE-UHFFFAOYSA-N 2-oxospiro[1h-indole-3,2'-1h-quinazoline]-4'-carboxylic acid Chemical compound O=C1NC2=CC=CC=C2C11N=C(C(=O)O)C2=CC=CC=C2N1 NNERWURVSCBMJE-UHFFFAOYSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 claims 1
- 229930182847 D-glutamic acid Natural products 0.000 claims 1
- 101000622137 Homo sapiens P-selectin Proteins 0.000 claims 1
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 claims 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 claims 1
- 235000013878 L-cysteine Nutrition 0.000 claims 1
- 239000004201 L-cysteine Substances 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- 229930195722 L-methionine Natural products 0.000 claims 1
- 108010035766 P-Selectin Proteins 0.000 claims 1
- 102000008212 P-Selectin Human genes 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000006841 cyclic skeleton Chemical group 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 229960002989 glutamic acid Drugs 0.000 claims 1
- 239000007791 liquid phase Substances 0.000 claims 1
- 229960004452 methionine Drugs 0.000 claims 1
- 229960005190 phenylalanine Drugs 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229960004441 tyrosine Drugs 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203314A EP1288222A1 (en) | 2001-09-03 | 2001-09-03 | Peptidic compounds selectively binding to P-selectin |
| PCT/NL2002/000566 WO2003020753A1 (en) | 2001-09-03 | 2002-08-28 | Peptidic compounds selectively binding to p-selectin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005501544A JP2005501544A (ja) | 2005-01-20 |
| JP2005501544A5 true JP2005501544A5 (https=) | 2006-01-05 |
| JP4227520B2 JP4227520B2 (ja) | 2009-02-18 |
Family
ID=8180873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003525023A Expired - Fee Related JP4227520B2 (ja) | 2001-09-03 | 2002-08-28 | Ｐ−セレクチンに対して選択的に結合するペプチド化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7531516B2 (https=) |
| EP (2) | EP1288222A1 (https=) |
| JP (1) | JP4227520B2 (https=) |
| CN (1) | CN100413883C (https=) |
| AT (1) | ATE446311T1 (https=) |
| BR (1) | BR0212219A (https=) |
| CA (1) | CA2459230C (https=) |
| DE (1) | DE60234108D1 (https=) |
| ES (1) | ES2337663T3 (https=) |
| HR (1) | HRP20040127A2 (https=) |
| HU (1) | HUP0401728A2 (https=) |
| MX (1) | MXPA04002055A (https=) |
| NO (1) | NO20040905L (https=) |
| PL (1) | PL369030A1 (https=) |
| WO (1) | WO2003020753A1 (https=) |
| ZA (1) | ZA200400956B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2299749T3 (es) * | 2002-08-09 | 2008-06-01 | Astellas Pharma Europe B.V. | Compuestos que se unen a p-selectina. |
| DE60329511D1 (de) | 2002-10-11 | 2009-11-12 | Astellas Pharma Europ B V | Verbindungen auf glukosebasis mit affinitüt für p-selektin |
| EP1481683A1 (en) * | 2003-05-30 | 2004-12-01 | Yamanouchi Pharmaceutical Co. Ltd. | P-selectin targeting ligand and compositions thereof |
| US9107963B2 (en) * | 2012-04-13 | 2015-08-18 | Case Western Reserve University | Heteromultivalent nanoparticle compositions |
| US9833518B2 (en) | 2012-04-13 | 2017-12-05 | Case Western Reserve University | Heteromultivalent particle compositions |
| US10279347B2 (en) * | 2014-04-08 | 2019-05-07 | Dna Medicine Institute, Inc. | Fluidics module |
| WO2019165513A1 (en) * | 2018-03-02 | 2019-09-06 | Peter Gillies | A method of modulating cell proliferation |
| CN111671905B (zh) * | 2020-06-23 | 2022-05-27 | 中国医学科学院医学实验动物研究所 | P-选择蛋白糖蛋白配体-1作为靶点在制备预防和/或治疗动脉瘤的药物中的应用 |
| CN117203219A (zh) | 2021-04-20 | 2023-12-08 | 拜斯科技术开发有限公司 | 特异性针对p-选择素的双环肽配体 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643873A (en) * | 1992-05-06 | 1997-07-01 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1 |
| WO1994005269A1 (en) * | 1992-09-08 | 1994-03-17 | Centocor, Inc. | Peptide inhibitors of selectin binding |
| WO1994014836A1 (en) * | 1992-12-18 | 1994-07-07 | Centocor, Inc. | Peptide inhibitors of selectin binding |
| WO1996000581A1 (en) * | 1994-06-29 | 1996-01-11 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin |
| US5663144A (en) * | 1995-05-03 | 1997-09-02 | The Trustees Of The University Of Pennsylvania | Compounds that bind to p185 and methods of using the same |
| US6114517A (en) * | 1998-12-10 | 2000-09-05 | Isis Pharmaceuticals Inc. | Methods of modulating tumor necrosis factor α-induced expression of cell adhesion molecules |
| US20020152495A1 (en) * | 1999-01-15 | 2002-10-17 | Toshiro Ito | Plants having seedless fruit |
-
2001
- 2001-09-03 EP EP01203314A patent/EP1288222A1/en not_active Withdrawn
-
2002
- 2002-08-28 MX MXPA04002055A patent/MXPA04002055A/es not_active Application Discontinuation
- 2002-08-28 JP JP2003525023A patent/JP4227520B2/ja not_active Expired - Fee Related
- 2002-08-28 DE DE60234108T patent/DE60234108D1/de not_active Expired - Lifetime
- 2002-08-28 BR BR0212219-7A patent/BR0212219A/pt not_active IP Right Cessation
- 2002-08-28 HU HU0401728A patent/HUP0401728A2/hu unknown
- 2002-08-28 US US10/488,509 patent/US7531516B2/en not_active Expired - Fee Related
- 2002-08-28 ES ES02758940T patent/ES2337663T3/es not_active Expired - Lifetime
- 2002-08-28 PL PL02369030A patent/PL369030A1/xx not_active Application Discontinuation
- 2002-08-28 CN CNB028171934A patent/CN100413883C/zh not_active Expired - Fee Related
- 2002-08-28 EP EP02758940A patent/EP1423413B1/en not_active Expired - Lifetime
- 2002-08-28 AT AT02758940T patent/ATE446311T1/de not_active IP Right Cessation
- 2002-08-28 WO PCT/NL2002/000566 patent/WO2003020753A1/en not_active Ceased
- 2002-08-28 HR HR20040127A patent/HRP20040127A2/hr not_active Application Discontinuation
- 2002-08-28 CA CA2459230A patent/CA2459230C/en not_active Expired - Fee Related
-
2004
- 2004-02-05 ZA ZA200400956A patent/ZA200400956B/en unknown
- 2004-03-02 NO NO20040905A patent/NO20040905L/no not_active Application Discontinuation
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