CA2459230C - Peptidic compounds selectively binding to p-selectin - Google Patents

Peptidic compounds selectively binding to p-selectin Download PDF

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Publication number
CA2459230C
CA2459230C CA2459230A CA2459230A CA2459230C CA 2459230 C CA2459230 C CA 2459230C CA 2459230 A CA2459230 A CA 2459230A CA 2459230 A CA2459230 A CA 2459230A CA 2459230 C CA2459230 C CA 2459230C
Authority
CA
Canada
Prior art keywords
selectin
compound
binding
amino acid
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2459230A
Other languages
English (en)
French (fr)
Other versions
CA2459230A1 (en
Inventor
Thomas Jacobus Maria Molenaar
Johan Kuiper
Theodorus Josephus Cornelis Van Berkel
Erik Anna Biessen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Europe BV
Original Assignee
Astellas Pharma Europe BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Europe BV filed Critical Astellas Pharma Europe BV
Publication of CA2459230A1 publication Critical patent/CA2459230A1/en
Application granted granted Critical
Publication of CA2459230C publication Critical patent/CA2459230C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2459230A 2001-09-03 2002-08-28 Peptidic compounds selectively binding to p-selectin Expired - Fee Related CA2459230C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01203314.8 2001-09-03
EP01203314A EP1288222A1 (en) 2001-09-03 2001-09-03 Peptidic compounds selectively binding to P-selectin
PCT/NL2002/000566 WO2003020753A1 (en) 2001-09-03 2002-08-28 Peptidic compounds selectively binding to p-selectin

Publications (2)

Publication Number Publication Date
CA2459230A1 CA2459230A1 (en) 2003-03-13
CA2459230C true CA2459230C (en) 2011-11-08

Family

ID=8180873

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2459230A Expired - Fee Related CA2459230C (en) 2001-09-03 2002-08-28 Peptidic compounds selectively binding to p-selectin

Country Status (16)

Country Link
US (1) US7531516B2 (https=)
EP (2) EP1288222A1 (https=)
JP (1) JP4227520B2 (https=)
CN (1) CN100413883C (https=)
AT (1) ATE446311T1 (https=)
BR (1) BR0212219A (https=)
CA (1) CA2459230C (https=)
DE (1) DE60234108D1 (https=)
ES (1) ES2337663T3 (https=)
HR (1) HRP20040127A2 (https=)
HU (1) HUP0401728A2 (https=)
MX (1) MXPA04002055A (https=)
NO (1) NO20040905L (https=)
PL (1) PL369030A1 (https=)
WO (1) WO2003020753A1 (https=)
ZA (1) ZA200400956B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2299749T3 (es) * 2002-08-09 2008-06-01 Astellas Pharma Europe B.V. Compuestos que se unen a p-selectina.
DE60329511D1 (de) 2002-10-11 2009-11-12 Astellas Pharma Europ B V Verbindungen auf glukosebasis mit affinitüt für p-selektin
EP1481683A1 (en) * 2003-05-30 2004-12-01 Yamanouchi Pharmaceutical Co. Ltd. P-selectin targeting ligand and compositions thereof
US9107963B2 (en) * 2012-04-13 2015-08-18 Case Western Reserve University Heteromultivalent nanoparticle compositions
US9833518B2 (en) 2012-04-13 2017-12-05 Case Western Reserve University Heteromultivalent particle compositions
US10279347B2 (en) * 2014-04-08 2019-05-07 Dna Medicine Institute, Inc. Fluidics module
WO2019165513A1 (en) * 2018-03-02 2019-09-06 Peter Gillies A method of modulating cell proliferation
CN111671905B (zh) * 2020-06-23 2022-05-27 中国医学科学院医学实验动物研究所 P-选择蛋白糖蛋白配体-1作为靶点在制备预防和/或治疗动脉瘤的药物中的应用
CN117203219A (zh) 2021-04-20 2023-12-08 拜斯科技术开发有限公司 特异性针对p-选择素的双环肽配体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643873A (en) * 1992-05-06 1997-07-01 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
WO1994005269A1 (en) * 1992-09-08 1994-03-17 Centocor, Inc. Peptide inhibitors of selectin binding
WO1994014836A1 (en) * 1992-12-18 1994-07-07 Centocor, Inc. Peptide inhibitors of selectin binding
WO1996000581A1 (en) * 1994-06-29 1996-01-11 Texas Biotechnology Corporation Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin
US5663144A (en) * 1995-05-03 1997-09-02 The Trustees Of The University Of Pennsylvania Compounds that bind to p185 and methods of using the same
US6114517A (en) * 1998-12-10 2000-09-05 Isis Pharmaceuticals Inc. Methods of modulating tumor necrosis factor α-induced expression of cell adhesion molecules
US20020152495A1 (en) * 1999-01-15 2002-10-17 Toshiro Ito Plants having seedless fruit

Also Published As

Publication number Publication date
ES2337663T3 (es) 2010-04-28
JP4227520B2 (ja) 2009-02-18
ATE446311T1 (de) 2009-11-15
US7531516B2 (en) 2009-05-12
EP1423413A1 (en) 2004-06-02
JP2005501544A (ja) 2005-01-20
NO20040905L (no) 2004-05-26
CN100413883C (zh) 2008-08-27
MXPA04002055A (es) 2004-07-08
EP1423413B1 (en) 2009-10-21
WO2003020753A1 (en) 2003-03-13
PL369030A1 (en) 2005-04-18
DE60234108D1 (en) 2009-12-03
CA2459230A1 (en) 2003-03-13
BR0212219A (pt) 2004-09-21
EP1288222A1 (en) 2003-03-05
CN1549824A (zh) 2004-11-24
US20050004035A1 (en) 2005-01-06
HUP0401728A2 (hu) 2004-11-29
ZA200400956B (en) 2005-04-18
HRP20040127A2 (en) 2004-06-30

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MKLA Lapsed

Effective date: 20140828