BR0212219A - Compostos peptìdicos que se ligam seletivamente à p-selectina - Google Patents
Compostos peptìdicos que se ligam seletivamente à p-selectinaInfo
- Publication number
- BR0212219A BR0212219A BR0212219-7A BR0212219A BR0212219A BR 0212219 A BR0212219 A BR 0212219A BR 0212219 A BR0212219 A BR 0212219A BR 0212219 A BR0212219 A BR 0212219A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- selectin
- peptide
- selectively bind
- amino acid
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 10
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 102000008212 P-Selectin Human genes 0.000 abstract 1
- 108010035766 P-Selectin Proteins 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000001476 gene delivery Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
"COMPOSTOS PEPTìDICOS QUE SE LIGAM SELETIVAMENTE à P-SELECTINA". A presente invenção relaciona-se a compostos que se ligam seletivamente à molécula de adesão P-selectina humana, e particularmente a tais compostos compreendendo um peptídeo com uma seq³ência de aminoácido XA~ x~A~ 3~A~ 1~A~2~A~ 1~Y, ou um equivalente funcional do referido peptídeo. Além disso, a invenção relaciona-se a métodos para preparar tais compostos, ao uso de tais compostos em métodos terapêuticos ou de diagnóstico e em composições farmacêuticas, a ácidos nucléicos codificando para materiais proteináceos compreendendo as seq³ências de aminoácido dos referidos compostos, aos veículos de entrega de gene compreendendo tais ácidos nucléicos, às moléculas de ligação que se ligam aos referidos compostos, e a um método para determinar se um composto é capaz de ligar-se à P-selectina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01203314A EP1288222A1 (en) | 2001-09-03 | 2001-09-03 | Peptidic compounds selectively binding to P-selectin |
PCT/NL2002/000566 WO2003020753A1 (en) | 2001-09-03 | 2002-08-28 | Peptidic compounds selectively binding to p-selectin |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0212219A true BR0212219A (pt) | 2004-09-21 |
Family
ID=8180873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0212219-7A BR0212219A (pt) | 2001-09-03 | 2002-08-28 | Compostos peptìdicos que se ligam seletivamente à p-selectina |
Country Status (16)
Country | Link |
---|---|
US (1) | US7531516B2 (pt) |
EP (2) | EP1288222A1 (pt) |
JP (1) | JP4227520B2 (pt) |
CN (1) | CN100413883C (pt) |
AT (1) | ATE446311T1 (pt) |
BR (1) | BR0212219A (pt) |
CA (1) | CA2459230C (pt) |
DE (1) | DE60234108D1 (pt) |
ES (1) | ES2337663T3 (pt) |
HR (1) | HRP20040127A2 (pt) |
HU (1) | HUP0401728A2 (pt) |
MX (1) | MXPA04002055A (pt) |
NO (1) | NO20040905L (pt) |
PL (1) | PL369030A1 (pt) |
WO (1) | WO2003020753A1 (pt) |
ZA (1) | ZA200400956B (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0313019A (pt) * | 2002-08-09 | 2005-07-12 | Yamanouchi Europ Bv | Compostos que se ligam a p-selectina |
MXPA05003844A (es) | 2002-10-11 | 2005-06-22 | Yamanouchi Europ Bv | Compuestos con base de glucosa con afinidad para p-selectina. |
EP1481683A1 (en) * | 2003-05-30 | 2004-12-01 | Yamanouchi Pharmaceutical Co. Ltd. | P-selectin targeting ligand and compositions thereof |
US9107963B2 (en) * | 2012-04-13 | 2015-08-18 | Case Western Reserve University | Heteromultivalent nanoparticle compositions |
US9833518B2 (en) | 2012-04-13 | 2017-12-05 | Case Western Reserve University | Heteromultivalent particle compositions |
US10279347B2 (en) * | 2014-04-08 | 2019-05-07 | Dna Medicine Institute, Inc. | Fluidics module |
US11879012B2 (en) | 2018-03-02 | 2024-01-23 | Peter GILLIES | Method of modulating cell proliferation |
CN111671905B (zh) * | 2020-06-23 | 2022-05-27 | 中国医学科学院医学实验动物研究所 | P-选择蛋白糖蛋白配体-1作为靶点在制备预防和/或治疗动脉瘤的药物中的应用 |
WO2022223969A1 (en) * | 2021-04-20 | 2022-10-27 | Bicycletx Limited | Bicyclic peptide ligands specific for p-selectin |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5643873A (en) * | 1992-05-06 | 1997-07-01 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1 |
WO1994005269A1 (en) * | 1992-09-08 | 1994-03-17 | Centocor, Inc. | Peptide inhibitors of selectin binding |
WO1994014836A1 (en) * | 1992-12-18 | 1994-07-07 | Centocor, Inc. | Peptide inhibitors of selectin binding |
EP0767674A4 (en) * | 1994-06-29 | 1999-06-16 | Texas Biotechnology Corp | METHOD FOR INHIBITING THE BINDING OF INTEGRIN ALPHA 4 BETA 1 TO VCAM-1 OR FIBRONECTIN |
US5663144A (en) * | 1995-05-03 | 1997-09-02 | The Trustees Of The University Of Pennsylvania | Compounds that bind to p185 and methods of using the same |
US6114517A (en) * | 1998-12-10 | 2000-09-05 | Isis Pharmaceuticals Inc. | Methods of modulating tumor necrosis factor α-induced expression of cell adhesion molecules |
US20020152495A1 (en) * | 1999-01-15 | 2002-10-17 | Toshiro Ito | Plants having seedless fruit |
-
2001
- 2001-09-03 EP EP01203314A patent/EP1288222A1/en not_active Withdrawn
-
2002
- 2002-08-28 DE DE60234108T patent/DE60234108D1/de not_active Expired - Lifetime
- 2002-08-28 ES ES02758940T patent/ES2337663T3/es not_active Expired - Lifetime
- 2002-08-28 CA CA2459230A patent/CA2459230C/en not_active Expired - Fee Related
- 2002-08-28 WO PCT/NL2002/000566 patent/WO2003020753A1/en active Application Filing
- 2002-08-28 BR BR0212219-7A patent/BR0212219A/pt not_active IP Right Cessation
- 2002-08-28 MX MXPA04002055A patent/MXPA04002055A/es not_active Application Discontinuation
- 2002-08-28 CN CNB028171934A patent/CN100413883C/zh not_active Expired - Fee Related
- 2002-08-28 PL PL02369030A patent/PL369030A1/xx not_active Application Discontinuation
- 2002-08-28 EP EP02758940A patent/EP1423413B1/en not_active Expired - Lifetime
- 2002-08-28 JP JP2003525023A patent/JP4227520B2/ja not_active Expired - Fee Related
- 2002-08-28 US US10/488,509 patent/US7531516B2/en not_active Expired - Fee Related
- 2002-08-28 HU HU0401728A patent/HUP0401728A2/hu unknown
- 2002-08-28 AT AT02758940T patent/ATE446311T1/de not_active IP Right Cessation
-
2004
- 2004-02-05 ZA ZA200400956A patent/ZA200400956B/en unknown
- 2004-02-06 HR HR20040127A patent/HRP20040127A2/hr not_active Application Discontinuation
- 2004-03-02 NO NO20040905A patent/NO20040905L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20050004035A1 (en) | 2005-01-06 |
ZA200400956B (en) | 2005-04-18 |
EP1423413B1 (en) | 2009-10-21 |
NO20040905L (no) | 2004-05-26 |
HUP0401728A2 (hu) | 2004-11-29 |
HRP20040127A2 (en) | 2004-06-30 |
CA2459230C (en) | 2011-11-08 |
US7531516B2 (en) | 2009-05-12 |
CN100413883C (zh) | 2008-08-27 |
CN1549824A (zh) | 2004-11-24 |
DE60234108D1 (en) | 2009-12-03 |
PL369030A1 (en) | 2005-04-18 |
MXPA04002055A (es) | 2004-07-08 |
WO2003020753A1 (en) | 2003-03-13 |
EP1288222A1 (en) | 2003-03-05 |
JP4227520B2 (ja) | 2009-02-18 |
ES2337663T3 (es) | 2010-04-28 |
JP2005501544A (ja) | 2005-01-20 |
EP1423413A1 (en) | 2004-06-02 |
ATE446311T1 (de) | 2009-11-15 |
CA2459230A1 (en) | 2003-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 5A., 6A. E 7A. ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2029 DE 24/11/2009. |