JP2005500373A - モルヒネ様オピオイド化合物の誘導体 - Google Patents

モルヒネ様オピオイド化合物の誘導体 Download PDF

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Publication number
JP2005500373A
JP2005500373A JP2003519071A JP2003519071A JP2005500373A JP 2005500373 A JP2005500373 A JP 2005500373A JP 2003519071 A JP2003519071 A JP 2003519071A JP 2003519071 A JP2003519071 A JP 2003519071A JP 2005500373 A JP2005500373 A JP 2005500373A
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JP
Japan
Prior art keywords
compound
formula
group
substituted
alkyl
Prior art date
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Abandoned
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JP2003519071A
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English (en)
Japanese (ja)
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JP2005500373A5 (https=
Inventor
ジャクソン、ウイリアム、ロイ
スバシィンゲ、カマニ、ルピカ
Original Assignee
ポリチップ ファーマスーティカルズ プロプライエタリイ リミテッド
モナシュ ユニバーシティ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPR6938A external-priority patent/AUPR693801A0/en
Priority claimed from AUPR9640A external-priority patent/AUPR964001A0/en
Application filed by ポリチップ ファーマスーティカルズ プロプライエタリイ リミテッド, モナシュ ユニバーシティ filed Critical ポリチップ ファーマスーティカルズ プロプライエタリイ リミテッド
Publication of JP2005500373A publication Critical patent/JP2005500373A/ja
Publication of JP2005500373A5 publication Critical patent/JP2005500373A5/ja
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
JP2003519071A 2001-08-10 2002-08-09 モルヒネ様オピオイド化合物の誘導体 Abandoned JP2005500373A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPR6938A AUPR693801A0 (en) 2001-08-10 2001-08-10 Therapeutic compounds
AUPR9640A AUPR964001A0 (en) 2001-12-19 2001-12-19 Therapeutic compounds
PCT/AU2002/001088 WO2003014122A1 (en) 2001-08-10 2002-08-09 Derivatives of morphine-like opioid compounds

Publications (2)

Publication Number Publication Date
JP2005500373A true JP2005500373A (ja) 2005-01-06
JP2005500373A5 JP2005500373A5 (https=) 2006-01-05

Family

ID=25646773

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003519071A Abandoned JP2005500373A (ja) 2001-08-10 2002-08-09 モルヒネ様オピオイド化合物の誘導体

Country Status (7)

Country Link
US (1) US7199129B2 (https=)
EP (1) EP1423392B1 (https=)
JP (1) JP2005500373A (https=)
AT (1) ATE341552T1 (https=)
AU (1) AU2002322169B2 (https=)
DE (1) DE60215195T2 (https=)
WO (1) WO2003014122A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040204862A1 (en) * 2003-04-11 2004-10-14 Wainer Irving W. Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors
TWI541246B (zh) 2008-12-08 2016-07-11 歐陸斯迪公司 二氫羥戊甲嗎啡
WO2013043518A1 (en) 2011-09-22 2013-03-28 Merck Sharp & Dohme Corp. Imidazopyridyl compounds as aldosterone synthase inhibitors
EP2757884B1 (en) 2011-09-22 2022-07-27 Merck Sharp & Dohme LLC Pyrazolopyridyl compounds as aldosterone synthase inhibitors
US9193724B2 (en) 2011-09-22 2015-11-24 Merck Sharp & Dohme Corp. Triazolopyridyl compounds as aldosterone synthase inhibitors
CA2879454A1 (en) 2012-07-19 2014-01-23 Drexel University Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method
CN105683630B (zh) * 2013-10-18 2017-11-21 株式会社理研 内燃机用活塞环
WO2019089902A1 (en) 2017-11-01 2019-05-09 Drexel University Compounds, compositions, and methods for treating diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3341538A (en) * 1965-06-18 1967-09-12 Geigy Chem Corp Certain 2, 6-methano-3-benzazocines
ATE314372T1 (de) 1998-01-29 2006-01-15 Univ Monash Therapeutische verbindungen
BR0113585A (pt) * 2000-08-31 2003-07-29 Hoffmann La Roche Derivados quinazolina como antagonistas adrenérgicos alfa-1

Also Published As

Publication number Publication date
DE60215195T2 (de) 2007-08-23
EP1423392A1 (en) 2004-06-02
US20040242616A1 (en) 2004-12-02
US7199129B2 (en) 2007-04-03
ATE341552T1 (de) 2006-10-15
EP1423392A4 (en) 2004-11-17
AU2002322169B2 (en) 2008-10-30
WO2003014122A1 (en) 2003-02-20
DE60215195D1 (de) 2006-11-16
EP1423392B1 (en) 2006-10-04

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