DE60215195D1 - Derivate morphinähnlicher opioidverbindungen - Google Patents

Derivate morphinähnlicher opioidverbindungen

Info

Publication number
DE60215195D1
DE60215195D1 DE60215195T DE60215195T DE60215195D1 DE 60215195 D1 DE60215195 D1 DE 60215195D1 DE 60215195 T DE60215195 T DE 60215195T DE 60215195 T DE60215195 T DE 60215195T DE 60215195 D1 DE60215195 D1 DE 60215195D1
Authority
DE
Germany
Prior art keywords
derivatives
compounds
morphinary
formula
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60215195T
Other languages
English (en)
Other versions
DE60215195T2 (de
Inventor
Roy Jackson
Rupika Subasinghe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monash University
Neuro Therapeutics Ltd
Original Assignee
Monash University
Neuro Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPR6938A external-priority patent/AUPR693801A0/en
Priority claimed from AUPR9640A external-priority patent/AUPR964001A0/en
Application filed by Monash University, Neuro Therapeutics Ltd filed Critical Monash University
Publication of DE60215195D1 publication Critical patent/DE60215195D1/de
Application granted granted Critical
Publication of DE60215195T2 publication Critical patent/DE60215195T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE60215195T 2001-08-10 2002-08-09 Derivate morphinähnlicher opioidverbindungen Expired - Fee Related DE60215195T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPR6938A AUPR693801A0 (en) 2001-08-10 2001-08-10 Therapeutic compounds
AUPR693801 2001-08-10
AUPR9640A AUPR964001A0 (en) 2001-12-19 2001-12-19 Therapeutic compounds
AUPR964001 2001-12-19
PCT/AU2002/001088 WO2003014122A1 (en) 2001-08-10 2002-08-09 Derivatives of morphine-like opioid compounds

Publications (2)

Publication Number Publication Date
DE60215195D1 true DE60215195D1 (de) 2006-11-16
DE60215195T2 DE60215195T2 (de) 2007-08-23

Family

ID=25646773

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60215195T Expired - Fee Related DE60215195T2 (de) 2001-08-10 2002-08-09 Derivate morphinähnlicher opioidverbindungen

Country Status (7)

Country Link
US (1) US7199129B2 (de)
EP (1) EP1423392B1 (de)
JP (1) JP2005500373A (de)
AT (1) ATE341552T1 (de)
AU (1) AU2002322169B2 (de)
DE (1) DE60215195T2 (de)
WO (1) WO2003014122A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040204862A1 (en) * 2003-04-11 2004-10-14 Wainer Irving W. Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors
TWI630208B (zh) 2008-12-08 2018-07-21 歐陸斯迪公司 二氫羥戊甲嗎啡
WO2013043518A1 (en) 2011-09-22 2013-03-28 Merck Sharp & Dohme Corp. Imidazopyridyl compounds as aldosterone synthase inhibitors
WO2013043521A1 (en) 2011-09-22 2013-03-28 Merck Sharp & Dohme Corp. Pyrazolopyridyl compounds as aldosterone synthase inhibitors
EP2757883B1 (de) 2011-09-22 2021-01-13 Merck Sharp & Dohme Corp. Triazolopyridylverbindungen als aldosteronsynthasehemmer
AU2013292519B2 (en) 2012-07-19 2017-12-07 Drexel University Sigma receptor ligands for modulating cellular protein homeostasis
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method
CN105683630B (zh) * 2013-10-18 2017-11-21 株式会社理研 内燃机用活塞环
WO2019089902A1 (en) 2017-11-01 2019-05-09 Drexel University Compounds, compositions, and methods for treating diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3341538A (en) * 1965-06-18 1967-09-12 Geigy Chem Corp Certain 2, 6-methano-3-benzazocines
JP2002501923A (ja) * 1998-01-29 2002-01-22 モナシュ ユニバーシティ 治療用化合物
BR0113585A (pt) 2000-08-31 2003-07-29 Hoffmann La Roche Derivados quinazolina como antagonistas adrenérgicos alfa-1

Also Published As

Publication number Publication date
JP2005500373A (ja) 2005-01-06
ATE341552T1 (de) 2006-10-15
US7199129B2 (en) 2007-04-03
EP1423392A4 (de) 2004-11-17
DE60215195T2 (de) 2007-08-23
EP1423392B1 (de) 2006-10-04
EP1423392A1 (de) 2004-06-02
WO2003014122A1 (en) 2003-02-20
AU2002322169B2 (en) 2008-10-30
US20040242616A1 (en) 2004-12-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee