JP2005500284A5 - - Google Patents
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- JP2005500284A5 JP2005500284A5 JP2003503226A JP2003503226A JP2005500284A5 JP 2005500284 A5 JP2005500284 A5 JP 2005500284A5 JP 2003503226 A JP2003503226 A JP 2003503226A JP 2003503226 A JP2003503226 A JP 2003503226A JP 2005500284 A5 JP2005500284 A5 JP 2005500284A5
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- halo
- aliphatic
- optionally substituted
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- compound
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 230000006433 tumor necrosis factor production Effects 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 241000701366 unidentified nuclear polyhedrosis viruses Species 0.000 description 1
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- 239000003871 white petrolatum Substances 0.000 description 1
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- IGJRPICXFFLHNU-UHFFFAOYSA-L zinc;1,3-benzoxazol-2-olate;s-(dimethylcarbamoylsulfanyl) n,n-dimethylcarbamothioate;1,2,3,4,5,6-hexachlorobenzene;1,2,3,4,5,6-hexachlorocyclohexane Chemical compound [Zn+2].C1=CC=C2OC([O-])=NC2=C1.C1=CC=C2OC([O-])=NC2=C1.CN(C)C(=O)SSC(=O)N(C)C.ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl.ClC1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl IGJRPICXFFLHNU-UHFFFAOYSA-L 0.000 description 1
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29742601P | 2001-06-11 | 2001-06-11 | |
| PCT/US2002/021130 WO2002100405A1 (en) | 2001-06-11 | 2002-06-11 | Isoquinoline inhibitors of p38 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009193707A Division JP2009275054A (ja) | 2001-06-11 | 2009-08-24 | Ｐ３８のイソキノリンインヒビター |
Publications (2)
| Publication Number | Publication Date |
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| JP2005500284A JP2005500284A (ja) | 2005-01-06 |
| JP2005500284A5 true JP2005500284A5 (https=) | 2009-11-05 |
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| JP2003503226A Pending JP2005500284A (ja) | 2001-06-11 | 2002-06-11 | Ｐ３８のイソキノリンインヒビター |
| JP2009193707A Withdrawn JP2009275054A (ja) | 2001-06-11 | 2009-08-24 | Ｐ３８のイソキノリンインヒビター |
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| JP2009193707A Withdrawn JP2009275054A (ja) | 2001-06-11 | 2009-08-24 | Ｐ３８のイソキノリンインヒビター |
Country Status (6)
| Country | Link |
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| US (3) | US6552019B1 (https=) |
| EP (2) | EP1414455B1 (https=) |
| JP (2) | JP2005500284A (https=) |
| AT (1) | ATE415162T1 (https=) |
| DE (1) | DE60230044D1 (https=) |
| WO (1) | WO2002100405A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY132496A (en) * | 1998-05-11 | 2007-10-31 | Vertex Pharma | Inhibitors of p38 |
| ATE415162T1 (de) * | 2001-06-11 | 2008-12-15 | Vertex Pharma | Isochinolin-inhibitoren von p38 |
| JP2006527197A (ja) * | 2003-06-06 | 2006-11-30 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | ｐ３８キナーゼ阻害剤組成物及びその使用方法 |
| AR058223A1 (es) * | 2005-11-25 | 2008-01-23 | Palau Pharma Sa | Un comuesto de derivados de pirazoloisoquinolina, un procedimiento para l a preparacion de dicho compuesto y una composicion farmaceutica que comprende dicho compuesto |
| EP2380878B1 (en) | 2009-01-19 | 2013-08-14 | Daiichi Sankyo Company, Limited | Cyclic compound having hetero atom |
| KR20140011780A (ko) | 2012-07-19 | 2014-01-29 | 한미약품 주식회사 | 단백질 키나아제 저해활성을 갖는 이소퀴놀린-5-카복스아미드 유도체 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| WO2019071147A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5559137A (en) | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| FI972970A7 (fi) | 1995-01-12 | 1997-09-11 | Smithkline Beecham Corp | Uusia yhdisteitä |
| US6147080A (en) | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| US6093742A (en) | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| FR2767539B1 (fr) | 1997-08-21 | 1999-10-01 | Vetrotex France Sa | Procede de fabrication d'un fil et produits comprenant ce fil |
| ATE404539T1 (de) * | 1997-10-02 | 2008-08-15 | Eisai R&D Man Co Ltd | Kondensierte pyridinderivate |
| GB9721964D0 (en) * | 1997-10-16 | 1997-12-17 | Pfizer Ltd | Isoquinolines |
| MY132496A (en) | 1998-05-11 | 2007-10-31 | Vertex Pharma | Inhibitors of p38 |
| JP2002517486A (ja) | 1998-06-12 | 2002-06-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | ｐ３８のインヒビター |
| AR023659A1 (es) | 1998-09-18 | 2002-09-04 | Vertex Pharma | Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos |
| WO2000017175A1 (en) | 1998-09-18 | 2000-03-30 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF p38 |
| ATE415162T1 (de) * | 2001-06-11 | 2008-12-15 | Vertex Pharma | Isochinolin-inhibitoren von p38 |
-
2002
- 2002-06-11 AT AT02749777T patent/ATE415162T1/de not_active IP Right Cessation
- 2002-06-11 EP EP02749777A patent/EP1414455B1/en not_active Expired - Lifetime
- 2002-06-11 EP EP08020480A patent/EP2036891A3/en not_active Withdrawn
- 2002-06-11 JP JP2003503226A patent/JP2005500284A/ja active Pending
- 2002-06-11 WO PCT/US2002/021130 patent/WO2002100405A1/en not_active Ceased
- 2002-06-11 US US10/171,017 patent/US6552019B1/en not_active Expired - Lifetime
- 2002-06-11 DE DE60230044T patent/DE60230044D1/de not_active Expired - Fee Related
-
2003
- 2003-03-25 US US10/400,269 patent/US6759535B2/en not_active Expired - Fee Related
-
2004
- 2004-07-01 US US10/883,305 patent/US6962996B2/en not_active Expired - Lifetime
-
2009
- 2009-08-24 JP JP2009193707A patent/JP2009275054A/ja not_active Withdrawn
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