JP2005288022A - Medical multi-chambered container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical multi-chambered container, not giving a dose of chemicals until partitioning weak seal part is peeled, and making preparation for dose by simple operation. <P>SOLUTION: This medical multi-chambered container 1 includes: a container body 2, divided into a first medicine chamber 21 and a second medicine chamber 22 by a separable partitioning weak seal part 9; a discharge port 3 communicating with the lower end part of the first medicine chamber 21; a first medicine stored in the first medicine chamber 21; and a second medicine stored in the second medicine chamber 22. The first medicine chamber 21 of the medical double-chamber container is formed to gradually decrease in width as it goes from the partitioning weak seal part 9 side to the discharge port 3 side, and the starting point of decreasing of the width is put on the partitioning weak seal part 9 side from the half of the first medicine chamber 21 in the vertical direction. Further, the container includes a communication inhibiting weak seal part 11 provided in the vicinity of the discharge port 3 and inhibiting communication between the first medicine chamber 21 and the discharge port 3. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a medical multi-chamber container that is divided into two drug chambers by a peelable weak seal portion and each drug chamber is filled with a drug.

Among drugs that administer nutritional components intravenously to patients, there are unstable drugs that tend to change over time when pre-mixed. For example, when an amino acid solution and a glucose solution are blended and stored in advance, the mixed solution is colored (brown) by the Maillard reaction. Moreover, when a calcium compound is blended with a phosphate compound, precipitation of calcium phosphate occurs in a solution having a high pH, and the product value is significantly reduced. When such a drug is administered to a patient, for example, as shown in Japanese Patent No. 2675075 (patent document 1), a medical multi-chamber container that individually accommodates components before mixing is used, and then mixed before administration. Is starting to do.
This medical multi-chamber container includes a plurality of chambers for individually storing different component drugs, and a partition weak seal that separates the chambers and peels and opens them by pressure from the outside.

However, in many cases, the multiple medical containers contain the liquid agent in the storage part on the discharge port side, and the bottle needle is inserted into the rubber stopper without peeling off the weak seal for partitioning, and the liquid agent is discharged from the discharge port. There is a possibility of taking it out.
For this reason, a method has been devised to ensure that drugs stored in each storage unit are mixed and then administered to the patient, and to prevent accidents in which the drug is administered to the patient without accidental mixing. For example, as shown in Japanese Patent Laid-Open No. 9-327498 (Patent Document 2) and Japanese Patent Application Laid-Open No. 2002-136570 (Patent Document 3), a weak seal portion for preventing communication is provided that separates a medicine discharge port from a compartment for storing the medicine. A multi-chamber container has been proposed.

Japanese Patent No. 2675075 JP-A-9-327498 JP 2002-136570 A

In the ones shown in Patent Documents 2 and 3, the possibility of inserting the bottle needle into the stopper and taking out the liquid agent from the discharge port without peeling off the partitioning weak seal portion is considerably reduced. However, since it has a plurality of weak seals for partitioning the weak seal part for partitioning the compartment for storing the medicine and the weak seal part for blocking communication between the medicine discharge port and the compartment for storing the medicine, the weak seal part for partition is provided. After peeling and mixing the chemicals, it is necessary to peel the weak seal portion for communication inhibition. For this reason, it took time to prepare for administration.
An object of the present invention is to divide into two drug chambers by a detachable partition weak seal portion, and in a medical multi-chamber container filled with a drug in the drug chamber, the partition weak seal portion is not peeled off. Thus, it is intended to provide a medical multi-chamber container in which a chemical solution is not administered and preparation for administration can be performed with an easy operation.

What achieves the above object is as follows.
(1) A container body that is formed of a flexible material and is divided into a first drug chamber and a second drug chamber by a partition weak seal portion that can be peeled off, and a lower end of the first drug chamber A medicine-filled medical multi-chamber container comprising a discharge port communicating with a portion, a first medicine housed in the first medicine chamber, and a second medicine housed in the second medicine chamber. The first drug chamber of the medical multi-chamber container is formed so that the width is narrowed from the partition weak seal part side toward the discharge port side, It is the partition weak seal part side from the up-down direction 1/2 of the first drug chamber, and the medical multi-chamber container is provided near the discharge port, and the first drug chamber and the discharge port With a weak seal part for inhibiting communication and inhibiting communication The medical weak chamber part is a medical multi-chamber container in which the lateral length of the medical multi-chamber container is shorter than the length of the partition weak seal part.

(2) In the medical multi-chamber container, the communication-inhibiting weak seal portion is peeled off simultaneously with or subsequent to the peeling of the partition weak seal portion by pressing the first drug chamber ( A medical multi-chamber container according to 1).
(3) The multi-chamber container for medical use is one in which the weak seal portion for communication inhibition is peeled off after the weak seal portion for partitioning is peeled by pressing the second drug chamber (1). A multi-chamber container for medical use according to 1.
(4) The medical multi-chamber container according to any one of (1) to (3), wherein the first drug and the second drug are liquid drugs.
(5) The lateral length of the medical multi-chamber container of the weak seal portion for communication inhibition is 1/6 to 5/6 of the length of the weak seal portion for partition (1) to (4) A medical multi-chamber container according to any one of the above.
(6) The first medicine chamber has a substantially triangular shape with a discharge port as a vertex or a trapezoidal shape with a short side on the discharge port side. (1) to (5) Medical multi-chamber container.
(7) The medical multi-chamber container according to (6), wherein an intersection angle of an extension line of an inner edge of the first drug chamber is 45 to 100 degrees.
(8) The medical multi-chamber container according to any one of (1) to (7), wherein the partition weak seal portion and the communication blocking weak seal portion are heat seal portions.
(9) The seal strength of the weak seal portion for blocking communication is substantially the same as that of the weak seal portion for partitioning, or is slightly weaker or slightly stronger, according to any one of (1) to (8) Medical multi-chamber container.
(10) The partition weak seal portion includes a portion having a stronger seal strength than other portions of the weak seal portion provided on both sides of the position above the communication inhibiting weak seal portion (1). Thru | or the medical multi-chamber container in any one of (9).

  The medical multi-chamber container of the present invention is made of a flexible material, and the container main body is divided into a first drug chamber and a second drug chamber by a partition weak seal part from which the internal space can be peeled, A medicine containing a discharge port communicating with the lower end of the first medicine chamber, a first medicine housed in the first medicine chamber, and a second medicine housed in the second medicine chamber The medical multi-chamber container, wherein the first drug chamber of the medical multi-chamber container is formed so that the width is narrowed from the partition weak seal portion side toward the discharge port side, The starting point where the width becomes narrower is on the side of the partition weak seal part from the vertical direction 1/2 of the first drug chamber, and the medical multi-chamber container is provided in the vicinity of the discharge port. A weak seal portion for inhibiting communication between the medicine chamber and the discharge port is provided; To, the communicating inhibitory weak seal portion, the lateral length of the multi-chamber medical container has has become shorter than the length of the partitioning weak seal portion. For this reason, by pressing the first drug chamber or the second drug chamber and applying internal pressure, the partition weak seal part is peeled off, the drugs are mixed with each other, and the partition weak seal part is simultaneously peeled off. Alternatively, the weak seal portion for inhibiting communication is also peeled off. For this reason, the medicine stored in the first chamber and the second chamber is prevented from being administered to the patient without mixing, and an independent peeling operation for the weak seal portion for preventing communication is unnecessary and easy. Can be prepared by simple operation.

The medical multi-chamber container of the present invention will be described using an embodiment shown in the drawings.
FIG. 1 is a plan view of an embodiment of the medical multi-chamber container of the present invention, FIG. 2 is a partially enlarged view of the vicinity of the discharge port of the medical multi-chamber container of FIG. 1, and FIG. 4 is a plan view of another embodiment of the medical multi-chamber container of the invention, FIG. 4 is a plan view of another embodiment of the medical multi-chamber container of the present invention, and FIG. 5 is a medical view of FIG. FIG. 6 to FIG. 9 are plan views of other embodiments of the medical multi-chamber container of the present invention.
In addition, the upper side in the figure is described as “upper end” and the lower side is described as “lower end”.

  The medical multi-chamber container 1 of the present invention is a container formed of a flexible material and divided into a first drug chamber 21 and a second drug chamber 22 by a partition weak seal portion 9 whose internal space can be peeled off. The main body 2, the discharge port 3 communicating with the lower end of the first drug chamber 21, the first drug stored in the first drug chamber 21, and the second drug stored in the second drug chamber 22 It is a medical multi-chamber container containing a medicine. The first drug chamber 21 of the medical multi-chamber container 1 is formed so that the width becomes narrower from the partitioning weak seal portion 9 side toward the discharge port 3 side, and the starting point where the width becomes narrower is the first. Further, the medical double-chamber container 1 is provided near the discharge port 3 on the side of the partition weak seal portion 9 from the vertical direction 1/2 of the drug chamber 21, and the first drug chamber 21, the discharge port 3, A weak seal portion 11 for inhibiting communication is provided. In the communication-inhibiting weak seal portion 11, the lateral length of the medical multi-chamber container 1 is shorter than the length of the partition weak seal portion 9.

The medical multi-chamber container 1 of this embodiment includes a container main body 2 formed of a sheet-like cylindrical body, and a partition weak seal portion 9 that partitions an internal storage portion is formed in the container main body. The storage section is divided into a first drug chamber 21 and a second drug chamber 22.
As shown in FIG. 1, seal portions 5 and 6 are provided on the upper end side and the lower end side of the container body 2. Further, the medical multi-chamber container 1 of this embodiment includes a medicine discharge port 3 provided on the first medicine chamber 21 side. Furthermore, the medical multi-chamber container 1 of this embodiment includes a drug injection port 4 provided on the second drug chamber 22 side.

  The container body 2 of the medical multi-chamber container 1 is formed of a soft synthetic resin. The container body 2 is preferably formed into a cylindrical shape by an inflation molding method. The container body 2 may be manufactured by various methods such as a blow molding method and a coextrusion inflation method. In addition, the container body 2 is one in which the entire outer periphery (four sides) of the cylindrical body as described above is sealed, two sheet materials are stacked, and the entire outer periphery is sealed, one sheet. It may be a bag-like object such as one that is folded in two and three sides other than the bent part are sealed. In addition, a hole 25 for suspending the medical multi-chamber container 1 on a hanger or the like is provided at a substantially central portion of the seal portion 5 on the upper end side of the container body 2.

The container body 2 preferably has a water vapor barrier property. As the degree of water vapor barrier property, the water vapor permeability is preferably 50 g / m ² · 24 hrs · 40 ° C. · 90% RH or less, more preferably 10 g / m ² · 24 hrs · 40 ° C. · 90% RH or less. More preferably, it is 1 g / m ² · 24 hrs · 40 ° C. · 90% RH or less. This water vapor permeability is measured by the method described in JISK7129 (Method A).
Thus, the container main body 2 has a water vapor barrier property, so that the evaporation of moisture from the inside of the medical multi-chamber container 1 can be prevented. As a result, it is possible to prevent reduction and concentration of the medicine (specifically, chemical solution) to be filled. Moreover, the invasion of water vapor from the outside of the medical multi-chamber container 1 can be prevented.

When polyolefin is contained as a material for forming such a container body 2, the usefulness of the present invention is great. Therefore, in the present invention, it is preferable that the material for forming the container body 2 includes polyolefins. Particularly preferable materials for forming the container body 2 include polyolefins such as polyethylene (PE), polypropylene (PP), polybutadiene, and ethylene-vinyl acetate copolymer (EVA), styrene-butadiene copolymer and styrene. -Flexible by blending styrene thermoplastic elastomers such as ethylene-butylene-styrene block copolymers or olefinic thermoplastic elastomers such as ethylene-propylene copolymers, ethylene-butene copolymers, propylene-α olefin copolymers This material can be soft and flexible, and has high strength and flexibility, heat resistance (especially heat resistance during sterilization), high water resistance, and particularly excellent workability, reducing production costs. It is preferable in that it can be achieved.
Further, when the above blend resin is used, two or more kinds of materials having different melting points are used. The seal part 5 on the upper end side and the seal part 6 on the front end side of the container main body 2, a first medicine described later. To easily and satisfactorily set each seal condition of the side seal portions 7 and 8 of the chamber 21, the partition weak seal portion 9 and the communication blocking weak seal portion 11 described later, and stabilize the seal strength of each seal portion. Can do.

  Further, the container body may have a single layer structure (single layer body) made of the material as described above, or a multilayer in which a plurality of layers (particularly layers of different materials) are stacked for various purposes. A laminated body may be sufficient. In the case of a multilayer laminate, a plurality of resin layers may be stacked, or a metal layer may be stacked on at least one resin layer. In the case where a plurality of resin layers are stacked, the advantages of the respective resins can be provided together. For example, the impact resistance of the container body 2 can be improved or anti-blocking properties can be imparted. Further, in the case of a metal layer, the gas barrier property of the container body 2 can be improved. For example, when a film such as an aluminum foil is laminated, the gas barrier property can be improved and the light shielding property can be imparted. In addition, when a layer made of an oxide such as titanium oxide, aluminum oxide, or silicon oxide is formed, the transparency of the container body 2 can be maintained while the gas barrier property is improved, and the internal visibility is ensured. Can do. In addition, when the container main body 2 is a multilayer laminated body, it is preferable that the material which forms the inner surface part is the material mentioned above.

The thickness of the sheet material constituting the container body 2 is appropriately determined according to the layer configuration and the characteristics of the material used (flexibility, strength, water vapor permeability, heat resistance, etc.), and is not particularly limited. However, it is usually preferably about 100 to 550 μm, and more preferably about 200 to 400 μm.
And the container main body 1 is provided with the weak seal part 9 for a partition, and the inside is divided into 2 chambers by this. The partition weak seal portion 9 includes a peelable weak seal portion 9 that traverses the container body 1 in the entire lateral direction, and a substantially non-peelable strong seal portion 9a provided in the branch portions of the weak seal portions 9 at both ends. I have.

The weak seal portion is preferably formed by heat sealing. Specifically, it is preferably performed by a hot press, and the mold temperature can be formed by a temperature lower by 10 ° C. or more than the melting temperature of the forming material of the container body 2.
The partition weak seal portion 9 in this embodiment is formed by fusing the sheet material of the container body 2 in a strip shape. The partition weak seal portion 9 presses, for example, the first drug chamber 21 or the second drug chamber 22 of the container body 2 by hand, and the first drug chamber 21 or the second drug chamber 22 By increasing the internal pressure, or by manually squeezing the first drug chamber 21 or the second drug 22 portion of the container body 2 with the medical multi-chamber container 1 hung on the hanger, the first drug chamber 21 Alternatively, it has a seal strength that can be peeled off by increasing the internal pressure of the second drug chamber 22. Thereby, the interruption | blocking by the weak seal part 9 for a partition is cancelled | released by a simple operation | work, without using a special instrument etc., and the chemical | medical agent of the 1st chemical | medical agent chamber 21 and the 2nd chemical | medical agent chamber 22 can be mixed.

In addition, the volume of the medical multi-chamber container 1 varies depending on the type of medicine accommodated therein, but it is usually preferable that the volume of the first medicine chamber is about 50 to 3000 mL, and the second medicine The chamber volume is preferably about 50 to 3000 mL.
By dividing the drug chamber into the first drug chamber 21 and the second drug chamber 22 in this way, it can be stored separately until a liquid containing a substance that causes alteration or deterioration due to reaction or the like is used. In use, it can be applied when it is preferable to mix both solutions. As a medicine stored in each medicine room, a medicine, a powder, etc. can be considered. In particular, in the medical multi-chamber container of the present invention, the first drug is preferably a chemical solution. The second drug may be either a chemical solution or a powder. A chemical solution is preferable. As a combination of the first drug and the second drug, for example, in the case of an infusion, a combination of an amino acid electrolyte solution and a glucose solution is used in order to prevent coloring due to the Maillard reaction. In addition, the pH of the side on which glucose is added as a peritoneal dialysis solution is adjusted to 3 to 5, and the other electrolyte solution is mixed, and then adjusted so that the pH is almost neutral at the time of administration. It is done.

In the present invention, the first drug and the second drug are not particularly limited. For example, physiological saline, electrolyte solution, Ringer's solution, high-calorie infusion, glucose solution, amino acid infusion, fat infusion, water for injection, peritoneum Any of dialysate, oral and enteral nutrients, etc. may be used.
A drug discharge port 3 that can communicate with the first drug chamber 21 is provided at the tip of the container body 2. The medicine discharge port 3 is fused in a state of being sandwiched between the sheet materials of the fixing portion 6 a portion of the seal portion 6 on the lower end side, and is firmly fixed to the container body 2.
The medicine discharge port 3 is for discharging the medicine (chemical solution) filled in the container body 2. As shown in FIG. 1, the discharge port 3 in this embodiment includes a cylindrical member 3a having an open upper end (first drug chamber side end), and a drug that is liquid-tightly attached to the lower end side of the cylindrical member. It has a communication part that can communicate with the discharge needle. The communicating part includes a cap member 3b and an elastic member 3c that seals the rear end opening and allows the needle for discharging the medicine to pass through. The communicating part is not limited to such a form.

The drug injection port 4 is for injecting a drug into the container body 2. As shown in FIG. 1, the injection port 4 in this embodiment includes a cylindrical member 4a having an open lower end (second drug chamber side end), and a drug that is liquid-tightly attached to the upper end side of the cylindrical member. A communication portion is provided which can be communicated with an injection needle. The communicating portion includes a cap member 4b and an elastic member 4c that seals the rear end opening and can be pierced with a drug injection needle. The communicating part is not limited to such a form.
The elastic members 3c and 4c can pierce a needle tube (not shown) such as a bottle needle or a cannula needle. When necessary, the elastic member 3c or 4c pierces the needle tube to discharge the medicine from the container body 2 or the container body 2. It is possible to add a drug or the like to the inside. In addition, the elastic member has a self-occlusion property, and after the needle tube is extracted from the elastic member, the puncture hole is instantaneously closed to prevent the medicine from leaking. Various materials such as styrene elastomers, olefin elastomers, polyamide elastomers, polyester elastomers and other thermoplastic elastomers, natural rubber, isoprene rubber, silicone rubber, butadiene rubber, styrene-butadiene rubber Elastic materials such as rubber materials, or combinations of any two or more of these (blends, laminates, etc.), polyolefins such as polyethylene, polypropylene, ethylene-propylene copolymers, or ethylene-vinyl acetate Examples thereof include a polymer, a crosslinked ethylene-vinyl acetate copolymer, polyester, polyvinyl chloride, polyurethane, polyamide, and other polymer materials.

  Constituent materials of the cylindrical member 3a and cap member 3b of the drug discharge port 3 and the cylindrical member 4a and cap member 4b of the drug injection port 4 include conditions, such as hardness, strength, toughness, and resistance to resistance. Materials having chemical properties, transparency, and other conditions are used, and it is preferable that the materials are composed of relatively hard materials. Examples of these materials include polyolefins such as polyethylene and polypropylene (low density to high density). ), Polyvinyl chloride (soft to hard), polycarbonate, polystyrene, polymethyl methacrylate, polyester (PET, PBT, etc.), polyamide, ABS resin, AS resin, polyacetal, polyphenylene sulfide, fluorine-based resin, etc. According to such conditions, it can select suitably and can be used.

  In the medical multi-chamber container 1 of this embodiment, a weak seal portion 11 for inhibiting communication is formed so as to surround the medicine discharge port 3. A third chamber 23 isolated from the first medicine chamber 21 is formed by the weak seal portion 11 for inhibiting communication. The third chamber 23 is an empty room. However, a predetermined liquid (for example, physiological saline) may be placed in the third chamber. The third chamber 23 may be in a dry state, but may be filled with a small amount of liquid for sterilization. Furthermore, a passage through which some water vapor or medicine passes through the communication inhibiting weak seal portion 11 may be formed and communicated with the first medicine chamber 21 at the above-described level. The weak seal portion 11 for inhibiting communication can be formed by heat-sealing the sheet material in a band shape (thermal fusion, high frequency fusion, ultrasonic fusion, etc.).

The first drug chamber 21 of the medical multi-chamber container 1 is formed so that the width becomes narrower from the partition weak seal portion 9 side toward the discharge port 3 side, and the starting point where the width becomes narrower is the first. It is the position on the side of the partition weak seal portion 9 from the vertical direction 1/2 of the one medicine chamber. And it is preferable that the width | variety of the 1st chemical | medical agent chamber 21 becomes narrow continuously toward the discharge port 3 side from the weak seal part 9 side for a partition. In addition, the starting point at which the width of the first drug chamber 21 becomes narrower is on the side of the partition weak seal portion 9 from 1/2 in the vertical direction of the first drug chamber. 3 is preferably located on the side of the partition weak seal portion 9.
The first drug chamber 21 in the medical multi-chamber container 1 of this embodiment has a trapezoidal shape in which the peripheral portion is continuously narrowed toward the drug discharge port 3 and the lower end side seal portion 6 is a short side. It has become. Specifically, the medical multi-chamber container 1 is on the upper side of the first drug chamber 21, and the side seal portion 7 extending in the discharge port direction from a position slightly on the discharge port side from the partition weak seal forming portion. , 8 are provided. The inner edges of the side seal portions 7 and 8 are preferably linear, but may be curved. In the case of a curved shape, the inner edges of the side seal portions 7 and 8 are preferably curved toward the center side (in other words, the inside) of the first drug chamber. By doing in this way, the effect of the present invention is more reliably exhibited.

And the crossing angle (R1: refer FIG. 2) of the extension line of the inner edge of the side seal parts 7 and 8 of the first medicine chamber 21 is 45 to 100 degrees. More preferably, it is 60 to 90 degrees. In addition, if said crossing angle is 45 degrees or more, the 1st chemical | medical agent chamber will not become too small, and if said crossing angle is 100 degrees or less, the effect of this invention is fully exhibited. To do.
Moreover, the shape of the lower end side seal part 6 of the 1st chemical | medical agent chamber 21 is not specifically limited. The lower end side seal portion 6 of the first drug chamber 21 is preferably shorter, and may be only the discharge port fixing portion. The effect of the present invention is more reliably exhibited when the lower end side seal portion 6 of the first drug chamber 21 is made shorter.
The medical multi-chamber container 1 includes a weak seal portion 11 for inhibiting communication that is provided in the vicinity of the discharge port 3 and inhibits communication between the first drug chamber 21 and the discharge port 3.
The seal strength (initial peel strength) of the partition weak seal portion 9 described above is not particularly limited, but it is usually preferably about 0.12 to 4.5 kgf / 20 mm width, preferably 0.35 to 2. More preferably, the width is 7 kgf / 20 mm. If the seal strength is within this range, the partition weak seal portion 9 will not be accidentally peeled off during transportation or storage, and the work of peeling off the partition weak seal portion 9 is easy.

Further, the seal strength (initial peel strength) of the weak seal portion 11 for inhibiting communication is not particularly limited, but it is usually preferably about 0.5 to 6.0 kgf / 20 mm width, and preferably 1.0 to 5 More preferably, the width is 0.0 kgf / 20 mm.
It is preferable that the seal strength of the weak seal portion 11 for inhibiting communication is substantially the same as that of the weak seal portion 9 for partitioning, or slightly weaker or slightly stronger. When it is recommended to peel the two weak seal portions 9 and 11 by compressing the first drug chamber 21, the seal strength of the weak seal portion 11 for blocking communication is almost equal to the seal strength of the weak seal portion 9 for partitioning. Preferably they are the same or slightly stronger. By doing in this way, when the 1st chemical | medical agent chamber 21 part of the container main body 2 is compressed, the weak seal part 11 for communication inhibition does not peel ahead of the weak seal part 9 for a partition.

Further, it may be recommended to peel off the two weak seal portions 9 and 11 by compressing the second drug chamber 22 portion. In this case, the seal strength of the weak seal portion 11 for inhibiting communication is determined by the partitioning. It is preferable that the sealing strength of the use weak seal portion 9 is substantially the same or slightly weaker. By doing in this way, the 1st chemical | medical agent chamber 21 part of the container main body 2 is pressed, and the weak seal part 11 for communication inhibition can be peeled with the force of the fluid at the time of peeling of the weak seal part 9 for a partition. .
Preferably, as described above, the seal strength of the communication-inhibiting weak seal portion 11 is slightly stronger than the seal strength of the partition weak seal portion 9.
The communication blocking weak seal portion 11 has a lateral length (Lb) of the medical multi-chamber container 1 and a lateral length (La) of the medical multi-chamber container 1 of the partition weak seal portion 9. It has become shorter. The lengths La and Lb are the lengths of the portion that functions as a weak seal in the lateral direction of the medical multi-chamber container 1 (in other words, the peelable portion).

The length (Lb) of the weak seal portion 11 for inhibiting communication according to the present invention is preferably 1/6 to 5/6 of the length (La) of the weak seal portion 9 for partitioning, more preferably 1/3. ~ 2/3. If the length of the weak seal part for communication inhibition is 1/6 or more of the length of the weak seal part for partitioning, an effective weak seal part for communication inhibition can be formed, and if it is 5/6 or less, The separation of the weak seal portion 9 for partitioning or the sequential separation is ensured.
And the weak seal | sticker part 11 for communication inhibition of this Example becomes the inverted U shape as shown in FIG.1 and FIG.2. Specifically, it has a U-shape that is reversed and slightly expanded.

The method for forming the partition weak seal portion 9 and the communication blocking weak seal portion 11 is not particularly limited, and can be performed using a heat seal heating mold (heat seal bar) or the like that is normally used. Moreover, you may use the method of producing blocking in the site | part of the weak seal part 9 for partition and the weak seal part 11 for communication inhibition at the time of heat sterilization, such as high pressure steam sterilization.
Hereinafter, a method for producing the medical multi-chamber container 1 will be described. The method is not limited to this method.
Upper end side seal portion 5 having a partially unsealed portion, lower end side seal portion 6 having a partially unsealed portion, side seal portion 7 having a partially unsealed portion, the other side seal portion 8, weak for partitioning A container body 2 having a seal portion 9 and a weak seal portion 11 for inhibiting communication is created. Then, the discharge port is inserted and fixed to the partially unsealed portion of the lower end side seal portion 5.

And the cylindrical member 4a of the injection | pouring port 4 adheres to the partially unsealed part of the upper end side seal part 5, a 2nd chemical | medical agent is inject | poured through the cylindrical member 4a, and the cylindrical member 4a becomes upper side With the container fixed in this manner, the elastic member 4c and the cap 4b are fixed to the cylindrical member 4 and sealed. And a 1st chemical | medical agent is inject | poured from the partially unsealed part of the side part seal part 7, and a non-seal part is strongly sealed in the state which fixed the container so that an unseal part may become upper. In this manner, a medical multi-chamber container filled with a medicine as shown in FIG. 1 is produced. The first medicine injection and the first medicine chamber sealing operation may be performed before the second medicine injection and the second medicine chamber sealing operation.
Moreover, you may perform preparation of the medical multiple-chamber container 1 as follows.
An upper end side seal portion 5 having a partially unsealed portion, a lower end side seal portion 6 having a partially unsealed portion, a side seal portion 7 and a side seal portion 8, and a container main body 2 having a partition weak seal portion 9 are provided. create.

  Then, the cylindrical member 3a of the discharge port 3 is fixed to the partially unsealed portion of the lower end side seal portion 6, and the first medicine is injected through the cylindrical member so that the cylindrical member 3a faces upward. After forming the weak seal portion 11 for inhibiting communication in a state where the container is fixed to the cylindrical member 3, the elastic member 3c and the cap 3b are fixed to the cylindrical member 3 and sealed. And the cylindrical member 4a of the injection | pouring port 4 adheres to the partially unsealed part of the upper end side seal part 5, a 2nd chemical | medical agent is inject | poured through the cylindrical member 4a, and the cylindrical member 4a becomes upper side With the container fixed in this manner, the elastic member 4c and the cap 4b are fixed to the cylindrical member 4 and sealed. In this manner, a medical multi-chamber container filled with a medicine as shown in FIG. 1 is produced. In addition, you may perform formation of the weak seal | sticker part 11 for communication inhibition after sealing an exhaust port. The first medicine may be injected from a partially unsealed portion of the lower end side seal portion 6 and the discharge port may be fixed after the injection. Further, the second drug injection and the second drug chamber sealing operation are performed before the first drug injection, the communication blocking weak seal portion 11 is formed, and the first drug chamber sealing operation is performed. It may be.

Next, the usage method of the medical multi-chamber container 1 of this invention is demonstrated.
The container body 2 in a state where the outer surface portion of the medical multi-chamber container 1 on the first drug chamber 21 side is pressed by hand or is hung on a hanger or the like through a hole 25 for hanging the medical multi-chamber container 1 When the internal pressure of the first drug chamber 21 is increased by manually squeezing the portion on the first drug chamber 21 side, the partition weak seal portion 9 is peeled off, and the first drug chamber 21 and the first drug chamber 21 are separated from each other. While the second medicine in the second medicine chamber is mixed, the weak seal of the communication inhibiting weak seal portion 11 is also peeled off simultaneously or slightly behind. Thereafter, a bottle needle or the like (not shown) is inserted into the medicine discharge port 3 to discharge the mixed medicine. Note that the bottle needle or the like may be inserted into the medicine discharge port 3 in advance before the partition weak seal portion 9 and the communication blocking weak seal portion 11 are peeled off.

As described above, the medical multi-chamber container of the present invention has been described based on the illustrated embodiments, but the present invention is not limited to these, and the configuration of each part is an arbitrary configuration that can exhibit the same function. In addition, an arbitrary configuration may be added.
The medical multi-chamber container of the present invention may be as shown in FIG. The only difference between this medical multi-chamber container 10 and the above-described medical multi-chamber container 1 is the shape of the weak seal portion 12 for inhibiting communication, and the others are the same, and are given the same reference numerals as described above. Refer to the description.

  The weak seal portion 12 for inhibiting communication of the medical multi-chamber container 10 of this embodiment has a curved portion 12a that curves toward the discharge port at the center. The width of the curved part 12a is slightly smaller than the width of the other part of the weak seal part 12 for inhibiting communication. By doing so, it is possible to suppress inadvertent separation of the weak seal portion 12 for inhibiting communication and to ensure separation at the central portion of the weak seal portion for inhibiting communication when the medical multi-chamber container is pressed. .

Further, the medical multi-chamber container of the present invention may be as shown in FIG. 4 and FIG. The difference between the medical multi-chamber container 20 and the medical multi-chamber container 1 described above is that the shape of the weak seal portion 13 for inhibiting communication is different and the shape of the first drug chamber 21 is slightly different. The same or similar parts are denoted by the same reference numerals, and the above description is referred to.
The weak seal portion 13 for preventing communication in the medical multi-chamber container 20 of this embodiment is formed in a substantially straight line so as to connect the positions slightly above the lower ends of the side seal portion 7 and the side seal portion 8. ing. In particular, in this embodiment, the communication inhibiting weak seal portion 13 is substantially parallel to the partition weak seal portion 9.

Moreover, it is preferable that the length (Lb) of the weak seal part 13 for communication inhibition shown in FIG. 5 is 1/6 to 5/6, and more preferably, the length (La) of the weak seal part 9 for partitioning. 1/3 to 2/3.
The first drug chamber 21 of the medical multi-chamber container 20 of this embodiment has a substantially triangular shape with the discharge port 3 as a vertex. And the crossing angle (R2: refer FIG. 5) of the extended line of the inner edge of the side seal parts 7 and 8 of the first drug chamber 21 is 45 to 100 degrees. More preferably, it is 60 to 90 degrees. In addition, if said crossing angle is 45 degrees or more, the 1st chemical | medical agent chamber will not become too small, and if said crossing angle is 100 degrees or less, the effect of this invention is fully exhibited. To do.
Moreover, like the medical multi-chamber container 30 shown in FIG. 6, the weak seal part 14 for communication inhibition connects the position of the upper end side slightly from the lower end of the side seal part 7 and the side part seal part 8, and the center part. May be a so-called substantially V-shape bent toward the discharge port.

Moreover, in the medical multi-chamber container of all the embodiments described above, the partition weak seal portion 9 is sealed from the other portions of the weak seal portion provided on both sides of the position above the communication blocking weak seal portion. It may be provided with a strong portion 9b. Conversely, the partition weak seal portion 9 may include a fragile seal portion having a lower seal strength than other portions provided at positions above the communication inhibiting weak seal portion.
In the medical multi-chamber container 40 of the embodiment shown in FIG. 7, the partition weak seal portion 9 has a sealing strength higher than other portions of the weak seal portion provided on both sides of the position above the communication inhibiting weak seal portion. The strong part 9b is provided. The length between the two strong seal portions 9b is preferably about 0.6 to 1.5 times the length (Lb) of the weak seal portion 13 for inhibiting communication, and particularly 0.8 to 1.2. Double is preferred. Further, the difference between the seal strength of the two strong portions 9b and the seal strength of the normal portion of the partition weak seal portion 9 is preferably 3 to 15 N in terms of peel strength, and particularly 6 to 10 N. It is preferable that In this case, it is preferable that the seal strength of the normal portion is about 4 to 10 N, and the seal strength of the strong portion is about 10 to 20 N. By configuring in this way, the weak seal for blocking communication can be more reliably peeled off almost simultaneously with the operation of the weak seal peeling operation for partitioning. The peel strength of each seal portion is cut at 10 mm intervals in the width direction from one bag side end of one of the two strong seal strength portions, and the cut pieces included in each seal strength portion are pulled. It is the average value of each seal strength portion of the value measured at a speed of 300 mm / min.

Moreover, as a form of the part 9b with strong sealing strength, a thing with a narrow width | variety like the medical multiple-chamber container 50 of the Example shown in FIG. 8 may be sufficient.
As a method of forming the above-described partition weak seal portion 9 with a portion 9b having a stronger seal strength than the other portions, the heat seal condition of the partition weak seal portion 9 is slightly changed only to the portion having the strong seal strength 9b. It can be performed by making it strong or by performing heat treatment again only on the part 9b having a strong seal strength. Specifically, heat sealing is performed using a heating mold under the sealing conditions (temperature, pressure, and time are adjusted) such that the entire width direction at one end is the seal strength of the normal portion of the weak seal portion for partitioning, The part where the seal strength is strong is formed by performing heat treatment again using the heating mold under the sealing conditions (temperature, pressure, and time are adjusted) so that the region where the seal strength is strong becomes the desired seal strength. can do.

Moreover, in the medical multi-chamber container of all the embodiments described above, the partitioning weak seal portion 9 includes a small width portion 9c provided at a position above the communication blocking weak seal portion. Also good.
In the medical multi-chamber container 60 of the embodiment shown in FIG. 9, the partition weak seal portion 9 includes small width portions 9 c formed on both sides of the position above the communication inhibition weak seal portion. The length of the narrow portion 9c is preferably about 0.6 to 1.5 times, and particularly preferably 0.8 to 1.2 times the length (Lb) of the communication inhibiting weak seal portion 13.

FIG. 1 is a plan view of an embodiment of the medical multi-chamber container of the present invention. 2 is a partially enlarged view of the vicinity of the discharge port of the medical multi-chamber container of FIG. FIG. 3 is a plan view of another embodiment of the medical multi-chamber container of the present invention. FIG. 4 is a plan view of another embodiment of the medical multi-chamber container of the present invention. FIG. 5 is a partially enlarged view of the vicinity of the discharge port of the medical multi-chamber container of FIG. FIG. 6 is a plan view of another embodiment of the medical multi-chamber container of the present invention. FIG. 7 is a plan view of another embodiment of the medical multi-chamber container of the present invention. FIG. 8 is a plan view of another embodiment of the medical multi-chamber container of the present invention. FIG. 9 is a plan view of another embodiment of the medical multi-chamber container of the present invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Medical multiple-chamber container 2 Container main body 3 Drug discharge port 4 Drug injection port 5, 6 Seal part 7, 8 Side seal part 9 Weak seal part 11 for partitioning Weak seal part 21 for communication inhibition First drug room 22 2 drug rooms

Claims (10)

A container body that is formed of a flexible material and is divided into a first drug chamber and a second drug chamber by a partition weak seal portion that can be separated from the internal space, and communicates with a lower end portion of the first drug chamber A medical multi-chamber container containing a discharge port, a first medicine housed in the first medicine chamber, and a second medicine housed in the second medicine chamber, The first drug chamber of the medical multi-chamber container is formed so that the width becomes narrower from the partition weak seal portion side toward the discharge port side, and the starting point where the width becomes narrower is the first chamber. It is on the side of the partition weak seal part from the vertical direction 1/2 of the medicine chamber, and the medical multi-chamber container is provided in the vicinity of the discharge port, and the communication between the first drug chamber and the discharge port A weak seal portion for inhibiting communication, and a weak seal portion for inhibiting communication. Le unit horizontal length of the multi-chamber medical container, a multi-chamber medical container, characterized in that has become shorter than the length of the partitioning weak seal portion. 2. The medical multi-chamber container is one in which the weak seal portion for communication inhibition is peeled off simultaneously with or subsequently to the peeling of the weak seal portion for partitioning by pressing the first drug chamber. The medical multi-chamber container as described. The said medical multi-chamber container presses the said 2nd chemical | medical chamber, The said weak seal part for communication inhibition peels following the peeling of the said weak seal part for a partition. Medical multi-chamber container. The medical multi-chamber container according to any one of claims 1 to 3, wherein the first drug and the second drug are liquid drugs. The length in the lateral direction of the medical multi-chamber container of the weak seal portion for communication inhibition is 1/6 to 5/6 of the length of the weak seal portion for partition. Medical multi-chamber container. 6. The medical multiple chamber according to claim 1, wherein the first medicine chamber has a substantially triangular shape with the discharge port as a vertex or a trapezoidal shape with the discharge port side as a short side. container. The medical multi-chamber container according to claim 6, wherein an intersection angle of an extension line of an inner edge of the first drug chamber is 45 to 100 degrees. The medical multi-chamber container according to any one of claims 1 to 7, wherein the partition weak seal portion and the communication blocking weak seal portion are heat seal portions. The medical multi-chamber container according to any one of claims 1 to 8, wherein the weak seal portion for blocking communication has substantially the same strength as that of the weak seal portion for partitioning, or is slightly weaker or slightly stronger. . 10. The partition weak seal portion includes a portion having a stronger seal strength than the other portions of the weak seal portion provided on both sides of the position above the communication inhibiting weak seal portion. The medical multi-chamber container according to any one of the above.

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