JPH0412755A - Bag for medical treatment - Google Patents

Abstract

PURPOSE:To suppress the cavity from being generated in the vicinity of a discharge port of the bag and to improve the discharge function of the contents by protruding a discharge tube to the inside of the bag main body, and also, forming an opening in the side part of this protruded part. CONSTITUTION:An end part 2b of the lower part of a bag main body 2 is sealed so that an outline of a containing space 4 of the bag main body 2 becomes a V-shape, and in an opening part formed in its top part, a discharge tube 5 for discharging a precipitant is inserted and installed. Since the tip part 51 of the discharge tube 5 protrudes into the containing space 4 of the bag main body 2, generation of a cavity is suppressed, and the precipitant is discharged smoothly. Also, in the side part of the protruded tip part 51 of the discharge tube 5, one or two or more (two pieces in the example shown in the figure) openings 6 are formed in positions turned to both end sides in the width direction ofthe bag main body 2, respectively. Moreover, the lower endside edge part of the opening 6 reaches the lower end side edge part of the containing space 4 so that the precipitant can be discharged to the ends.

Description

[Detailed Description of the Invention] <Industrial Application Field> The present invention relates to a medical bag for storing powder or liquid, particularly for use in supplying powder or granular drugs used in plasma purification methods. relates to a suitable medical bag.

<Prior Art> It is generally known that various intractable diseases occur due to the accumulation of high molecular weight proteins such as immunoglobulin, immune complexes, complement, and fibrinogen in the blood. For this reason, in recent years, so-called plasmapheresis therapy, in which a patient's plasma is exchanged with a replacement fluid such as fresh frozen plasma or an albumin preparation, has become widespread in order to remove high molecular weight proteins present in the blood.

However, in this plasmapheresis therapy, a large amount of replacement fluid is required to exchange the patient's plasma with the replacement fluid, which increases costs and makes it difficult to supply a sufficient amount of fresh frozen plasma, for example. This will cause inconvenience. In particular, when using someone else's plasma, avoid hepatitis or acquired immune deficiency syndrome (acquired immunodeficiency syndrome).
There is a big problem of concern about the onset of diseases such as AIDS.

Therefore, a plasma purification method has been proposed in which high molecular weight proteins accumulated in the patient's own plasma are removed and the purified plasma is returned to the patient again.

Regarding this type of plasma purification method, the applicant has proposed that by using an alkali metal chloride (for example, sodium chloride or a mixture of sodium chloride and an amino acid) as a precipitating agent (fractionation separation agent) for plasma proteins by salting out, We have proposed a method to selectively precipitate only high-molecular-weight proteins in plasma (JP-A-60-99265, JP-A-60-99266).
No. 61-64259).

Furthermore, blood is extracted from the patient's body, this blood is separated into plasma and blood cell components, and the above-mentioned precipitant is added and dissolved in the plasma in a column to selectively precipitate and remove high molecular weight proteins in the plasma. A plasma purification system has also been disclosed in which the purified plasma is then desalinated and this and the blood cell components are returned to the patient (Japanese Patent Laid-Open No. 63-281653).
issue).

By the way, the precipitant used in such a system is
A predetermined amount of the precipitant is supplied into the column from a bag-shaped container containing the precipitant. This container 10, as shown in FIG.
A discharge pipe 14 forming a precipitant discharge port 13 at the center of the lower end.
are connected, and the lower end 12 of the container 10 is mainly composed of a horizontal portion (Japanese Patent Laid-Open No. 63-281653).

However, the container 20 having such a shape has the disadvantage that the amount of precipitant 16 is small (as the amount of precipitant 16 becomes small, the precipitant 16 remains on the horizontal part of the lower end 12 of the container (see Fig. 3). .

Therefore, in order to prevent such residual precipitant from remaining, a container (bag) 11 in which the bottom end of the container is shaped like a 7 is also disclosed (Japanese Patent Laid-Open No. 61-1852).
No. 73, No. 63-3867).

However, since this container 11 is made of a soft resin material, when it is used in a suspended state, the body of the container 11 swells due to the weight of the precipitant 16, causing the wall of the container near the outlet 13 to swell. A force that pulls it upward acts. This action causes the container wall near the discharge port 13 to sag, creating a depression (depression) 15 near the tip of the discharge pipe 14 toward the inside of the bag, which impedes the discharge of the precipitant 16. The drawback is that it can get clogged.

Also, in the container 10 having the shape shown in FIG. 3, a depression is similarly formed near the outlet 13.

<Problems to be Solved by the Invention> The present invention has been made in view of the above-mentioned drawbacks of the prior art, and its purpose is to suppress the formation of depressions near the outlet of the bag and improve the ability to drain the contents. We aim to provide medical bags that can improve your medical needs.

Means for Solving the Problems> Such objects are achieved by the present invention as described in (1) to (3) below.

(1) A medical bag having a discharge pipe for discharging the contents at one end of a bag-like bag body made of a soft material, wherein the discharge pipe protrudes into the inside of the bag body, and this protrusion A medical bag characterized by having an opening formed on the side of the closed portion.

(2) The one end of the bag body has a 7-shape, and a discharge pipe is installed at the top thereof, and the openings are formed at positions facing both ends of the discharge pipe in the width direction of the bag body. The medical bag described in (1) above.

(3) The medical bag according to (1) or (2) above, wherein the contents stored in the medical bag are powder or granules.

<Function> According to the present invention having such a configuration, since the discharge pipe protrudes into the inside of the bag body, it is possible to suppress the formation of a dent (in the vicinity of the discharge port of the bag), and to reduce the amount of dents in the outer diameter of the discharge pipe at least. A corresponding amount of space is secured.Also, the contents are discharged through an opening formed on the side of the discharge pipe.

This allows the contents inside the bag to be smoothly discharged without clogging the vicinity of the discharge port.

<Example> Hereinafter, the medical bag of the present invention will be described in detail based on a preferred example shown in the accompanying drawings.

FIG. 1 is a front view showing an example of the configuration of a medical bag according to the present invention. A medical bag 1 shown in the figure is a container for storing a precipitant used in the salting-out method, which is the plasma purification method described above.

The medical bag 1 has a bag body 2, and the bag body 2 is made by stacking two flexible (flexible) synthetic resin sheet materials and fusing their edges (thermal fusing, The seal part 3) is sealed by high frequency welding, etc.) or by adhesion, and is shaped into a bag.

A storage space 4 for storing the contents of the bag is formed in a portion surrounded by the seal portion 3.

In this configuration example, a precipitating agent (not shown), which will be described later, is a powder or granular material.
is stored.

As the sheet material constituting the bag body 2, it is preferable to use a material that is flexible and does not substantially allow bacteria to pass through.Specific examples include polyvinyl chloride, polyester, polypropylene, and ethylene. Examples include synthetic resin films such as vinyl acetate copolymer (EVA), and laminates of two or more of these. Among these, when using polyvinyl chloride, the average degree of polymerization is 900 to 150o,
Hardness (JIS K7215) 70~100A (20
'C), tensile strength (JIS K 6732) 20
0 to 400 kg/cfil" is preferably used.

In addition, examples of plasticizers added to polyvinyl chloride include di(ethylhexyl) phthalate (DEHP), di(n
-decyl) phthalate (DnDP), dioctyl phthalate (DOP), etc. are preferred, and the amount added is 30 to 70 parts by weight, particularly 45 parts by weight, per 100 parts by weight of polyvinyl chloride.
It is preferable to set it as 60 parts by weight. If it is less than 30 parts by weight, the flexibility of the bag body 2 will be poor, and therefore, if the contents are powder or granules, it will be difficult to avoid blocking of the powder or granules by kneading the bag body. If the amount exceeds 70 parts by weight, the bag body 2 becomes too flexible and cannot maintain its shape.

Alternatively, a material obtained by copolymerizing polyvinyl chloride with an average degree of polymerization of 1000 to 150o and vinyl acetate in a weight ratio of 2 to 5% without using a plasticizer may also be used.

Note that in order to ensure visibility, the sheet material is preferably substantially transparent.

The thickness of such a sheet material is preferably about 0.05 to 1 ml11, particularly about 0.2 to 0.6n++n. If the thickness is less than 0.05 mm, the strength will decrease and damage such as tearing or pinholes will occur easily when subjected to vibration or impact.If it exceeds 1 nm, the flexibility of the bag body 2 will decrease. Therefore, similar to the above, work such as avoiding blocking becomes difficult. Also,
When storing a liquid, a negative pressure is created inside the bag as the liquid is discharged, but if the bag has poor flexibility, the bag will not deform and its volume will not decrease, making it difficult to discharge the bag.

The width T of the bag body 2 is not particularly limited, but is preferably about io to 50 times the inner diameter of the discharge pipe 5, which will be described later.

Further, the volume of the storage space 4 of the bag body 2 is not particularly limited, but it is preferably about 100 to 200%, particularly about 110 to 15%, of the volume occupied by the stored items.

The illustrated medical bag 1 is normally used by being suspended so that a discharge pipe 5, which will be described later, is on the lower end side. Therefore,
The sealing portion 3a at the upper end in the figure of the bag body 2 (hereinafter referred to as the upper end 2a) has a sealing width t larger than that of the sealing portion 3 at other parts.

Furthermore, near the center of the seal portion 3a in the width direction of the bag,
A through hole 7 is formed for hanging the medical bag 1 by hanging it on a hook or the like.

The reason why the seal width t of the seal portion 3a is made larger than that of other seal portions 3 is, firstly, to secure a space for forming the through hole 7, and secondly, to ensure that the through hole 7 is hooked on a hook or the like. This is to obtain enough strength to prevent the bag body 2 from bending due to its own weight when the medical bag 1 is suspended.

The seal width of the seal portion 3a and the seal portions 3 other than the seal portion 3a is determined as appropriate in relation to the thickness and width T of the sheet material constituting the bag body 2, the weight of the stored items, etc. .

It goes without saying that the configuration of the upper end portion 2a of the bag body 2 is not limited to that shown in the drawings.

The lower end of the bag body 2 in the figure (hereinafter referred to as the lower end 2b) is sealed so that the outline of the storage space 4 of the bag body 2 is V-shaped, and the opening formed at the top is sealed. , a discharge pipe 5 for discharging the precipitant is inserted and installed.

Since the lower end 2b of the bag body 2 is V-shaped, the precipitant can be discharged without remaining inside the bag.

The insertion and installation of the discharge pipe 5 into the lower end portion 2b of the bag main body is accomplished by sandwiching the discharge pipe 5 between two sheet materials from both sides at the sealing portion 3 and sealing the discharge pipe 5 airtightly.

This discharge pipe 5 is made of polyvinyl chloride, EVA, etc.
, polyethylene, polypropylene, ABS resin, etc., but in terms of ease and reliability of attachment to the bag body 1, a resin material of the same type or with a melting point similar to that of the sheet material of the bag body 1 is used. is preferable.

The inner diameter of the discharge pipe 5 (if the discharge pipe 5 is not a straight pipe, the inner diameter of the narrowest part) is the Ill! of the bag body 2! T's 11
Approximately 50 to 1/10 is preferable.

By setting in this way, the precipitant can be discharged smoothly.

The distal end 51 of the discharge pipe 5 projects into the storage space 4 of the bag body 2, as shown in FIG. Since the discharge pipe 5 protrudes into the bag, the formation of the above-mentioned depression 15 is suppressed, and the precipitant is smoothly discharged.

In particular, if the discharge of precipitant is delayed and the discharge rate (discharge amount per unit time) decreases, the supply of precipitant becomes insufficient.
This is not preferable for the salting-out method, which requires stable supply of a precipitant, but the present invention solves this problem.

Further, one or more (in the illustrated example, two) openings 6 are formed on the side of the protruding portion (tip portion 51) of the discharge pipe 5. This opening 6 functions as a discharge port for the precipitant, introducing the precipitant into the discharge pipe 5 and discharging it.

In the present invention, the position and number of openings 6 are not particularly limited, but as shown in FIGS. 1 and 2, one pair (or more than two pairs) of openings 6. It is preferable that they are formed at positions facing both ends in the width direction. That is, at the lower end 2b of the bag main body 2, as shown by the arrow in FIG. It is preferable for the opening 6 to be formed at a position facing the flow in order to improve the discharge performance, and furthermore, the opening 6 is not present in the portion of the sheet material of the bag body 2 where dents are likely to occur, thereby preventing the occurrence of dents. suppress effectively.

Moreover, it is preferable that the lower end side edge of the opening 6 reaches the lower end side edge of the storage space 4 so that the precipitant can be discharged to the end.

The shape of such opening 6 is not particularly limited, and for example,
Examples include polygons such as circles, ellipses, triangles, and quadrangles, slit shapes, and combinations thereof.

The distal end end surface 52 of the discharge pipe 5 may be open or closed. If it is open, the precipitant is also discharged from this part.

The other end of the discharge pipe 5 (the end opposite to the bag body 2) may be an open end or a closed end. ) may be connected.

The precipitating agent stored in the storage space 4 of the bag body 2 includes a salting-out agent (for example, an alkali metal compound such as sodium chloride, potassium chloride, lithium chloride, or calcium carbonate) for precipitating unnecessary high-molecular proteins in plasma. alkaline earth metal compounds such as) and V L D L (V
ery low density 1ipoprotei
n), L D L (low density j,
precipitants (e.g. sulfate polysaccharide salts such as heparin sodium and dextran sulfate), accelerators (aspartic acid, cystine, tyrosine, glycine, N-acetyl Amino acids such as tryptophan), accelerators that promote the effect of the latter precipitants (alumina, aluminum silicate, phosphoric acid, citrate, etc.), and adsorbents that adsorb unnecessary substances in the blood through adsorption reactions (activated carbon, anion exchange resin,
styrene-divinylbenzene copolymer, other copolymers, etc.), and also includes various pH adjusters, anticoagulants, etc. that set the processing conditions using these drugs, and furthermore, injection drugs, etc. .

The medical bag of the present invention has been described above, taking as an example a precipitant storage bag for supplying a precipitant used in a salting-out method. It can also be applied to medical bags that store.

Examples of the bag for storing liquid include a blood bag (blood collection bag), a platelet storage bag, a plasma storage bag, an infusion bag, and the like. Especially in blood bags,
The blood collected in the bag is centrifuged and separated into a red blood cell layer, a buffy coat layer containing white blood cells and platelets, and a plasma layer, and each layer is discharged. When the liquid is suppressed, turbulence of the liquid flow toward the discharge port is prevented, and there is an advantage that the liquid can be easily and reliably discharged and separated without stirring the interface between the layers.

In addition, when comparing powder and granular materials with liquid, the effects of the present invention are as follows:
Since this phenomenon occurs more noticeably in a bag containing powder or granular material, it is preferable to apply it to a bag containing powder or granular material.

In this case, the average particle size of the powder is about 0.1 to 3 mm,
Particularly preferred is about 0.2 to 2 mm.

<Effects of the Invention> As described above, according to the medical bag of the present invention, it is possible to suppress the occurrence of dents and the like in the bag and improve the ability to discharge contents, particularly powder and granules.

In particular, when the present invention is applied to a container for supplying a precipitant used in the salting-out method, which is a plasma purification method, the precipitant can be supplied smoothly and stably, and an appropriate and safe method can be achieved. High plasma purification can be achieved.

[Brief explanation of drawings]

FIG. 1 is a front view showing an example of the configuration of a medical bag according to the present invention. FIG. 2 is an enlarged sectional view taken along II-rl All in FIG. 1. FIG. 3 is a front view showing an example of the configuration of a conventional precipitant storage container. Explanation of symbols 1... Medical bag 2... Bag body 2a... Upper end 2b... Lower end 3.3a... Seal portion 4... Storage space 5... Discharge pipe 51. ...Tip portion 52...Tip end face 6...Opening a...Through hole 8...Tapered portion 10.11...Container 12...Lower end portion 13...Drain port 14...・Discharge pipe 15...Indentation 16...Precipitant application Person's representative Person's representative Person's representative Chill

Claims (3)

[Claims] (1) A medical bag having a discharge pipe for discharging the contents at one end of a bag-like bag body made of a soft material, wherein the discharge pipe protrudes into the inside of the bag body, and this protrusion A medical bag characterized by having an opening formed on the side of the closed portion. (2) The one end of the bag body has a V-shape, and a discharge pipe is installed at the top thereof, and the openings are formed at positions facing both ends of the discharge pipe in the width direction of the bag body. The medical bag according to claim 1. (3) The medical bag according to claim 1 or 2, wherein the contents stored in the medical bag are powder or granules.