JP2005237328A5 - - Google Patents
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- Publication number
- JP2005237328A5 JP2005237328A5 JP2004053795A JP2004053795A JP2005237328A5 JP 2005237328 A5 JP2005237328 A5 JP 2005237328A5 JP 2004053795 A JP2004053795 A JP 2004053795A JP 2004053795 A JP2004053795 A JP 2004053795A JP 2005237328 A5 JP2005237328 A5 JP 2005237328A5
- Authority
- JP
- Japan
- Prior art keywords
- base sequence
- immunostimulatory oligonucleotide
- immunomodulator
- seq
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 230000003308 immunostimulating effect Effects 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 230000002584 immunomodulator Effects 0.000 claims 2
- 229940121354 immunomodulator Drugs 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004053795A JP3976742B2 (ja) | 2004-02-27 | 2004-02-27 | インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド |
| US10/590,761 US7718623B2 (en) | 2004-02-27 | 2005-02-25 | Immunostimulatory oligonucleotide that induces interferon alpha |
| PCT/JP2005/003693 WO2005083076A1 (ja) | 2004-02-27 | 2005-02-25 | インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004053795A JP3976742B2 (ja) | 2004-02-27 | 2004-02-27 | インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005237328A JP2005237328A (ja) | 2005-09-08 |
| JP2005237328A5 true JP2005237328A5 (cg-RX-API-DMAC7.html) | 2006-10-12 |
| JP3976742B2 JP3976742B2 (ja) | 2007-09-19 |
Family
ID=34908763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004053795A Expired - Lifetime JP3976742B2 (ja) | 2004-02-27 | 2004-02-27 | インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US7718623B2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP3976742B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005083076A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4817599B2 (ja) * | 2003-12-25 | 2011-11-16 | 独立行政法人科学技術振興機構 | 免疫活性増強剤とこれを用いた免疫活性の増強方法 |
| CA2653939C (en) | 2006-05-31 | 2013-01-22 | Toray Industries, Inc. | Immunostimulatory oligonucleotides and use thereof in pharmaceuticals |
| US20100317112A1 (en) * | 2007-04-27 | 2010-12-16 | Hyunjin Yang | Scaffolds increased specific gravity for cell culture and method for manufacturing thereof |
| WO2009069448A1 (ja) * | 2007-11-28 | 2009-06-04 | Toray Industries, Inc. | 日本脳炎ワクチン用のアジュバント及び日本脳炎ワクチン |
| WO2009069682A1 (ja) * | 2007-11-28 | 2009-06-04 | Toray Industries, Inc. | 肝炎の治療剤又は予防剤 |
| WO2009069447A1 (ja) * | 2007-11-28 | 2009-06-04 | Toray Industries, Inc. | インフルエンザワクチン用のアジュバント及びインフルエンザワクチン |
| AU2009323766B2 (en) | 2008-12-02 | 2016-10-06 | Wave Life Sciences Ltd. | Method for the synthesis of phosphorus atom modified nucleic acids |
| SG177564A1 (en) | 2009-07-06 | 2012-02-28 | Ontorii Inc | Novel nucleic acid prodrugs and methods of use thereof |
| EP2620428B1 (en) | 2010-09-24 | 2019-05-22 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
| GB201021867D0 (en) * | 2010-12-23 | 2011-02-02 | Mologen Ag | Non-coding immunomodulatory DNA construct |
| JP5906019B2 (ja) * | 2011-03-31 | 2016-04-20 | 国立大学法人福井大学 | 免疫刺激ｇ９．１の抗結核ブースターワクチン創出への応用 |
| US9605019B2 (en) | 2011-07-19 | 2017-03-28 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| US12268718B2 (en) | 2012-01-16 | 2025-04-08 | Labyrinth Holdings Llc | Control of cellular redox levels |
| KR20140121818A (ko) | 2012-01-16 | 2014-10-16 | 엘라자베스 맥켄나 | 간 질환들 및 장애들의 치료를 위한 조성물들 및 방법들 |
| AR091569A1 (es) * | 2012-06-28 | 2015-02-11 | Intervet Int Bv | Receptores de tipo toll |
| JP6268157B2 (ja) | 2012-07-13 | 2018-01-24 | 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ | 不斉補助基 |
| JP6246121B2 (ja) * | 2012-07-13 | 2017-12-13 | 株式会社新日本科学 | キラル核酸アジュバント |
| SG10201912895PA (en) | 2012-07-13 | 2020-02-27 | Wave Life Sciences Ltd | Chiral control |
| HK1213017A1 (zh) | 2012-09-21 | 2016-06-24 | Elizabeth Mckenna | 天然存在的cpg寡聚核苷酸组合物及其治疗应用 |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| EP3095460A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| PT3094728T (pt) | 2014-01-16 | 2022-05-19 | Wave Life Sciences Ltd | Desenho quiral |
| LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
| GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
| WO2023049275A2 (en) * | 2021-09-23 | 2023-03-30 | Arnay Sciences, Llc | Cyclic structured oligonucleotides as therapeutic agents |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0468520A3 (en) * | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
| CA2293489C (en) | 1997-06-06 | 2009-09-29 | The Regents Of The University Of California | Inhibitors of dna immunostimulatory sequence activity |
| CA2323929C (en) | 1998-04-03 | 2004-03-09 | University Of Iowa Research Foundation | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| IL148844A0 (en) * | 1999-09-27 | 2002-09-12 | Coley Pharm Group Inc | Methods related to immunostimulatory nucleic acid-induced interferon |
| US7585847B2 (en) * | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
| WO2002002172A1 (en) * | 2000-06-30 | 2002-01-10 | Univ Jefferson | Dna palindrome - oligoguanylic acid compositions and uses thereof |
| US20030050268A1 (en) * | 2001-03-29 | 2003-03-13 | Krieg Arthur M. | Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases |
| WO2003024480A2 (en) | 2001-09-14 | 2003-03-27 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| AU2002339224B2 (en) * | 2001-09-14 | 2008-10-09 | Kuros Us Llc | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
| DE60335186D1 (de) * | 2002-06-20 | 2011-01-13 | Cytos Biotechnology Ag | Verpackte virusartige partikel in kombination mit cpg zur verwendung als adjuvantien mit allergenen. herstellungsverfahren und verwendung |
-
2004
- 2004-02-27 JP JP2004053795A patent/JP3976742B2/ja not_active Expired - Lifetime
-
2005
- 2005-02-25 US US10/590,761 patent/US7718623B2/en not_active Expired - Lifetime
- 2005-02-25 WO PCT/JP2005/003693 patent/WO2005083076A1/ja not_active Ceased