JP2005213205A - 酵母抽出分画物を用いた脳機能改善剤および食品 - Google Patents
酵母抽出分画物を用いた脳機能改善剤および食品 Download PDFInfo
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- JP2005213205A JP2005213205A JP2004022380A JP2004022380A JP2005213205A JP 2005213205 A JP2005213205 A JP 2005213205A JP 2004022380 A JP2004022380 A JP 2004022380A JP 2004022380 A JP2004022380 A JP 2004022380A JP 2005213205 A JP2005213205 A JP 2005213205A
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- brain function
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- yeast extract
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Abstract
【解決手段】サッカロマイセス属、カンディダ属、クルイベロマイセス属に属する酵母抽出分画物中の成分を有効成分とし、更にその成分が作用するように抽出条件を定めたことを特徴とする脳機能改善作用を有する脳機能改善剤および食品の提供。
【選択図】図1
Description
学習機能改善効果及び記憶力改善作用等の脳機能改善作用の成分を有すること。
安全性の点で満足できるものであること。
経済性の点で満足できるものであること。
ビール醸造で廃棄された酵母を70℃、7分間の温風乾燥したものを乾燥酵母粉末とし、抽出操作に供した。抽出操作は振とう抽出を使用した。すなわち粉末化した乾燥酵母100gを1,500mlの50%エタノールに混合し、振とう数毎分290回、抽出時間2日間の条件で振とう抽出を行い、酵母抽出液1,250mlを得た。
24週齢のddY系雌マウスを購入し、環境に慣らしながら高週齢のマウスを作成するために、48週齢まで予備飼育し実験に供した。酵母群、酵母抽出液低用量群、酵母抽出液高用量群にわけて行った。飼育環境は、室温24〜26℃、湿度50〜60%とし、自然採光とした。飼料組成は全て市販粉末飼料のCE-2に添加する方法で行った。すなわち、酵母群は乾燥酵母粉末を乾燥重量10%添加し、酵母抽出液低用量群は実施例1で得られた酵母抽出液を37.5ml/kgで添加し、酵母抽出液高用量群は酵母抽出液を375ml/kg添加した。いずれの酵母抽出液群もエタノールを揮発させた後、試験に供した。摂取期間は7週間で、その間、週に1度、体重と飼料摂取量・飲水量を測定した。摂取期間終了後、ステップダウン型回避学習テストを行った。統計手法はSASを用い、ダンカンの新多重範囲検定法を用いた。
学習試験1の終了後、実験食を各々同一マウスに与えながら1週間飼育を行った後、2回目のステップダウン型回避学習テストを行い、学習試験1の結果に対する2回目の学習効果を調べた。
学習試験2の終了後、更に実験食を各々同一マウスに与えながら学習試験2の終了翌日から水慣れを2日間させ、1日1回、3回の水迷路型学習テストを行った。
Claims (5)
- サッカロマイセス属、カンディダ属、クルイベロマイセス属に属する酵母の抽出分画物を含有する脳機能改善剤およびその抽出分画物中の脳機能改善作用成分を含有する食品。
- 請求項1記載の酵母の抽出分画物中成分が、脳機能改善作用を有するような抽出条件として、酵母の抽出溶媒は、水、無水或いは含水有機溶媒として1価アルコール、多価アルコールまたはその誘導体、ケトン、エステル、エーテル、石油エーテル、脂肪族炭化水素またはハロゲン化物、芳香族炭化水素より選択された1種または2種以上であることを特徴とする請求項1記載の脳機能改善剤および食品。
- 請求項2記載の抽出溶媒は、好ましくは水と極性溶媒の混合溶媒であることを特徴とする請求項1記載の脳機能改善剤および食品。
- 請求項1記載の酵母の抽出分画物中成分が、脳機能改善作用を有するような抽出条件として、酵母の添加濃度は、溶媒容量に対して0.1〜10%乾燥重量濃度であることを特徴とする請求項1記載の脳機能改善剤および食品。
- 請求項4記載の添加濃度は、溶媒容量に対して好ましくは1〜5%乾燥重量濃度であることを特徴とする請求項1記載の脳機能改善剤および食品。
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CN116406758A (zh) * | 2021-12-30 | 2023-07-11 | 安琪酵母(德宏)有限公司 | 一种浅色酵母抽提物的制备方法 |
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JPH0477430A (ja) * | 1990-07-19 | 1992-03-11 | Asahi Breweries Ltd | 酵母エキス含有抗痴呆剤 |
JPH08198754A (ja) * | 1995-01-23 | 1996-08-06 | Yakult Honsha Co Ltd | 脳機能改善剤 |
US20040001861A1 (en) * | 2002-06-28 | 2004-01-01 | Cheung Ling Yuk | Dietary supplements for improving memory |
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JPH0477430A (ja) * | 1990-07-19 | 1992-03-11 | Asahi Breweries Ltd | 酵母エキス含有抗痴呆剤 |
JPH08198754A (ja) * | 1995-01-23 | 1996-08-06 | Yakult Honsha Co Ltd | 脳機能改善剤 |
US20040001861A1 (en) * | 2002-06-28 | 2004-01-01 | Cheung Ling Yuk | Dietary supplements for improving memory |
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CN116406758A (zh) * | 2021-12-30 | 2023-07-11 | 安琪酵母(德宏)有限公司 | 一种浅色酵母抽提物的制备方法 |
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