JP2005200308A - Hair tonic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To prepare a hair tonic having excellent effects such as hair-regrowing, hair fostering/hair growing, depilation-preventing and scurf-preventing effects. <P>SOLUTION: This hair tonic contains one or more kinds of polysaccharides selected from the group consisting of fenugreek gum, guar gum, tara gum and locust bean gum. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a hair nourishing agent, and more particularly to a hair nourishing agent excellent in effects such as hair growth, hair growth / hair nourishing, hair loss prevention, dandruff prevention and the like. Specifically, the hair nourishing agent of the present invention is used in the fields of pharmaceuticals, quasi drugs, and cosmetics.

  In general, alopecia is thought to be caused by complex intertwining of various factors such as poor blood circulation, decreased hair matrix activity, and sex hormone imbalance. Especially in modern society, aging society and stress society As said, there are many opportunities to be at risk of hair loss due to various causes. However, the mechanism and mechanism of hair loss have not been fully elucidated yet. Conventional hair nourishing agents are expected to have hair growth and hair-growth effects, for example, red pepper tincture, assembly extract, ginseng extract, nicotinic acid derivative and other scalp blood circulation promoting substances, cephalanthin and other skin function enhancing substances, Prevents hair loss by combining vasodilators such as acetylcholine derivatives, female hormone agents such as estradiol, melanin synthesis catalyst agents such as pantothenic acid derivatives, keratolytic agents such as salicylic acid and resorcin, and anti-inflammatory agents such as glycyrrhetinic acid and azulene. And used for treatment (see, for example, Non-Patent Document 1). However, since these components may cause skin irritation in some cases, the amount of these components is limited, and a sufficient effect is not achieved. On the other hand, in consideration of skin irritation and safety, development of a hair nourishing agent using natural plant ingredients has been attempted. As an example using a seed viscous substance, a hair growth agent containing tamarind seed polysaccharide ( For example, see Patent Literature 1), and a hair nourishing agent (for example, see Patent Literature 2) containing at least one acidic polysaccharide selected from the group consisting of alginic acid, carrageenan, pectin and dextran sulfate. However, it cannot be said that these natural ingredients have sufficient effects such as hair growth, hair loss prevention, and dandruff prevention. Therefore, a more effective hair nourishing agent is strongly demanded.

Tajima Masahiro “Current Status and Challenges of Hair Growth Agents” Fragrance Journal, May 1997, p. 43-51 JP 7-53335 A JP-A-5-117131

  Under such circumstances, an object of the present invention is to provide a hair nourishing agent having excellent hair growth, hair growth / hair growth, hair loss prevention, and anti-dandruff action against alopecia.

  As a result of intensive studies to achieve the above object, the present inventor has found that fenugreek gum, guar gum, tara gum, locust bean having D-galactose and D-mannose as constituent units among plant-based natural polysaccharides. The present invention has been completed by finding that the gum has an effect of promoting hair growth and an effect of promoting hair growth, and also exhibits a remarkable effect of preventing hair loss and preventing dandruff.

That is, the present invention resides in a hair nourishing agent comprising at least one polysaccharide selected from the group consisting of fenugreek gum, guar gum, tara gum and locust bean gum.

  According to the present invention, it is possible to provide a hair nourishing agent having an effect of preventing hair loss, a hair growth action and a hair growth action with respect to alopecia.

  Hereinafter, embodiments of the present invention will be described in detail. In the present invention, at least one polysaccharide selected from fenugreek gum, guar gum, tara gum and locust bean gum is contained, and these polysaccharides contain D-galactose and D-mannose as constituent units as main components. It is.

  Fenugreek gum is the main component of the endosperm of the annual leguminous plant, Trigonella foenum-graecum, cultivated in the Middle East, Africa, India, and central China, originating from the Mediterranean region, mainly consisting of galactose and mannose It is a polysaccharide that is bound in a 1: 1 ratio. Extract fenugreek seed or endosperm powder with hot water and add a water-soluble organic solvent to the extract to precipitate the gum, or add neutral sulfate to the extract to precipitate the gum. It is done. In the present invention, those prepared from seeds or endosperm powder by a literature description or a known method may be used, or commercially available fenugreek gum may be used. Either hot water soluble or cold water soluble can be used.

  Guar gum is the main component contained in the endosperm part of seeds of leguminous plant guar (Cyamopsis tetragonolobus) cultivated in West India, West Pakistan, and the United States, and is mainly composed of galactose and mannose in a ratio of 1: 2. Is a polysaccharide. It is obtained by hot water extraction of guar seed or endosperm powder and adding a water-soluble organic solvent to the extract to precipitate the gum, or adding neutral sulfate to the extract to precipitate the gum. It is done. In the present invention, those prepared from seeds or endosperm powder by a literature description or a known method may be used, or commercially available guar gum may be used. Either hot water soluble or cold water soluble can be used.

  Tara gum is a main component contained in the endosperm part of seeds of the cotyridae plant cod (Caesalpinia spinosa) that grows in Chile, South America, and is a polysaccharide in which galactose and mannose are mainly bound at a ratio of 1: 3. Obtained by purification methods such as hot water extraction of cod endosperm powder and precipitation of gum by adding a water-soluble organic solvent to the extract, or precipitation of neutral sulfate by adding neutral sulfate to the extract . In the present invention, a product prepared from endosperm powder by a literature description or a known method may be used, or commercially available tara gum may be used. Either hot water soluble or cold water soluble can be used.

  Locust bean gum is the main component contained in the endosperm part of the seed of the leguminous plant carob (Ceratonia siliquae) that grows in the high-temperature dry zone of the Mediterranean coast, and mainly binds galactose and mannose in a ratio of 1: 3-4. It is a polysaccharide. Obtained by a purification method such as hot water extraction of carob endosperm powder and precipitation of gum by adding a water-soluble organic solvent to the extract, or precipitation of neutral sulfate by adding neutral sulfate to the extract . In the present invention, a product prepared from endosperm powder by a literature description or a known method may be used, or commercially available tara gum may be used. Either hot water soluble or cold water soluble can be used.

In the present invention, these fenugreek gum, guar gum, tara gum and locust bean gum can be used alone or in combination of two or more. Of these, fenugreek gum is more preferred in terms of hair growth, hair growth / hair growth, hair loss prevention, and anti-dandruff action against alopecia. The blending amount of these polysaccharides into the hair nourishing agent is preferably 0.01 to 5.0% by mass (hereinafter referred to as%), more preferably 0.1 to 2.0%. When the blending amount of these polysaccharides is less than 0.01%, the intended effect of the present invention may not be sufficiently obtained. When the blending amount exceeds 5.0%, the viscosity of the solution increases, May cause problems during use.

  Moreover, in this invention, the hair growth promotion effect can be increased more by mix | blending a blood flow promoter and using fenugreek gum and a blood flow promoter together. The blood flow promoting agent is not particularly limited as long as the blood flow is promoted when applied to the skin, and there is no safety problem as a compounding component of the external preparation, the action mechanism is also questioned. It shouldn't be. Specifically, nicotinic acid derivatives such as diisopropylamine dichloroacetate, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, benzyl nicotinate, tocopherol nicotinate, β-butoxyethyl nicotinate, nicotinamide, minoxidil and Derivatives and analogs thereof, cephalanthin, vitamin E and derivatives thereof, γ-oryzanol, alkoxycarbonylpyridine N-oxide, capronium chloride, acetylcholine and derivatives thereof, peripheral blood circulation disorders (prostaglandins, carbacyclin, papaverine, cyclande Rate, cinnarizine, nyridrin, kallikrein), calcium antagonists, phosphodiesterase inhibitors, nitrites, adenosine potentiating vasodilators, hydrazine, etc. What is used can be selected as appropriate. Moreover, although these blood flow promoters can be blended alone in the hair nourishing agent of the present invention, they can be blended in combination of two or more. In the hair nourishing agent of the present invention, the blood flow promoter is preferably blended in the range of 0.001 to 5.0% with respect to the entire hair nourishing agent, and 0.01 to 2.0% of the same. It is particularly preferable to blend in a range. If the blending amount of the blood flow promoter exceeds 5.0% with respect to the whole hair nourishing agent, it may cause problems from the viewpoint of safety such as skin irritation and the like.

  The hair nourishing agent of the present invention can be used in various forms, for example, blended into a dosage form to be applied directly to the scalp such as hair tonic, hair lotion, hair cream, shampoo, rinse, hair foam, hair gel, aerosol, etc. Can be produced according to a conventional method.

  In addition to the above-mentioned components, the hair nourishment of the present invention is variously used in cosmetics, quasi-drugs, pharmaceuticals, etc. as necessary and within the range not impairing the effects of the present invention. Ingredients such as oils, moisturizers, thickeners, dyes, fragrances, bactericides, preservatives, UV absorbers, solvents, water, keratolytic agents, anti-inflammatory agents, antiandrogens, hair nourishing agents, antioxidants, refreshing Agents, herbal extracts, vitamins and the like can be appropriately blended.

  EXAMPLES Hereinafter, although an Example demonstrates this invention concretely, the technical scope of this invention is not limited by these Examples. In addition, the test method regarding the hair growth promotion effect test, the hair growth promotion effect test, the hair loss prevention effect test, and the anti-dandruff effect test described in Examples is shown below.

(1) C3H mouse hair growth promoting effect test method C3H mice (8 weeks old, male, average weight 35 g) dorsal skin (2 cm × 4 cm) were cut with an electric clipper and a shaver, and samples of Examples and Comparative Examples from the next day Was applied to the skin of the test area twice a day in the morning and evening for 2 weeks. A group of 10 animals was used for one sample. On the 14th day from the start of application, the skin of the test part of each sample was photographed with a video camera, and the areas of the hair cutting part and the hair growth part were measured with an image analyzer.
The hair growth effect was determined by comparing the hair growth rate (%) shown below with the control group.
Hair growth rate (%) = (Area of hair growth part / Area of hair cutting part) × 100

(2) Human scalp hair growth promoting effect test method Shaving the head hair 5 cm above the ears of the heads of 10 test subjects who are male pattern baldness in a circular shape with a diameter of 1 cm at two left and right positions. About 3 mL of each sample of Example and Comparative Example was applied to the left side twice a day in the morning and evening every day, and compared with the untreated right side. On the 28th day after the start of the test, the effect was determined by shaving 20 hairs on each of the left and right test sites, and evaluating the degree of hair growth promotion with the value determined by the following formula.
Hair growth promotion level = (B) / (A)
(A): Average value of length of 20 hairs on the right side (no treatment) (B): Average value of length of 20 hairs on the left side (the sample of the example and the comparative example is applied)

(3) Hair loss prevention test method The test was carried out twice a day for 4 months on the heads of 10 test subjects who were male pattern baldness patients, and the hair was washed by a professional hairdresser for 3 days before the test was started. The hair that was lost during shampooing was collected, the number of hairs was measured, and the number of hairs lost per day was calculated. In the fourth month after the application of the sample, hair washing was again performed by a professional hairdresser for 3 days, the hair that was lost during the hair washing was collected, the number of hairs was measured, and the number of hair loss per day was calculated. The hair removal prevention effect was evaluated based on the value obtained by the following formula for the number of hairs removed per day before the start of the test and after 4 months.
Hair loss prevention effect = (C) / (D)
(C): Number of hair loss per day before application (D): Number of hair loss per day 4 months after application

(4) Dandruff Prevention Test Method The occurrence of dandruff after application to the heads of 10 test subjects who are male pattern baldness patients twice a day for 4 months was evaluated. The test results are shown by the number of respondents who answered that “dandruff was reduced”.

Examples 1-6, Comparative Examples 1-3
A hair nourishing agent having the formulation shown in Table 1 was prepared according to a conventional method, and the above tests were conducted for evaluation. The results are also shown in Table 1.

  As apparent from Table 1, the hair nourishing agent of the present invention was clearly superior in all evaluations of hair growth rate, hair growth promotion degree, hair loss prevention, and dandruff prevention as compared with the comparative example.

Hereinafter, other prescription examples of the present hair nourishing agent are given as examples. In addition, as for the hair nourishing agent of the present invention of these examples, the above-described hair growth rate, hair growth promotion degree, hair loss prevention, anti-dandruff effect were examined. It was good.

Example 7 (Tonic)
Compounding amount (%)
(1) 95% ethanol 40.0
(2) Fenugreek gum 0.3
(3) Benzyl nicotinate 0.05
(4) Acetic acid α-DL-tocopherol 0.5
(5) Propylene glycol 1.0
(6) Polyethylene glycol 200 1.0
(7) Fragrance 0.1
(8) Dye proper amount
(9) Purified water balance

(Manufacturing method) To (1), (2) to (7) were dissolved, then (8) to (9) were added and stirred to obtain a transparent liquid tonic.

Example 8 (hair growth lotion)
Compounding amount (%)
(1) 95% ethanol 50.0
(2) Fenugreek gum 0.2
(3) Tara gum 0.2
(4) Nicotinamide 0.5
(5) Cephalanthin 0.01
(6) Dipropylene glycol 2.0
(7) Disodium phosphate 0.08
(8) Monopotassium phosphate 0.02
(9) L-menthol 0.3
(10) Fragrance 0.05
(11) Hydrogenated bisabolol 0.5
(12) Balance of purified water

(Production Method) (2) to (6), (9) and (10) were dissolved in (1). Subsequently, it mixed and stirred with what dissolved (7)-(8) in (12), and obtained the transparent liquid hair nourishing lotion.

Example 9 (aerosol hair nourishing agent)
Compounding amount (%)
<Undiluted solution formulation>
(1) 95% ethanol 50.0
(2) Glycyrrhetinic acid 0.1
(3) Fenugreek gum 0.5
(4) Assembly extract 2.0
(5) Sodium lauryl sulfate 0.1
(6) Polyoxyethylene (60) hydrogenated castor oil 0.5
(7) Lactic acid appropriate amount (8) Sodium lactate appropriate amount (9) Fragrance appropriate amount (10) Dye amount (11) Purified water balance <filling formula>
(12) Stock solution 50.0
(13) Liquefied petroleum gas 50.0

(Manufacturing method) Each component of the stock solution formulation was mixed and dissolved to prepare a stock solution, which was filled in a can, and after mounting a valve, liquefied petroleum gas was filled to prepare an aerosol hair nourishing agent.

Example 10 (Emulsion type hair nourishing agent)
Compounding amount (%)
<A phase>
(1) Fenugreek gum 0.5
(2) Polyoxyethylene (60) hydrogenated castor oil 2.0
(3) Glycerin 10.0
(4) Dipropylene glycol 10.0
(5) 1,3-butylene glycol 5.0
(6) Polyethylene glycol 1500 5.0
<Phase B>
(7) Cetyl isooctanoate 10.0
(8) Squalane 5.0
(9) Vaseline 2.0
(10) Propylparaben 2.0
<Phase C>
(11) Locust bean gum 0.3
(12) Sodium hexametaphosphate 0.03
(13) Purified water 8.0
<Phase D>
(14) Purified water 5.0
<Phase E>
(15) Balance of purified water

(Manufacturing method) Each of the A phase and the B phase was heated and dissolved at 70 ° C, mixed and homomixed to prepare a gel. Phase D was gradually added to this gel and dispersed with a homomixer. Next, phase C dissolved in advance in this gel dispersion was added, phase E dissolved in advance was further added and emulsified with a homomixer to produce an emulsion type hair nourishing agent.

  In addition, the fragrance | flavor used in each prescription mentioned above is the following.

  As described above, according to the present invention, it is possible to provide a hair nourishing agent having an effect of preventing hair loss, a hair growth action and a hair growth action with respect to alopecia.

Claims (1)

A hair nourishing agent comprising at least one polysaccharide selected from the group consisting of fenugreek gum, guar gum, tara gum and locust bean gum.