JP2005104960A - Internal liquid agent and taste quality change-preventing liquid agent for glucuronolactone-containing solution - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an internal liquid agent blended with glucuronolactone having an improving activity of the liver function and showing less change of taste quality for a long period irrespective of preservation conditions, and a taste quality change-preventing liquid agent for a glucuronolactone-containing solution. <P>SOLUTION: This internal liquid agent contains glucuronolactone, and at least any one of hydrochloric acid and phosphoric acid. The internal liquid agent containing glucuronolactone of which taste quality change is prevented by at least any one of hydrochloric acid or phosphoric acid, is provided. The liquid agent for preventing the taste quality change of the glucuronolactone-containing solution contains at least any one of the hydrochloric acid or phosphoric acid. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a liquid for internal use containing glucuronolactone having an ability to improve liver function and having little change in taste over a long period of time regardless of storage conditions, and a liquid for preventing taste change in a solution containing glucuronolactone About.

Conventionally, glucuronolactone has been known as a liver function improving component, and is blended in drinks and the like together with vitamin B group and the like (see, for example, Patent Document 1).
However, the conventional drink containing the glucuronolactone has a problem that so-called “egumi” occurs over time, the taste quality changes, and it becomes difficult to drink. A liquid for internal use that contains glucuronolactone that has the ability to improve liver function and has little change in taste over a long period of time regardless of storage conditions, and a liquid that prevents changes in taste of glucuronolactone-containing solutions are still available The current situation is not.

Japanese Patent Laid-Open No. 10-298093

  An object of the present invention is to solve the conventional problems and achieve the following objects. That is, the present invention comprises glucuronolactone having an ability to improve liver function, and a liquid for internal use with little change in taste over a long period of time regardless of storage conditions, and a change in taste of a solution containing glucuronolactone An object is to provide a preventive liquid.

Means for solving the problems are as follows. That is,
<1> A liquid for internal use comprising glucuronolactone and at least one of hydrochloric acid and phosphoric acid. In the internal use liquid preparation described in <1>, the taste quality is kept constant over a long period of time by at least one of the hydrochloric acid and phosphoric acid.
<2> The liquid for internal use according to <1>, wherein the content of glucuronolactone is 0.01 to 6.7% by mass. In the internal use liquid preparation described in <2>, since the content of the glucuronolactone is within a predetermined range, the taste quality is kept constant over a long period of time.
<3> Of the hydrochloric acid and phosphoric acid in the internal use liquid preparation, the content of the hydrochloric acid when the hydrochloric acid is used alone is 0.2 × 10 ^{−3 to} 1.0% by volume. <2> A liquid preparation for internal use according to any one of the above. In the internal use liquid preparation described in <3>, since the content of the hydrochloric acid is within a predetermined range, the taste quality is maintained constant and well over a long period of time.
<4> Of the hydrochloric acid and phosphoric acid in the liquid for internal use, the content of the phosphoric acid when the phosphoric acid is used alone is 0.4 × 10 ^{−3 to} 2.0% by mass <1 > To <2>. In the internal use liquid preparation described in <4>, since the content of the phosphoric acid is within a predetermined range, the taste quality is maintained constant and well over a long period of time.
<5> The content of the hydrochloric acid and phosphoric acid in the case of containing the hydrochloric acid and phosphoric acid in the liquid for internal use is the content of the hydrochloric acid × a + the content of the phosphoric acid × b (provided that a + b ≧ 1) The liquid for internal use according to any one of <1> to <2>. In the internal use liquid preparation described in <5>, since the contents of the hydrochloric acid and phosphoric acid are within a predetermined range, the taste quality is maintained constant and well over a long period of time.
<6> The ratio of glucuronolactone (mg) to hydrochloric acid (ml) is such that the glucuronolactone is 5.0 × 10 ⁴ mg or less with respect to 1 ml of the hydrochloric acid. 5> The liquid for internal use as described in any one of 5>. In the internal use liquid preparation described in <6>, since the ratio of the glucuronolactone to the hydrochloric acid is within a predetermined range, the taste quality is maintained constant and well over a long period of time.
<7> From the above <1> to <2>, wherein the ratio of glucuronolactone (mg) to phosphoric acid (mg) is 2.5 × 10 ⁴ mg or less with respect to 1 mg of phosphoric acid. And <4> to <5>. In the internal use liquid preparation described in <7>, since the ratio of the glucuronolactone and the phosphoric acid is within a predetermined range, the taste quality is maintained constant and well over a long period of time.
<8> The ratio of glucuronolactone (mg) to hydrochloric acid (ml) and phosphoric acid (mg) is based on the hydrochloric acid a (ml) + phosphoric acid 2b (mg) (provided that a + b = 1) The liquid for internal use according to any one of <1> to <2> and <5>, wherein the glucuronolactone is 5.0 × 10 ⁴ mg or less. In the liquid preparation for internal use described in <8>, since the ratio of the glucuronolactone to the hydrochloric acid and phosphoric acid is within a predetermined range, the taste quality is constantly and well maintained over a long period of time. Is done.
<9> The liquid for internal use according to any one of <1> to <8>, further containing an organic acid. In the internal use liquid preparation described in <9>, the acidity is appropriately adjusted by the organic acid, and it is easy to drink.
<10> The aforementioned <9, wherein the organic acid is at least one selected from malic acid, citric acid, aspartic acid, glutamic acid, adipic acid, gluconic acid, tartaric acid, succinic acid, lactic acid, acetic acid, maleic acid and fumaric acid > For internal use. In the internal use liquid preparation described in <10>, the acidity is appropriately adjusted by the organic acid, and the medicinal effect of the organic acid itself is added.
<11> The liquid for internal use according to any one of <9> to <10>, wherein the content of the organic acid in the liquid for internal use is 10 mg / 50 ml to 2,000 mg / 50 ml. In the internal use liquid preparation described in <11>, since the content of the organic acid is within a predetermined range, the acidity is more appropriately adjusted, and it is easy to drink and has excellent medicinal properties.
<12> A liquid preparation for internal use comprising glucuronolactone, wherein taste change is suppressed by at least one of hydrochloric acid and phosphoric acid. In the internal use liquid preparation described in <12>, a taste change in the internal use liquid preparation is prevented over a long period of time by at least one of the hydrochloric acid and phosphoric acid.
<13> A solution for preventing change in taste of a glucuronolactone-containing solution, characterized by containing at least one of hydrochloric acid and phosphoric acid. In the taste change preventing liquid preparation of the glucuronolactone-containing solution according to <13>, taste change is prevented over a long period of time by at least one of the hydrochloric acid and phosphoric acid.

  ADVANTAGE OF THE INVENTION According to this invention, the problem in the past can be solved, and the internal use liquid agent with little change of taste quality over a long period of time regardless of a preservation | save condition, and the taste change prevention liquid agent of a glucuronolactone containing solution are provided. be able to.

(Liquid preparation for internal use)
The liquid for internal use of the present invention contains glucuronolactone and at least one of hydrochloric acid and phosphoric acid, and further contains an organic acid and other components as necessary.

-Glucuronolactone-
The glucuronolactone is a component that improves the function of the liver. Specifically, it has the effect of increasing the blood flow of the liver and enhancing the detoxification ability, has almost no side effects, such as urticaria, eczema, pregnancy intoxication, etc. It is also applicable to.

  The glucuronolactone is represented by the following structural formula (1), and the properties are white to slightly yellowish white crystals or crystalline powder. Moreover, it becomes unstable when the pH is 4 or more.

  The glucuronolactone may be a commercially available product or an appropriately synthesized product. The method for synthesizing the glucuronolactone is not particularly limited and may be appropriately selected depending on the intended purpose.

  There is no restriction | limiting in particular as content in the said liquid for internal use of the said glucuronolactone, Although it can select suitably according to the objective, For example, 0.01-6.7 mass% is preferable in a mass% unit. 0.02-3.4 mass% is more preferable. Moreover, in mg / ml unit, for example, 5 mg / 50 ml to 2,000 mg / 30 ml is preferable, and 10 mg / 50 ml to 1,000 mg / 30 ml is more preferable.

-At least one of hydrochloric acid and phosphoric acid-
By at least one of the hydrochloric acid and phosphoric acid, the taste quality change in the liquid for internal use containing the glucuronolactone is suppressed.
The hydrochloric acid and phosphoric acid may be the hydrochloric acid alone, the phosphoric acid alone, or a combination thereof, but the hydrochloric acid alone is more preferable.
The content of the hydrochloric acid in the liquid for internal use when the hydrochloric acid is used alone is not particularly limited and may be appropriately selected depending on the intended purpose. 10 ^{< -3} > -1.0 volume% is preferable and 0.2 * 10 ^<-2 > -0.5 volume% is more preferable.

The ratio of glucuronolactone (mg) to hydrochloric acid (ml) (glucuronolactone: hydrochloric acid) is not particularly limited and may be appropriately selected depending on the intended purpose. The glucuronolactone is preferably 5.0 × 10 ⁴ mg or less, and more preferably 2.5 × 10 ⁴ mg or less.

There is no restriction | limiting in particular as content of this phosphoric acid in the said internal use liquid agent at the time of using the said phosphoric acid alone, Although it can select suitably according to the objective, For example, it is 85% phosphoric acid, and is 0.00. 4 * 10 < ^-3 > -2.0 mass% is preferable, and 0.4 * 10 ^<-2 > -1.5 mass% is more preferable.

The ratio of glucuronolactone (mg) to phosphoric acid (mg) (glucuronolactone: phosphoric acid) is not particularly limited and may be appropriately selected depending on the intended purpose. For example, 1 mg of phosphoric acid The glucuronolactone is preferably 2.5 × 10 ⁴ mg or less.

  There is no restriction | limiting in particular as content of this hydrochloric acid and phosphoric acid in the said liquid for internal use in the case of containing the said hydrochloric acid and phosphoric acid, Although it can select suitably according to the objective, For example, content of the said hydrochloric acid Xa + Phosphoric acid content × b (where a + b ≧ 1).

The ratio of the glucuronolactone (mg) to the hydrochloric acid (ml) and phosphoric acid (mg) is not particularly limited and may be appropriately selected depending on the intended purpose. For example, the hydrochloric acid a (ml ) + Phosphoric acid 2b (mg) (where a + b = 1), but the glucuronolactone is preferably 5.0 × 10 ⁴ mg or less.

-Organic acid-
The organic acid has a function of adjusting the sourness of the liquid for internal use.
The organic acid is not particularly limited and may be appropriately selected depending on the intended purpose.For example, malic acid, citric acid, aspartic acid, glutamic acid, adipic acid, gluconic acid, tartaric acid, succinic acid, lactic acid, acetic acid, Examples include maleic acid and fumaric acid. Among these, citric acid and DL-malic acid are preferable in terms of good acidity. These may be used individually by 1 type and may use 2 or more types together.

  The content of the organic acid in the liquid for internal use of the present invention is not particularly limited and may be appropriately selected depending on the intended purpose. However, in mg / ml units, for example, 10 mg / 50 ml to 2,000 mg / 2,000 50 ml is preferable, and 100 mg / 50 ml to 1,000 mg / 50 ml is more preferable. Moreover, in the mass% unit, 0.02-4 mass% is preferable, for example, and 0.2-2 mass% is more preferable.

-Other ingredients-
The other components are not particularly limited and may be appropriately selected depending on the purpose. For example, vitamins, sweeteners, preservatives, stabilizers, pH adjusters, preservatives, solubilizers, taste masking Agents, solvents, solubilizers, suspending agents, antioxidants, flavoring agents / fragrances, herbal medicines, cooling agents, coloring agents, buffering agents, caffeine, royal jelly, and the like.
The hydrochloric acid and phosphoric acid may be added as other components such as a preservative, a stabilizer, a pH adjuster, a preservative, a solubilizer, a corrigent, a solvent, a solubilizer, and a suspending agent. In these cases, the effects of the present invention can be achieved.

  The vitamins are not particularly limited and may be appropriately selected depending on the intended purpose. For example, vitamin A; vitamin B1 such as thiamine nitrate; vitamin B2 such as riboflavin phosphate; vitamin B3 such as nicotinamide; Vitamin B6 such as pyridoxine hydrochloride; vitamin B12, vitamin D, vitamin E, vitamin C such as ascorbic acid; calcium pantothenate, and the like. These may be used individually by 1 type and may use 2 or more types together.

  The sweetener is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include aspartame, amateur, amacha powder, licorice, licorice extract, licorice crude extract, licorice powder, liquid sugar, fructose, and fructose glucose. Liquid, glucose fructose liquid sugar, reduced maltose water candy, glycine, glycerin, dipotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, monoammonium glycyrrhizinate, brown sugar, high fructose liquid sugar, glucose, powdered reduced maltose water Candy, water candy, high glucose water candy, lactose, sucrose, purified sucrose, purified sucrose spherical granules, honey, purified honey, saccharin, saccharin sodium, stevia, sucralose, erythritol, xylitol, D-sorbitol, D-sorbitol solution, maltitol , Ma Chitoru solution, maltose, D- mannitol, simple syrup, acesulfame potassium, and the like. These may be used individually by 1 type and may use 2 or more types together.

  The preservative is not particularly limited and may be appropriately selected depending on the intended purpose. For example, benzoic acid, sodium benzoate, ethanol, sodium edetate, dried sodium sulfite, citric acid, glycerin, salicylic acid, sodium salicylate , Dibutylhydroxytoluene, D-sorbitol, sorbic acid, potassium sorbate, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, And propylene glycol. These may be used individually by 1 type and may use 2 or more types together.

  There is no restriction | limiting in particular as said stabilizer, According to the objective, it can select suitably, For example, adipic acid, ascorbic acid, L-ascorbic acid stearate, L-ascorbic acid sodium, L-aspartic acid, L-sodium aspartate, aminoethylsulfonic acid, DL-alanine, sodium bisulfite, sodium sulfite, L-arginine, sodium alginate, propylene glycol alginate, albumin, benzoic acid, sodium benzoate, sulfur, inositol, fennel powder, ethanol , Calcium edetate, sodium edetate, erythorbic acid, sodium ersorbate, calcium chloride, sodium chloride, magnesium chloride, cysteine hydrochloride, cacao butter, fructose, carboxyvinyl poly -Carmellose calcium, carmellose sodium, hydrous silicon dioxide, dry sodium sulfite, dry aluminum hydroxide gel, dry aluminum hydroxide gel, dry sodium carbonate, xanthan gum, xylitol, citric acid, calcium citrate, sodium citrate, glycine Glycerin, glycerin fatty acid ester, disodium glycyrrhizinate, glucono-δ-lactone, calcium gluconate, light anhydrous silicic acid, cinnamon powder, crystalline cellulose, acetic acid, tocopherol acetate, sodium acetate, sodium salicylate, phenyl salicylate, β-cyclo Dextrin, dibutylhydroxytoluene, tartaric acid, sucrose fatty acid ester, calcium hydroxide, sodium hydroxide, magnesium hydroxide, purified gelatin, purified soybean lecithin Purified sucrose, sorbitan sesquioleate, cetanol, gelatin, sorbitan fatty acid ester, D-sorbitol, D-sorbitol solution, soybean oil unsaponifiable matter, dextran, natural vitamin E, tocopherol, d-δ-tocopherol, nicotinamide, lactic acid , Lactose, concentrated glycerin, sucrose, ethyl paraoxybenzoate, butyl paraoxybenzoate, methyl paraoxybenzoate, calcium pantothenate, microcrystalline cellulose, hydroxypropylcellulose, glacial acetic acid, sodium pyrosulfite, butylhydroxyanisole, glucose, fumaric acid , Monosodium fumarate, propylene glycol, bentonite, boric acid, propyl gallate, povidone, partially neutralized polyacrylic acid, polyoxyethylene hydrogenated castor oil, polyoxyethylene polio Xylpropylene glycol, polysorbate, polyvinyl alcohol, polyvinyl alcohol / dibutyl ether mixture, macrogol, maltose, maleic acid, malonic acid, D-mannitol, anhydrous citric acid, anhydrous sodium citrate, anhydrous sodium pyrophosphate, maleic anhydride, metalin Examples include sodium acid, methylcellulose, l-menthol, aluminum monostearate, glyceryl monostearate, medicinal charcoal, sodium lauryl sulfate, ovalbumin, agate powder, DL-malic acid, and the like. These may be used individually by 1 type and may use 2 or more types together.

  The pH adjuster is not particularly limited and may be appropriately selected depending on the intended purpose. For example, citric acid, sodium citrate, glycine, glucono-δ-lactone, succinic acid, acetic acid, tartaric acid, D-tartaric acid Sodium hydroxide, magnesium hydroxide, lactic acid, calcium lactate, glacial acetic acid, monosodium fumarate, maleic acid, anhydrous citric acid, DL-malic acid, and the like. These may be used individually by 1 type and may use 2 or more types together.

  The preservative is not particularly limited and may be appropriately selected depending on the intended purpose. For example, aminoethylsulfonic acid, benzoic acid, sodium benzoate, ethanol, sodium edetate, agar, dl-camphor, citric acid , Sodium citrate, salicylic acid, sodium salicylate, phenyl salicylate, dibutylhydroxytoluene, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetate, 2-naphthol, sucrose, honey, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, paraoxy Examples thereof include ethyl benzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, l-menthol, and eucalyptus oil. These may be used individually by 1 type and may use 2 or more types together.

There is no restriction | limiting in particular as a method of preparing the liquid for internal use of this invention, According to the objective, it can select suitably from well-known methods.
There is no restriction | limiting in particular as pH of the liquid for internal use of this invention, Although it can select suitably according to the objective, For example, less than 4 is preferable. If the pH is 4 or more, the glucuronolactone may become unstable and decompose.
There is no restriction | limiting in particular as a usage method of the liquid for internal use of this invention, According to the objective, it can select suitably, For example, it can use suitably as a pharmaceutical, a quasi-drug, a drink, etc.
There is no restriction | limiting in particular as an ingestion amount of the liquid for internal use of this invention, Although it can select suitably according to the objective, For example, when it is an adult, 0.3-1g is mentioned as said glucuronolactone. Preferably taken orally three times a day.

  The liquid for internal use of the present invention contains glucuronolactone having an ability to improve liver function, and is suitable for oral ingestion as a liquid medicine, a drink or the like. The liquid preparation for internal use does not require strict storage conditions in order to suppress itchiness, is easy to handle, and can be maintained constant without changing the taste quality over a long period of time.

(Glucuronolactone-containing solution for preventing taste change)
The taste change preventing liquid of the glucuronolactone-containing solution of the present invention contains at least one of hydrochloric acid and phosphoric acid, and has other components appropriately selected as necessary.
The glucuronolactone and other components are as described above.

At least one of the hydrochloric acid and phosphoric acid prevents a taste change in the taste change inhibitor of the glucuronolactone-containing solution.
The hydrochloric acid and phosphoric acid are as described above.
There is no restriction | limiting in particular as content of the said hydrochloric acid in the taste change prevention liquid agent of the said glucuronolactone containing solution at the time of using the said hydrochloric acid alone, Although it can select suitably according to the objective, for example, 36 % Hydrochloric acid is preferably 0.2 × 10 ^{−3 to} 1.0% by volume, more preferably 0.2 × 10 ^{−2 to} 0.5% by volume.

The ratio of glucuronolactone (mg) to hydrochloric acid (ml) (glucuronolactone: hydrochloric acid) is not particularly limited and may be appropriately selected depending on the intended purpose. The glucuronolactone is preferably 5.0 × 10 ⁴ mg or less, and more preferably 2.5 × 10 ⁴ mg or less.

The content of the phosphoric acid in the taste change prevention liquid of the glucuronolactone-containing solution when the phosphoric acid is used alone is not particularly limited and can be appropriately selected according to the purpose. 85% phosphoric acid, preferably 0.4 × 10 ^{−3 to} 2.0 mass%, more preferably 0.4 × 10 ^{−2 to} 1.5 mass%.

The ratio of glucuronolactone (mg) to phosphoric acid (mg) (glucuronolactone: phosphoric acid) is not particularly limited and may be appropriately selected depending on the intended purpose. For example, 1 mg of phosphoric acid The glucuronolactone is preferably 2.5 × 10 ⁴ mg or less.

  The content of the hydrochloric acid and phosphoric acid in the taste change preventing liquid when containing the hydrochloric acid and phosphoric acid is not particularly limited and may be appropriately selected depending on the intended purpose. It is preferable that the content xa + the phosphoric acid content × b (where a + b ≧ 1).

The ratio of the glucuronolactone (mg) to the hydrochloric acid (ml) and phosphoric acid (mg) is not particularly limited and may be appropriately selected depending on the intended purpose. For example, the hydrochloric acid a (ml ) + Phosphoric acid 2b (mg) (where a + b = 1), but the glucuronolactone is preferably 5.0 × 10 ⁴ mg or less.

  The taste change preventing liquid of the glucuronolactone-containing solution of the present invention contains at least one of the hydrochloric acid and phosphoric acid, so that it is not necessary to strictly preserve storage conditions and the like, and is easy to handle and can be used for a long time. Thus, it is possible to keep the taste quality constant by suppressing the taste change caused by the glucuronolactone.

  EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples, but the present invention is not limited thereto.

(Examples 1-4 and Comparative Examples 1-4)

-Preparation of liquid for internal use-
50 ml of an internal use liquid preparation was prepared by a conventional method so as to have the composition and pH shown in Table 1 below. In Comparative Examples 1 to 3, the pH was adjusted to 2.70 by adding an appropriate amount of a mixture of DL-malic acid and citric acid (DL-malic acid: citric acid = 2: 1 (mass ratio)).

-Evaluation (pH)-
Each obtained liquid for internal use was placed in a light-shielding bottle and allowed to stand for 2 weeks at 60 ° C. (hereinafter, the obtained liquid for internal use may be referred to as “60 ° C. 2 W”). Similarly, it was left for 1 month under the condition of 50 ° C. (hereinafter, the obtained liquid for internal use may be expressed as “50 ° C. 1M”). When the pH of these liquids for internal use was measured, it was as shown in Table 2.

表中、初期値とは、調製直後の内服用液剤のｐＨを示す。

In the table, the initial value indicates the pH of the liquid for internal use immediately after preparation.

-Evaluation (acidity)-
Seven panelists swallowed the same internal liquids immediately after preparation and internal liquids left for 2 weeks at 60 ° C. in this order, and evaluated the difference in sourness compared to the internal liquid immediately after the preparation. . The results are shown in Table 3.

  In addition, seven panelists drank the same internal liquid preparation immediately after preparation and the internal liquid preparation left for one month under the condition of 50 ° C. in this order, and the sour taste compared to the internal preparation liquid immediately after the preparation. The method (change in taste quality) was evaluated. The results are shown in Table 4.

  From Table 3 and Table 4, from the results of the liquids for internal use in Comparative Examples 1 and 4, when glucuronolactone was not contained, there was no change in sourness and taste over time, so glucuronolactone affected, It was speculated that “gumami” accompanied by sourness occurred and the taste quality changed. Further, from the results of the liquid preparations for internal use of Comparative Example 2 and Comparative Example 3, when glucuronolactone was contained and hydrochloric acid was not contained, “egumi” was produced over time, and the taste quality Can be seen to change. On the other hand, from the results of the internal use liquid preparations of Examples 1 to 4, when hydrochloric acid is contained, “egumi” accompanied by sourness does not occur over time, and the taste quality does not change and is constant. I understand that.

(Examples 5-7)
In Example 1, the sourness was evaluated in the same manner as in Example 1 except that the liquid for internal use was replaced with the liquid for internal use prepared by a conventional method in the composition shown in Table 5 below. The evaluation results when left for 2 weeks at 60 ° C. are shown in Table 6, and the evaluation results when left for 1 month at 50 ° C. are shown in Table 7.

表６及び表７より、実施例５〜７の内服用液剤の結果から、塩酸がグルクロノラクトン含有溶液の味質変化を防止することが判る。

From Table 6 and Table 7, it can be seen from the results of the internal use liquid preparations of Examples 5 to 7 that hydrochloric acid prevents a change in taste quality of the glucuronolactone-containing solution.

Since the liquid for internal use of the present invention contains glucuronolactone, it can be used in fields such as the medical industry, and can be suitably used as, for example, pharmaceuticals, quasi drugs, beverages, and the like. . The solution for preventing change in taste of a glucuronolactone-containing solution of the present invention contains at least one of hydrochloric acid and phosphoric acid, and is therefore suitable for pharmaceuticals, quasi-drugs, beverages and the like containing glucuronolactone. Can be used for

Claims (6)

  A liquid for internal use comprising glucuronolactone and at least one of hydrochloric acid and phosphoric acid.   The liquid for internal use according to claim 1, wherein the content of glucuronolactone is 0.01 to 6.7% by mass.   The liquid for internal use in any one of Claim 1 to 2 which further contains an organic acid.   The organic acid is at least one selected from malic acid, citric acid, aspartic acid, glutamic acid, adipic acid, gluconic acid, tartaric acid, succinic acid, lactic acid, acetic acid, maleic acid and fumaric acid. Liquid for internal use.   A liquid for internal use, comprising glucuronolactone, wherein taste change is suppressed by at least one of hydrochloric acid and phosphoric acid. A taste change preventing liquid for a glucuronolactone-containing solution, characterized by containing at least one of hydrochloric acid and phosphoric acid.