JP2005089403A - External anti-pruritic agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an external anti-pruritic agent excellent in anti-pruritic effect, effective for relaxation of skin pruritus such as atopic dermatitis, senile xerosis and pruritus in winder season, free from adverse effect even when continuously used and excellent also in safety, a cosmetic composition, a bathing agent composition and a cleansing agent composition each containing the anti-pruritic agent. <P>SOLUTION: The external anti-pruritic agent is composed of an extract of a composition which is similar to prescription of traditional Chinese medicine called as Unseiin, namely an extract of a mixture of 3-4 pts. wt. Angeliace Radix with 3-4 pts. wt. Rehmanniae radix, 3-4 pts. wt. Paeoniae Radix, 3-4 pts. wt. Cnidium rhizome, 1-1.5 pts. wt. Coptidis Rhizoma, 1.5-3 pts. wt. Scutellariae radix, 1.5-2 pts. wt. fruit of Gardenia jasminoides and 1-1.5 Phellodendri Cortex, and exhibits synergistically excellent anti-pruritic effect. The cosmetic composition, the bathing agent composition and a cleansing agent composition comprise each the external anti-pruritic agent. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention has an anti-pruritic effect, is effective for alleviating skin pruritus such as atopic dermatitis, senile xerosis, and winter pruritus, and has no side effects even when used continuously, and is excellent in safety. The present invention relates to an antipruritic agent and a cosmetic composition, a bath composition, a detergent composition and the like containing the antipruritic agent.

  In patients with atopic dermatitis, senile xeroderma, and patients with winter pruritus, one of the main symptoms is a strong pruritus sensation, which is a major obstacle to living everyday life. ing. Cutaneous pruritus may be systemic or local, and may be caused by external factors, visceral disease, mental, etc. from another aspect. Specifically, there are atopic dermatitis, senile pruritus, winter pruritus, anal pruritus, etc., and an increasing number of people are particularly worried about pruritus of atopic dermatitis. These diseases often cause scratching due to ugliness, thereby exacerbating the symptoms.

  These pruritus are considered to be sensitive to external factors due to the disruption of the epidermal barrier, or to cause itchiness due to increased transdermal water transpiration and drying of the skin. Vaseline, ester oil, etc. Humectants such as oil, hyaluronic acid and urea are used. In addition, anti-inflammatory agents, antihistamines, antiallergic agents, and corticosteroids are also used in the form of external and internal use.

  However, when the humidity in the air is low, the moisturizing agent absorbs moisture from the skin and may dry the skin. In addition, there are other problems such as stickiness and other uncomfortable feelings in use, a sufficient anti-itching effect cannot be obtained, and side effects are caused by long-term use.

As an external antipruritic agent by a natural extract, for example, an external antipruritic agent (Patent Document 1) consisting of a hawthorn extract, a ginseng extract, and a clara extract, asenyaku, pegasenyaku, salamander, clove, agez, kina, Skin external preparations consisting of extracts of licorice, loquat, saxifrage, firewood, grape, birch plant, perilla plant, mugwort plant, button genus plant, genus genus plant, jujudama genus plant, linden plant, plant genus plant ( Patent document 2) and the like have been proposed, but further development of technology has been demanded.
JP 2002-29990 A JP 2003-89658 A

  The problem to be solved is an external anti-pruritic agent that is highly safe and excellent in anti-pruritic effect, and is effective in alleviating skin pruritus such as atopic dermatitis, senile xerosis, and winter pruritus, and the anti-itch It is to provide a cosmetic composition, a bath composition, a detergent composition and the like containing an agent.

  In order to solve the above-mentioned problems, the present inventors searched various plant extracts and mixtures thereof, and as a result, the extract having the same composition as the Kampo prescription called “Shinkei” has a synergistically excellent anti-pruritic effect. The present invention has been completed. That is, the present invention is an anti-pruritic agent for external use comprising an extract of a mixture of toki, jiou, peony, senkyu, ouren, ougon, sanshishi and oak, and more specifically, 1-6 parts of touki, 1-6 parts of jiou, peony. 1-6 parts, 1-6 parts of nematode, 0.3-4 parts of auren, 0.5-5 parts of gourd, 0.5-4 parts of sanshishi, and 0.3-4 parts of buckwheat It is an antipruritic agent. More specifically, 3-4 parts of Toki, 3-4 parts of peony, 3-4 parts of peony, 3-4 parts of senkyu, 1-1.5 parts of oulen, 1.5-3 parts of oxon, An anti-pruritic agent for external use comprising an extract of a mixture of 1.5 to 2 parts of Sanshishi and 1 to 1.5 parts of buckwheat, more specifically, the external anti-pruritic agent which is an extract of water, alcohols or a mixture thereof. Agent More specifically, the external anti-pruritic agent, wherein the amount of the extraction solvent is 10 to 100 times the amount of the extract, and the external skin composition containing the external anti-pruritic agent, A cosmetic composition containing the external anti-pruritic agent, a bath composition containing the external anti-pruritic agent, and a detergent composition containing the external anti-pruritic agent.

  An external antipruritic agent that is safe and has no skin irritation and is effective for pruritus such as atopic dermatitis, senile xerosis, and winter pruritus can be obtained.

The plants used in the present invention are shown below, and any of them can use leaves, stems, roots, flowers, seeds or whole plants.
(1) Touki Angelica acutiloba Kitagawa (Apiaceae)
(2) Peony Paeonia lactiflora Pallas (button family)
(3) Cnidium officinale Makino (Apiaceae)
(4) Giant Rehmannia glutinosa Liboschitz var.purpurea Makino
(5) Ouren Coptis japonica Makino (Ranunculaceae)
(6) Phellodendron amurense Ruprecht (Rutaceae)
(7) Ogon Scutellaria baicalensis Georgi (Lamiaceae)
(8) Sanshi Gardenia jasminoides Ellis (Rubiaceae)
The kind of each plant is not limited to this, and varieties, genera, and other related species can also be used.

  The active ingredient is extracted from these plants using a suitable solvent. Examples of the solvent include water, alcohols (for example, lower alcohols such as methanol, ethanol, and propanol, or polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, and dipropylene glycol). It can be used as a mixed liquid. Moreover, after extraction, it can also be used by filtering and diluting or concentrating and drying the extract as necessary.

  The extraction method is not particularly limited, but may be in the range up to the boiling point of the solvent at normal temperature or normal pressure. After extraction, adsorption or decolorization / purification is performed using filtration or ion exchange resin. Then, it may be in the form of a solution, paste, gel, or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and usual means generally applied depending on the extracted substance may be arbitrarily selected.

  As for the plant used in the present invention, an extract having a high effect is obtained from those extracted by combining eight kinds. Therefore, it is more effective than individual extraction from each, extraction by arbitrarily combining up to 7 kinds of plants, and mixing and using each extract or extract. In addition, since the durability of the anti-pruritic effect is further improved by combining and extracting eight kinds of plants, and the result that the improvement effect against rough skin, dandruff, kayumi, and inflammatory diseases is further improved, It seems that it is sufficiently meaningful to use a product extracted by combining eight kinds of plants.

  The blending amount of each plant used in the present invention is a collection of experienced Chinese herbal prescriptions (published by Nippon Shokudo Inc., 9th edition of 1993) and general Kampo prescriptions (supervised by the Ministry of Health and Welfare , April 30, 1992, 4th edition), particularly preferred amounts are 3-4 parts (parts by weight) of Toki, which is the amount of warm drinks (hereinafter the same), 3-4 parts, Peonies 3-4 parts, Senkyu 3-4 parts, Auren 1-1.5 parts, Ogon 1.5-3 parts, Sanshishi 1.5-2 parts, and Oat 1-1.5 parts. .

  In addition to the essential anti-pruritic plant extract of the present invention, the external preparation composition, cosmetic composition, bath preparation composition and detergent composition according to the present invention are usually used in cosmetics as described below, for example. It can be produced by using the bases and additives used together.

  (1) Various fats and oils: avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber oil, safflower Oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, Coconut oil, beef tallow, lard, or hydrogenated products of these oils (hardened oil, etc.).

  (2) Waxes: beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, squalene, squalane, pristane and the like.

  (3) Mineral oil: liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

  (4) Fatty acids: natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2 -Synthetic fatty acids such as ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

  (5) Alcohols: natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol.

  (6) Polyhydric alcohols: ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, glycerin, diglycerin, pentaerythritol, sorbitol, mannitol and the like.

  (7) Esters: isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate , Diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.

  (8) Metal soaps: aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

  (9) Gum, sugars or water-soluble polymer compounds: gum arabic, benzoin rubber, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose or esters thereof , Trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan to which alkylene (C2-C4) oxide such as ethylene oxide is added, low molecule Chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, heparin, ethylcellulose, methylcellulose , Carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide, polypropylene oxide, etc. Polyalkylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, polyethyleneimine and the like.

  (10) Surfactant: Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt), Amphoteric surfactant [carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant], nonionic surfactant Agents (ether type nonionic surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing type nonionic surfactants), other surfactants Agents (natural surfactants, derivatives of protein hydrolysates, polymer surfactants, surfactants containing titanium and silicon, Carbon-based surface active agent), such as.

  (11) Various vitamins Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), Riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: Ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydrotaxosterol, vitamin E group: vitamin E or derivatives thereof, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), Menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eliocitrin, hesperidin), vitamin U and the like.

  (12) Various amino acids: valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxy Amino acid derivatives such as lysine, arginine, ornithine, histidine, and their sulfates, phosphates, nitrates, citrates, or pyrrolidone carboxylic acids.

  (13) Various additives derived from plant or animal materials: These are processed in a conventional manner according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, fermentation, Purify, squeeze, extract, fractionate, filter, dry, pulverize, granulate, dissolve, sterilize, adjust pH, deodorize, decolorize, etc.) And serve.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, a water-soluble organic solvent (for example, ethanol, propylene glycol) , 1,3-butylene glycol, and the like) are preferably used. However, when it is not preferable to contain an organic solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. The thing extracted and extracted may be sufficient.

  In addition, when using additives derived from plant or animal-based ingredients for systemic or topical external preparations and cosmetics, not only the protection of skin and hair, but also moisturizing, improvement of touch / feel, imparting flexibility, stimulation Relaxation, stress relief by fragrance, cell activation (cell aging prevention), suppression of inflammation, improvement of skin and hair quality, prevention of rough skin and its improvement, hair growth, hair growth, hair loss prevention, imparting gloss, cleansing effect, In addition to cosmetic effects such as fatigue relief, blood flow promotion, and bathing effects, effects such as flavoring, deodorizing, thickening, preserving, and buffering can also be expected.

  In addition to this, various cosmetic and pharmaceutical effects of each of the known raw materials are expected, and by combining these, the intended effect can be promoted or multifunctional. It is also possible to make the product expected to be effective.

Specific materials used as raw materials include, for example, plants (herbal medicines) such as almonds, eyes, blue pods, Aoki, Aogiri or Kenashia Ogiri, Aotsuki-rafuji, acacia, red pepper, red currant, red grapes, redwood (logwood), red-crowned wrinkles, red pine Or Ziou, Agi, Aki larch, Akinire, Aguahe (Omanten palm), Akebi, Asa, Maruba Asagao or Asagao, Hydrangea, Ashitaba, Azuki, Acerola, Asenyaku, Athira (Shokuyokanna), Anise, Abemakaki, Amacha, Amacha Amadokororo, Amana, Amaranth (Amaranthus, Hagaitou, Senninkoku, Sugimorigateto, Hosoaogeito, Aogateoto, Haribiyu, Amaranthus Hippochondriacus) Is alba (alcanna), algarrobo (cabbage), altea, arnica, alpinia or katsudai (suzukuku), aloe, aloe vera, angelica, apricot or honanzu, ansokkou, igakozorina, ikarisou or yatsuma taikiso Itadori, Yew, Strawberry, Fig, Ichihatsu, Ichibi, Ichiyakuso, Ginkgo, Itohimegi, Locust Bean, Inazuna (Taileki), Inubiyu (Hanagainubiyu), Rice, Inond, Ibukikakuso, Nettle, Iranian Iwam Fennel, Wheat (Chibusanoki), Spiraea, Prunus vulgaris, Dinosaur, Duckweed, Usubasaicin or Keirinsaicin or Oyusaishin, Usvenio , Usbenitachaoi, moray moth, udo or shishiudo, unyadegato (unkalia, cat's claw), ura tea, ume, urajirogashi, waulourushi (kusokobomomo), sushi mandarin, estragon, euzocogi, echinas Cassia Tora, El Campre, Elderberry, Elemi, Elingy or Pre-Lotus Elinge, Enju, Ogi or Kibanaougi, Ouren, Oouri Ura (Calcon), Ooguruma, Ootsuki-rafuji, Obaco, Toucanami, Oubara Okera, Oba ), Ooyabaya Shabushi, Oha hawthorn or Hawthorn, Ousei (Naruko Yuri, Kagikarumabaru Yuri), Sasayuki Yuki or Sasano Yuki, barley, Oshigusa, Oka, Okazeri, Oguruma, Okra, Panax ginseng or Tochibaninjin, Hypericum pertussis or Loraceae, Hypericum perforatum, Olycium, Onamomi, Onigurumi, Onidokoro, Tokoro, Scorpion, Ori , Yuuko, Dutch mustard (watercress), Dutch jellies, Dutch honey bees, olives, oregano, oranges, silkworm, cacao, oysters, oysters, oysters or anteaters, cassia, casino oysters, gadgets, oaks, cascarillas, casserole, gypsophila, Cynomolgus, kaniwa, valerian, birch or fern birch, pumpkin, kapok, kahoku salamander, cattail, chamomile or -Macamitre, Camellia deer, Cam cam (camo duck), Carax salmon man, Calla cucumber or Sinakara cucumber, Callas bishak, Oats, Garana, Carahoo, Karaya, Karin, Garcinia, Kawamidori, Kawarasaicho, Kawadisha, Kawaratake quasi Daylily, Kantarasa, Kandelilla, Kanto, Kanna, Raspberry (Ezo Strawberry, Dutch Strawberry, Shrimp Strawberry, Nawashiro Strawberry, Momiji Strawberry, European Strawberry), Kiwi, Kikarasuri, Kyoji, Chrysanthemum (Chrysanthemum, Ginseng, Kizushi, Kijutsu, Kizutsu) Kidachi Aloe, Kidachi Hakka, Kina, Kinaki (Shinkona, Akinaki), Kinua, Kinahada, Gymnema Silve , Cabbage, cabbage, cucumber, gourd, Kiraja saponaria, Kiraya, Kiran Sou, kumquat, betel, goldfish, guava, guayule, quercus infectoria, cucumber nut, wolfberry, peony, kudu, cinnamon, gooseberry, xanthine , Kunugi, Kupuas, Kumazasa, Kumanusura, Clara, Cranberry, Chestnut, Curcumigo lachifolia, Grapefruit, Black-bellied red beetle, Black-bellied or Black-bellied, or Gambina (Sekimei, Sekimei-shi), Kei-gai, Kate-bara, Gecko-arum Kemponashi (Kigushi), Koki Sekkoku, Kishimizukan (Koji, Tachibana, Obenimikan, Fukurimikan, Sagamikou) Ji, Ponkan, Santara, Koushimbara, Kousuihakka, Kozo, Kocha, Kohone, Kohon, Koryang, Koryokyo, Cilantro, Kourien, Koganebana, Cowberry, Coconut, Goshuyu, Goshostrawberry, Pepper, Copaiba Balsam, Coffee, Cobu Burdock, Kobotanru, Sesame seeds, Sesame seeds, Garlic, Sanekazura or Binankazura or Matsubusa, Wheat, Rice or Rice bran, Rice oil, Cola acminata, Cola bella, Koroha, Colombo, Konzlango, Comb, Konjac, Comfrey, Sisal (Sisal asa) , Saxima button eel or cinnamon bud or cinnamon, cherry (Ooshima cherry, Yamazakura, Oyamazakura, Edhigashi, Bean cherry, Miyazakura, Yoshino cherry, Takane Kura, Kasumi-zakura, Choji-zakura, Kohigan, Sato-zakura, Kanzakura, Cherry, Pomegranate, Sasa, Sasanka, Sagimodaka, Sweet potato, Sugarcane, Sugar beet, Sunflower jujube, Saffron, Pomegranate, Savonso, Salmonberry, Salamander, Salvia Sawagurumi, Sangre de Grado (croton), Salamander, Sancynin carrot, Sanshuyu, Salamander, Sandscon, Shea (carite), Cyanoki, Shiitake mushroom, Zion, Diquitaris, Sikkunshi, Perilla or Aojizo, Chirimendoso or Catamendizo, Shitan, Shinano , Shinohonoki, Chinese forsythia, Shimeji (Hinshimeji, Shakashimeji, Hatake-shimeji, Oshiroi-shimeji, Beech-shimeji, Honjimeshi, Shirotamogi-take) Potato, Peonies, Shajin, Jasmine (Matsurika), Janohige, Shukukonkamiso, Shukushamitsu, Juzudama, Shiro, Giant Hydrangea, Shobu, Shozuk, Shirakashi, Robo butterfly, White-headed Azuki, White-faced Squirrel Konasakushirabura, Ginkgo biloba, Cinnamon, Watermelon, Honeysuckle, Sorrel, Swimberry, Stevia, Strawberry, Psycho, Horsetail, Prunus, Plum, Scots Pine, Larch ), Pear, psyllium, elder, prunus (juniper), yarrow (milf) Il), rose, pearl butterfly, mistletoe, Atlantic mint or wild mint , Ginseng, soka, buckwheat, some potato, daikon, radish, soybean, daidai, takasaburo, takatodai, hawk arabi, dark sweet cherry, hollyhock, hollyhock (thyme), tachidokoro (hikai), tachiyanagi, tamarind, onion Tarwi, Tanjin, Dandelion or Shirobana Dandelion or Mouko Dandelion, Danmaru, Cherry, Chigaya, Chixetsujinjin, Chicory, Chanka Piedra (Kidachicomika) , Ginseng, Ginseng, Ginseng, Choreimaitake, Chorogi, Tsuki-miso, Tsukutake, Mushroom, Camellia, Clover, Clover, Azalea, Cran's Azuki, Crested Duck, Tulna, Tsuninjin, Tsubaki, Gurudori , Tencha, Tendai Yaku, Toga, Toka Kazura, Pepper, Toki, Toki-Senka (Marigold), Tounabena, Corn or Corn, Toadskin, Tori-Gindo, Toxa, Dokudami, Tokon, Toshi or Toshio Ash, tomato, tragacanth, triacanthus, tormentilla, dronoki, troll mallow, nigerian berry, yam or yam, Giikada (Butcher Bloom), Naginata Koju, Nazuna, Rapeseed, Natsume or Vertical Spoon, Natsumikan, Jujube, Naniwaibara, Navena, Nameko, Naruko Yuri, Nankin Bean, Nanten, Namban Karashi, Nigaki, Niigamugi, Kei or Nikei , Leek, elderberry, garlic, nulde, leeks, nemony or neb or nebi or nemlinoki or digokubana, white thistle, white rose, yarrow, nodake, nobara, peach tree, palm, pineapple, hibiscus Urabosi, Haxen, Hackleberry, Jacobe, Hazel, Hasilikoro, Basil, Lotus, Parsley (Dutch Jelly), Hadakamugi, Batata, Hachiku or Madake, Pachi Yorye, mint, pearl barley (Yokuinin), Hanasuge, banana, Hanahaku, Hanabishi (Sitoshi, Shishitsuri), vanillabins, Azalea, Pahalobobo, Hub, Paprika, Hamago or Mitsuba Hamago, Hamasuge, Hamabishi, Hamanasu (Makaifu) , Roses, Agaric (Agaric, White-faced Agaric, Ukimorinokasa), Haran, Pariurus (Prunus japonicus), Parietalia, Balsamina (Villus serrata) , Astragalus, Himawari, Pistachio, Beet, Hitotsuba, Hitosuba Enishida, Hinata Taikozuchi, Cypress, Hiba, Castor, Sunflower, Pepper, Himezu, Himegama, Himematsutake (Kawari) (Agaricus, Hiromatsutake), Pimenta, Sandalwood, Sandalwood, Panthera, Yellow-tailed Oyen, Hirohakinagusa, Biwa, Betel Nut, Fuyu-kazura, Fuuki, Dandelion, Fujibakama, Fuji-bean, Grape, Beech, Fusumina-Tsukura, Ninja Samurai Currant, Blackberry, Plum, Fruceraria, Blueberry (Prunus aegypti), Prunes, Blond Psyllium, Bundow, Hazelnut, Loofah, Safflower, Heneken, Belladonna, Berry, Pervianburg, Benquis or Duckweed, Boysenberry, Buffalo or Duckweed or Nendou or Hahagigi Kokia, spinach, spinach, boufu, spinach, physalis, physalis, bokeh, scallops, psyllium, scorpio Barengiku, Bodaiju, Button, Buttonpi, Hop, Jojoba, Bordeaux, White berry, Hononiku, Honsekoku, Mizurutennanshow, Maitake, Maou, Maca, Macadamia nut, Macri, Magwa, Magnolia sprengeri, Mashua (Kyukonkinrenka), Matatabi, Matsukasa, pine, Matsuhodo, Matico (Cordon sillo), Mayoram (Hanahakka), Malvano jardin, Mulberry, Quince, Mangosteen (Mandesagna) Or mizuasagao, mizukakushi, misohagi, michiyanagi or niwayanagi, mitsugasiwa, honeybee, green mint, mimosa, mioga, miracle fruit, myrrh, milo Balun, wheat straw, mugwort, mugwort, mugwort, munya, murasaki, murasakikibu or murasakikikibu, murasaki corn, murasakifuji, swordfish, snakefish, melaroika, melissa, merirot,
Melon, Moukomugi, Mosouchiku, Mogi (Pepper), Mokko, Momijidaio, Peach, Moyashi, Morello Cherry, Morohaya, Yakawa Murasakiimo, Yakuchi, Cornflower (Yagarumakka), Yagurumakka, Yakon, Yashabushi or Hishabushi , Willow, mistletoe, mistletoe, willow , Yabu cigarette, pokeweed, Yamahanoki, Yamabomo, Yamamugigi, Eucalyptus, Yukinoshita, Yucca or flevifolia, Yuzu, Yuri, Yo Longus, mugwort, ligan, lime, rye, lacanca, raspberry, latania (chlamelia), raccoon or shallot, lavender, agave, agave (Aonorus agave, fuchlin agave), ryokcha, apple, gentian, rubus or suabisimus Chisha), red currant, lemon, lemongrass, forsythia or forsythia, forsythia, wax palm, locon (yoshi), logan berry, rosemary (mannenrou), rosehip (nobara), wasabi, walmocow.

  In addition, other seawaters such as sea salt, dried seawater, dead sea or Atlantic or Pacific seawater (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango), such as Sea mud or mud in various regions such as Italy, France, Germany, Eifel and Franceburg (Contained components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide) Strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone and so on.

  As seaweeds, seaweed [Green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaoonori, Hiraonori), seaweed [Brown algae: Kombu, Macub Hosome Kombu, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis pirifera, Macrocystis integrifolia, Hijiki, Hibamata), seaweed [Red algae: Hijirimen, Maxa (Tengusa), Nettle, cypress, prickly pear, caterpillar, yatabegusa, yui-kiri, striped primrose, crested beetle, spruce rhinoceros, crested rhinoceros, giraffe rhinoceros, ginseng giraffe, horned mackerel, plover Data, carrageen (Yahazutsunomata), Ezotsunomata, Togetsunomata, Hirakotoji, Kotojitsunomata, Suginori, Shikin'nori, Kainori, Ibotsunomata, Yareusubanori, Kagiusubanori, Sujiusubanori, Haiusubanori, Akamomijinori] and the like as a representative.

  In addition, other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Anemone: Quanomomo, Volbox: Ougenmawari, Volbox, Palmera, Yotsumeo, Aomido: Chrysanthemum, Aoumidro, Tirgimidro, Hibidoro: Hibidoro, Aosa: Anaaaosa, Amiaosa, Nagaaosa, Kawanori: Kawanori, Friccella, Shiogusa Magama genus: Magamata, Iwagata: Fusaikawa, Surichogi, Heraiwata, Kurokita, Hanemo, Genus: Mill, Chromel, Sakibuchimil, Nagamil, Hihi Mill, Casanori genus: Casanori, Jusmo genus: Jujusmo, Tamajusmo, Mizojusmo, Mizuna genus, Collecaete genus, Tufts genus: Dendrobium genus: Human genus: Human genus, Acer genus, Plum Sumiremo: Sumiremo, Hoshimamidro, Fushinashimidoro etc.).

  Cyanobacteria (Suizenjinori: Suizinori, Aoko, Nenjumo: Kawatake, Ishijelly, Hassai, Yuremo, Rasenmo (Spirulina): Spirulina, Trichodesmium (Iaciasio), etc.

  Brown alga Sanadagusa: Sanadagusa, Fukurimamiji, Commongusa: Commongusa, Yahazugusa: Ezoyahaz, Yahazugusa, Uraboshiyahaz, Digamigusa: Djimigusa, Umichiwagakusa, Umamisugakuwa, Hakusou : Navarimo, Chasomen genus: Motsuki Chasomen, Matsumo genus: Matsumo, Nagamatsumo genus: Nagamatsumo, Okinawa mozuku: Okinawa mozuku, fake Tomozuku: Niseft Mozuku, Futomozuku: Futomozuku, Ishimozuku: Ishimozuku, Kuromo: Kuromo, Nisemozuku: Nisemozuku, Mozuku: Mozuku, Ishige: Ishige, Iroro, Ichimosa: Ichimegasa Umibosu, Urushigusu: Urushigusa, Keurushigusa, Tobacco gussa, Compositae: Compositinum, Habasmodoki: Haberodoki, Habanori: Habanori, Habanori: Common Haburori, Commonbukuro, Ezobukuro, Ezobukuro Chishima fukuronori genus: Chishima fukuronori, Kagomenori genus: Kagomenori, Muraridori genus: Murachidori, shark genus: shark zusa, genus genus: lobster, genus genus: yokojimamanori, Ganoderma genus: cynomolgus, fennel spider: fennel spider, genus cirrus: turmo, turtle genus: shark, genus genus: sujime, misjikonbu genus: misjikonbu, atsuba misjikonbu, konbu genus: tsutsugarakonbu, kakijima konbu, onikombu, gakonbubu Barracuda, Trolocomb, Anthrome, Antokume, Antarctic, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikombu, Kikuishikonbu, Nejirumubu: Nejirebubu, Kuroshiome: Kuroshiome, Nekoshikonbu, Aramei Genus: Ainuwakame, Chigaiso, Oniwakame Ezoi Shige: Ezoi Shige, Yabane Moku: Yabane Moku, Rappa Moku: Rappa Moku, Joromoku: Ugano Moku, Jo Lomoku, Hiemoku, Honda Walla: Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Honda Walla, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yatsumata Moku, Umitranoo, Obamoku, Fushishimoku, Hahamokumoku ), Genus Ukimo: Ouki, genus Burukimo: burukimo, genus genus: mosquito mono).

  Red algae Genus: Sea urchin, Tsukumonori, Anemone crispula, Astragalus serrata Genus: Tamaitadaki, Kaikekenori Genus: Kaginori, Kaikekenori, Tengusa: Himetengususa, Hytengususa, Oobusa, Nambugu , Kohira, Yohira, Kinukusa, Hibiro, Genus: Hibirodo, Himebiro, Isommedo: Isommedo, Aedes: Rhizome, Ryumons: Ryumon, Ranunculaceae Naminohana: Hosobanaminohana, Naminohana, Sangomodoki: Ragaramomodoki, Shiogusagoromo: Shiogusagoromo, Iwanokawa: Etsukiiwakawa, Kainokawa Scarlet, cherry blossom, Nikumukade, Tambanori, Tsurutsuru, Isonohana: Nurakusa, Cronouraxa, Oumkadeno , Hirakintoki spp. Mafunori, Karekigusa: Karekigusa, Tosakamodoki: Hosobanotosakamodoki, Hirohatosakamodoki, Yatsudegatatosakamodoki, Kurotosakamodoki, Nezashinotosakamodoki, Kinuhasada, Ezotosaka , Anopheles genus: Honoo, genus genus: genus genus, Usuginu, genus Anemone: genus genus, genus Venus: genus Venice, genus Suskakebeni: Skakebeni, Okamuragusa: Yamadagusa, Mirin: Mirin, Hosobamyrin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari, Ibaranori: Phellinus genus, Isodantsu: Isodantsu, Atsubanori: Atsuba nori, Ogonori: Ogonori, Tsurushiramo, Shiramo, Oonogori, Mizokonori, Birch, Amanita spp. , Genus genus: cypress, genus: cypress, cygnus, spinach, spinach genus: spinach, cedar genus: staghorn, hosoibono Li, Novonori, Black-headed genus: Black-backed dragon, Red-backed wings: Red-backed horn-headed, Red-billed dragon : Hana Eda, Hirataka Goat genus: Hora Taoya goat, Darus genus: Darus, Masagobari, Anadalus, Uebagsa genus: Uebagsa, Benifukuronori: Benifukuronori, Fushitsunagi genus: Futsutsunagi, Himefushisunagi, Hirohasuwasunai, Tsukiwiso : Igis, Keigis, Harigis, Hanegis, Amixa, Egonori genus: Egonori, Fuyugisu, Saeda genus: Saeda, Chilemomoji: Chirimomiji, Kono Clamaceae: Habutaenori, Conohanori, Suzuronori, Usubeni: Usbeni, Hasujiginu: Hasujiginu, Nagakonohanori: Nagakononohanori, Sugiginu: Sugiginu, Atsubasuginu, Haiusubari, Yasuba nori , Ayanishiki: Ayanishiki, Aaginu: Ayaginu, Dadia: Enashidadia, Shimadadia: Isohagi, Shimadadia, Dajimodoki: Daimodomoki, Engussa , Plywood, moss willow, sasabayagi nori, sozo: Kurosozo, kubsozo, nesozo, sozonohana, sedge genus: sedge, sage Cozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Himegoke: Himegoke, Kurohimegoke, Hyodosigus: Chrysanthemum, Hyodosigusa, Usubahiodosi, Isomegusa: Isomegusa, Pterosus (Sakisawiri, Kawamoku, Kawamoku, Aokawa Mozuku, Himekawa Mozuku, Ideyugogome: Ideyugogome, Okichimozuku: Okichimozuku, Engussa, Chinorimo: Chinomori, Chisujinori, etc.)

  Axal algae (Shajikumo spp., Shiratamamo spp., Hoshitsurimo spp .: Hoshitsurimo, Rikunotamus spp., Flask spp .: Hime flaskmo, Chaboflaskmo, Tripera spp., Etc.), Yellow algae (Hikarimo spp .: Hikarimo, etc.), etc.

  In addition, animal-derived materials include poultry extract, bovine, porcine or human placenta extract, porcine or bovine stomach, duodenum or intestinal extract or its degradation product, porcine or bovine spleen extract Or a degradation product thereof, an extract of porcine or bovine brain tissue, a water-soluble collagen, a collagen derivative such as acylated collagen, a collagen hydrolyzate, elastin, an elastin hydrolyzate, a water-soluble elastin derivative, keratin and a degradation product thereof, or Derivatives thereof, silk proteins and degradation products thereof or derivatives thereof, porcine or bovine blood cell protein degradation products (globin peptides), porcine or bovine hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, Casein and its degradation products or their derivatives, skim milk powder and their degradation products or their derivatives, lactoferrin or their degradation products, chicken Component, fish meat decomposition products such as.

  (14) Microbial culture metabolite yeast metabolite, yeast extract, natto metabolite, natto extract, rice fermented extract, rice bran fermented extract, Euglena extract, lactic acid fermented milk or trehalose or its derivatives Such.

  (15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

  (16) Inorganic pigment, anhydrous silicic acid, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide , Bengala, black iron oxide, Gunjo, chromium oxide, chromium hydroxide, carbon black, calamine and so on.

  (17) UV absorber / blocker: benzophenone derivative (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium, Dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-aminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, paradimethylaminobenzoate) Amyl acid, octyl paradimethylaminobenzoate), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, paramethoxycinnamon) Octyl, 2-methoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomentyl salicylate, dipropylene glycol salicylate) , Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (such as urocanic acid, ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, Imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, Lantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, Escalol, zinc oxide, talc, kaolin, etc.

  (18) Whitening agent: p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound, benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivative, kojic acid or its derivative, naphthol or its derivative Naphthol glycosides or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract, ellagic acid, lucinol and the like.

  (19) Tyrosinase activity inhibitor: Vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), kojic acid or a derivative thereof, naphthol or a derivative thereof, Naphthol glycoside or derivative thereof, vitamin E or derivative thereof, N-acetyltyrosine or derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (camomile , Mulberry, touki, firewood, clara, mugwort, honeysuckle, yellowfin, dolphin, pine-hod, pearl barley, nettle, hop, hawthorn, eucalyptus, yarrow, altea, keihi, mankei, hamamelis, yamagwa, Lifegrass, bellflower, toshishi, sequel, shotfish, mahuang, senkyu, dokatsu, psycho, bowfish, kingfisher, peony, peony, peony, genus shochu, kudzu, licorice, quintuplet, aloe, shouma, safflower, green tea, tea, Asen).

  (20) Melanin pigment reduction / decomposition substance: phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether), vitamin C or its derivative ( Vitamin C phosphate magnesium salt, vitamin C glucoside), naphthol or a derivative thereof, naphthol glycoside or a derivative thereof, and the like.

  (21) Turnover promoting action / cell activator: hydroquinone, lactic acid bacteria extract, placenta extract, ganoderma extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe , Ogon, Horsetail, Gentian, Burdock, Sikon, Carrot, Clam, Hop, Yokuinin, Odorikosou, Semburi, Toki, Ginseng, Achacha, Hypericum, Cucumber, Pleurotus, Rosemary, Parsley).

  (22) Astringent: succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compound) and the like.

  (23) Active oxygen scavenger: SOD, catalase, glutathione peroxidase and the like.

  (24) Antioxidants: Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxy Anisole, propyl gallate, sesamol, sesamorin, gossypol, etc.

  (25) Lipid peroxide production inhibitor: β-carotene, plant extract (sesame culture cells, hamcha, hypericum, clams, clove, melissa, birch, birch, sage, rosemary, nanjimi, agetsu, ginkgo, green tea) .

  (26) Anti-inflammatory agents: ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or Its salt, glycyrrhetinic acid or its salt, licorice extract, sicon extract, age extract, allantoin, etc.

  (27) Antibacterial / bactericidal / disinfectant: Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T , Salicy powder, iodine compound, iodoform, sorbic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p -Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohexyl , Ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octyl Phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, potassium lauroyl sarcosine, etc.), cationic surfactants (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, Hexamine, brilliant green, malachite green, crystal violet, jamal, photosensitizer 10 No. 1, Photosensitive Element 201, Photosensitive Element 401, N-long chain acyl basic amino acid derivatives and acid addition salts thereof, zinc oxide, hinokitiol, kudin and the like.

  (28) Moisturizer: glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt , Sodium lactate, mini sasanishiki extract, natto bacteria metabolite, natto extract and so on.

  (29) Elastase activity inhibitors: diisopropyl fluorophosphate, plant extracts (Ogon, Hypericum, Clara, Mulberry leaves, Keihi, Gennosho, Comfrey, Sage, Elderberry, Bodaige, Buttonpi), seaweed extract and the like.

  (30) Hair preparation: selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castari tincture, pepper tincture, red pepper tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, sodium bromate, Such as thioglycolic acid.

  (31) Antiandrogens: follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone, etc.

  (32) Peripheral vascular blood flow promoter: Vitamin E or its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, toki extract, cephalanthin, carpronium chloride, minoxidil and the like.

  (33) Local stimulants: chili pepper tincture, capsaicin, capsaicin glycoside, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

  (34) Metabolic active agents: Photosensitive element 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.

  (35) Antiseborrheic agents: pyridoxine or derivatives thereof, sulfur, vitamin B6 and the like.

  (36) Keratolytic agents: resorcin, salicylic acid, lactic acid and the like.

  (37) Oxidizing agent: hydrogen peroxide, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate Sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

  (38) Hair remover: inorganic reducing agent such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, thioglycolic acid Magnesium, strontium thioglycolate) and the like.

  (39) Hair swelling agent: ethanolamine, urea, guanidine and the like.

  (40) Bath sensation agent: sodium bicarbonate, sodium carbonate, sodium sesquicarbonate, sodium sulfate, dry sodium sulfate, anhydrous sodium sulfate, anhydrous silicic acid, calcium silicate, etc.

  (41) Dye agent: 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3′-iminodiphenol, hydrochloric acid 2,4-diaminophenoxyethanol, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoamino Phenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylene Diamine, paraaminophenol, Lanitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picramate, N, N′-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- ( 2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorcresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, sulfuric acid Orthochloroparaphenylenediamine, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylene sulfate Amine, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannin Acid, sodium 2-hydroxy-5-nitro-2 ′, 4′-diaminoazobenzene-5′-sulfonate, hematein and the like.

  (42) Fragrance: Natural animal fragrance such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guaiac wood Essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam, coriander essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, Otsuka perfume essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, trout balsam, patchouli essential oil, rose essential oil, palmarosa essential oil, persimmon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiver essential oil, bergamot Oil, Peru balsam, bois de rose essential oils, Yoshikusunoki essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oils, such as vegetable flavoring such as Japanese mint essential oil. Synthetic perfume ingredients include aliphatic hydrocarbons, terpene hydrocarbons, aromatic hydrocarbons and other hydrocarbons, aliphatic alcohols, terpene alcohols, aromatic alcohols and other alcohols, aliphatic ethers, aromatic ethers and other ethers Oxides, aliphatic oxides, terpene oxides, aliphatic aldehydes, terpene aldehydes, hydrogenated aromatic aldehydes, aldehydes such as thioaldehydes, aromatic aldehydes, aliphatic ketones, terpene ketones, hydrogenated aromatics Ketones such as aromatic ketones, aliphatic cyclic ketones, non-benzene aromatic ketones, aromatic ketones, acetals, ketals, phenols, phenol ethers, fatty acids, terpene carboxylic acids, hydrogenated aromatic carboxylic acids, Acids such as aromatic carboxylic acids, acid amides, aliphatic lactones Lactones such as cyclic lactones, terpene lactones, hydrogenated aromatic lactones, aromatic lactones, aliphatic esters, furan carboxylic acid esters, aliphatic cyclic carboxylic acid esters, esters such as aromatic carboxylic acid esters, Nitrogen-containing compounds such as nitromusks, nitriles, amines, pyridines, quinolines, pyrrole and indole. More specific examples of synthetic fragrances include, for example, 1996 published by Chemical Industries Daily, Motoichi Into (Synthetic fragrance chemistry and product knowledge), 1969, by Stefan Arcamder (Perfume and Flavor Chemicals <Perfume and Flavors described in Flavor Chemicals>) and the like can be suitably used. The main fragrances are shown below. Aldehyde C6-C12, anisaldehyde, acetal R, acetophenone, acetyl cedrene, adoxal, allyl amyl glycolate, allyl cyclohexane propionate, alpha damascon, beta damascon, delta damascon, ambrette lid, ambroxan, amyl Synamic aldehyde, amyl cinnamic aldehyde dimethyl acetal, amyl valericate, amyl salicylate, isoamyl acetate, isoamyl salicylate, auranthiol, acetyl eugenol, bacdanol, benzyl acetate, benzyl alcohol, benzyl salicylate, bergamyl acetate, bornyl acetate , Butyl butyrate, para tertiary butyl cyclohexanol, para tertiary butyl Rohexyl acetate, ortho-tertiary butyl cyclohexanol, benzaldehyde, benzyl formate, caryophyllene, cashemaran, carvone, cedro amber, cedryl acetate, cedrol, ceristolide, cinnamic alcohol, cinnamic aldehyde, cis jasmon, citral, citral dimethyl Acetal, citrusal, citronellol, citronellyl acetate, citronellyl formate, citronellyl nitrile, cyclaset, cyclamenaldehyde, cyclaprop, caron, coumarin, cinnamyl acetate, delta C6-C13 lactone, dimethylbenzyl carbinol, dihydrojasmon, Dihydrolinalool, dihydromyrcenol, dimethol, dimyrcetol, diph Nyl oxide, ethyl vanillin, eugenol, fluitate, fenthyl alcohol, phenylethyl phenyl cetate, galaki solid, gamma C6-C13 lactone, geraniol, geranyl acetate, geranyl formate, geranyl nitrile, hedion, helional, heliotropin, cis-3- Hexenol, cis-3-hexenyl acetate, cis-3-hexenyl salicylate, hexyl cinnamic aldehyde, hexyl salicylate, hyacinth dimethyl acetal, hydrotropic alcohol, hydroxy citronellal, indole, ionone, isobornyl acetate, isocyclohexane Citral, iso-E super, isoyuugenol, isononyl acetate, isobutyl quinoline, jasmar, ja Examples include sumolactone, jasmofilan, coabon, ligustral, lyial, lime oxide, limonene, linalool, linalool oxide, and linalyl acetate.

  (43) Dye: Colorant Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye, Krill Dye, Amber Dye, Caramel, Gold, Silver, Gardenia Dye, Corn Dye, Onion Dye , Tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin etc.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, cooling agents, stabilizers, emulsifiers, animal / plant proteins or their degradation products, animal / plant polysaccharides or the like Degradation products, animal / plant glycoproteins or their degradation products, anti-inflammatory agents / antiallergic agents, wound treatment agents, foaming / foaming agents, thickeners, oral preparations, deodorants / deodorants, enzymes, etc. In combination with these, various additive or synergistic effects can be expected.

  The cosmetic composition, bath preparation composition, detergent composition, etc. of the present invention are liquid, emulsion, paste, gel, powder (powder), granule, pellet, stick, solid, etc., respectively. It may be provided as any form.

  Cosmetic compositions include lotion, milky lotion, cream, oil, ointment, pack, lip, lipstick, foundation, eyeliner, blusher, mascara, eye shadow, nail polish / pedicure, nail coating, nail coating removal Agent, shaving agent, shampoo, rinse, hair treatment, hair tonic, hair spray, hair cream, hair lotion, hair conditioner, hair restorer, permanent liquid, hair dye, hand soap / body soap, toothpaste, mouthwash And facial cleansers and soaps.

  The bath agent composition is used by bathing in bath water at the time of bathing, and may be in any form such as liquid, powder, granule or solid. In the case of a powder, granule or solid, the external antipruritic agent of the present invention can be produced by spraying and drying in a liquid state without drying.

  Examples of the detergent composition include daily detergents for kitchens, bathrooms, washbasins or toilets, glass cleaners, glasses / contact lens cleaners, car cleaners, and building material cleaners.

  In addition, it can be impregnated in sanitary goods, wet type tissue paper, non-woven fabric, paper towel, cotton and the like.

  In the cosmetic composition and the detergent composition of the present invention, the anti-pruritic plant extract is used as a dry extract containing about 0.001 to 5% by weight, preferably about 0.01 to 1% by weight. Good properties can be obtained. Moreover, in a bath agent composition, it can be used at 0.001 to 99 weight%, Preferably when it contains 0.1 to 30 weight%, usability is good and a favorable result is obtained. The amount used in one batch may be set so that the concentration in the bath water when actually used is 0.00001 to 0.01% by weight, preferably about 0.0005 to 0.005% by weight.

[Example 1]
500 ml of water is added to each of herbal drinks, ie, 4 g of touki, 3 g of peony, 3 g of senkyu, 4 g of ginger, 1.5 g of ollen, 1.5 g of oak, 3 g of ogon, and 2 g of sushi. Extracted at reflux for hours. Next, this was filtered to obtain an extract, and further dried to obtain 9 g of a tan powder.

[Example 2]
500 L of ethanol was added to each of herbal drinks, ie, 4 kg of Toki, 3 kg of peony, 3 kg of peony, 4 kg of peony, 1.5 kg of owl, 1.5 kg of buckwheat, 3 kg of ugone, and 2 kg of sanshi and extracted by immersion overnight. Next, this was filtered to obtain an extract, and further dried to obtain 2.6 kg of a light brown powder.

[Test Example 1]
Safety test Evaluation of skin irritation In order to evaluate the skin irritation of the external antipruritic agent of the present invention, a patch test was conducted with 42 healthy persons (men and women aged 24 to 58).
(Sample) The anti-pruritic agent for external use obtained in Examples 1 and 2 was swollen with purified water (Method) The skin sensitization test tape “Fin Chamber” (manufactured by Taisho Pharmaceutical Co., Ltd.) was used for each sample. The occlusal side of the upper arm and the inner side of the forehead were subjected to occlusion for 24 hours for determination. That is, the sample was removed at the time when 24 hours had passed after the application, and after 1 hour, the skin condition was observed and judged, and the average value was shown in Table 1.
(Criteria) Judgment was performed according to the following criteria.
(+) Positive: Those with erythema.
(±) false positive: Minor erythema or suspected erythema.
(-) Negative: No reaction was observed.

上記試験の結果、本発明の外用抗掻痒剤は皮膚刺激性が見られなかった。

As a result of the above test, the external antipruritic agent of the present invention did not show skin irritation.

[Test Example 2]
The topical anti-pruritic combination lotion of the present invention was applied to humans with winter pruritus and evaluated.
(1) Purpose: To examine the degree to which the external antipruritic agent of the present invention suppresses itching and dryness.
(2) Period: Period until itching is healed
(3) Monitor: Under the consent of the person, seven volunteers who develop itchiness due to dryness in the winter.
(4) Test lotion formula:
Example 1 0.5
1,3-butylene glycol 10
Purified water 89.5
100% (w / w)
It was filtered through a 0.45 μM membrane filter to obtain a test lotion.
(5) Test method:
After a few sprays on the part that feels itching in a timely manner, an appropriate amount was applied with the palm of the hand, and after several hours, the degree of itchiness in the applied part was evaluated in three levels: “mild”, “moderate”, and “strength”. At this time, if similar stagnation appeared again, the evaluation was performed after repeated application.
(6) Results:
It is shown in Appendix Table 2. Effective rate 71%.
(7) Consideration:
Although the number of monitors is small, the number of examples that can be statistically processed is considered to have been evaluated. As for the external antipruritic agent of the present invention, 5 out of 7 cases were effective and the effective rate was 71%. Although the application site differs depending on the monitor, the external anti-pruritic agent of the present invention shows a high effective rate, and is considered effective for winter pruritus.

[Example 3]
According to Formulation Example 1, a cosmetic base in which purified water is mixed with moisturizers such as 1,3-butylene glycol and glycerin, skin nutrients such as oleyl alcohol, and preservatives and ethyl alcohol in which a fragrance is dissolved at room temperature. In the preparation, 0.3% of the external antipruritic agent of the present invention was blended to prepare the lotion of the present invention.

Formulation Example 1 (Lotion)
1,3-butylene glycol 6.0
Glycerin 4.0
Oleyl alcohol 0.1
Polyoxyethylene monolaurate (20)
Sorbitan 0.5
Polyoxyethylene (15) lauryl ether 0.5
Ethyl alcohol 10.0
Preservative 0.1
Fragrance 0.1
External antipruritic agent of the present invention 0.3
Purified water 78.4
Total 100.0

[Example 4]
In accordance with Formulation Example 2, a mixture of purified water and a moisturizer such as 1,3-butylene glycol and glycerin was prepared as an aqueous phase part, and 0.3% of the external antipruritic agent of the present invention was added thereto. As the oil phase part, a solid oil component such as beeswax, cetyl alcohol and petrolatum, a liquid oil component such as squalane, an oily component such as an antiseptic and a surfactant, and the mixture heated to about 80 ° C. were prepared. A thickener such as quince seed was added to the aqueous phase heated to about 80 ° C., and the oil phase was gradually added and emulsified while stirring with a homomixer to obtain the emulsion of the present invention.

Formulation example 2 (milky lotion)
Cetyl alcohol 1.0
Beeslow 0.5
Octyldodecanol 2.0
Vaseline 2.0
Squalane 6.0
Ethyl alcohol 5.0
Glycerin 4.0
1,3-butylene glycol 4.0
Polyethylene glycol monooleate (10) 1.0
Lipophilic glyceryl monostearate 1.0
Quince Seed (Quince Seed) 1.0
Preservative 0.1
Fragrance 0.1
External antipruritic agent of the present invention 0.3
Purified water 72.0
Total 100.0

[Example 5]
In accordance with Formulation Example 3, as the water phase part, a mixture of purified water and a moisturizing agent such as 1,3-butylene glycol and polyethylene glycol 1500 is prepared, and the anti-pruritic agent for external use of the present invention is added to this by 0.3% Blended. As the oil phase part, a solid oil component such as stearic acid, stearyl alcohol and hydrogenated lanolin, a liquid oil component such as squalane and octyldodecanol, and oily components such as preservatives and surfactants were prepared. When the water phase portion was gradually heated and reached about 80 ° C., the oil phase portion heated to almost the same temperature was added little by little and emulsified to obtain the cream of the present invention.

Formulation Example 3 (Cream)
Stearic acid 2.0
Stearyl alcohol 6.0
Hydrogenated lanolin 4.0
Squalane 9.0
Octyldodecanol 10.0
1,3-butylene glycol 6.0
Polyethylene glycol 1500 4.0
Polyoxyethylene (25) cetyl ether 3.0
Glycerol monostearate 2.0
Preservative 0.1
Fragrance 0.1
External antipruritic agent of the present invention 0.3
Purified water 53.5
Total 100.0

[Example 6]
In accordance with Formulation Example 4, moisturizing agents such as 1,3 butylene glycol and glycerin were blended in purified water, and 0.3% of the external antipruritic agent of the present invention was blended therein. This is heated to 70 to 80 ° C., a thickener such as carboxymethyl cellulose, a film agent such as polyvinyl alcohol is added and dissolved by stirring, and a solution obtained by dissolving a preservative, a surfactant, etc. in ethyl alcohol is added. Solubilized to obtain a pack of the present invention.

Formulation example 4 (pack)
Polyvinyl alcohol 15.0
Carboxymethylcellulose 5.0
1,3-butylene glycol 4.0
Glycerin 1.0
Ethyl alcohol 12.0
Preservative 0.1
Fragrance 0.1
External antipruritic agent of the present invention 0.3
Polyoxyethylene oleyl ether 0.5
Purified water 62.0
Total 100.0

[Example 7]
In accordance with Formulation Example 5, the water phase portion was formulated with a moisturizing agent such as 1,3-butylene glycol in purified water, and 0.5% of the external antipruritic agent of the present invention was added thereto. The oil phase part is prepared by mixing preservatives and surfactants with solid oils such as beeswax, paraffin wax, microcrystalline wax, higher fatty acids, semi-solids such as petrolatum and lanolin, and liquid oils such as liquid paraffin. Dissolved by heating. Next, the water phase part was heated and dissolved at 80 ° C., and the oil phase part heated to the same degree was gradually added and emulsified with stirring to obtain the ointment of the present invention. The external antipruritic agent in the present invention is arbitrarily blended into the external composition base, but when the external composition is composed of an aqueous phase and an oil phase, it is usually blended in the aqueous phase part. It is preferable.

Formulation Example 5 (ointment)
Beeswax 1.0
Paraffin wax 2.5
Microcrystalline wax 0.5
Stearic acid 2.0
Cetyl alcohol 1.0
Behenyl alcohol 3.0
Polyoxyethylene monostearate (20)
Sorbitan 1.0
Tetraoleic acid polyoxyethylene (60)
Sorbitan 1.0
Self-emulsifying glyceryl monostearate 1.5
Liquid paraffin 5.0
Lanolin 1.0
Vaseline 4.0
1,3-butylene glycol 5.0
Preservative 0.1
Fragrance 0.1
Anti-pruritic agent for external use of the present invention 0.5
Purified water 70.8
Total 100.0

[Example 8]
In accordance with Formulation Example 6, purified water containing a humectant such as glycerin or urea was prepared as an aqueous phase part, and 0.5% of the external antipruritic agent of the present invention was added thereto. As the oil phase part, a mixture of solid oils such as cetanol and petrolatum, liquid oils such as liquid paraffin, tocopherol acetate and vitamin D, preservatives, surfactants and other oily components was prepared. When the water phase part was gradually heated and reached about 80 ° C., the oil phase part heated to substantially the same temperature was added little by little and emulsified to obtain the hand cream of the present invention.

Formulation Example 6 (hand cream)
Cetanol 4.0
Vaseline 2.0
Liquid paraffin 10.0
Tocopherol acetate 0.1
Vitamin D 0.1
Urea 2.0
Glycerin 20.0
Polyoxyethylene (60)
Glycerol isostearate 2.5
Glycerol monostearate 1.5
Preservative 0.1
Fragrance 0.1
Anti-pruritic agent for external use of the present invention 0.5
Purified water 57.1
Total 100.0

[Example 9]
In accordance with Formulation Example 7, a mixture of known humectants such as 1,3-butylene glycol and polyethylene glycol 1500 in purified water was prepared as the water phase part, and 0.5% of the external antipruritic agent of the present invention was added thereto. % Blended. As the oil phase part, a solid oil component such as stearic acid, stearyl alcohol and glyceryl monostearate, a liquid oil component such as squalane and octyldodecanol, and oily components such as preservatives and surfactants were prepared. When the water phase is gradually heated to about 80 ° C., the oil phase heated to almost the same temperature is added little by little and emulsified to obtain a cream. To this was gradually added purified water in which potassium hydroxide was dissolved, and the mixture was saponified to obtain the face-washing cream of the present invention.

Formulation Example 7 (face wash cream)
Stearic acid 2.0
Stearyl alcohol 6.0
Hydrogenated lanolin 4.0
Squalane 9.0
Octyldodecanol 10.0
1,3-butylene glycol 6.0
Polyethylene glycol 1500 4.0
Polyoxyethylene (25) cetyl ether 3.0
Glycerol monostearate 2.0
Potassium hydroxide 0.5
Preservative 0.1
Fragrance 0.1
Anti-pruritic agent for external use of the present invention 0.5
Purified water 52.8
Total 100.0

[Example 10]
In accordance with Formulation Example 8, a mixture of purified water and a moisturizing agent such as propylene glycol and O- [2-hydroxy-3-trimethylammoniopropyl] hydroxyethylcellulose as purified water is prepared as an aqueous phase part. 0.5% of an external antipruritic agent was blended. As the oil phase part, a blend of oily components such as polyoxyethylene (2) sodium lauryl ether sulfate, sodium lauryl sulfate, coconut oil fatty acid amidopropyl betaine, highly polymerized methylpolysiloxane, ethylene glycol distearate was prepared. When the water phase portion was gradually heated and reached about 80 ° C., the oil phase portion heated to almost the same temperature was added little by little and stirred to obtain the hair shampoo of the present invention.

Formulation Example 8 (hair shampoo)
Polyoxyethylene (2) sodium lauryl ether sulfate 9.0
Sodium lauryl sulfate 4.0
Palm oil fatty acid amidopropyl betaine 3.0
Highly polymerized methylpolysiloxane 2.0
Methyl polysiloxane 1.0
Palm oil fatty acid monoethanolamide 1.0
Propylene glycol 2.0
O- [2-hydroxy-3-trimethylammoniopropyl] hydroxyethylcellulose chloride 0.5
Ethylene glycol distearate 2.0
Preservative 0.1
Fragrance 0.1
Anti-pruritic agent for external use of the present invention 0.5
Purified water 74.8
Total 100.0

[Example 11]
According to the formulation example 9, what mixed known moisturizers, such as glycerol, with purified water as an aqueous phase part was prepared, and 0.5% of the external antipruritic agent of this invention was mix | blended with this. Contains oil components such as solid oils such as stearyltrimethylammonium chloride, stearyl alcohol and cetyl alcohol, liquid oils such as highly polymerized methylpolysiloxane, methylpolysiloxane and liquid paraffin, preservatives and surfactants as the oil phase part I prepared what I did. When the water phase portion was gradually heated and reached about 80 ° C., the oil phase portion heated to almost the same temperature was added little by little and emulsified to obtain the hair rinse of the present invention.

Formulation Example 9 (hair rinse)
Stearyltrimethylammonium chloride 2.0
Stearyl alcohol 1.0
Cetyl alcohol 2.0
Highly polymerized methylpolysiloxane 2.0
Methyl polysiloxane 1.0
Liquid paraffin 1.0
Glycerin 6.0
Preservative 0.1
Fragrance 0.1
Anti-pruritic agent for external use of the present invention 0.5
Purified water 84.3
Total 100.0

[Example 12]
According to the formulation example 10, what mixed known moisturizers, such as propylene glycol and glycerol, with purified water as an aqueous phase part was prepared, and 0.5% of the external antipruritic agent of this invention was mix | blended with this. As the oil phase part, a blend of oily components such as polyoxyethylene (2) sodium lauryl ether sulfate, triethanolamine lauryl sulfate, coconut oil fatty acid amidopropyl betaine, and ethylene glycol distearate was prepared. When the water phase part was gradually heated and reached about 80 ° C., the oil phase part heated to substantially the same temperature was added little by little and stirred to obtain the body soap of the present invention.

Formulation Example 10 (Body soap)
Polyoxyethylene (2) sodium lauryl ether sulfate 15.0
Lauryl sulfate triethanolamine 5.0
Palm oil fatty acid amidopropyl betaine 5.0
Ethylene glycol distearate 2.0
Glycerol monopalmitate 1.0
Adsorption refined lanolin 2.0
Glycerin 2.0
Propylene glycol 3.0
Preservative 0.1
Fragrance 0.1
Anti-pruritic agent for external use of the present invention 0.5
Purified water 64.3
Total 100.0

[Example 13]
In accordance with Formulation Example 11, a soap base was prepared by blending titanium oxide, preservative, and fragrance, and 1.0% of the external antipruritic agent of the present invention was blended therein. This was die-cut and finished to obtain the solid soap of the present invention.

Formulation Example 11 (Soap)
Soap base 94.5
Titanium oxide 3.0
Preservative 0.5
Fragrance 1.0
Anti-pruritic agent for external use of the present invention 1.0
Total 100.0

[Example 14]
In accordance with Formulation Example 12, a base agent for a bath prepared by adding a fragrance and the like to sodium sulfate and sodium hydrogen carbonate was prepared, and 2.0% of the anti-pruritic agent for external use of the present invention was blended. It was.

Formulation Example 12 (Bath Agent a)
Sodium sulfate 48.0
Sodium bicarbonate 48.0
Fragrance 2.0
Anti-pruritic agent for external use of the present invention 2.0
Total 100.0

[Example 15]
According to Formulation Example 13, an oily component such as liquid paraffin, jojoba oil, or preservative was blended with a surfactant and dissolved at about 60 ° C. A fragrance | flavor, purified water, etc. are added to this, and the antipruritic agent for external use of this invention is made into 2 .. 0% was blended to make a bath preparation b of the present invention.

Formulation Example 13 (Bath Agent b)
Polyoxyethylene (5) oleyl ether 10.0
Liquid paraffin 80.0
Jojoba oil 5.0
Preservative 0.2
Fragrance 1.8
Anti-pruritic agent for external use of the present invention 2.0
Purified water 1.0
Total 100.0

[Example 16]
According to Formulation Example 14, a cosmetic base prepared by mixing hair nutrients such as assembly extract, tocopherol acetate, pantothenyl ethyl ether, etc. with ethyl alcohol in which preservatives, fragrances and the like are dissolved at room temperature is purified. 0.3% of water and the external antipruritic agent of this invention were mix | blended, and it was set as the hair restorer of this invention.

Formulation Example 14 (Hair restorer)
Ethyl alcohol 60.0
Assembly extract 5.0
Tocopherol acetate 0.2
Pantothenyl ethyl ether 0.2
Propylene glycol 5.0
Preservative 0.1
Fragrance 0.2
External antipruritic agent of the present invention 0.3
Purified water 29.0
Total 100.0

[Example 17]
In accordance with Formulation Example 15, as an aqueous phase part, purified water containing ascorbic acid, preservatives and the like was prepared, and 0.3% of the external antipruritic agent of the present invention was added thereto. As the oil phase portion, a solid oil component such as polyoxyethylene (10) oleyl ether, a liquid oil component such as oleic acid and isopropyl alcohol, and an oil component such as a preservative were prepared. When the water phase part was gradually heated and reached about 80 ° C., the oil phase part heated to substantially the same temperature was added little by little and emulsified to obtain the first hair dye of the present invention. .

Formulation Example 15 (Hair dye 1st agent)
Oxidative dye 4.0
Polyoxyethylene (10) oleyl ether 15.0
Oleic acid 20.0
Isopropyl alcohol 10.0
Ammonia water (28%) 10.0
Ascorbic acid 0.5
Preservative 0.1
Fragrance 0.3
External antipruritic agent of the present invention 0.3
Purified water 39.8
Total 100.0

[Example 18]
According to Formulation Example 16, 0.3% of the external antipruritic agent of the present invention is blended with a base obtained by mixing hydrogen peroxide water and a fragrance at room temperature with purified water, and the hair dye second agent of the present invention and did.

Formulation Example 16 (Hair dye 2nd agent)
Hydrogen peroxide solution (30%) 20.0
Fragrance 0.1
External antipruritic agent of the present invention 0.3
Purified water 79.6
Total 100.0

[Example 19]
In accordance with Formulation Example 17, prepared is a mixture of purified water with a known humectant such as glycerin, and a thickener such as sodium carboxymethylcellulose and carrageenan as the aqueous phase, and dicalcium phosphate dihydrate and anhydrous silicic acid. Then, sodium lauryl sulfate was mixed and 0.3% of the external antipruritic agent of the present invention was blended. Sodium saccharin, a fragrance, and a preservative were added to a part of the purified water, and this was mixed and deaerated into the aqueous phase part to obtain a toothpaste of the present invention.

Formulation Example 17 (Toothpaste)
Dicalcium phosphate dihydrate 45.0
Silica anhydride 2.0
Glycerin 15.0
Sodium carboxymethylcellulose 1.0
Carrageenan 0.3
Sodium lauryl sulfate 1.5
Saccharin sodium 0.1
Preservative 0.1
Fragrance 0.1
External antipruritic agent of the present invention 0.3
Purified water 34.6
Total 100.0

[Example 20]
According to Formulation Example 18, glycerin and polyoxyethylene hydrogenated castor oil were added to and dissolved in purified water. To this, 1-menthol and a fragrance dissolved in ethyl alcohol were added and mixed and dissolved. Further, sodium saccharin and chlorhexidine gluconate were added and dissolved with 0.3% of the external antipruritic agent of the present invention to obtain the mouthwash of the present invention.

Formulation Example 18 (Mouthwash)
Ethyl alcohol 40.0
Glycerin 10.0
Polyoxyethylene hydrogenated castor oil 1.0
1-menthol 0.5
Saccharin sodium 0.05
Chlorhexidine gluconate 0.02
Fragrance 0.1
External antipruritic agent of the present invention 0.3
Purified water 48.03
Total 100.0

[Example 21]
According to the formulation example 19, what mixed the polypropylene glycol, ethyl alcohol, and antiseptic | preservative with purified water as an aqueous phase part was prepared, and 0.3% of the external antipruritic agent of this invention was mix | blended with this. As an oil phase part, what mix | blended polyoxyethylene (2) sodium dodecyl sulfate, lauryl glucoside, and the fragrance | flavor oil component was prepared. When the water phase portion was gradually heated and reached about 80 ° C., the oil phase portion was added little by little and stirred to obtain the dishwashing detergent of the present invention.

Formulation Example 19 (Dishwashing detergent)
Polyoxyethylene (2)
Sodium dodecyl sulfate 15.0
Lauryl glucoside 12.5
Ethyl alcohol 5.0
Polypropylene glycol 3.0
Preservative 0.1
Fragrance 0.1
External antipruritic agent of the present invention 0.3
Purified water 64.0
Total 100.0

  INDUSTRIAL APPLICABILITY According to the present invention, it is possible to obtain an external antipruritic agent that is safe and has no skin irritation and is effective for pruritus such as atopic dermatitis, senile xerosis, and winter pruritus.

Claims (9)

An anti-pruritic agent for external use comprising an extract of a mixture of toki, jiou, peony, senkyu, auren, ougon, sanshishi and oak. 1-6 parts (parts by weight) of Toki (the same shall apply hereinafter), 1-6 parts of peony, 1-6 parts of peony, 1-6 parts of peony, 0.3-4 parts of oolen, 0.5-5 parts of urgon, 0 An external antipruritic agent comprising an extract of a mixture of .5 to 4 parts and 0.3 to 4 parts of buckwheat. 3-4 parts (parts by weight) of Toki (the same shall apply hereinafter), 3-4 parts of peony, 3-4 parts of peony, 3-4 parts of nematode, 1-1.5 parts of lauren, 1.5-3 parts of ougon, 1 An external antipruritic agent comprising an extract of a mixture of .5 to 2 parts and 1 to 1.5 parts of buckwheat. The external antipruritic agent according to any one of claims 1 to 3, which is an extract of water, alcohols or a mixture thereof. The external antipruritic agent according to any one of claims 1 to 4, wherein the amount of the extraction solvent is 10 to 100 times that of the extract. A skin external preparation composition comprising the external antipruritic agent according to any one of claims 1 to 5. A cosmetic composition comprising the external antipruritic agent according to any one of claims 1 to 5. A bath agent composition comprising the external antipruritic agent according to any one of claims 1 to 5. A detergent composition comprising the external antipruritic agent according to any one of claims 1 to 5.