JP2005028009A - Biological tissue adhesive applicator - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an applicator having a medical liquid passage that can be extended to a spray head by using a tube or a like, which has a wide spray angle, can be used intermittently and gives a strong coating film by spraying a biological tissue adhesive stably and favorably without using an aseptic gas. <P>SOLUTION: The spray head comprises at least an external cylinder and a core cylinder 1 inserted into and fixed to the external cylinder. The core cylinder 1 is provided with a spiral medical liquid passage, and the end of the core cylinder 1 has a conically expanded shape. Preferably, the biological tissue adhesive applicator has a hollow core cylinder 1 having a passage that extends in the axial direction to the side face, and a core cylinder 2 having a conically expanded shape is inserted into and fixed to the end of the core cylinder 1. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a biological tissue adhesive applicator. For example, it relates to a tissue adhesive application tool that is mainly applied as a multi-component preparation. Hemostasis closure of postoperative closures such as the resected stumps of the liver and lungs, the digestive tract, and the dura of the head The present invention relates to a biological tissue adhesive applicator for spraying and applying to an affected part of a living body, which can be used in a narrow surgical field and closed space such as endoscopic surgery.

  Fibrinogen is a coagulation factor that plays a very important role in the final stage of the so-called blood coagulation cascade. Fibrinogen is converted by thrombin from its soluble form to insoluble fibrin, which makes an important contribution to hemostasis and wound treatment, for example in the activation of the blood clotting system after injury. A tissue adhesive utilizing the principle of the final phase of blood coagulation has been developed and used in surgical operations as an adhesive for suturing a soft organ such as the liver or spleen, or as a suturing aid. At the same time, it is applied in a wide range of clinical settings.

  In general, the method of dropping the fibrinogen solution and the thrombin solution separately stored in the syringe separately or simultaneously to the application site has been taken, but in recent years it has been stored in two syringes because the adhesive effect is insufficient. A spray coating method in which the fibrinogen solution and the thrombin solution thus injected are simultaneously injected and the two liquids injected using a sterile gas are sprayed and mixed in the form of a mist has begun to spread. A suitable example of such a device is disclosed, for example, in WO / 947420.

  However, such sprays using aseptic gas cannot be used for surgery in a closed space, such as endoscopic surgery that has been frequently performed in recent years, because it is puffed, and the brain The use in a site where the periphery is narrowly surrounded, such as in the operation of the pituitary gland, has a problem that the adhesive is blown away by aseptic gas and efficient application cannot be performed.

  On the other hand, as in Japanese Patent No. 2923448 shown in FIG. 6, an application tool that sprays only by pressurization of a liquid using a spray head having a one-fluid nozzle structure, a so-called atomizer, has been put into practical use. This is a mechanism in which a premixing chamber (26) for mixing two liquids is provided inside the spray head (25) and the mixed liquid is sprayed from the jet outlet (27). Since mixing of two liquids is performed, it is not only impossible to resume spraying when spraying is temporarily interrupted, but it is difficult to obtain a good spray because a liquid whose viscosity is relatively high due to mixing of two liquids is sprayed. There was a problem.

  In addition, the increase in liquid viscosity in the spray head caused by mixing the two liquids inside restricts the length of the chemical flow path. For example, the liquid flow path necessary for application to a narrow and deep part is applied. The length could not be obtained, and the application was limited.

Also, when using under an endoscope, if the application target site is in a narrow and bent part, it is difficult to move the nozzle and spray the coating liquid uniformly, and spraying uniformly over a wide area without moving the nozzle. A tool that could be used was desired.
WO / 947420 Publication Japanese Patent No. 2923448

  The present invention is intended to solve the conventional problems as described above, and a high-strength coating film can be obtained by stable and good spraying of a biological tissue adhesive without using aseptic gas. In addition, it is possible to extend the chemical flow path to the spray head part by a tube or the like, and to provide an application tool having a large spray angle that can be sprayed over a wide range even when the distance from the application target site to the nozzle is short. .

(1) An application tool for applying several components of a chemical solution, each type of chemical solution having a spray head having a one-fluid nozzle structure, a chemical solution flow passage, and a chemical solution injection port; In a biological tissue adhesive applicator that is hermetically connected to a chemical liquid injection port by a chemical liquid flow passage embedded in a tube, the spray head includes at least an outer cylinder and a core 1 that is inserted and fixed to the outer cylinder. A living tissue adhesive applicator characterized in that a spiral chemical solution flow path is attached to 1 and the end of the core 1 has a conical shape.
(2) The core 1 is hollow, the core 1 has a flow path extending from the axial direction to the side surface, and the core 2 having a shape that expands in a conical shape is inserted and fixed ( 1) The tissue adhesive application tool according to 1),
It is.

  If the biological tissue adhesive applicator of the present invention is used, by providing a spray head having a one-fluid nozzle structure for each chemical solution, high strength can be obtained by stable and good spraying of the biological tissue adhesive without using aseptic gas. The coating film can be obtained intermittently, and the chemical flow path to the spray head can be extended by a tube or the like, which is extremely useful as a tissue adhesive application tool.

  The biological tissue adhesive applicator of the present invention has a chemical flow passage (1) and a chemical injection port (2), and a spray head (3) having a one-fluid nozzle structure and a chemical injection port (2) are connected to the chemical flow passage ( 1) A biological tissue adhesive applicator characterized in that it is hermetically connected to the spray head (3) by 1). The spray head (3) includes at least an outer cylinder (5) and a core 1 (6). The structure of the spray head (3) will be described in detail below (FIG. 2).

(1) Outer cylinder The outer cylinder (5) is substantially equal to the size of the spray head (3). In many cases, the application operation is performed in a narrow space, and it is preferable that the spray head (3) has a compact shape as much as possible because it is easy to secure a surgical field. The outer cylinder (5) is cylindrical and preferably smaller, and preferably has a diameter of 5 mm or less. It is preferable to keep the inner diameter as large as possible. The length is preferably 10 mm or less.

  It is preferable that the outer cylinder (5) is provided with a rib (51) for fixing and positioning the core 1 (6) because it is easy to assemble. A chemical liquid passage (1) is attached to one end of the outer cylinder (5). The outer cylinder (5) is preferably made of a material that does not irritate the living body because it comes into contact with the living tissue. Although it may be made of aluminum, stainless steel, or a titanium alloy, it is cheaper and more preferable to make it by injection molding using a general-purpose plastic resin material such as ABS resin, polypropylene resin, or vinyl chloride resin.

(2) Core 1
The core 1 (6) is inserted and fixed to the outer cylinder (5) (FIG. 2). The core 1 (6) is provided with an umbrella portion (61) and a spiral flow path (62) that expand in a conical shape toward the chemical solution outlet. When the core 2 (7) is attached, a flow path (63) different from the spiral flow path (62) is attached near the central axis (FIG. 3). The size of the umbrella portion (61) is preferably designed to be approximately the same as the diameter of the outer cylinder (5), and more preferably 5 mm or less. The angle of the umbrella portion (61) is preferably designed to be 15 to 60 ° as shown in FIG. A plurality of helical channels (62) are preferably provided, but it is sufficient to attach two to four helical channels (62). As for the dimension of the spiral flow path (62), it is preferable that the total cross-sectional area of the flow path outlet is 0.5 mm ² or less because fine particles are formed at a small flow rate.

  The clearance between the core 1 (6) and the outer cylinder (5) (A in FIG. 2) is adjusted so that the dimensional flow is turbulent at the practical protruding speed of the coating liquid. Although it may be made of aluminum, stainless steel, or a titanium alloy, it is cheaper and more preferable to make it by injection molding using a general-purpose plastic resin material such as ABS resin, polypropylene resin, or vinyl chloride resin.

(2) Core 2
In order to increase the spray radius, the angle of the umbrella portion (61) of the core 1 (6) may be increased, but the sprayed form becomes a donut shape (FIG. 4-A), and the spray to the center is reduced. . In such a case, spraying to the center becomes possible by attaching the core 2 (7) to the core 1 (6). The form to be sprayed is shown in FIG.

  The core 2 (7) includes an umbrella part (71) and a connection part (72) connected to the core 1 (6). The shape of the core 2 may be the same as that of the core 1, but when the size is small and it is difficult to manufacture, the structure shown in FIG. In that case, a flow path (74) is attached to the core 2 (7), and the flow path (74) is attached so as to communicate with the surface of the umbrella part (71) from the inside of the connection part (72). . Although it may be made of aluminum, stainless steel, or a titanium alloy, it is cheaper and more preferable to make it by injection molding using a general-purpose plastic resin material such as ABS resin, polypropylene resin, or vinyl chloride resin.

  The bioadhesive applicator of the present invention can spray the coating liquid without using aseptic gas, and has a wide spray angle. It is useful as a bioadhesive applicator for use in various fields where these characteristics are required, for example, an endoscope.

It is a perspective view which shows the bioadhesive application tool of one Example of this invention. It is sectional drawing which shows the internal structure of the spray head of this invention. It is sectional drawing which shows the internal structure of the spray head in the case of using the core 2. FIG. It is a reference figure which shows the comparison of the spray form of the case where the core 2 is used (B), and the case where it is not used (A). FIG. 6 is a cross-sectional view showing the internal structure of a spray head according to another embodiment using the core 2. It is the perspective view and sectional drawing of the conventional applicator.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Chemical solution flow path 2 Chemical solution injection port 3 Spray head 4 Liquid feeding means, such as a syringe 5 Outer cylinder 51 Rib 6 Core 1
61 Umbrella part 62 Spiral flow path 63 Flow path 7 Core 2
71 Umbrella part 72 Connection part 73 Flow path

Claims (2)

An application tool for applying a chemical solution of a plurality of components, and each type of chemical liquid has a spray head having a one-fluid nozzle structure, a chemical liquid flow passage, and a chemical liquid inlet, and a spray head having a one-fluid nozzle structure and a chemical liquid inlet In a biological tissue adhesive applicator that is hermetically connected by a chemical flow passage embedded in a tube, the spray head is composed of at least an outer cylinder and a core 1 that is inserted and fixed into the outer cylinder. A living tissue adhesive applicator characterized in that a spiral chemical solution flow path is provided and the end of the core 1 has a conical shape. The core 1 has a hollow shape, has a flow path extending from the axial direction to the side surface in the core 1, and a core 2 having a shape in which the end portion expands in a conical shape is inserted and fixed. The biological tissue adhesive applicator.

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