JP2005028009A - Biological tissue adhesive applicator - Google Patents

Biological tissue adhesive applicator Download PDF

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JP2005028009A
JP2005028009A JP2003273091A JP2003273091A JP2005028009A JP 2005028009 A JP2005028009 A JP 2005028009A JP 2003273091 A JP2003273091 A JP 2003273091A JP 2003273091 A JP2003273091 A JP 2003273091A JP 2005028009 A JP2005028009 A JP 2005028009A
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core
tissue adhesive
spray head
biological tissue
adhesive applicator
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JP4141916B2 (en
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Seiki Arikawa
清貴 有川
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Sumitomo Bakelite Co Ltd
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Sumitomo Bakelite Co Ltd
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Abstract

<P>PROBLEM TO BE SOLVED: To provide an applicator having a medical liquid passage that can be extended to a spray head by using a tube or a like, which has a wide spray angle, can be used intermittently and gives a strong coating film by spraying a biological tissue adhesive stably and favorably without using an aseptic gas. <P>SOLUTION: The spray head comprises at least an external cylinder and a core cylinder 1 inserted into and fixed to the external cylinder. The core cylinder 1 is provided with a spiral medical liquid passage, and the end of the core cylinder 1 has a conically expanded shape. Preferably, the biological tissue adhesive applicator has a hollow core cylinder 1 having a passage that extends in the axial direction to the side face, and a core cylinder 2 having a conically expanded shape is inserted into and fixed to the end of the core cylinder 1. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

本発明は、生体組織接着剤塗布用具に関する。例えば、主に複数成分系製剤として適用される組織接着剤の塗布用具に関するものであり、肝臓や肺の切除断端や消化管、また頭部の硬膜などの術後閉鎖部の止血閉鎖など狭い術野での使用、及び内視鏡的手術等の閉鎖された空間にも適応できる、生体の患部に噴霧して塗布するための生体組織接着剤塗布用具に関する。   The present invention relates to a biological tissue adhesive applicator. For example, it relates to a tissue adhesive application tool that is mainly applied as a multi-component preparation. Hemostasis closure of postoperative closures such as the resected stumps of the liver and lungs, the digestive tract, and the dura of the head The present invention relates to a biological tissue adhesive applicator for spraying and applying to an affected part of a living body, which can be used in a narrow surgical field and closed space such as endoscopic surgery.

繊維素原(フィブリノゲン)は、いわゆる血液凝固カスケードの最終段階に存在する非常に重要な役割を担う凝固因子である。フィブリノゲンは、例えば損傷後の血液凝固系の活性化において、トロンビンにより、その可溶性形態から止血及び創傷治療に重要な寄与をする不溶性のフィブリンに変換される。この血液凝固の最終相の原理を利用した組織接着剤が開発され、外科手術において肝臓または脾臓のような軟部器官の縫合代用の接着剤として、または縫合補助剤として使用されている。同時に、幅広い臨床の現場で応用されている。   Fibrinogen is a coagulation factor that plays a very important role in the final stage of the so-called blood coagulation cascade. Fibrinogen is converted by thrombin from its soluble form to insoluble fibrin, which makes an important contribution to hemostasis and wound treatment, for example in the activation of the blood clotting system after injury. A tissue adhesive utilizing the principle of the final phase of blood coagulation has been developed and used in surgical operations as an adhesive for suturing a soft organ such as the liver or spleen, or as a suturing aid. At the same time, it is applied in a wide range of clinical settings.

一般には、シリンジに別々に収納されたフィブリノゲン溶液およびトロンビン溶液を別々、または同時に適用部位へ滴下する方法が取られていたが、接着効果が不十分であるため近年は、2本のシリンジに収納されたフィブリノゲン溶液およびトロンビン溶液を同時に射出し、無菌ガスを利用して射出させた2液を霧状に噴霧して混合するスプレー塗布法が普及し始めている。このような器具の好適な例は、例えばWO/947420号に開示されている。   In general, the method of dropping the fibrinogen solution and the thrombin solution separately stored in the syringe separately or simultaneously to the application site has been taken, but in recent years it has been stored in two syringes because the adhesive effect is insufficient. A spray coating method in which the fibrinogen solution and the thrombin solution thus injected are simultaneously injected and the two liquids injected using a sterile gas are sprayed and mixed in the form of a mist has begun to spread. A suitable example of such a device is disclosed, for example, in WO / 947420.

しかしながら、このような無菌ガスを利用したスプレーは、近年頻繁に実施されてきている内視鏡下手術のように閉じた空間での手術には、気腹されているため使用できず、また脳下垂体の手術等のように狭く周囲が囲まれている部位での使用は、接着剤が無菌ガスで飛ばされてしまい、効率のよい塗布ができないという問題があった。   However, such sprays using aseptic gas cannot be used for surgery in a closed space, such as endoscopic surgery that has been frequently performed in recent years, because it is puffed, and the brain The use in a site where the periphery is narrowly surrounded, such as in the operation of the pituitary gland, has a problem that the adhesive is blown away by aseptic gas and efficient application cannot be performed.

一方、図6に示した特許第2923448号のように1流体ノズル構造のスプレーヘッド、所謂アトマイザを応用した液体の加圧のみで噴霧を行う塗布用具が実用化されている。これは、スプレーヘッド(25)内部に2液の混合を行う予備混合室(26)を設け、混合された液体を噴出口(27)より噴霧する仕組みであるが、スプレーヘッド(25)内部で2液の混合が行われるため、噴霧を一時中断した場合の噴霧の再開が不可能であるばかりか、2液の混合により比較的粘度が高くなっている液体を噴霧するため良好な噴霧を得難いという問題があった。   On the other hand, as in Japanese Patent No. 2923448 shown in FIG. 6, an application tool that sprays only by pressurization of a liquid using a spray head having a one-fluid nozzle structure, a so-called atomizer, has been put into practical use. This is a mechanism in which a premixing chamber (26) for mixing two liquids is provided inside the spray head (25) and the mixed liquid is sprayed from the jet outlet (27). Since mixing of two liquids is performed, it is not only impossible to resume spraying when spraying is temporarily interrupted, but it is difficult to obtain a good spray because a liquid whose viscosity is relatively high due to mixing of two liquids is sprayed. There was a problem.

また2液を内部で混合することに起因するスプレーヘッド内での液粘度の増加現象は薬液流通路の長さの制限となり、例えば狭く奥まった部位への塗布の際に必要な薬液流通路の長さを得ることが出来ず、用途が限られていた。   In addition, the increase in liquid viscosity in the spray head caused by mixing the two liquids inside restricts the length of the chemical flow path. For example, the liquid flow path necessary for application to a narrow and deep part is applied. The length could not be obtained, and the application was limited.

また、内視鏡下で使用する際、塗布目的部位が狭く屈曲した部位にある場合、ノズルを動かして塗布液を均一に噴霧する操作が困難であり、ノズルを動かさずとも広範囲に均一に噴霧できる用具が望まれていた。
WO/947420号公報 特許第2923448号公報
Also, when using under an endoscope, if the application target site is in a narrow and bent part, it is difficult to move the nozzle and spray the coating liquid uniformly, and spraying uniformly over a wide area without moving the nozzle. A tool that could be used was desired.
WO / 947420 Publication Japanese Patent No. 2923448

本発明は、従来のこのような問題点を解決することを目的とするもので、無菌ガスを用いなくとも生体組織接着剤の安定且つ良好な噴霧による高強度の塗膜が得られ、間欠使用を可能とし、更にチューブ等によるスプレーヘッド部までの薬液流通路の延長が可能で、塗布目的部位からノズルまでの距離が近くても広範囲に噴霧できる噴霧角の大きな塗布用具を提供するものである。   The present invention is intended to solve the conventional problems as described above, and a high-strength coating film can be obtained by stable and good spraying of a biological tissue adhesive without using aseptic gas. In addition, it is possible to extend the chemical flow path to the spray head part by a tube or the like, and to provide an application tool having a large spray angle that can be sprayed over a wide range even when the distance from the application target site to the nozzle is short. .

(1)数成分の薬液を塗布するための塗布用具であって、薬液の種類毎に1流体ノズル構造のスプレーヘッド、薬液流通路、薬液注入口を有し、1流体ノズル構造のスプレーヘッドと薬液注入口とがチューブに埋設された薬液流通路によって気密接続された生体組織接着剤塗布用具において、スプレーヘッドが、少なくとも外筒と外筒に挿入固定される中子1から構成され、中子1にはらせん状薬液流路が付設されており、中子1の端部は円錐状に広がった形状であることを特徴とする生体組織接着剤塗布用具。
(2)中子1が中空状であり、中子1の中に軸方向から側面に通じる流路を持ち、端部は円錐状に広がった形状である中子2が挿入固定されている(1)記載の生体組織接着剤塗布用具、
である。
(1) An application tool for applying several components of a chemical solution, each type of chemical solution having a spray head having a one-fluid nozzle structure, a chemical solution flow passage, and a chemical solution injection port; In a biological tissue adhesive applicator that is hermetically connected to a chemical liquid injection port by a chemical liquid flow passage embedded in a tube, the spray head includes at least an outer cylinder and a core 1 that is inserted and fixed to the outer cylinder. A living tissue adhesive applicator characterized in that a spiral chemical solution flow path is attached to 1 and the end of the core 1 has a conical shape.
(2) The core 1 is hollow, the core 1 has a flow path extending from the axial direction to the side surface, and the core 2 having a shape that expands in a conical shape is inserted and fixed ( 1) The tissue adhesive application tool according to 1),
It is.

本発明の生体組織接着剤塗布用具を用いれば、薬液毎に個別に1流体ノズル構造のスプレーヘッドを設けることにより、無菌ガスを使用せずとも生体組織接着剤の安定且つ良好な噴霧による高強度の塗膜を得られ、間欠使用を可能とし、更にチューブ等によるスプレーヘッド部までの薬液流通路の延長が可能であり、組織接着剤の塗布用具として極めて有用である。   If the biological tissue adhesive applicator of the present invention is used, by providing a spray head having a one-fluid nozzle structure for each chemical solution, high strength can be obtained by stable and good spraying of the biological tissue adhesive without using aseptic gas. The coating film can be obtained intermittently, and the chemical flow path to the spray head can be extended by a tube or the like, which is extremely useful as a tissue adhesive application tool.

本発明の生体組織接着剤塗布用具は薬液流通路(1)、薬液注入口(2)を有し、1流体ノズル構造のスプレーヘッド(3)と薬液注入口(2)とが薬液流通路(1)によってスプレーヘッド(3)と気密接続されたことを特徴とする生体組織接着剤塗布用具である(図1)。スプレーヘッド(3)は少なくとも、外筒(5)、中子1(6)から構成される。以下スプレーヘッド(3)について詳細に構造を説明する(図2)。   The biological tissue adhesive applicator of the present invention has a chemical flow passage (1) and a chemical injection port (2), and a spray head (3) having a one-fluid nozzle structure and a chemical injection port (2) are connected to the chemical flow passage ( 1) A biological tissue adhesive applicator characterized in that it is hermetically connected to the spray head (3) by 1). The spray head (3) includes at least an outer cylinder (5) and a core 1 (6). The structure of the spray head (3) will be described in detail below (FIG. 2).

(1)外筒
外筒(5)は、スプレーヘッド(3)の大きさとほぼ等しくなる。塗布操作は、狭い空間での作業となることが多く、スプレーヘッド(3)は、可能な限りコンパクトな形状となっている方が術野を確保しやすく好ましい。外筒(5)は、円筒状で小さい方が好ましく、直径5mm以下であることが好ましい。内径は可能な限り大きく確保する方が好ましい。長さは10mm以下であることが好ましい。
(1) Outer cylinder The outer cylinder (5) is substantially equal to the size of the spray head (3). In many cases, the application operation is performed in a narrow space, and it is preferable that the spray head (3) has a compact shape as much as possible because it is easy to secure a surgical field. The outer cylinder (5) is cylindrical and preferably smaller, and preferably has a diameter of 5 mm or less. It is preferable to keep the inner diameter as large as possible. The length is preferably 10 mm or less.

外筒(5)には、中子1(6)を固定し位置決めするリブ(51)が付設される方が、組立てが容易となり好ましい。外筒(5)の一端には、薬液流通路(1)が付設される。外筒(5)は、生体組織と接触するため、生体に対する刺激がない材料で作製することが望ましい。アルミニウムやステンレス、チタニウム合金で作製しても良いが、ABS樹脂、ポリプロピレン樹脂、塩化ビニル樹脂等の汎用のプラスチック樹脂材料で射出成形にて作製するほうが安価であり好ましい。   It is preferable that the outer cylinder (5) is provided with a rib (51) for fixing and positioning the core 1 (6) because it is easy to assemble. A chemical liquid passage (1) is attached to one end of the outer cylinder (5). The outer cylinder (5) is preferably made of a material that does not irritate the living body because it comes into contact with the living tissue. Although it may be made of aluminum, stainless steel, or a titanium alloy, it is cheaper and more preferable to make it by injection molding using a general-purpose plastic resin material such as ABS resin, polypropylene resin, or vinyl chloride resin.

(2)中子1
中子1(6)は、外筒(5)に挿入固定される(図2)。中子1(6)には、薬液出口方向に円錐状に広がった傘部分(61)とらせん状流路(62)が付設される。中子2(7)を付設する場合は、中心軸付近にらせん状流路(62)とは別の流路(63)が付設される(図3)。傘部分(61)の大きさは、外筒(5)の直径と同等程度に設計することが好ましく、直径5mm以下にすることが更に好ましい。傘部分(61)の角度は、図2に示すように15〜60°に設計することが好ましい。らせん状流路(62)は、複数個付設することが好ましいが、2〜4つ付設すれば十分である。らせん状流路(62)の寸法は、流路出口の総断面積が0.5mm2以下となるようにした方が少ない流量で微粒子となるため好ましい。
(2) Core 1
The core 1 (6) is inserted and fixed to the outer cylinder (5) (FIG. 2). The core 1 (6) is provided with an umbrella portion (61) and a spiral flow path (62) that expand in a conical shape toward the chemical solution outlet. When the core 2 (7) is attached, a flow path (63) different from the spiral flow path (62) is attached near the central axis (FIG. 3). The size of the umbrella portion (61) is preferably designed to be approximately the same as the diameter of the outer cylinder (5), and more preferably 5 mm or less. The angle of the umbrella portion (61) is preferably designed to be 15 to 60 ° as shown in FIG. A plurality of helical channels (62) are preferably provided, but it is sufficient to attach two to four helical channels (62). As for the dimension of the spiral flow path (62), it is preferable that the total cross-sectional area of the flow path outlet is 0.5 mm 2 or less because fine particles are formed at a small flow rate.

中子1(6)と外筒(5)とのクリアランス(図2のA)は、塗布液の実用突出速度で乱流となるようなに寸法値を調整する。アルミニウムやステンレス、チタニウム合金で作製しても良いが、ABS樹脂、ポリプロピレン樹脂、塩化ビニル樹脂等の汎用のプラスチック樹脂材料で射出成形にて作製するほうが安価であり好ましい。   The clearance between the core 1 (6) and the outer cylinder (5) (A in FIG. 2) is adjusted so that the dimensional flow is turbulent at the practical protruding speed of the coating liquid. Although it may be made of aluminum, stainless steel, or a titanium alloy, it is cheaper and more preferable to make it by injection molding using a general-purpose plastic resin material such as ABS resin, polypropylene resin, or vinyl chloride resin.

(2)中子2
噴霧半径を大きくしたい場合、中子1(6)の傘部分(61)の角度を大きくすれば良いが、噴霧される形態がドーナツ型(図4−A)となり、中心への噴霧が少なくなる。このような場合は、中子2(7)を中子1(6)に付設することにより、中心への噴霧が可能となる。噴霧される形態を図4−Bに示した。
(2) Core 2
In order to increase the spray radius, the angle of the umbrella portion (61) of the core 1 (6) may be increased, but the sprayed form becomes a donut shape (FIG. 4-A), and the spray to the center is reduced. . In such a case, spraying to the center becomes possible by attaching the core 2 (7) to the core 1 (6). The form to be sprayed is shown in FIG.

中子2(7)は、傘部(71)と中子1(6)に接続する接続部(72)からなる。中子2の形状は、中子1と同じ構造でよいが、寸法が小さくなり作製が困難となる場合は、図5に示すような構造としても良い。その場合、中子2(7)には流路(74)が付設され、流路(74)は、接続部(72)の内部から傘部(71)の表面に連通するように付設される。アルミニウムやステンレス、チタニウム合金で作製しても良いが、ABS樹脂、ポリプロピレン樹脂、塩化ビニル樹脂等の汎用のプラスチック樹脂材料で射出成形にて作製するほうが安価であり好ましい。   The core 2 (7) includes an umbrella part (71) and a connection part (72) connected to the core 1 (6). The shape of the core 2 may be the same as that of the core 1, but when the size is small and it is difficult to manufacture, the structure shown in FIG. In that case, a flow path (74) is attached to the core 2 (7), and the flow path (74) is attached so as to communicate with the surface of the umbrella part (71) from the inside of the connection part (72). . Although it may be made of aluminum, stainless steel, or a titanium alloy, it is cheaper and more preferable to make it by injection molding using a general-purpose plastic resin material such as ABS resin, polypropylene resin, or vinyl chloride resin.

本発明の生体接着剤塗布用具は、無菌ガスを使用しなくても塗布液を噴霧することが可能であり、噴霧角度が広範囲である。これらの特性が要求されるさまざまな分野例えば、内視鏡下で使用する生体接着剤塗布用具として有用である。   The bioadhesive applicator of the present invention can spray the coating liquid without using aseptic gas, and has a wide spray angle. It is useful as a bioadhesive applicator for use in various fields where these characteristics are required, for example, an endoscope.

本発明の一実施例の生体接着剤塗布用具を示す斜視図である。It is a perspective view which shows the bioadhesive application tool of one Example of this invention. 本発明のスプレーヘッドの内部構造を示す断面図である。It is sectional drawing which shows the internal structure of the spray head of this invention. 中子2を用いる場合のスプレーヘッドの内部構造を示す断面図である。It is sectional drawing which shows the internal structure of the spray head in the case of using the core 2. FIG. 中子2を用いた場合(B)と用いない場合(A)の噴霧形態の 比較を示す参考図である。It is a reference figure which shows the comparison of the spray form of the case where the core 2 is used (B), and the case where it is not used (A). 中子2を用いた別の実施例のスプレーヘッド内部構造を示す断 面図である。FIG. 6 is a cross-sectional view showing the internal structure of a spray head according to another embodiment using the core 2. 従来の塗布用具の斜視図及び断面図である。It is the perspective view and sectional drawing of the conventional applicator.

符号の説明Explanation of symbols

1 薬液流通路
2 薬液注入口
3 スプレーヘッド
4 シリンジ等の送液手段
5 外筒
51 リブ
6 中子1
61 傘部
62 らせん状流路
63 流路
7 中子2
71 傘部
72 接続部
73 流路
DESCRIPTION OF SYMBOLS 1 Chemical solution flow path 2 Chemical solution injection port 3 Spray head 4 Liquid feeding means, such as a syringe 5 Outer cylinder 51 Rib 6 Core 1
61 Umbrella part 62 Spiral flow path 63 Flow path 7 Core 2
71 Umbrella part 72 Connection part 73 Flow path

Claims (2)

複数成分の薬液を塗布するための塗布用具であって、薬液の種類毎に1流体ノズル構造のスプレーヘッド、薬液流通路、薬液注入口を有し、1流体ノズル構造のスプレーヘッドと薬液注入口とがチューブに埋設された薬液流通路によって気密接続された生体組織接着剤塗布用具において、スプレーヘッドが、少なくとも外筒と外筒に挿入固定される中子1から構成され、中子1にはらせん状薬液流路が付設されており、中子1の端部は円錐状に広がった形状であることを特徴とする生体組織接着剤塗布用具。 An application tool for applying a chemical solution of a plurality of components, and each type of chemical liquid has a spray head having a one-fluid nozzle structure, a chemical liquid flow passage, and a chemical liquid inlet, and a spray head having a one-fluid nozzle structure and a chemical liquid inlet In a biological tissue adhesive applicator that is hermetically connected by a chemical flow passage embedded in a tube, the spray head is composed of at least an outer cylinder and a core 1 that is inserted and fixed into the outer cylinder. A living tissue adhesive applicator characterized in that a spiral chemical solution flow path is provided and the end of the core 1 has a conical shape. 中子1が中空状であり、中子1の中に軸方向から側面に通じる流路を持ち、端部は円錐状に広がった形状である中子2が挿入固定されている請求項1記載の生体組織接着剤塗布用具。 The core 1 has a hollow shape, has a flow path extending from the axial direction to the side surface in the core 1, and a core 2 having a shape in which the end portion expands in a conical shape is inserted and fixed. The biological tissue adhesive applicator.
JP2003273091A 2003-07-10 2003-07-10 Biological tissue adhesive applicator Expired - Fee Related JP4141916B2 (en)

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658305B2 (en) 2006-10-25 2010-02-09 Ethicon Endo-Surgery, Inc. Adhesive applier with articulating tip
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US7833216B2 (en) 2006-11-08 2010-11-16 Ethicon Endo-Surgery, Inc. Fluid plunger adhesive dispenser
US7892250B2 (en) 2006-11-01 2011-02-22 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive on inflatable device for gastric restriction
US7914511B2 (en) 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
US8603138B2 (en) 2006-10-04 2013-12-10 Ethicon Endo-Surgery, Inc. Use of an adhesive to treat intraluminal bleeding
US8608642B2 (en) 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel
US8876844B2 (en) 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device
JP2014238095A (en) * 2006-10-11 2014-12-18 テネコ オートモティブ オペレーティング カンパニー インコーポレイテッドTenneco Automotive Operating Company Inc. Dual injector device for reducing diesel exhaust substance

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8603138B2 (en) 2006-10-04 2013-12-10 Ethicon Endo-Surgery, Inc. Use of an adhesive to treat intraluminal bleeding
JP2014238095A (en) * 2006-10-11 2014-12-18 テネコ オートモティブ オペレーティング カンパニー インコーポレイテッドTenneco Automotive Operating Company Inc. Dual injector device for reducing diesel exhaust substance
US7914511B2 (en) 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US7658305B2 (en) 2006-10-25 2010-02-09 Ethicon Endo-Surgery, Inc. Adhesive applier with articulating tip
US7892250B2 (en) 2006-11-01 2011-02-22 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive on inflatable device for gastric restriction
US8876844B2 (en) 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device
US7833216B2 (en) 2006-11-08 2010-11-16 Ethicon Endo-Surgery, Inc. Fluid plunger adhesive dispenser
US8608642B2 (en) 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel

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