JP2004534959A5 - - Google Patents
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- Publication number
- JP2004534959A5 JP2004534959A5 JP2003513921A JP2003513921A JP2004534959A5 JP 2004534959 A5 JP2004534959 A5 JP 2004534959A5 JP 2003513921 A JP2003513921 A JP 2003513921A JP 2003513921 A JP2003513921 A JP 2003513921A JP 2004534959 A5 JP2004534959 A5 JP 2004534959A5
- Authority
- JP
- Japan
- Prior art keywords
- solid support
- group
- support
- formula
- biological molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 26
- -1 hydride functionality Chemical group 0.000 claims description 7
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims description 6
- 238000010511 deprotection reaction Methods 0.000 claims description 6
- 229910000077 silane Inorganic materials 0.000 claims description 6
- 229910052801 chlorine Inorganic materials 0.000 claims description 4
- 125000005843 halogen group Chemical group 0.000 claims description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- 229910008326 Si-Y Inorganic materials 0.000 claims description 2
- 229910006773 Si—Y Inorganic materials 0.000 claims description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims 18
- 150000001735 carboxylic acids Chemical group 0.000 claims 7
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
- 125000004663 dialkyl amino group Chemical group 0.000 claims 4
- 238000006459 hydrosilylation reaction Methods 0.000 claims 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 150000001336 alkenes Chemical class 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000007523 nucleic acids Chemical group 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims 3
- 238000005406 washing Methods 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 2
- 150000001345 alkine derivatives Chemical class 0.000 claims 2
- 230000001588 bifunctional effect Effects 0.000 claims 2
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 claims 2
- 239000000356 contaminant Substances 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 238000001704 evaporation Methods 0.000 claims 2
- 230000008020 evaporation Effects 0.000 claims 2
- 229930195733 hydrocarbon Natural products 0.000 claims 2
- 150000002430 hydrocarbons Chemical class 0.000 claims 2
- 230000003100 immobilizing effect Effects 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 150000002902 organometallic compounds Chemical class 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 238000002444 silanisation Methods 0.000 claims 2
- 239000000377 silicon dioxide Substances 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 229910052786 argon Inorganic materials 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 125000006267 biphenyl group Chemical group 0.000 claims 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000009849 deactivation Effects 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 239000007789 gas Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 230000033444 hydroxylation Effects 0.000 claims 1
- 238000005805 hydroxylation reaction Methods 0.000 claims 1
- 238000007654 immersion Methods 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229910044991 metal oxide Inorganic materials 0.000 claims 1
- 150000004706 metal oxides Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000012074 organic phase Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 150000003961 organosilicon compounds Chemical class 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000012071 phase Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 1
- 239000002798 polar solvent Substances 0.000 claims 1
- 150000003141 primary amines Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 239000004065 semiconductor Substances 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 150000003377 silicon compounds Chemical class 0.000 claims 1
- 238000006884 silylation reaction Methods 0.000 claims 1
- 235000009518 sodium iodide Nutrition 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 229960002703 undecylenic acid Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0109082A FR2826957B1 (fr) | 2001-07-09 | 2001-07-09 | Procede de fonctionnalisation de supports solides, supports solides fonctionnalises et leurs utilisations |
| PCT/FR2002/002364 WO2003008360A1 (fr) | 2001-07-09 | 2002-07-05 | Procede de fonctionnalisation de supports solides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004534959A JP2004534959A (ja) | 2004-11-18 |
| JP2004534959A5 true JP2004534959A5 (https=) | 2006-01-05 |
| JP4248393B2 JP4248393B2 (ja) | 2009-04-02 |
Family
ID=8865276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003513921A Expired - Fee Related JP4248393B2 (ja) | 2001-07-09 | 2002-07-05 | 固形支持体の機能化方法、機能化された固形支持体、およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7303924B2 (https=) |
| EP (1) | EP1404631B1 (https=) |
| JP (1) | JP4248393B2 (https=) |
| AT (1) | ATE308491T1 (https=) |
| CA (1) | CA2453303C (https=) |
| DE (1) | DE60207080T2 (https=) |
| ES (1) | ES2254728T3 (https=) |
| FR (1) | FR2826957B1 (https=) |
| WO (1) | WO2003008360A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7148017B1 (en) * | 2000-07-12 | 2006-12-12 | Cornell Research Foundation, Inc. | High sensitivity mechanical resonant sensor |
| JP2002199881A (ja) * | 2000-12-28 | 2002-07-16 | Toyo Kohan Co Ltd | Ｄｎａ固定化基体の再使用法 |
| EP1617217A4 (en) * | 2003-03-14 | 2009-10-28 | Kitakyushu Foundation | IMMOBILIZATION CHIP OF AN ORGANIC SUBSTANCE AND USE THEREOF |
| DE602004020570D1 (de) * | 2003-12-18 | 2009-05-28 | Biomethodes | Verfahren zur ortspezifischen Massenmutagenese |
| KR100896380B1 (ko) * | 2005-01-07 | 2009-05-08 | 화이자 프로덕츠 인코포레이티드 | 헤테로방향족 퀴놀린 화합물 및 ｐｄｅ10 저해제로서의그의 용도 |
| WO2006128776A1 (de) * | 2005-05-30 | 2006-12-07 | Qiagen Gmbh | Vorrichtung und verfahren zur normalisierung von nukleinsäure-konzentrationen |
| JP4697944B2 (ja) * | 2005-06-10 | 2011-06-08 | キヤノン株式会社 | 非特異吸着を低減するプローブ固定担体の製造方法 |
| WO2006138272A1 (en) * | 2005-06-13 | 2006-12-28 | Northwestern University | Metal ion-based immobilization |
| US7923054B2 (en) | 2006-04-19 | 2011-04-12 | Gore Enterprise Holdings, Inc. | Functional porous substrates for attaching biomolecules |
| JP2008107315A (ja) * | 2006-09-29 | 2008-05-08 | Fujifilm Corp | 生体分子の固定化方法 |
| US20080245135A1 (en) * | 2006-11-15 | 2008-10-09 | Cornell Research Foundation, Inc. | Microfluidic encapsulated nems resonators |
| DE102009026622A1 (de) | 2009-05-29 | 2010-12-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Formkörper mit eingebetteten Kopplungspartikeln für Biomoleküle |
| US9126890B2 (en) * | 2011-10-20 | 2015-09-08 | International Flavors & Fragrances Inc. | Low volatile reactive malodor counteractives and methods of use thereof |
| US10226544B2 (en) | 2015-06-05 | 2019-03-12 | International Flavors & Fragrances Inc. | Malodor counteracting compositions |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2533507B2 (ja) * | 1987-01-06 | 1996-09-11 | 株式会社資生堂 | 改質固体材料 |
| US6235488B1 (en) * | 1988-09-29 | 2001-05-22 | Agilent Technologies, Inc. | Surface preparation for chemical-specific binding |
| EP0496699B1 (de) * | 1991-01-25 | 1995-04-26 | Ciba-Geigy Ag | Silangruppen enthaltende Diphosphine, immobilisierte Diphosphine und deren Verwendung als Hydrierkatalysatoren |
| US5466766A (en) * | 1991-05-09 | 1995-11-14 | Phillips Petroleum Company | Metallocenes and processes therefor and therewith |
| WO1997023497A1 (en) * | 1995-12-22 | 1997-07-03 | University Technologies International Inc. | Linker arm for solid support oligonucleotide synthesis and process for production thereof |
| US6048695A (en) * | 1998-05-04 | 2000-04-11 | Baylor College Of Medicine | Chemically modified nucleic acids and methods for coupling nucleic acids to solid support |
| CA2317179A1 (en) * | 1999-09-01 | 2001-03-01 | Affymetrix, Inc. | Macromolecular arrays on polymeric brushes and methods for preparing the same |
| JP2001108683A (ja) * | 1999-10-14 | 2001-04-20 | Fuji Photo Film Co Ltd | Ｄｎａ断片固定固相担体、ｄｎａ断片の固定方法および核酸断片の検出方法 |
| JP2001165894A (ja) * | 1999-12-08 | 2001-06-22 | Fuji Photo Film Co Ltd | 縫い込み型インターカレータ、核酸断片の検出方法、及び核酸断片の検出キット |
-
2001
- 2001-07-09 FR FR0109082A patent/FR2826957B1/fr not_active Expired - Fee Related
-
2002
- 2002-07-05 WO PCT/FR2002/002364 patent/WO2003008360A1/fr not_active Ceased
- 2002-07-05 JP JP2003513921A patent/JP4248393B2/ja not_active Expired - Fee Related
- 2002-07-05 US US10/483,180 patent/US7303924B2/en not_active Expired - Fee Related
- 2002-07-05 AT AT02764946T patent/ATE308491T1/de not_active IP Right Cessation
- 2002-07-05 ES ES02764946T patent/ES2254728T3/es not_active Expired - Lifetime
- 2002-07-05 EP EP02764946A patent/EP1404631B1/fr not_active Expired - Lifetime
- 2002-07-05 DE DE60207080T patent/DE60207080T2/de not_active Expired - Lifetime
- 2002-07-05 CA CA2453303A patent/CA2453303C/fr not_active Expired - Fee Related
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