JP2004534579A5 - - Google Patents

Info

Publication number

JP2004534579A5

JP2004534579A5 JP2003506947A JP2003506947A JP2004534579A5 JP 2004534579 A5 JP2004534579 A5 JP 2004534579A5 JP 2003506947 A JP2003506947 A JP 2003506947A JP 2003506947 A JP2003506947 A JP 2003506947A JP 2004534579 A5 JP2004534579 A5 JP 2004534579A5

Authority

JP

Japan

Prior art keywords

group

macromers

monomer

polysaccharide

medical device

Prior art date

2002-06-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229920000642 polymer Polymers 0.000 claims 25
• 239000000178 monomer Substances 0.000 claims 24
• 150000004676 glycans Chemical class 0.000 claims 20
• 229920001282 polysaccharide Polymers 0.000 claims 20
• 239000005017 polysaccharide Substances 0.000 claims 20
• 238000000034 method Methods 0.000 claims 17
• 239000000017 hydrogel Substances 0.000 claims 9
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 8
• 229920000669 heparin Polymers 0.000 claims 8
• 229960002897 heparin Drugs 0.000 claims 8
• 230000000379 polymerizing effect Effects 0.000 claims 8
• 239000000203 mixture Substances 0.000 claims 7
• 239000011248 coating agent Substances 0.000 claims 6
• 238000000576 coating method Methods 0.000 claims 6
• 239000000463 material Substances 0.000 claims 6
• 238000006116 polymerization reaction Methods 0.000 claims 5
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 5
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 5
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims 5
• 238000002360 preparation method Methods 0.000 claims 5
• BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims 4
• 238000009472 formulation Methods 0.000 claims 4
• 239000002904 solvent Substances 0.000 claims 4
• 150000001768 cations Chemical class 0.000 claims 3
• SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 2
• NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 2
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 2
• 229920001287 Chondroitin sulfate Polymers 0.000 claims 2
• 229920000045 Dermatan sulfate Polymers 0.000 claims 2
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
• 229920002683 Glycosaminoglycan Polymers 0.000 claims 2
• 229920002971 Heparan sulfate Polymers 0.000 claims 2
• 229920000288 Keratan sulfate Polymers 0.000 claims 2
• CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 2
• CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 2
• VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 2
• 125000003636 chemical group Chemical group 0.000 claims 2
• 229940059329 chondroitin sulfate Drugs 0.000 claims 2
• AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 2
• 229940051593 dermatan sulfate Drugs 0.000 claims 2
• 238000005538 encapsulation Methods 0.000 claims 2
• PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
• KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000003960 organic solvent Substances 0.000 claims 2
• 229920001296 polysiloxane Polymers 0.000 claims 2
• 239000000126 substance Substances 0.000 claims 2
• QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
• 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 2
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
• 239000004743 Polypropylene Substances 0.000 claims 1
• 210000004204 blood vessel Anatomy 0.000 claims 1
• 238000006243 chemical reaction Methods 0.000 claims 1
• 125000001033 ether group Chemical group 0.000 claims 1
• 239000004744 fabric Substances 0.000 claims 1
• 125000000524 functional group Chemical group 0.000 claims 1
• 229920002521 macromolecule Polymers 0.000 claims 1
• -1 polypropylene Polymers 0.000 claims 1
• 229920001155 polypropylene Polymers 0.000 claims 1
• 229920001451 polypropylene glycol Polymers 0.000 claims 1