JP2004533841A - アグレカナーゼ分子 - Google Patents

アグレカナーゼ分子 Download PDF

Info

Publication number
JP2004533841A
JP2004533841A JP2003510766A JP2003510766A JP2004533841A JP 2004533841 A JP2004533841 A JP 2004533841A JP 2003510766 A JP2003510766 A JP 2003510766A JP 2003510766 A JP2003510766 A JP 2003510766A JP 2004533841 A JP2004533841 A JP 2004533841A
Authority
JP
Japan
Prior art keywords
aggrecanase
seq
protein
sequence
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003510766A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004533841A5 (enExample
Inventor
マイケル・ジェイ・アゴスティノ
エリザベス・ディ・ブラシオ
エドワード・アール・ラバリー
リサ・エイ・レイシー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of JP2004533841A publication Critical patent/JP2004533841A/ja
Publication of JP2004533841A5 publication Critical patent/JP2004533841A5/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2003510766A 2001-07-05 2002-07-05 アグレカナーゼ分子 Pending JP2004533841A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30305101P 2001-07-05 2001-07-05
US34913302P 2002-01-16 2002-01-16
PCT/US2002/021056 WO2003004607A2 (en) 2001-07-05 2002-07-05 Aggrecanase molecules

Publications (2)

Publication Number Publication Date
JP2004533841A true JP2004533841A (ja) 2004-11-11
JP2004533841A5 JP2004533841A5 (enExample) 2006-01-05

Family

ID=26973233

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003510766A Pending JP2004533841A (ja) 2001-07-05 2002-07-05 アグレカナーゼ分子

Country Status (9)

Country Link
US (1) US20030148306A1 (enExample)
EP (1) EP1409658A4 (enExample)
JP (1) JP2004533841A (enExample)
BR (1) BR0210835A (enExample)
CA (1) CA2451374A1 (enExample)
MX (1) MXPA03011715A (enExample)
NZ (1) NZ530949A (enExample)
PL (1) PL367675A1 (enExample)
WO (1) WO2003004607A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003066822A2 (en) * 2002-02-05 2003-08-14 Wyeth Truncated aggrecanase molecules
AU2003261269A1 (en) * 2002-07-29 2004-02-16 Wyeth Modified adamts4 molecules and method of use thereof
EP1663300A1 (en) * 2003-09-16 2006-06-07 Pharmacia Corporation Inhibitors of pace4 for the treatment of arthritis
JP2007535920A (ja) * 2004-04-16 2007-12-13 ワイス トランケート型adamts分子

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
CA2383592A1 (en) * 1999-03-31 2000-10-05 Curagen Corporation 2384891 acids including open reading frames encoding polypeptides; orfx
JP2001008687A (ja) * 1999-06-25 2001-01-16 Yamanouchi Pharmaceut Co Ltd 新規金属プロテアーゼ及び該金属プロテアーゼ遺伝子
AU1230201A (en) * 1999-10-25 2001-05-08 Millennium Pharmaceuticals, Inc. 27875 a human adam-ts homolog
EP1134286A3 (en) * 2000-03-14 2003-05-02 Pfizer Products Inc. Adamts polypeptides, nucleic acids encoding them, and uses thereof

Also Published As

Publication number Publication date
US20030148306A1 (en) 2003-08-07
CA2451374A1 (en) 2003-01-16
PL367675A1 (en) 2005-03-07
WO2003004607A2 (en) 2003-01-16
EP1409658A2 (en) 2004-04-21
WO2003004607A3 (en) 2003-07-31
EP1409658A4 (en) 2006-08-23
NZ530949A (en) 2005-09-30
MXPA03011715A (es) 2004-03-19
BR0210835A (pt) 2004-07-13

Similar Documents

Publication Publication Date Title
AU2009201274A1 (en) Aggrecanase molecules
US6521436B1 (en) Nucleic acids encoding aggrecan degrading metallo proteases
AU2003207795A1 (en) Aggrecanase molecules
EP1344821B9 (en) Novel aggrecanase
EP0921197A2 (en) Human disintegrin metalloprotease related to drosophila kuz gene
US20030224430A1 (en) Regulation of human eosinophil serine protease 1-like enzyme
JP2004533841A (ja) アグレカナーゼ分子
US7150983B2 (en) Truncated aggrecanase molecules
JP2002503472A (ja) メタロプロテアーゼ‐ディスインテグリンsvph3−13およびsvph3−17のdnaおよびポリペプチド
WO2003064597A2 (en) Aggrecanase molecules
JP2007535920A (ja) トランケート型adamts分子
EP0888375A1 (en) A novel disintegrin metalloprotease and methods of use
US7125701B2 (en) Aggrecanase molecules
US20030228676A1 (en) Aggrecanase molecules
JPH10117788A (ja) ヒト・myt−1キナーゼクローン
AU2002312623A1 (en) Aggrecanase molecules
ZA200400929B (en) Aggrecanase molecules
JP2002508969A (ja) 精巣特異的ヒトsvph1−8プロテイナーゼ
JP2008301813A (ja) 新規アグレカナーゼ分子

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050518

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050518

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080603

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20081104