JP2004528293A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004528293A5 JP2004528293A5 JP2002560642A JP2002560642A JP2004528293A5 JP 2004528293 A5 JP2004528293 A5 JP 2004528293A5 JP 2002560642 A JP2002560642 A JP 2002560642A JP 2002560642 A JP2002560642 A JP 2002560642A JP 2004528293 A5 JP2004528293 A5 JP 2004528293A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- mixture
- refluxing
- substituent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 238000010992 reflux Methods 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- SWELIMKTDYHAOY-UHFFFAOYSA-N 2,4-diamino-6-hydroxypyrimidine Chemical compound NC1=CC(=O)N=C(N)N1 SWELIMKTDYHAOY-UHFFFAOYSA-N 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 238000001816 cooling Methods 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 239000002244 precipitate Substances 0.000 claims 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229910052740 iodine Inorganic materials 0.000 claims 3
- 239000011630 iodine Substances 0.000 claims 3
- 239000000047 product Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 239000011593 sulfur Substances 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
- 108010022394 Threonine synthase Proteins 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 230000003796 beauty Effects 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- -1 carvone ester Chemical class 0.000 claims 2
- 125000006165 cyclic alkyl group Chemical group 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229930195712 glutamate Natural products 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000002367 halogens Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 230000002194 synthesizing effect Effects 0.000 claims 2
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 1
- 239000005973 Carvone Substances 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 241001467578 Microbacterium Species 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 241000233870 Pneumocystis Species 0.000 claims 1
- 102000005497 Thymidylate Synthase Human genes 0.000 claims 1
- 241000223997 Toxoplasma gondii Species 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 1
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Natural products CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000008121 dextrose Substances 0.000 claims 1
- 102000004419 dihydrofolate reductase Human genes 0.000 claims 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000002504 physiological saline solution Substances 0.000 claims 1
- 201000000317 pneumocystosis Diseases 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 0 *C1=C(*)N=C(*)NC1=O Chemical compound *C1=C(*)N=C(*)NC1=O 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/775,064 US6423720B1 (en) | 2001-02-01 | 2001-02-01 | Pyrimidine compounds and methods for making and using the same |
| PCT/US2002/002358 WO2002060450A1 (en) | 2001-02-01 | 2002-01-23 | Pyrimidine compounds and methods for making and using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004528293A JP2004528293A (ja) | 2004-09-16 |
| JP2004528293A5 true JP2004528293A5 (enExample) | 2006-01-05 |
Family
ID=25103214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002560642A Pending JP2004528293A (ja) | 2001-02-01 | 2002-01-23 | ピリミジン化合物並びに該化合物の製造及び使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6423720B1 (enExample) |
| EP (1) | EP1363637B1 (enExample) |
| JP (1) | JP2004528293A (enExample) |
| CA (1) | CA2435958A1 (enExample) |
| DE (1) | DE60213763D1 (enExample) |
| WO (1) | WO2002060450A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6423720B1 (en) * | 2001-02-01 | 2002-07-23 | Duquesne University Of The Holy Ghost | Pyrimidine compounds and methods for making and using the same |
| WO2005026148A1 (en) * | 2003-09-08 | 2005-03-24 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| AU2005229331B2 (en) | 2004-03-05 | 2011-10-13 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as P2X3 and P2X2/3 antagonists |
| US8030319B2 (en) * | 2005-02-10 | 2011-10-04 | Duquesne University Of The Holy Ghost | Methods for treating cancer and other pathological proliferating disorders by inhibiting mitosis using pyrrolo[2 3-d]pyrimidines |
| WO2007025899A1 (en) * | 2005-09-01 | 2007-03-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| EP1924565B1 (en) * | 2005-09-01 | 2016-09-14 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p3x2/3 modulators |
| EP1924566B1 (en) | 2005-09-01 | 2016-01-13 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| WO2010142027A1 (en) * | 2009-06-12 | 2010-12-16 | Socpra - Sciences Et Genie S. E. C. | Guanine riboswitch binding compounds and their use as antibiotics |
| NZ713361A (en) * | 2009-08-17 | 2017-06-30 | Memorial Sloan Kettering Cancer Center | Heat shock protein binding compounds, compositions, and methods for making and using same |
| TWI699204B (zh) | 2014-05-13 | 2020-07-21 | 美國紀念斯隆 凱特琳癌症中心 | Ｈｓｐ７０調節子及其製造及使用方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG52739A1 (en) * | 1992-12-16 | 1998-09-28 | Agouron Pharma | Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds |
| WO1994030007A1 (en) * | 1993-06-04 | 1994-12-22 | David Sarnoff Research Center, Inc. | System and method for electronic image stabilization |
| US5426110A (en) * | 1993-10-06 | 1995-06-20 | Eli Lilly And Company | Pyrimidinyl-glutamic acid derivatives |
| EP0697788A3 (en) * | 1994-08-19 | 1997-03-26 | Eastman Kodak Co | Adaptive and global motion compensated cancellation of the interlacing of successive video images with post-processing |
| US5973733A (en) * | 1995-05-31 | 1999-10-26 | Texas Instruments Incorporated | Video stabilization system and method |
| EP0868815A2 (en) * | 1996-10-24 | 1998-10-07 | Koninklijke Philips Electronics N.V. | Noise filtering |
| US6140351A (en) * | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| JP4389371B2 (ja) * | 2000-09-28 | 2009-12-24 | 株式会社ニコン | 画像修復装置および画像修復方法 |
| US6423720B1 (en) * | 2001-02-01 | 2002-07-23 | Duquesne University Of The Holy Ghost | Pyrimidine compounds and methods for making and using the same |
-
2001
- 2001-02-01 US US09/775,064 patent/US6423720B1/en not_active Expired - Fee Related
-
2002
- 2002-01-23 JP JP2002560642A patent/JP2004528293A/ja active Pending
- 2002-01-23 EP EP02706007A patent/EP1363637B1/en not_active Expired - Lifetime
- 2002-01-23 DE DE60213763T patent/DE60213763D1/de not_active Expired - Lifetime
- 2002-01-23 CA CA002435958A patent/CA2435958A1/en not_active Abandoned
- 2002-01-23 WO PCT/US2002/002358 patent/WO2002060450A1/en not_active Ceased
- 2002-06-27 US US10/185,562 patent/US20030040524A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI354666B (en) | Heterocyclic aspartyl protease inhibitors | |
| JP4344235B2 (ja) | タキソール増強剤化合物 | |
| JP4344234B2 (ja) | タキソール増強剤化合物 | |
| RU2214398C2 (ru) | Производное циклоалкена, способ его получения (варианты), фармацевтическая композиция, способ ингибирования, способ профилактики или лечения | |
| CA2506242A1 (en) | 4-tetrazolyl-4phenylpiperidine derivatives for treating pain | |
| HRP20110252T1 (hr) | Fenil-karboksamidni spojevi korisni za liječenje boli | |
| CA2315713A1 (en) | Inhibition of raf kinase using aryl and heteroaryl substituted heterocyclic ureas | |
| RU2005128550A (ru) | Ингибиторы гистондезацетилазы из новых производных бензамида с сильной дифференцировочной и антипролиферативной активностью | |
| RU2001104339A (ru) | Производные тиобензимидазола | |
| JP2004528293A5 (enExample) | ||
| JP2008511601A5 (enExample) | ||
| RU2005109913A (ru) | Азабициклоалкильные эфиры и их применение в качестве агонистов альфа7-nachr | |
| JP2006513268A5 (ja) | アンタゴニスト活性を有するベンゾアゾリルピペラジン誘導体 | |
| JP2003508388A5 (enExample) | ||
| CA2382940A1 (fr) | 2-arylimino-2,3-dihydrothiazoles et leur utilisation comme ligands des recepteurs de la somatostatine | |
| RU2007123235A (ru) | Противоопухолевые соединения | |
| JP2007505922A5 (enExample) | ||
| JP2006525944A5 (enExample) | ||
| RU2011133128A (ru) | Противоопухолевые соединения дигидропиран-2-она | |
| MA27390A1 (fr) | Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique | |
| RU2004130427A (ru) | Производные нитрозодифениламина и их фармацевтическое применение против патологий окислительного стресса | |
| JP2007505044A5 (enExample) | ||
| RU99101081A (ru) | Режим введения ингибиторов н+, к+-атфазы | |
| CN1597662A (zh) | 一类芳香酰胺化合物、制备方法及用途 | |
| CA2486872A1 (en) | Nf-kb inhibitors and uses thereof |