JP2004527535A - 抗発作発生剤および/または抗癲癇誘発剤としてのピリミジン化合物 - Google Patents
抗発作発生剤および/または抗癲癇誘発剤としてのピリミジン化合物 Download PDFInfo
- Publication number
- JP2004527535A JP2004527535A JP2002581407A JP2002581407A JP2004527535A JP 2004527535 A JP2004527535 A JP 2004527535A JP 2002581407 A JP2002581407 A JP 2002581407A JP 2002581407 A JP2002581407 A JP 2002581407A JP 2004527535 A JP2004527535 A JP 2004527535A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- subject
- pharmaceutically acceptable
- hydrogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CN(C(C(*)=C(*)N1*)=O)C1=O Chemical compound CN(C(C(*)=C(*)N1*)=O)C1=O 0.000 description 10
- KWGWBNPZFDYNMY-UHFFFAOYSA-N CCCCC(OC1=N2)=CC1=CN(Cc1ccccc1)C2=O Chemical compound CCCCC(OC1=N2)=CC1=CN(Cc1ccccc1)C2=O KWGWBNPZFDYNMY-UHFFFAOYSA-N 0.000 description 1
- YLMMYIIRADIZJQ-UHFFFAOYSA-N CSCC(C(N1)=O)=CNC1=O Chemical compound CSCC(C(N1)=O)=CNC1=O YLMMYIIRADIZJQ-UHFFFAOYSA-N 0.000 description 1
- UGUILUGCFSCUKR-KVARREAHSA-N C[C@H]([C@H](C1)O)OC1N(C=C(C)C(N1)=O)C1=O Chemical compound C[C@H]([C@H](C1)O)OC1N(C=C(C)C(N1)=O)C1=O UGUILUGCFSCUKR-KVARREAHSA-N 0.000 description 1
- QJMZJTNUJGSRPS-UHFFFAOYSA-N Cc1cc(C(CC(N2)=O)NC2=O)ccc1 Chemical compound Cc1cc(C(CC(N2)=O)NC2=O)ccc1 QJMZJTNUJGSRPS-UHFFFAOYSA-N 0.000 description 1
- PFKWRQJXKGRFJV-UHFFFAOYSA-N NC(CC(O)=O)c(cc1)ccc1Oc1ccccc1 Chemical compound NC(CC(O)=O)c(cc1)ccc1Oc1ccccc1 PFKWRQJXKGRFJV-UHFFFAOYSA-N 0.000 description 1
- VRBVHVJSUKYDRK-UHFFFAOYSA-N NC(c1c[n](-c2cccc(N)c2)nc1)=O Chemical compound NC(c1c[n](-c2cccc(N)c2)nc1)=O VRBVHVJSUKYDRK-UHFFFAOYSA-N 0.000 description 1
- QMSAQHYISIINGO-UHFFFAOYSA-N NCC(CCc1ccccc1)C(O)=O Chemical compound NCC(CCc1ccccc1)C(O)=O QMSAQHYISIINGO-UHFFFAOYSA-N 0.000 description 1
- CZMHRWQUXXQUFG-UHFFFAOYSA-N OC(CCNCCCc1ccccc1)=O Chemical compound OC(CCNCCCc1ccccc1)=O CZMHRWQUXXQUFG-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28298701P | 2001-04-11 | 2001-04-11 | |
US28594001P | 2001-04-23 | 2001-04-23 | |
US31074801P | 2001-08-07 | 2001-08-07 | |
US9993402A | 2002-03-13 | 2002-03-13 | |
PCT/CA2002/000512 WO2002083651A2 (fr) | 2001-04-11 | 2002-04-11 | Composes de pyrimidine en tant qu'agents anti-ictogeniques et/ou anti-epileptiques |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2004527535A true JP2004527535A (ja) | 2004-09-09 |
Family
ID=27493095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002581407A Withdrawn JP2004527535A (ja) | 2001-04-11 | 2002-04-11 | 抗発作発生剤および/または抗癲癇誘発剤としてのピリミジン化合物 |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1385831A2 (fr) |
JP (1) | JP2004527535A (fr) |
CA (1) | CA2444148A1 (fr) |
WO (1) | WO2002083651A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017502967A (ja) * | 2014-01-03 | 2017-01-26 | ユニバーシティ オブ サザン カリフォルニア | ヘテロ原子含有デオキシウリジントリホスファターゼ阻害剤 |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003249812A1 (en) * | 2002-07-18 | 2004-02-09 | Queen's University At Kingston | Dihydrouracil compounds as anti-ictogenic or anti-epileptogenic agents |
AU2004234110A1 (en) * | 2003-04-25 | 2004-11-11 | Rega Foundation | Heterocyclic compounds for use in the treatment of viral infections |
BRPI0508310A (pt) | 2004-03-02 | 2007-07-24 | Hoffmann La Roche | derivados de 4-(sulfanil-pirimidin-4-ilmetil)-morfolina e compostos relacionados como ligandos do receptor gaba, para o tratamento de ansiedade, depressão e epilepsia |
JP5291124B2 (ja) * | 2008-01-30 | 2013-09-18 | シン・プーン・ファーマシューティカル・カンパニー・リミテッド | 新規なキナゾリン−2,4−ジオン誘導体、及びこれを含有する脳神経系疾患の予防及び治療用医薬組成物 |
DE102008030091B4 (de) | 2008-06-25 | 2011-03-03 | Resprotect Gmbh | Uracilderivate und deren Verwendung |
WO2014107622A1 (fr) | 2013-01-07 | 2014-07-10 | University Of Southern California | Inhibiteurs de la désoxyuridine triphosphatase |
CN103788095A (zh) * | 2014-01-20 | 2014-05-14 | 四川大学华西医院 | 2,4(1h,3h)-嘧啶二酮衍生物及其制备方法 |
CN104788389A (zh) * | 2015-04-09 | 2015-07-22 | 新乡市创新生物科技有限公司 | 一种5-溴尿嘧啶的制备方法 |
WO2017006271A1 (fr) | 2015-07-08 | 2017-01-12 | University Of Southern California | Inhibiteurs de désoxyuridine triphosphatase contenant une liaison sulfonyle aminée |
EP3319939A1 (fr) | 2015-07-08 | 2018-05-16 | CV6 Therapeutics (NI) Limited | Hydantoïne contenant des inhibiteurs de la désoxyuridine triphosphatase |
US10544105B2 (en) | 2015-07-08 | 2020-01-28 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
US10577321B2 (en) | 2015-07-08 | 2020-03-03 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
WO2017123823A1 (fr) * | 2016-01-12 | 2017-07-20 | Bioelectron Technology Corporation | Inhibiteurs de sulfure:quinone oxydoréductase alkyle, acyle, urée, et aza-uracile |
US11168059B2 (en) | 2016-11-23 | 2021-11-09 | Cv6 Therapeutics (Ni) Limited | Amino sulfonyl compounds |
US10829457B2 (en) | 2016-11-23 | 2020-11-10 | Cv6 Therapeutics (Ni) Limited | Nitrogen ring linked deoxyuridine triphosphatase inhibitors |
WO2018098207A1 (fr) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Hydantoïne contenant des inhibiteurs de la désoxyuridine triphosphatase |
US11174271B2 (en) | 2016-11-23 | 2021-11-16 | Cv6 Therapeutics (Ni) Limited | 6-membered uracil isosteres |
WO2018098206A1 (fr) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Hydantoïne contenant des inhibiteurs de la désoxyuridine triphosphatase |
US11247984B2 (en) | 2017-01-05 | 2022-02-15 | Cv6 Therapeutics (Ni) Limited | Uracil containing compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0425669B1 (fr) * | 1988-07-18 | 1995-01-25 | Yamasa Shoyu Kabushiki Kaisha also trading as Yamasa Corporation | 1-amino-5-halogeno-uraciles, procede de preparation de ces composes, et agents depresseurs du systeme nerveux central les contenant en tant qu'ingredients actifs |
DE4300912A1 (de) * | 1993-01-15 | 1994-07-21 | Merck Patent Gmbh | Chinazolinderivate |
GB9400680D0 (en) * | 1994-01-14 | 1994-03-09 | Sandoz Ltd | Improvements in or relating to organic compounds |
US6472378B2 (en) * | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
PT1171137E (pt) * | 1999-02-23 | 2008-03-17 | Univ California | Utilização de triacetiluridina para o tratamento de perturbações mitocondriais |
WO2001051490A1 (fr) * | 2000-01-14 | 2001-07-19 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Analogues nucleosidiques de methanocarba cycloalkyle |
-
2002
- 2002-04-11 WO PCT/CA2002/000512 patent/WO2002083651A2/fr active Application Filing
- 2002-04-11 EP EP02717913A patent/EP1385831A2/fr not_active Withdrawn
- 2002-04-11 JP JP2002581407A patent/JP2004527535A/ja not_active Withdrawn
- 2002-04-11 CA CA002444148A patent/CA2444148A1/fr not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017502967A (ja) * | 2014-01-03 | 2017-01-26 | ユニバーシティ オブ サザン カリフォルニア | ヘテロ原子含有デオキシウリジントリホスファターゼ阻害剤 |
Also Published As
Publication number | Publication date |
---|---|
WO2002083651A2 (fr) | 2002-10-24 |
WO2002083651A3 (fr) | 2002-12-19 |
EP1385831A2 (fr) | 2004-02-04 |
CA2444148A1 (fr) | 2002-10-24 |
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Legal Events
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A761 | Written withdrawal of application |
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