JP2004525888A5 - - Google Patents
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- Publication number
- JP2004525888A5 JP2004525888A5 JP2002559370A JP2002559370A JP2004525888A5 JP 2004525888 A5 JP2004525888 A5 JP 2004525888A5 JP 2002559370 A JP2002559370 A JP 2002559370A JP 2002559370 A JP2002559370 A JP 2002559370A JP 2004525888 A5 JP2004525888 A5 JP 2004525888A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- methoxy
- phenylsulfonyl
- integer
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 13
- -1 4-methoxy-phenylsulfonyl group Chemical group 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000004432 carbon atoms Chemical group C* 0.000 claims 7
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 7
- 239000003112 inhibitor Substances 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 229920001515 polyalkylene glycol Polymers 0.000 claims 3
- 101700006801 THBI Proteins 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 230000001737 promoting Effects 0.000 claims 2
- 239000003868 thrombin inhibitor Substances 0.000 claims 2
- NKCXQMYPWXSLIZ-PSRDDEIFSA-N (2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-3-m Chemical compound O=C([C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)C(C)C)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O NKCXQMYPWXSLIZ-PSRDDEIFSA-N 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 230000036826 Excretion Effects 0.000 claims 1
- 210000003722 Extracellular Fluid Anatomy 0.000 claims 1
- 210000003734 Kidney Anatomy 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 108090000190 Thrombin Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000005140 aralkylsulfonyl group Chemical group 0.000 claims 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 230000029142 excretion Effects 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 125000005842 heteroatoms Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 230000000268 renotropic Effects 0.000 claims 1
- 229960004072 thrombin Drugs 0.000 claims 1
- 0 *OC([C@](CCC1)N1C([C@@](CC1CCCCC1)NCC(NCC*O)=O)=O)=O Chemical compound *OC([C@](CCC1)N1C([C@@](CC1CCCCC1)NCC(NCC*O)=O)=O)=O 0.000 description 3
- LDDXTZJQVINROX-UHFFFAOYSA-N CNCc(cc1)ccc1C(N)=N Chemical compound CNCc(cc1)ccc1C(N)=N LDDXTZJQVINROX-UHFFFAOYSA-N 0.000 description 2
- MSPORBDQRNSRAM-UHFFFAOYSA-N CNCC(CC1)CCN1C(N)=N Chemical compound CNCC(CC1)CCN1C(N)=N MSPORBDQRNSRAM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10102878A DE10102878A1 (de) | 2001-01-23 | 2001-01-23 | Oligo- oder Polyalkylengekoppelte Thrombininhibitoren |
PCT/EP2002/000652 WO2002059065A2 (de) | 2001-01-23 | 2002-01-23 | Oligo- oder polyalkylenglycolgekoppelte thrombininhibitoren |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2004525888A JP2004525888A (ja) | 2004-08-26 |
JP2004525888A5 true JP2004525888A5 (US07981874-20110719-C00313.png) | 2008-04-10 |
JP4461217B2 JP4461217B2 (ja) | 2010-05-12 |
Family
ID=7671444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002559370A Expired - Fee Related JP4461217B2 (ja) | 2001-01-23 | 2002-01-23 | オリゴまたはポリアルキレングリコール結合トロンビン阻害剤 |
Country Status (7)
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10162521A1 (de) * | 2001-12-19 | 2003-07-17 | Goetz Nowak | Verwendung von molekulargewichtserweiterten Substanzen in der Tumortherapie |
US7838560B2 (en) * | 2002-03-11 | 2010-11-23 | The Medicines Company (Leipzig) Gmbh | Urokinase inhibitors, production and use thereof |
DE10301300B4 (de) * | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
DE10342108A1 (de) * | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
PT1737889E (pt) | 2004-10-19 | 2010-12-13 | Lonza Ag | Método para síntese de péptidos em fase sólida |
DE102005044319A1 (de) * | 2005-09-16 | 2007-03-22 | Curacyte Chemistry Gmbh | 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa |
DE102006048300A1 (de) | 2006-01-26 | 2007-08-02 | Hellstern, Peter, Prof. Dr.med. | Inhibitoren des Blutgerinnungsfaktors Xa zur Verwendung als Antikoagulans |
CN103071192B (zh) * | 2006-09-15 | 2016-04-27 | 东丽株式会社 | 基材及其制造方法 |
WO2008032400A1 (fr) * | 2006-09-15 | 2008-03-20 | Toray Industries, Inc. | Procédé pour la production d'un substrat modifié |
DE102006050672A1 (de) * | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
DE102007033787A1 (de) | 2007-07-09 | 2009-01-15 | Aesculap Ag | Gefäßprothese mit reduzierter Thrombogenität |
JP2012502906A (ja) * | 2008-09-17 | 2012-02-02 | ネクター セラピューティックス | オリゴマー−プロテアーゼ阻害剤コンジュゲート |
US8835710B2 (en) * | 2009-03-24 | 2014-09-16 | Mead Johnson Nutrition Company | Animal model for infant pathologies |
EP2518100B1 (en) | 2009-12-24 | 2015-02-18 | Toray Industries, Inc. | Hydrophilic polymer compound having anticoagulation effect |
US9492439B2 (en) | 2010-03-11 | 2016-11-15 | New York University | Amido compounds as RORγt modulators and uses thereof |
WO2012083436A1 (en) * | 2010-12-21 | 2012-06-28 | The Medicines Company (Leipzig) Gmbh | Trypsin-like serine protease inhibitors, their preparation and use as selective inhibitors of the clotting factors iia and xa |
TW201309354A (zh) | 2011-06-23 | 2013-03-01 | Toray Industries | 醫療材料 |
TW201311774A (zh) * | 2011-06-23 | 2013-03-16 | Toray Industries | 具有抗血液凝固作用的疏水性高分子化合物 |
KR20140023286A (ko) * | 2011-06-24 | 2014-02-26 | 칸지 이노우에 | 유리 혈전 포획 기구 |
US20160067066A1 (en) * | 2013-04-12 | 2016-03-10 | Toray Industries, Inc. | Antithrombotic artificial blood vessel |
US20170157303A1 (en) * | 2013-11-28 | 2017-06-08 | Toray Industries, Inc. | Anti-thrombotic material |
WO2015122429A1 (ja) * | 2014-02-12 | 2015-08-20 | 東レ株式会社 | 人工血管 |
WO2018066476A1 (ja) | 2016-10-07 | 2018-04-12 | 東レ株式会社 | 筒状織物 |
RU2019133671A (ru) | 2017-03-31 | 2021-04-30 | Торэй Индастриз, Инк. | Цилиндрическая структура |
CN117497842B (zh) * | 2023-12-27 | 2024-03-12 | 江苏蓝固新能源科技有限公司 | 一种聚合物电解质和制备方法及其在二次电池中的应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3187044B2 (ja) * | 1989-12-01 | 2001-07-11 | ビーエーエスエフ アクチェンゲゼルシャフト | ヒルジン突然変異蛋白質及びヒルジンポリアルキレングリコール複合体 |
US5583146A (en) * | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
DE4342154A1 (de) * | 1993-12-10 | 1995-06-14 | Behringwerke Ag | Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien |
US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
US5798377A (en) * | 1996-10-21 | 1998-08-25 | Merck & Co., Inc. | Thrombin inhibitors |
DE69800640T2 (de) | 1997-01-29 | 2001-07-05 | Polymasc Pharmaceuticals Plc, London | Pegylationsverfahren |
-
2001
- 2001-01-23 DE DE10102878A patent/DE10102878A1/de not_active Ceased
-
2002
- 2002-01-23 EP EP02708308A patent/EP1355674B1/de not_active Expired - Lifetime
- 2002-01-23 CA CA2431487A patent/CA2431487C/en not_active Expired - Fee Related
- 2002-01-23 US US10/344,722 patent/US7407982B2/en not_active Expired - Fee Related
- 2002-01-23 DE DE50214734T patent/DE50214734D1/de not_active Expired - Lifetime
- 2002-01-23 AT AT02708308T patent/ATE485838T1/de active
- 2002-01-23 JP JP2002559370A patent/JP4461217B2/ja not_active Expired - Fee Related
- 2002-01-23 WO PCT/EP2002/000652 patent/WO2002059065A2/de active Application Filing