JP2004525607A - オリゴヌクレオチドを付着させたナノ粒子とその使用方法 - Google Patents

オリゴヌクレオチドを付着させたナノ粒子とその使用方法 Download PDF

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Publication number
JP2004525607A
JP2004525607A JP2002522548A JP2002522548A JP2004525607A JP 2004525607 A JP2004525607 A JP 2004525607A JP 2002522548 A JP2002522548 A JP 2002522548A JP 2002522548 A JP2002522548 A JP 2002522548A JP 2004525607 A JP2004525607 A JP 2004525607A
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Prior art keywords
oligonucleotide
nanoparticles
nucleic acid
nanoparticle
sequence
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Pending
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JP2002522548A
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English (en)
Japanese (ja)
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JP2004525607A5 (fr
Inventor
マーキン、チャド　エイ．
レッシンガー、ロバート　エル．
ミューシク、ロバート　シー．
ストーホフ、ジェームズ　ジェイ．
エルガニアン、ロバート
タトン、トーマス　アンドリュー
ガリメラ、ビスワナダム
リ、ジー
パーク、ソ−ジョン
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Nanosphere LLC
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Nanosphere LLC
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Priority claimed from US09/760,500 external-priority patent/US6767702B2/en
Priority claimed from US09/820,279 external-priority patent/US6750016B2/en
Application filed by Nanosphere LLC filed Critical Nanosphere LLC
Publication of JP2004525607A publication Critical patent/JP2004525607A/ja
Publication of JP2004525607A5 publication Critical patent/JP2004525607A5/ja
Pending legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Saccharide Compounds (AREA)
JP2002522548A 2000-08-11 2001-08-10 オリゴヌクレオチドを付着させたナノ粒子とその使用方法 Pending JP2004525607A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22463100P 2000-08-11 2000-08-11
US25439200P 2000-12-08 2000-12-08
US25523500P 2000-12-11 2000-12-11
US09/760,500 US6767702B2 (en) 1996-07-29 2001-01-12 Nanoparticles having oligonucleotides attached thereto and uses therefor
US09/820,279 US6750016B2 (en) 1996-07-29 2001-03-28 Nanoparticles having oligonucleotides attached thereto and uses therefor
PCT/US2001/025237 WO2002018643A2 (fr) 2000-08-11 2001-08-10 Nanoparticules comportant des oligonucleotides fixes dessus et utilisations associees

Publications (2)

Publication Number Publication Date
JP2004525607A true JP2004525607A (ja) 2004-08-26
JP2004525607A5 JP2004525607A5 (fr) 2005-02-17

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JP2002522548A Pending JP2004525607A (ja) 2000-08-11 2001-08-10 オリゴヌクレオチドを付着させたナノ粒子とその使用方法

Country Status (5)

Country Link
EP (1) EP1362121A2 (fr)
JP (1) JP2004525607A (fr)
AU (1) AU2001281248A1 (fr)
CA (1) CA2418502A1 (fr)
WO (1) WO2002018643A2 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
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JP2006322709A (ja) * 2005-05-17 2006-11-30 Institute Of Physical & Chemical Research 物質固定化基板
JP2007064927A (ja) * 2005-09-02 2007-03-15 Nipro Corp 定性反応用試験片
US7491496B2 (en) 2004-04-01 2009-02-17 Seiko Epson Corporation Method for immobilizing nucleic acid and method for manufacturing biosensor using the same method
JP2009511042A (ja) * 2005-10-14 2009-03-19 ラプレジーン インコーポレーテッド 核酸の等温増幅方法及び核酸と信号プローブの同時等温増幅を用いた核酸の検出方法
JP2009122088A (ja) * 2006-08-10 2009-06-04 Furukawa Electric Co Ltd:The 吸光物質含有コロイドシリカ粒子を用いた生体分子の検出ないしは定量方法
JP2014507394A (ja) * 2010-12-23 2014-03-27 エフ．ホフマン−ラ ロシュ アーゲー 二価結合剤によるポリペプチド二量体の検出
JP2020046269A (ja) * 2018-09-18 2020-03-26 株式会社東芝 有機物プローブおよび分子検出装置

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US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
CA2262018C (fr) 1996-07-29 2007-10-02 Nanosphere Llc Nanoparticules sur lesquelles sont attaches des oligonucleotides et utilisations desdites nanoparticules
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
CA2396113C (fr) 2000-01-13 2009-04-07 Nanosphere, Inc. Nanoparticules auxquelles sont attaches des oligonucleotides et utilisations de ces dernieres
CA2415494C (fr) 2000-07-11 2007-09-18 Northwestern University Procede de detection par accroissement du marquage a l'argent
ATE403751T1 (de) 2001-11-09 2008-08-15 Nanosphere Inc Biokonjugat-nanopartikelsonden
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
FR2841156B1 (fr) * 2002-06-19 2004-09-10 Bio Merieux Nouvelles particules magnetiques fluorescentes,ainsi que les conjugues de telles particules et les compositions diagnostiques , therapeutiques ou prophylactiques les contenant
US7153687B2 (en) 2002-08-13 2006-12-26 Hong Kong Dna Chips Limited Apparatus and methods for detecting DNA in biological samples
JP4732683B2 (ja) * 2003-12-29 2011-07-27 ユニバーサル・バイオ・リサーチ株式会社 標的物質の検出方法
ES2242528B1 (es) * 2004-03-25 2006-12-01 Consejo Sup. Investig. Cientificas Nanoparticulas magneticas de metales nobles.
US20080213177A1 (en) * 2004-05-24 2008-09-04 Thomas William Rademacher Nanoparticles Comprising Rna Ligands
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
WO2012085064A1 (fr) 2010-12-23 2012-06-28 Roche Diagnostics Gmbh Détection d'un polypeptide à modification post-translationnelle par un agent de liaison bivalent
WO2012085111A1 (fr) 2010-12-23 2012-06-28 F. Hoffmann-La Roche Ag Complexe polypeptide-polynucléotide et son utilisation dans l'administration d'une fraction effectrice ciblée
US9335292B2 (en) 2011-10-13 2016-05-10 Auburn University Electrochemical proximity assay
GB2504240B (en) 2012-02-27 2015-05-27 Cellular Res Inc Compositions and kits for molecular counting of nucleic acids
JP6545682B2 (ja) 2013-08-28 2019-07-17 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 大規模並列単一細胞分析
EP3262192B1 (fr) 2015-02-27 2020-09-16 Becton, Dickinson and Company Codage à barres moléculaire à adressage spatial
ES2934982T3 (es) 2015-03-30 2023-02-28 Becton Dickinson Co Métodos para la codificación con códigos de barras combinatorios
US11390914B2 (en) 2015-04-23 2022-07-19 Becton, Dickinson And Company Methods and compositions for whole transcriptome amplification
CN108026524A (zh) 2015-09-11 2018-05-11 赛卢拉研究公司 用于核酸文库标准化的方法和组合物
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
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KR102522023B1 (ko) 2016-09-26 2023-04-17 셀룰러 리서치, 인크. 바코딩된 올리고뉴클레오티드 서열을 갖는 시약을 이용한 단백질 발현의 측정
US11319583B2 (en) 2017-02-01 2022-05-03 Becton, Dickinson And Company Selective amplification using blocking oligonucleotides
US10852274B2 (en) 2017-03-09 2020-12-01 Auburn University Differential circuit for background correction in electrochemical measurements
CA3059559A1 (fr) 2017-06-05 2018-12-13 Becton, Dickinson And Company Indexation d'echantillon pour des cellules uniques
US11505799B2 (en) 2017-07-07 2022-11-22 Innamed, Inc. Aptamers for measuring lipoprotein levels
CN112272710A (zh) 2018-05-03 2021-01-26 贝克顿迪金森公司 高通量多组学样品分析
CN112243461B (zh) 2018-05-03 2024-07-12 贝克顿迪金森公司 在相对的转录物末端进行分子条形码化
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US11932849B2 (en) 2018-11-08 2024-03-19 Becton, Dickinson And Company Whole transcriptome analysis of single cells using random priming
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US11661631B2 (en) 2019-01-23 2023-05-30 Becton, Dickinson And Company Oligonucleotides associated with antibodies
EP4004231A1 (fr) 2019-07-22 2022-06-01 Becton, Dickinson and Company Dosage de séquençage par immunoprécipitation de la chromatine monocellulaire
CN114729350A (zh) 2019-11-08 2022-07-08 贝克顿迪金森公司 使用随机引发获得用于免疫组库测序的全长v(d)j信息
CN115244184A (zh) 2020-01-13 2022-10-25 贝克顿迪金森公司 用于定量蛋白和rna的方法和组合物
US11661625B2 (en) 2020-05-14 2023-05-30 Becton, Dickinson And Company Primers for immune repertoire profiling
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
WO2022109343A1 (fr) 2020-11-20 2022-05-27 Becton, Dickinson And Company Profilage de protéines hautement exprimées et faiblement exprimées
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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491496B2 (en) 2004-04-01 2009-02-17 Seiko Epson Corporation Method for immobilizing nucleic acid and method for manufacturing biosensor using the same method
JP2006322709A (ja) * 2005-05-17 2006-11-30 Institute Of Physical & Chemical Research 物質固定化基板
JP2007064927A (ja) * 2005-09-02 2007-03-15 Nipro Corp 定性反応用試験片
JP2009511042A (ja) * 2005-10-14 2009-03-19 ラプレジーン インコーポレーテッド 核酸の等温増幅方法及び核酸と信号プローブの同時等温増幅を用いた核酸の検出方法
JP2009122088A (ja) * 2006-08-10 2009-06-04 Furukawa Electric Co Ltd:The 吸光物質含有コロイドシリカ粒子を用いた生体分子の検出ないしは定量方法
JP5089589B2 (ja) * 2006-08-10 2012-12-05 古河電気工業株式会社 吸光物質含有コロイドシリカ粒子、ナノ吸光材料、及び吸光標識ナノビーズキット
JP2014507394A (ja) * 2010-12-23 2014-03-27 エフ．ホフマン−ラ ロシュ アーゲー 二価結合剤によるポリペプチド二量体の検出
JP2020046269A (ja) * 2018-09-18 2020-03-26 株式会社東芝 有機物プローブおよび分子検出装置
JP7158969B2 (ja) 2018-09-18 2022-10-24 株式会社東芝 有機物プローブおよび分子検出装置

Also Published As

Publication number Publication date
CA2418502A1 (fr) 2002-03-07
EP1362121A2 (fr) 2003-11-19
WO2002018643A3 (fr) 2003-09-04
WO2002018643A9 (fr) 2003-11-06
AU2001281248A1 (en) 2002-03-13
WO2002018643A2 (fr) 2002-03-07

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