JP2004524837A5 - - Google Patents
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- JP2004524837A5 JP2004524837A5 JP2002560518A JP2002560518A JP2004524837A5 JP 2004524837 A5 JP2004524837 A5 JP 2004524837A5 JP 2002560518 A JP2002560518 A JP 2002560518A JP 2002560518 A JP2002560518 A JP 2002560518A JP 2004524837 A5 JP2004524837 A5 JP 2004524837A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- sequence number
- oligonucleotide
- nucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000002773 nucleotide Substances 0.000 claims 61
- 125000003729 nucleotide group Chemical group 0.000 claims 61
- 108091034117 Oligonucleotide Proteins 0.000 claims 51
- 108091033319 polynucleotide Proteins 0.000 claims 46
- 239000002157 polynucleotide Substances 0.000 claims 46
- 102000040430 polynucleotide Human genes 0.000 claims 46
- 239000012634 fragment Substances 0.000 claims 32
- 230000000295 complement effect Effects 0.000 claims 29
- 206010028980 Neoplasm Diseases 0.000 claims 28
- 238000000034 method Methods 0.000 claims 26
- 108020004414 DNA Proteins 0.000 claims 18
- 230000003211 malignant effect Effects 0.000 claims 17
- 201000011510 cancer Diseases 0.000 claims 15
- 230000011987 methylation Effects 0.000 claims 12
- 238000007069 methylation reaction Methods 0.000 claims 12
- 108091008146 restriction endonucleases Proteins 0.000 claims 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
- 208000032612 Glial tumor Diseases 0.000 claims 8
- 206010018338 Glioma Diseases 0.000 claims 8
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 7
- 206010006187 Breast cancer Diseases 0.000 claims 7
- 208000026310 Breast neoplasm Diseases 0.000 claims 7
- 206010009944 Colon cancer Diseases 0.000 claims 7
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 7
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 7
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 7
- 206010057644 Testis cancer Diseases 0.000 claims 7
- 208000029742 colonic neoplasm Diseases 0.000 claims 7
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 7
- 201000010536 head and neck cancer Diseases 0.000 claims 7
- 208000014829 head and neck neoplasm Diseases 0.000 claims 7
- 201000005202 lung cancer Diseases 0.000 claims 7
- 208000020816 lung neoplasm Diseases 0.000 claims 7
- 208000029340 primitive neuroectodermal tumor Diseases 0.000 claims 7
- 201000003120 testicular cancer Diseases 0.000 claims 7
- 108091029523 CpG island Proteins 0.000 claims 5
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 5
- 208000035269 cancer or benign tumor Diseases 0.000 claims 5
- 208000009277 Neuroectodermal Tumors Diseases 0.000 claims 3
- 229940104302 cytosine Drugs 0.000 claims 3
- 239000000499 gel Substances 0.000 claims 3
- 208000033383 Neuroendocrine tumor of pancreas Diseases 0.000 claims 2
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- 239000007795 chemical reaction product Substances 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000001962 electrophoresis Methods 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 2
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 239000000026 Pentaerythritol tetranitrate Substances 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 210000001654 germ layer Anatomy 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 238000003752 polymerase chain reaction Methods 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/775,398 US6893820B1 (en) | 2001-01-31 | 2001-01-31 | Detection of methylated CpG rich sequences diagnostic for malignant cells |
| PCT/US2002/003077 WO2002060318A2 (en) | 2001-01-31 | 2002-01-31 | Detection of methylated cpg rich sequences diagnostic for malignant cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004524837A JP2004524837A (ja) | 2004-08-19 |
| JP2004524837A5 true JP2004524837A5 (enExample) | 2005-08-04 |
Family
ID=25104283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002560518A Pending JP2004524837A (ja) | 2001-01-31 | 2002-01-31 | 悪性細胞についての、診断的メチル化ＣｐＧリッチ配列の検出 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US6893820B1 (enExample) |
| EP (1) | EP1373567A4 (enExample) |
| JP (1) | JP2004524837A (enExample) |
| CA (1) | CA2435770A1 (enExample) |
| WO (1) | WO2002060318A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6893820B1 (en) * | 2001-01-31 | 2005-05-17 | The Ohio State University Research Foundation | Detection of methylated CpG rich sequences diagnostic for malignant cells |
| AU2002323945B2 (en) * | 2001-08-23 | 2008-08-07 | Japan As Represented By President Of National Cancer Center | Method of evaluating degree of canceration of mammal-origin specimen |
| WO2004018668A1 (ja) * | 2002-08-23 | 2004-03-04 | Sumitomo Chemical Company, Limited | ヒト由来の検体の癌化度を評価する方法 |
| US8206913B1 (en) | 2003-03-07 | 2012-06-26 | Rubicon Genomics, Inc. | Amplification and analysis of whole genome and whole transcriptome libraries generated by a DNA polymerization process |
| EP1649052A1 (en) * | 2003-08-01 | 2006-04-26 | The University Of Western Australia | Methods and kits for predicting the likelihood of successful treatment of cancer |
| CN101985619B (zh) * | 2003-10-08 | 2014-08-20 | 波士顿大学信托人 | 染色体异常的产前诊断方法 |
| US20050208538A1 (en) | 2003-12-29 | 2005-09-22 | Nurith Kurn | Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids |
| EP1725682B1 (en) * | 2004-03-08 | 2015-09-09 | Rubicon Genomics, Inc. | Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of dna methylation |
| US20070048751A1 (en) * | 2005-02-15 | 2007-03-01 | Jae-Heup Kim | Method of diagnosing type II diabetes mellitus using multilocus marker, polynucleotide including marker associated with type II diabetes mellitus, and microarray and diagnostic kit including the polynucleotide |
| EP1924705A1 (en) | 2005-08-02 | 2008-05-28 | Rubicon Genomics, Inc. | Isolation of cpg islands by thermal segregation and enzymatic selection-amplification method |
| EP1924704B1 (en) | 2005-08-02 | 2011-05-25 | Rubicon Genomics, Inc. | Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction |
| US7465544B2 (en) * | 2006-01-11 | 2008-12-16 | Wisconsin Alumni Research Foundation | Synthetic cofactor analogs of S-adenosylmethionine as ligatable probes of biological methylation and methods for their use |
| US20080003609A1 (en) * | 2006-05-10 | 2008-01-03 | The Cleveland Clinic Foundation | Method of detecting bladder urothelial carcinoma |
| US20090181078A1 (en) * | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| US8273361B2 (en) | 2006-09-26 | 2012-09-25 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| CN101153336B (zh) * | 2006-09-27 | 2011-09-07 | 香港中文大学 | 检测dna甲基化程度的方法和试剂盒 |
| US20080102452A1 (en) * | 2006-10-31 | 2008-05-01 | Roberts Douglas N | Control nucleic acid constructs for use in analysis of methylation status |
| JP5151167B2 (ja) * | 2007-01-31 | 2013-02-27 | 住友化学株式会社 | Ｄｎａメチル化測定方法 |
| US20100184037A1 (en) * | 2007-03-02 | 2010-07-22 | The Ohio State University Research Foundation | Death associated protein kinase 1 (dapk1) and uses thereof for the treatment of chronic lympocytic leukemia |
| LT2437753T (lt) | 2009-06-05 | 2016-12-12 | Infectious Disease Research Institute | Sintetiniai gliukopiranozillipidų adjuvantai ir juos turinčios vakcinų kompozicijos |
| WO2012141984A1 (en) | 2011-04-08 | 2012-10-18 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| EP2769007B1 (en) | 2011-10-19 | 2016-12-07 | Nugen Technologies, Inc. | Compositions and methods for directional nucleic acid amplification and sequencing |
| WO2013112923A1 (en) | 2012-01-26 | 2013-08-01 | Nugen Technologies, Inc. | Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation |
| US11510875B2 (en) | 2012-02-07 | 2022-11-29 | Access To Advanced Health Institute | Adjuvant formulations comprising TLR4 agonists and methods of using the same |
| LT2850431T (lt) | 2012-05-16 | 2018-06-25 | Immune Design Corp. | Vakcinos, skirtos hsv-2 |
| WO2013191775A2 (en) | 2012-06-18 | 2013-12-27 | Nugen Technologies, Inc. | Compositions and methods for negative selection of non-desired nucleic acid sequences |
| US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
| WO2014144092A1 (en) | 2013-03-15 | 2014-09-18 | Nugen Technologies, Inc. | Sequential sequencing |
| KR102039520B1 (ko) | 2013-04-18 | 2019-11-01 | 이뮨 디자인 코포레이션 | 암 치료에 이용하기 위한 gla 단일요법 |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| WO2015073711A1 (en) | 2013-11-13 | 2015-05-21 | Nugen Technologies, Inc. | Compositions and methods for identification of a duplicate sequencing read |
| IL310015B1 (en) | 2013-12-31 | 2025-10-01 | Access To Advanced Health Inst | Single vial formulation |
| WO2015131107A1 (en) | 2014-02-28 | 2015-09-03 | Nugen Technologies, Inc. | Reduced representation bisulfite sequencing with diversity adaptors |
| US10102337B2 (en) | 2014-08-06 | 2018-10-16 | Nugen Technologies, Inc. | Digital measurements from targeted sequencing |
| EP3209801B1 (en) | 2014-10-20 | 2023-06-28 | Commonwealth Scientific and Industrial Research Organisation | Genome methylation analysis |
| JP7140684B2 (ja) | 2016-06-01 | 2022-09-21 | アクセス ツー アドバンスト ヘルス インスティチュート | サイジング剤含有ナノアラム粒子 |
| US12492430B2 (en) | 2017-04-11 | 2025-12-09 | Tecan Genomics, Inc. | Library quantitation and qualification |
| CA3078223A1 (en) | 2017-09-08 | 2019-03-14 | Infectious Disease Research Institute | Liposomal formulations comprising saponin and methods of use |
| US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
| CN114340665A (zh) | 2019-05-25 | 2022-04-12 | 传染病研究所 | 用于对佐剂疫苗乳剂进行喷雾干燥的组合物和方法 |
| CN113275053A (zh) | 2020-02-03 | 2021-08-20 | 帝肯基因组学公司 | 试剂存储系统 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6017704A (en) * | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| DE19754482A1 (de) | 1997-11-27 | 1999-07-01 | Epigenomics Gmbh | Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke |
| US6331393B1 (en) * | 1999-05-14 | 2001-12-18 | University Of Southern California | Process for high-throughput DNA methylation analysis |
| US6893820B1 (en) * | 2001-01-31 | 2005-05-17 | The Ohio State University Research Foundation | Detection of methylated CpG rich sequences diagnostic for malignant cells |
-
2001
- 2001-01-31 US US09/775,398 patent/US6893820B1/en not_active Expired - Lifetime
-
2002
- 2002-01-31 WO PCT/US2002/003077 patent/WO2002060318A2/en not_active Ceased
- 2002-01-31 EP EP02709295A patent/EP1373567A4/en not_active Withdrawn
- 2002-01-31 CA CA 2435770 patent/CA2435770A1/en not_active Abandoned
- 2002-01-31 JP JP2002560518A patent/JP2004524837A/ja active Pending
-
2004
- 2004-05-10 US US10/842,072 patent/US20050158731A1/en not_active Abandoned
-
2007
- 2007-05-01 US US11/742,663 patent/US20070259364A1/en not_active Abandoned
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