JP2004524806A5 - - Google Patents
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- Publication number
- JP2004524806A5 JP2004524806A5 JP2002507992A JP2002507992A JP2004524806A5 JP 2004524806 A5 JP2004524806 A5 JP 2004524806A5 JP 2002507992 A JP2002507992 A JP 2002507992A JP 2002507992 A JP2002507992 A JP 2002507992A JP 2004524806 A5 JP2004524806 A5 JP 2004524806A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- chimeric protein
- seq
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 description 22
- 102000037865 fusion proteins Human genes 0.000 description 13
- 108020001507 fusion proteins Proteins 0.000 description 13
- 238000000034 method Methods 0.000 description 13
- 239000003795 chemical substances by application Substances 0.000 description 9
- 102000039446 nucleic acids Human genes 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 150000007523 nucleic acids Chemical class 0.000 description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
- 108010029697 CD40 Ligand Proteins 0.000 description 5
- 102100032937 CD40 ligand Human genes 0.000 description 5
- 108010002350 Interleukin-2 Proteins 0.000 description 5
- 102000000588 Interleukin-2 Human genes 0.000 description 5
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 5
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 5
- 239000002955 immunomodulating agent Substances 0.000 description 5
- 230000002584 immunomodulator Effects 0.000 description 5
- 229940121354 immunomodulator Drugs 0.000 description 5
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 5
- 102000003814 Interleukin-10 Human genes 0.000 description 4
- 108090000174 Interleukin-10 Proteins 0.000 description 4
- 108010090804 Streptavidin Proteins 0.000 description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
- 102000019034 Chemokines Human genes 0.000 description 3
- 108010012236 Chemokines Proteins 0.000 description 3
- 102000013462 Interleukin-12 Human genes 0.000 description 3
- 108010065805 Interleukin-12 Proteins 0.000 description 3
- 102000003812 Interleukin-15 Human genes 0.000 description 3
- 108090000172 Interleukin-15 Proteins 0.000 description 3
- 108090000978 Interleukin-4 Proteins 0.000 description 3
- 102100035304 Lymphotactin Human genes 0.000 description 3
- 229960002685 biotin Drugs 0.000 description 3
- 235000020958 biotin Nutrition 0.000 description 3
- 239000011616 biotin Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 108010019677 lymphotactin Proteins 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- 101710112752 Cytotoxin Proteins 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 231100000599 cytotoxic agent Toxicity 0.000 description 2
- 239000002619 cytotoxin Substances 0.000 description 2
- 230000003828 downregulation Effects 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000003827 upregulation Effects 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000009329 Graft vs Host Disease Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 208000024908 graft versus host disease Diseases 0.000 description 1
- 210000002064 heart cell Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- JJGWLCLUQNFDIS-GTSONSFRSA-M sodium;1-[6-[5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoyloxy]-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)CCCCCNC(=O)CCCC[C@H]1[C@H]2NC(=O)N[C@H]2CS1 JJGWLCLUQNFDIS-GTSONSFRSA-M 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21558000P | 2000-06-30 | 2000-06-30 | |
| PCT/US2001/020946 WO2002002751A2 (en) | 2000-06-30 | 2001-07-02 | Alteration of cell membrane |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004524806A JP2004524806A (ja) | 2004-08-19 |
| JP2004524806A5 true JP2004524806A5 (https=) | 2008-08-07 |
Family
ID=22803538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002507992A Pending JP2004524806A (ja) | 2000-06-30 | 2001-07-02 | 新しい機能のための細胞膜の変更 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US7238360B2 (https=) |
| EP (1) | EP1299522B1 (https=) |
| JP (1) | JP2004524806A (https=) |
| AT (1) | ATE531789T1 (https=) |
| AU (2) | AU1676302A (https=) |
| CA (1) | CA2413237C (https=) |
| WO (1) | WO2002002751A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7927602B2 (en) * | 2002-07-23 | 2011-04-19 | University Of Louisville Research Foundation, Inc. | Fas ligand-avidin/streptavidin fusion proteins |
| EP1299522B1 (en) | 2000-06-30 | 2011-11-02 | University Of Louisville Research Foundation, Inc. | Alteration of cell membrane |
| EP1558086A4 (en) * | 2002-06-14 | 2008-03-05 | Univ Case Western Reserve | Cell taring process and compositions |
| US7373559B2 (en) * | 2003-09-11 | 2008-05-13 | Copan Systems, Inc. | Method and system for proactive drive replacement for high availability storage systems |
| CA2605863C (en) * | 2005-04-29 | 2016-07-05 | University Of Louisville Research Foundation, Inc. | Cell-surface decoration with active agents |
| CN101355965A (zh) | 2005-06-08 | 2009-01-28 | 达纳－法伯癌症研究院 | 通过抑制程序性细胞死亡1（pd-1）途经治疗持续性感染和癌症的方法及组合物 |
| JP5564181B2 (ja) * | 2005-12-08 | 2014-07-30 | シルワン，ハヴァル | 免疫刺激組成物および方法 |
| WO2007067683A2 (en) * | 2005-12-08 | 2007-06-14 | University Of Louisville Research Foundation, Inc. | Methods and compositions for expanding t regulatory cells |
| WO2007123636A2 (en) * | 2006-03-27 | 2007-11-01 | Children's Hospital & Regional Medical Center | Compositions and methods comprising the use of cell surface displayed homing endonucleases |
| CN103536915A (zh) * | 2006-12-27 | 2014-01-29 | 埃默里大学 | 用于治疗传染病和肿瘤的组合物和方法 |
| CA2744449C (en) * | 2008-11-28 | 2019-01-29 | Emory University | Methods for the treatment of infections and tumors |
| WO2012011113A2 (en) * | 2010-07-22 | 2012-01-26 | Shai Yarkoni | Regulatory immune cells with enhanced targeted cell death effect |
| EP3313429B1 (en) | 2015-06-19 | 2021-10-06 | University Of Louisville Research Foundation, Inc. | Immunomodulation for the long term prevention and treatment of autoimmune diseases and foreign tissue rejection |
| ES2970269T3 (es) | 2015-07-29 | 2024-05-27 | Onk Therapeutics Ltd | Linfocitos citolíticos naturales modificados y líneas de linfocitos citolíticos naturales que tienen citotoxicidad aumentada |
| US10906951B2 (en) | 2015-07-29 | 2021-02-02 | Onk Therapeutics Limited | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
| EP3592392B1 (en) * | 2017-03-10 | 2023-09-13 | University of Louisville Research Foundation, Inc. | Fasl-engineered biomaterials with immunomodulatory function |
| CA3096533C (en) | 2018-04-27 | 2023-08-29 | Aimed Bio Inc. | Magnetic-based biopanning method through attachment of magnetic bead to cell |
| US11504335B2 (en) | 2018-06-18 | 2022-11-22 | University Of Kentucky Research Foundation | Increased cell retention in diseased site when cells encapsulated in gelatin methacrylate and polyethylene glycol diacrylate hydrogels |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04501808A (ja) * | 1989-07-06 | 1992-04-02 | セラジェン・インコーポレーテッド | ハイブリッド分子 |
| US6071716A (en) | 1990-10-01 | 2000-06-06 | Dana-Farber Cancer Institute | DNA encoding, B7, a new member of the IG superfamily with unique expression on activated and neoplastic B cells |
| US5470701A (en) * | 1993-02-24 | 1995-11-28 | The Regents Of The University Of California | Method for determining favorable prognosis in an HIV positive subject using HLA-DR+ /CD38- CD8bright cells |
| US5858776A (en) | 1993-11-03 | 1999-01-12 | Repligen Corporation | Tumor cells with increased immunogenicity and uses therefor |
| US6130316A (en) | 1993-07-26 | 2000-10-10 | Dana Farber Cancer Institute | Fusion proteins of novel CTLA4/CD28 ligands and uses therefore |
| US6218510B1 (en) | 1994-03-02 | 2001-04-17 | Brigham & Woman's Hospital | B7-1 and B7-2 polypeptides |
| AU708239B2 (en) | 1995-06-29 | 1999-07-29 | Immunex Corporation | Cytokine that induces apoptosis |
| US6004942A (en) | 1995-08-30 | 1999-12-21 | The Regents Of The University Of California | Methods for treating arthritis by administering an apoptosis regulator |
| GB9523469D0 (en) | 1995-11-16 | 1996-01-17 | Sandoz Ltd | Organic compounds |
| WO1997033617A1 (en) | 1996-03-13 | 1997-09-18 | Protein Design Labs, Inc. | Fas ligand fusion proteins and their uses |
| US6060054A (en) | 1996-04-10 | 2000-05-09 | National Jewish Medical And Research Center | Product for T lymphocyte immunosuppression |
| AU5437098A (en) | 1996-11-15 | 1998-06-03 | Health Research Inc. | A method for inducing apoptosis of primary central nervous system b cell lymphomas |
| GB9721075D0 (en) | 1997-10-03 | 1997-12-03 | Cancer Res Campaign Tech | Materials and methods relating to the stimulation of cells |
| US7144991B2 (en) | 1999-06-07 | 2006-12-05 | Aletheon Pharmaceuticals, Inc. | Streptavidin expressed gene fusions and methods of use thereof |
| EP1238095A4 (en) | 1999-12-16 | 2004-07-28 | Univ Louisville Res Found | COMPOSITIONS AND METHODS FOR CASPASE-INDUCED APOPTOSIS |
| US7927602B2 (en) | 2002-07-23 | 2011-04-19 | University Of Louisville Research Foundation, Inc. | Fas ligand-avidin/streptavidin fusion proteins |
| ATE481475T1 (de) | 2000-01-24 | 2010-10-15 | Univ Louisville Res Found | Immunmodulation mit rezeptorinduziertem tod durch apoptosis |
| EP1299522B1 (en) | 2000-06-30 | 2011-11-02 | University Of Louisville Research Foundation, Inc. | Alteration of cell membrane |
| WO2007067683A2 (en) | 2005-12-08 | 2007-06-14 | University Of Louisville Research Foundation, Inc. | Methods and compositions for expanding t regulatory cells |
| JP5564181B2 (ja) | 2005-12-08 | 2014-07-30 | シルワン，ハヴァル | 免疫刺激組成物および方法 |
-
2001
- 2001-07-02 EP EP01984107A patent/EP1299522B1/en not_active Expired - Lifetime
- 2001-07-02 WO PCT/US2001/020946 patent/WO2002002751A2/en not_active Ceased
- 2001-07-02 AT AT01984107T patent/ATE531789T1/de active
- 2001-07-02 JP JP2002507992A patent/JP2004524806A/ja active Pending
- 2001-07-02 CA CA2413237A patent/CA2413237C/en not_active Expired - Fee Related
- 2001-07-02 AU AU1676302A patent/AU1676302A/xx active Pending
- 2001-07-02 AU AU2002216763A patent/AU2002216763B2/en not_active Ceased
- 2001-07-02 US US10/312,245 patent/US7238360B2/en not_active Expired - Lifetime
-
2007
- 2007-06-25 US US11/819,080 patent/US8076096B2/en not_active Expired - Fee Related
-
2011
- 2011-12-12 US US13/316,915 patent/US8728747B2/en not_active Expired - Fee Related
-
2014
- 2014-05-19 US US14/280,940 patent/US9255133B2/en not_active Expired - Fee Related
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