JP2004523747A - ２−ｄｇｅ用試料調製のための免疫サブトラクション法 - Google Patents

２−ｄｇｅ用試料調製のための免疫サブトラクション法 Download PDF

Info

Publication number
JP2004523747A
JP2004523747A JP2002556705A JP2002556705A JP2004523747A JP 2004523747 A JP2004523747 A JP 2004523747A JP 2002556705 A JP2002556705 A JP 2002556705A JP 2002556705 A JP2002556705 A JP 2002556705A JP 2004523747 A JP2004523747 A JP 2004523747A
Authority
JP
Japan
Prior art keywords
receptor
ligand
protein
matrix
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2002556705A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004523747A5 (enExample
Inventor
ピーパー，レムバート
アンダーソン，エヌ・レイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2004523747A publication Critical patent/JP2004523747A/ja
Publication of JP2004523747A5 publication Critical patent/JP2004523747A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/14—Preparation by elimination of some components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44773—Multi-stage electrophoresis, e.g. two-dimensional electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2002556705A 2001-01-09 2002-01-09 ２−ｄｇｅ用試料調製のための免疫サブトラクション法 Ceased JP2004523747A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26021701P 2001-01-09 2001-01-09
US09/977,358 US7691645B2 (en) 2001-01-09 2001-10-16 Immunosubtraction method
PCT/US2002/000060 WO2002055654A2 (en) 2001-01-09 2002-01-09 Immunosubtraction method for sample preparation for 2-dge

Publications (2)

Publication Number Publication Date
JP2004523747A true JP2004523747A (ja) 2004-08-05
JP2004523747A5 JP2004523747A5 (enExample) 2005-12-22

Family

ID=26947809

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002556705A Ceased JP2004523747A (ja) 2001-01-09 2002-01-09 ２−ｄｇｅ用試料調製のための免疫サブトラクション法

Country Status (4)

Country Link
US (2) US7691645B2 (enExample)
EP (1) EP1349915A4 (enExample)
JP (1) JP2004523747A (enExample)
WO (1) WO2002055654A2 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002951240A0 (en) 2002-08-23 2002-09-19 Royal Women's Hospital Depletion of plasma proteins
AU2003250621C1 (en) * 2002-08-23 2010-03-11 Inex Innovations Exchange Pte Ltd Depletion of plasma proteins
US7632686B2 (en) 2002-10-03 2009-12-15 Anderson Forschung Group High sensitivity quantitation of peptides by mass spectrometry
WO2004072647A1 (en) * 2003-02-07 2004-08-26 Beyond Genomics Removal of proteins from a sample
US20050233390A1 (en) * 2003-04-09 2005-10-20 Allen John W Device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor
US20050037331A1 (en) * 2003-08-13 2005-02-17 William Galbraith Apparatuses and methods for reducing albumin in samples
AU2004205158B1 (en) * 2003-08-21 2005-02-10 Macquarie University Detecting molecules
WO2005019243A1 (en) * 2003-08-21 2005-03-03 Macquarie University Detecting molecules
US20050106740A1 (en) * 2003-11-13 2005-05-19 Boyes Barry E. Methods, systems and devices for performing analytical protocols
US20060275923A1 (en) * 2004-03-23 2006-12-07 Hammond David J Methods for reducing the range in concentrations of analyte species in a sample
EP1580559B1 (en) 2004-03-23 2013-12-25 Bio-Rad Laboratories, Inc. Methods for reducing the variance between analyte concentrations taken from complex sample mixtures
US20060154318A1 (en) * 2004-06-09 2006-07-13 Anderson Norman L Stable isotope labeled polypeptide standards for protein quantitation
WO2006008143A2 (en) * 2004-07-19 2006-01-26 Grace Gmbh & Co. Kg Apparatus components and methods of using apparatus components to detect the presence of an analyte
US7449116B2 (en) 2004-10-01 2008-11-11 Agilent Technologies, Inc. Methods and systems for protein separation
US7943046B2 (en) 2004-10-01 2011-05-17 Agilent Technologies, Inc Methods and systems for on-column protein delipidation
US20110077164A1 (en) * 2004-10-23 2011-03-31 Andras Guttman Expression profiling platform technology
ATE553385T1 (de) * 2004-10-23 2012-04-15 Biosystems Technology Corp Plattformtechnologie zur expressionsprofilierung
AU2006204591B2 (en) * 2005-01-06 2011-08-04 Macquarie University Detecting molecules
WO2006072140A1 (en) * 2005-01-06 2006-07-13 Macquarie University Detecting molecules
US7704360B2 (en) * 2005-03-14 2010-04-27 Agilent Technologies, Inc. Devices and methods for separating sample constituents
WO2006102542A2 (en) * 2005-03-23 2006-09-28 Bio-Rad Laboratories, Inc. Diverse chemical libraries bound to small particles with paramagnetic properties
US20090247421A1 (en) * 2005-03-23 2009-10-01 Egisto Boschetti Diverse chemical libraries bound to small particles with paramagnetic properties
JP4841618B2 (ja) * 2005-03-23 2011-12-21 バイオ−ラッド ラボラトリーズ インコーポレーティッド タンパク質を精製するための方法
US20070048795A1 (en) * 2005-08-26 2007-03-01 Xiangming Fang Immunoaffinity separation and analysis compositions and methods
US20080008699A1 (en) * 2005-10-28 2008-01-10 Jianxun Li Method for proteomic analysis utilizing immune recognition and cumulative subtraction
US20070161120A1 (en) * 2006-01-10 2007-07-12 Viorica Lopez-Avila Ceruloplasmin Assay
WO2008058325A1 (en) * 2006-11-13 2008-05-22 Healthlinx Limited Immunoaffinity compositions for immunodepletion of proteins
JP5346289B2 (ja) 2007-07-20 2013-11-20 国立大学法人岩手大学 ネコタンパク尿診断薬
US8444935B2 (en) * 2009-06-12 2013-05-21 Bose Corporation Multiple-specimen device testing with particle measurement
CN103180727B (zh) * 2010-10-27 2015-12-16 通用电气健康护理生物科学股份公司 具有保护柱的色谱系统
EP2726877B1 (en) * 2011-06-29 2018-10-17 GE Healthcare Bio-Sciences AB Method for specific identification of target biomolecules
EP2656892A1 (en) * 2012-04-23 2013-10-30 Merck Patent GmbH Chromatography method
US9494606B2 (en) * 2012-05-09 2016-11-15 President And Fellows Of Harvard College Quantification of lipoproteins
DE102012018234A1 (de) * 2012-09-17 2014-03-20 Magnamedics Gmbh Abtrennung von Proteinen
US20160231334A1 (en) * 2013-10-28 2016-08-11 The Forsyth Institute Compositions and Methods for Evaluating Metabolic Syndrome and Related Diseases
JP6694509B2 (ja) * 2015-12-18 2020-05-13 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 自動化された臨床診断システムおよび方法
US11067548B2 (en) 2016-04-04 2021-07-20 Entech Instruments Inc. Multi-capillary column pre-concentration system for enhanced sensitivity in gas chromatography (GC) and gas chromatography-mass spectrometry (GCMS)
WO2018067686A2 (en) * 2016-10-04 2018-04-12 The Regents Of The University Of Michigan Multi-channel multi-dimensional comprehensive gas chromatography
WO2019084039A1 (en) 2017-10-25 2019-05-02 Entech Instruments Inc. SAMPLE PRECONCENTRATION SYSTEM AND METHOD FOR USE WITH GAS PHASE CHROMATOGRAPHY
US11162925B2 (en) 2017-11-03 2021-11-02 Entech Instruments Inc. High performance sub-ambient temperature multi-capillary column preconcentration system for volatile chemical analysis by gas chromatography
CN115087866A (zh) * 2020-02-21 2022-09-20 株式会社岛津制作所 液相色谱仪
WO2022006335A1 (en) 2020-06-30 2022-01-06 Entech Instruments Inc. System and method for trace-level analysis of chemical compounds
EP3961207B1 (en) * 2020-08-25 2024-10-23 Postnova Analytics GmbH Method of fractionating a heterogeneous sample and apparatus for such a method

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4375414A (en) * 1971-05-20 1983-03-01 Meir Strahilevitz Immunological methods for removing species from the blood circulatory system and devices therefor
BE793185A (fr) * 1971-12-23 1973-04-16 Atomic Energy Commission Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques
JPS59962B2 (ja) * 1973-08-15 1984-01-10 富士写真フイルム株式会社 ジキキロクバイタイヨウフンマツジセイザイリヨウ オヨビ セイゾウホウホウ
DE2632478A1 (de) * 1975-07-23 1977-02-24 Coulter Electronics Verfahren zur erfassung und trennung von antigenen und antikoerperchen im blut und in anderen proben
US4722896A (en) * 1981-01-26 1988-02-02 The Beth Israel Hospital Association Method for affinity purification of hybridoma antibodies
US4427653A (en) * 1981-01-26 1984-01-24 President And Fellows Of Harvard College Method of making monoclonal antibodies
US4708931A (en) * 1984-06-01 1987-11-24 Regents Of University Of California Laminated rod having alternating detection and spacer layers for binding assays
US5879881A (en) * 1985-04-04 1999-03-09 Hybritech, Incorporated Solid phase system for use in ligand-receptor assays
US4806313A (en) * 1985-04-12 1989-02-21 E. I. Du Pont De Nemours And Company Rapid assay processor
CA1291031C (en) * 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US5470560A (en) * 1987-01-20 1995-11-28 Genentech, Inc. Method for evaluating immunogenicity
US5137808A (en) * 1987-04-07 1992-08-11 Syntex (U.S.A.) Inc. Immunoassay device
US4963263A (en) * 1988-03-24 1990-10-16 Terrapin Technologies, Inc. Method of identity analyte-binding peptides
FR2638848B1 (fr) * 1988-11-04 1993-01-22 Chemunex Sa Procede de detection et/ou de dosage dans un milieu liquide ou semi-liquide d'au moins une substance organique, biologique ou medicamenteuse soluble, par une methode d'agglutination
US5135627A (en) * 1990-10-15 1992-08-04 Soane Technologies, Inc. Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography
CA2083820A1 (en) * 1991-03-28 1992-09-29 Noubar B. Afeyan On-line product identification in a chromatography effluent by substraction
US5228960A (en) * 1992-07-17 1993-07-20 Beckman Instruments, Inc. Analysis of samples by capillary electrophoretic immunosubtraction
US5372783A (en) * 1992-08-03 1994-12-13 Sapidyne, Inc. Assay system
EP0688426A1 (en) * 1993-03-08 1995-12-27 WAINWRIGHT, Norman Aligned fiber diagnostic chromatography
US5998222A (en) * 1993-11-29 1999-12-07 Utah State University Reconditioning antibiotic-adulterated milk products
US5695928A (en) * 1993-12-10 1997-12-09 Novartis Corporation Rapid immunoassay for detection of antibodies or antigens incorporating simultaneous sample extraction and immunogenic reaction
US5567282A (en) * 1994-01-25 1996-10-22 Wang; Hann-Ping On-capillary electrophoretic immunosubtraction for classification and typing of M-proteins
EP0671626B1 (en) * 1994-03-08 2000-01-12 Zeptosens AG Device and method for combined bioaffinity assay and electrophoretic separation
EP0835446B1 (en) 1995-06-26 2003-04-09 Perseptive Biosystems, Inc. High speed, automated, continuous flow, multi-dimensional molecular selection and analysis
JPH0933504A (ja) 1995-07-25 1997-02-07 Nikon Corp イムノクロマトグラフィカラム、その製造方法 及び使用方法
WO1998005791A1 (en) * 1996-08-02 1998-02-12 Immunivest Corporation Method to select and transfect cell subpopulations
AU735213B2 (en) * 1996-09-05 2001-07-05 Research Foundation Of State University Of New York, The Phospholipase D and DNA sequences
ATE239274T1 (de) * 1996-10-25 2003-05-15 Larsen Peter Mose Proteom-analyse zum charakterisieren von auf- und abgeregelten proteinen in biologischen proben
GB9705949D0 (en) * 1997-03-21 1997-05-07 Electrophoretics International Diagnosis of tumours and other abnormalities of body cells
US5958738A (en) * 1997-03-24 1999-09-28 Roche Diagnostics Corporation Procedure for subtractive hybridization and difference analysis
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US5993627A (en) * 1997-06-24 1999-11-30 Large Scale Biology Corporation Automated system for two-dimensional electrophoresis
US5952423A (en) 1997-07-18 1999-09-14 Baxter International Inc. Plastic compositions for medical containers and methods for providing such containers and for storing red blood cells
US6242262B1 (en) * 1997-10-24 2001-06-05 The University Of North Carolina At Chapel Hill Method and apparatus for screening catalyst libraries
WO1999064867A1 (en) * 1997-12-04 1999-12-16 Amersham Pharmacia Biotech Uk Limited Multiple assay method
US6410692B2 (en) * 1998-02-02 2002-06-25 Novadx, Inc. Removal of abundant interfering proteins from a liquid sample using a collapsible affinity matrix
AU6261998A (en) 1998-02-02 1999-08-16 Novadx Removal of abundant interfering proteins from a liquid sample using a collapsible affinity matrix
US6455263B2 (en) * 1998-03-24 2002-09-24 Rigel Pharmaceuticals, Inc. Small molecule library screening using FACS
EP1068532A4 (en) * 1998-04-15 2003-07-16 Univ Utah State REAL-TIME DETECTION OF ANTIBODIES
GB9811656D0 (en) * 1998-05-29 1998-07-29 Oxford Glycosciences Uk Ltd Gels, methods and apparatus for identification and characterization of biomolecules
GB9814008D0 (en) 1998-06-30 1998-08-26 Cambridge Sensors Ltd Method for the analysis of fluids
US6642062B2 (en) * 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
US6245227B1 (en) * 1998-09-17 2001-06-12 Kionix, Inc. Integrated monolithic microfabricated electrospray and liquid chromatography system and method
US6136610A (en) * 1998-11-23 2000-10-24 Praxsys Biosystems, Inc. Method and apparatus for performing a lateral flow assay
EP1006362A1 (en) 1998-12-02 2000-06-07 Michael Dr. Cahill Method and apparatus for the separation of components from a biological material
DE60044490D1 (de) * 1999-02-23 2010-07-15 Caliper Life Sciences Inc Manipulation von mikroteilchen in mikrofluiden systemen
US6696304B1 (en) * 1999-02-24 2004-02-24 Luminex Corporation Particulate solid phase immobilized protein quantitation
US20030186329A1 (en) * 1999-03-22 2003-10-02 The Scripps Research Institute Use of substrate subtraction libraries to distinguish enzyme specificities
US6309605B1 (en) * 1999-05-05 2001-10-30 Millipore Corporation Well(s) containing filtration devices
US6294392B1 (en) * 1999-07-21 2001-09-25 The Regents Of The University Of California Spatially-encoded analyte detection
US6783929B1 (en) * 1999-11-02 2004-08-31 Chiron Corporation Biological sample component purification and differential display
ATE333718T1 (de) * 1999-11-19 2006-08-15 Ami Semiconductor Belgium Bvba Regler für einen sinuswellengenerator und sinuswellengenerator mit einem solchen regler
FR2801586B1 (fr) * 1999-11-29 2002-09-20 Oreal Compositions cosmetiques photoprotectrices contenant des derives aminoamidines et utilisations
WO2001044269A2 (en) * 1999-12-17 2001-06-21 Large Scale Proteomics Corporation Brain protein markers
US6539102B1 (en) * 2000-09-01 2003-03-25 Large Scale Proteomics Reference database
US6980674B2 (en) 2000-09-01 2005-12-27 Large Scale Proteomics Corp. Reference database
US20020072492A1 (en) * 2000-09-12 2002-06-13 Myers Timothy G. Non-genetic based protein disease markers
WO2002039120A1 (en) 2000-11-09 2002-05-16 Bionova Pharmaceutials, Inc. A method for identifying the proteome of cells using an antibody library microarray
US6649419B1 (en) * 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation
US20030032017A1 (en) 2001-08-03 2003-02-13 Large Scale Proteomics, Corp. Quantification of low molecular weight and low abundance proteins using high resolution two-dimensional electrophoresis and mass spectrometry
US7632686B2 (en) 2002-10-03 2009-12-15 Anderson Forschung Group High sensitivity quantitation of peptides by mass spectrometry

Also Published As

Publication number Publication date
WO2002055654A2 (en) 2002-07-18
US20020127739A1 (en) 2002-09-12
US20040115725A1 (en) 2004-06-17
US7642089B2 (en) 2010-01-05
US7691645B2 (en) 2010-04-06
WO2002055654A3 (en) 2002-09-19
EP1349915A2 (en) 2003-10-08
EP1349915A4 (en) 2008-02-27

Similar Documents

Publication Publication Date Title
US7642089B2 (en) Immunosubtraction method
Pieper et al. Multi‐component immunoaffinity subtraction chromatography: An innovative step towards a comprehensive survey of the human plasma proteome
Křenková et al. Immobilized microfluidic enzymatic reactors
US6794148B2 (en) High speed, automated, continuous flow, multi-dimensional molecular selection and analysis
CA2501000C (en) High sensitivity quantitation of peptides by mass spectrometry
JP3287578B2 (ja) 生物学および医学に応用される被保持物クロマトグラフィーおよびタンパク質チップアレイ
Ahmed et al. Strategies for revealing lower abundance proteins in two-dimensional protein maps
JP2004523747A5 (enExample)
Hage et al. Affinity chromatography: a historical perspective
JP2003010647A (ja) 蛋白質を操作する方法及び装置
CA2032389A1 (en) Reagents
Simó et al. Performance of combinatorial peptide libraries in capturing the low-abundance proteome of red blood cells. 1. Behavior of mono-to hexapeptides
JP2007513327A (ja) 分析プロトコルを実行するための方法、システム、及び装置
US6635420B1 (en) Purification of substances from a biological sample
US20080176254A1 (en) Affinity separation compositions and methods
US20050095726A1 (en) Novel high protein tortillas
Bachi et al. Performance of combinatorial peptide libraries in capturing the low-abundance proteome of red blood cells. 2. Behavior of resins containing individual amino acids
US20070048795A1 (en) Immunoaffinity separation and analysis compositions and methods
CA2489151A1 (en) Method for enriching and tracking pathologic modified prions-proteins (prpsc)
Millea et al. Subproteomics in analytical chemistry: Chromatographic fractionation techniques in the characterization of proteins and peptides
Anusha et al. A overview on affinity chromatography: a review
EP1806584A1 (en) Compositions for separation of a plurality of distinct targets from a sample
US20030082560A1 (en) Method of making interactive protein arrays
EP1300679A2 (en) Molecular selection and analysis
JP2006026607A (ja) アフィニティークロマトグラフィー用吸着体

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050111

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050111

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080205

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080507

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080909

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081209

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081216

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090109

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090602

A045 Written measure of dismissal of application [lapsed due to lack of payment]

Free format text: JAPANESE INTERMEDIATE CODE: A045

Effective date: 20091027