JP2004523545A5 - - Google Patents
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- Publication number
- JP2004523545A5 JP2004523545A5 JP2002564485A JP2002564485A JP2004523545A5 JP 2004523545 A5 JP2004523545 A5 JP 2004523545A5 JP 2002564485 A JP2002564485 A JP 2002564485A JP 2002564485 A JP2002564485 A JP 2002564485A JP 2004523545 A5 JP2004523545 A5 JP 2004523545A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- amino
- cyclopropylmethoxy
- benzenesulfonyl
- acetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- AKPBWCUNVIPWOM-MQQKCMAXSA-N (2E,4E)-N-hydroxyhexa-2,4-dienamide Chemical compound C\C=C\C=C\C(=O)NO AKPBWCUNVIPWOM-MQQKCMAXSA-N 0.000 claims 1
- 125000001607 1,2,3-triazol-1-yl group Chemical group [*]N1N=NC([H])=C1[H] 0.000 claims 1
- -1 1,2,3-triazol-2-yl Chemical group 0.000 claims 1
- 125000001401 1,2,4-triazol-4-yl group Chemical group N=1N=C([H])N([*])C=1[H] 0.000 claims 1
- ZSSHTTSHAOJMKY-UHFFFAOYSA-N 2-[[2-(cyclopropylmethoxy)phenyl]sulfonyl-[[4-(1,2,4-triazol-4-yl)phenyl]methyl]amino]-N-hydroxyacetamide Chemical compound C=1C=CC=C(OCC2CC2)C=1S(=O)(=O)N(CC(=O)NO)CC(C=C1)=CC=C1N1C=NN=C1 ZSSHTTSHAOJMKY-UHFFFAOYSA-N 0.000 claims 1
- RFHNRJMEXSXGFO-UHFFFAOYSA-N 2-[[2-(cyclopropylmethoxy)phenyl]sulfonyl-[[4-(diethylamino)phenyl]methyl]amino]-N-hydroxyacetamide Chemical compound C1=CC(N(CC)CC)=CC=C1CN(CC(=O)NO)S(=O)(=O)C1=CC=CC=C1OCC1CC1 RFHNRJMEXSXGFO-UHFFFAOYSA-N 0.000 claims 1
- ZOVRVIVUIBBCAW-UHFFFAOYSA-N 2-[[2-(cyclopropylmethoxy)phenyl]sulfonyl-[[4-(dimethylamino)phenyl]methyl]amino]-N-hydroxyacetamide Chemical compound C1=CC(N(C)C)=CC=C1CN(CC(=O)NO)S(=O)(=O)C1=CC=CC=C1OCC1CC1 ZOVRVIVUIBBCAW-UHFFFAOYSA-N 0.000 claims 1
- SECUOMRDOIZQHH-UHFFFAOYSA-N 2-[[2-(cyclopropylmethoxy)phenyl]sulfonyl-[[4-(dimethylamino)phenyl]methyl]amino]-N-hydroxyacetamide;hydrochloride Chemical compound Cl.C1=CC(N(C)C)=CC=C1CN(CC(=O)NO)S(=O)(=O)C1=CC=CC=C1OCC1CC1 SECUOMRDOIZQHH-UHFFFAOYSA-N 0.000 claims 1
- KHUZQRKCIZHSEE-UHFFFAOYSA-N 2-[[2-(cyclopropylmethoxy)phenyl]sulfonyl-[[4-(triazol-1-yl)phenyl]methyl]amino]-N-hydroxyacetamide Chemical compound C=1C=CC=C(OCC2CC2)C=1S(=O)(=O)N(CC(=O)NO)CC(C=C1)=CC=C1N1C=CN=N1 KHUZQRKCIZHSEE-UHFFFAOYSA-N 0.000 claims 1
- MIQASBNREKILQS-UHFFFAOYSA-N 2-[[2-(cyclopropylmethoxy)phenyl]sulfonyl-[[4-(triazol-2-yl)phenyl]methyl]amino]-N-hydroxyacetamide Chemical compound C=1C=CC=C(OCC2CC2)C=1S(=O)(=O)N(CC(=O)NO)CC(C=C1)=CC=C1N1N=CC=N1 MIQASBNREKILQS-UHFFFAOYSA-N 0.000 claims 1
- CITWIOBNNXEOMH-UHFFFAOYSA-N 2-[[2-(cyclopropylmethoxy)phenyl]sulfonyl-[[4-(triazol-2-yl)phenyl]methyl]amino]-N-hydroxyacetamide;hydrochloride Chemical compound Cl.C=1C=CC=C(OCC2CC2)C=1S(=O)(=O)N(CC(=O)NO)CC(C=C1)=CC=C1N1N=CC=N1 CITWIOBNNXEOMH-UHFFFAOYSA-N 0.000 claims 1
- MGHWAUDUMIVYRP-UHFFFAOYSA-N N-hydroxyacetamide;hydrochloride Chemical compound Cl.CC(=O)NO MGHWAUDUMIVYRP-UHFFFAOYSA-N 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
Claims (2)
- 式Ｉ
Ｒはジ−低級アルキルアミノ、１,２,３−トリアゾール−１−イル、１,２,３−トリアゾール−２−イルもしくは１,２,４−トリアゾール−４−イルであり、
ｍは１〜１０（１０を含む）の整数を表し、そして
ｎは０〜１０（１０を含む）の整数を表す。]
のα−アミノ−Ｎ−ヒドロキシ−アセトアミド誘導体またはその塩。 - 請求項１に記載の式Ｉの化合物であって、
２−[(シクロプロピルメトキシ−ベンゼンスルホニル)−(４−[１,２,３]トリアゾール−２−イル−ベンジル)−アミノ]−Ｎ−ヒドロキシ−アセトアミド、
２−[(シクロプロピルメトキシ−ベンゼンスルホニル)−(４−[１,２,３]トリアゾール−２−イル−ベンジル)−アミノ]−Ｎ−ヒドロキシ−アセトアミド塩酸塩、
２−[(シクロプロピルメトキシ−ベンゼンスルホニル)−(４−ジメチルアミノベンジル)−アミノ]−Ｎ−ヒドロキシ−アセトアミド、
２−[(シクロプロピルメトキシ−ベンゼンスルホニル)−(４−ジメチルアミノベンジル)−アミノ]−Ｎ−ヒドロキシ−アセトアミド塩酸塩、
２−[(シクロプロピルメトキシ−ベンゼンスルホニル)−(４−[１,２,３]トリアゾール−１−イル−ベンジル)−アミノ]−Ｎ−ヒドロキシ−アセトアミド、
２−[(シクロプロピルメトキシ−ベンゼンスルホニル)−(４−[１,２,４]トリアゾール−４−イル−ベンジル)−アミノ]−Ｎ−ヒドロキシ−アセトアミド、
２−[(シクロプロピルメトキシ−ベンゼンスルホニル)−(４−ジエチルアミノベンジル)−アミノ]−Ｎ−ヒドロキシ−アセトアミド、および
２−[(シクロプロピルメトキシ−ベンゼンスルホニル)−(４−ジエチルアミノベンジル)−アミノ]−Ｎ−ヒドロキシ−アセトアミド塩酸塩
からなる群から選択される化合物またはその塩。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0103303.4A GB0103303D0 (en) | 2001-02-09 | 2001-02-09 | Organic compounds |
| PCT/EP2002/001345 WO2002064552A1 (en) | 2001-02-09 | 2002-02-08 | 1g(a)-AMINO-N-HYDROXY-ACETAMIDE DERIVATIVES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004523545A JP2004523545A (ja) | 2004-08-05 |
| JP2004523545A5 true JP2004523545A5 (ja) | 2005-08-25 |
| JP4262982B2 JP4262982B2 (ja) | 2009-05-13 |
Family
ID=9908475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002564485A Expired - Fee Related JP4262982B2 (ja) | 2001-02-09 | 2002-02-08 | α−アミノ−Ｎ−ヒドロキシ−アセトアミド誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7112611B2 (ja) |
| EP (1) | EP1360175A1 (ja) |
| JP (1) | JP4262982B2 (ja) |
| CN (1) | CN100509773C (ja) |
| AR (1) | AR032553A1 (ja) |
| AU (1) | AU2002249197A1 (ja) |
| CA (1) | CA2435611C (ja) |
| GB (1) | GB0103303D0 (ja) |
| PE (1) | PE20020845A1 (ja) |
| WO (1) | WO2002064552A1 (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9918684D0 (en) | 1999-08-09 | 1999-10-13 | Novartis Ag | Organic compounds |
| GB0103303D0 (en) * | 2001-02-09 | 2001-03-28 | Novartis Ag | Organic compounds |
| WO2005090297A1 (en) * | 2004-03-19 | 2005-09-29 | Biotie Therapies Corporation | Sulphonamide derivatives |
| WO2007117981A2 (en) * | 2006-03-29 | 2007-10-18 | Novartis Ag | Selective hydroxamate based mmp inhibitors |
| WO2008024784A1 (en) * | 2006-08-22 | 2008-02-28 | Array Biopharma, Inc. | Alkylsulfonamide-substituted triazoles as matrix metalloprotease inhibitors |
| WO2008147764A1 (en) * | 2007-05-23 | 2008-12-04 | Array Biopharma, Inc. | Mmp inhibitors and methods of use thereof |
| EP2934555B1 (en) | 2012-12-21 | 2021-09-22 | Astellas Institute for Regenerative Medicine | Methods for production of platelets from pluripotent stem cells |
| US20180353175A1 (en) * | 2017-06-13 | 2018-12-13 | Ethicon Llc | Surgical Fastener with Broad Spectrum MMP Inhibitors |
| CN110740764B (zh) * | 2017-06-13 | 2022-05-27 | 爱惜康有限责任公司 | 具有广谱mmp抑制剂的外科紧固件 |
| US11058804B2 (en) | 2017-06-13 | 2021-07-13 | Ethicon Llc | Surgical fastener device for the prevention of ECM degradation |
| US10939911B2 (en) | 2017-06-13 | 2021-03-09 | Ethicon Llc | Surgical stapler with end effector coating |
| JP7143334B2 (ja) * | 2017-06-13 | 2022-09-28 | エシコン エルエルシー | 治癒を制御させる手術用ステープラ |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2513826A (en) * | 1946-12-05 | 1950-07-04 | Gen Aniline & Film Corp | Aromatic sulfonhydrazides |
| US4772733A (en) | 1986-07-17 | 1988-09-20 | Hercules Incorporated | Epoxy-azides |
| US4806528A (en) * | 1987-09-04 | 1989-02-21 | Hanreich Reinhard G | Process for the preparation of 2-(2-chloroethoxy)-benzenesulfonamide |
| US5338755A (en) * | 1990-07-31 | 1994-08-16 | Elf Sanofi | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present |
| FR2682498A1 (fr) * | 1991-10-15 | 1993-04-16 | Kodak Pathe | Colorants comprenant des macrocycles thioethers. |
| US5663431A (en) * | 1992-01-30 | 1997-09-02 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| US5646167A (en) | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
| US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| US5506242A (en) | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
| US5552419A (en) * | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| GB9503749D0 (en) * | 1995-02-24 | 1995-04-12 | British Biotech Pharm | Synthesis of hydroxamic acid derivatives |
| CZ298814B6 (cs) * | 1996-01-23 | 2008-02-13 | Shionogi & Co., Ltd. | Sulfonované deriváty aminokyselin a metaloproteasové inhibitory obsahující tyto deriváty |
| CA2242416C (en) * | 1996-01-23 | 2006-03-21 | Shionogi & Co., Ltd. | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same |
| EA001561B1 (ru) | 1996-05-17 | 2001-04-23 | Варнер-Ламберт Компани | Бифенилсульфонамидные ингибиторы матричных металлопротеиназ |
| JPH10265452A (ja) | 1996-05-24 | 1998-10-06 | Ono Pharmaceut Co Ltd | フェニルスルホンアミド誘導体 |
| WO1998018754A1 (en) | 1996-10-28 | 1998-05-07 | Versicor, Inc. | Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof |
| NZ334897A (en) | 1996-12-09 | 2001-02-23 | Warner Lambert Co | Medicaments for treating and preventing heart failure and ventricular dilatation |
| NZ336840A (en) | 1997-02-03 | 2001-01-26 | Pfizer Prod Inc | Arylsulfonylamino hydroxamic acid derivatives useful in the treatment of tumor necrosis factor and matrix metalloproteinase mediated diseases |
| GB9708133D0 (en) | 1997-04-22 | 1997-06-11 | British Biotech Pharm | Novel use of matrix metalloproteinase inhibitors |
| ES2165640T3 (es) | 1997-05-09 | 2002-03-16 | Hoechst Ag | Acidos diaminocarboxilicos sustituidos. |
| DE19719621A1 (de) | 1997-05-09 | 1998-11-12 | Hoechst Ag | Sulfonylaminocarbonsäuren |
| WO1999006340A2 (en) | 1997-07-31 | 1999-02-11 | The Procter & Gamble Company | Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors |
| IL127496A0 (en) | 1997-12-19 | 1999-10-28 | Pfizer Prod Inc | The use of MMP inhibitors for the treatment of ocular angiogenesis |
| SK11692000A3 (sk) | 1998-02-04 | 2001-02-12 | Novartis Ag | Sulfonylaminoderiváty, ktoré inhibujú metaloproteinázy degradujúce matricu, spôsob ich prípravy a farmaceutická kompozícia, ktorá ich obsahuje |
| JPH11236369A (ja) | 1998-02-23 | 1999-08-31 | Kotobuki Seiyaku Kk | スルホンアミド誘導体及びその製造法並びにこれを含有する医薬組成物 |
| PA8469301A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Procedimientos para la preparacion de acidos hidroxamicos. |
| TR200101868T2 (tr) | 1998-12-22 | 2001-11-21 | F. Hoffmann-La Roche Ag | Sülfonamit hidroksamatlar. |
| AR035313A1 (es) | 1999-01-27 | 2004-05-12 | Wyeth Corp | Inhibidores de tace acetilenicos de acido hidroxamico de sulfonamida a base de alfa-aminoacidos, composiciones farmaceuticas y el uso de los mismos para la manufactura de medicamentos. |
| AR035311A1 (es) | 1999-01-27 | 2004-05-12 | Wyeth Corp | Derivados de acido hidroxamico que contienen alquinilo, como inhibidores de las metalloproteinasas de matriz y de la tace, composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento |
| GB9918684D0 (en) * | 1999-08-09 | 1999-10-13 | Novartis Ag | Organic compounds |
| GB0103303D0 (en) * | 2001-02-09 | 2001-03-28 | Novartis Ag | Organic compounds |
-
2001
- 2001-02-09 GB GBGB0103303.4A patent/GB0103303D0/en not_active Ceased
-
2002
- 2002-02-07 AR ARP020100398A patent/AR032553A1/es unknown
- 2002-02-07 PE PE2002000088A patent/PE20020845A1/es not_active Application Discontinuation
- 2002-02-08 AU AU2002249197A patent/AU2002249197A1/en not_active Abandoned
- 2002-02-08 WO PCT/EP2002/001345 patent/WO2002064552A1/en active Application Filing
- 2002-02-08 JP JP2002564485A patent/JP4262982B2/ja not_active Expired - Fee Related
- 2002-02-08 CN CNB028047133A patent/CN100509773C/zh not_active Expired - Fee Related
- 2002-02-08 US US10/467,611 patent/US7112611B2/en not_active Expired - Fee Related
- 2002-02-08 CA CA2435611A patent/CA2435611C/en not_active Expired - Fee Related
- 2002-02-08 EP EP02718115A patent/EP1360175A1/en not_active Withdrawn
-
2006
- 2006-08-07 US US11/500,138 patent/US7291634B2/en not_active Expired - Fee Related
-
2007
- 2007-10-05 US US11/868,032 patent/US7659293B2/en not_active Expired - Fee Related
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