JP2004523490A - 二置換カルボサイクリックサイクロフィリン結合化合物とその用途 - Google Patents

二置換カルボサイクリックサイクロフィリン結合化合物とその用途 Download PDF

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JP2004523490A
JP2004523490A JP2002546496A JP2002546496A JP2004523490A JP 2004523490 A JP2004523490 A JP 2004523490A JP 2002546496 A JP2002546496 A JP 2002546496A JP 2002546496 A JP2002546496 A JP 2002546496A JP 2004523490 A JP2004523490 A JP 2004523490A
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substituted
amino
dichlorophenyl
alkenyl
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JP2004523490A5 (enExample
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グレゴリー・エス・ハミルトン
セルゲイ・ベリヤコフ
マーク・バール
リン・ウェイ
ヤング−クイアン・ウー
ヨセフ・ピー・スタイナー
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ギルフォード ファーマシュウティカルズ インコーポレイテッド
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    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
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    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2002546496A 2000-11-28 2001-11-28 二置換カルボサイクリックサイクロフィリン結合化合物とその用途 Pending JP2004523490A (ja)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008093674A1 (ja) * 2007-01-29 2008-08-07 Santen Pharmaceutical Co., Ltd. キナーゼ阻害活性を有する新規チアジアゾール誘導体
JPWO2013111798A1 (ja) * 2012-01-27 2015-05-11 国立大学法人富山大学 セリンラセマーゼ阻害剤

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10121003A1 (de) 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
MXPA02010231A (es) * 2001-11-27 2004-12-13 Warner Lambert Co Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas.
EP1402888A1 (en) * 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors
SI2656854T1 (sl) * 2003-02-04 2015-09-30 Cornell Research Foundation, Inc. Uporabe aromatsko-kationskega peptida
US20040192738A1 (en) * 2003-03-18 2004-09-30 Aventis Pharma Deutschland Gmbh 2-(Butyl-1-sulfonylamino)-N-[1(R)-(6-methoxypyridin-3-yl)propyl] benzamide, its use as a medicament, and pharmaceutical preparations comprising it
WO2005005389A2 (en) * 2003-07-07 2005-01-20 Merck Patent Gmbh Malonamide derivatives
TW200510305A (en) * 2003-07-25 2005-03-16 Wyeth Corp Process for the preparation of CPLA2 inhibitors
WO2005046683A1 (en) 2003-10-07 2005-05-26 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
CA3024434A1 (en) 2004-01-23 2005-08-11 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
WO2006078986A2 (en) * 2005-01-21 2006-07-27 Vertex Pharmaceuticals Incorporated Quorum sensing modulators
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
US7312181B2 (en) 2005-04-08 2007-12-25 Cropsolution, Inc. Acylated thiosemicarbazides as herbicides
JP5495206B2 (ja) * 2006-10-24 2014-05-21 コンジエニア・ソシエタ・ア・レスポンサビリタ・リミタータ 変性性組織障害をmptの阻害により防止するための薬剤としてのフェニル置換マレイミド
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
US9079880B2 (en) 2010-07-07 2015-07-14 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
US8697911B2 (en) 2010-07-07 2014-04-15 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
US9000154B2 (en) 2010-10-19 2015-04-07 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
WO2013066836A1 (en) * 2011-10-31 2013-05-10 Glaxosmithkline Llc Compounds and methods
KR20140135835A (ko) 2012-03-20 2014-11-26 아다메드 에스피. 제트 오.오. Cns 질환의 치료를 위한 벤질아민의 설폰아미드 유도체
US9186361B2 (en) 2013-03-15 2015-11-17 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
WO2014144952A2 (en) 2013-03-15 2014-09-18 Peter Walter Modulators of the eif2alpha pathway
US9296754B2 (en) 2013-03-15 2016-03-29 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
WO2014151630A2 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
ES2968371T3 (es) 2013-10-10 2024-05-09 Eastern Virginia Medical School Derivados de 4-((2-hidroxi-3-metoxibencil)amino) bencenosulfonamida como inhibidores de la 12-lipoxigenasa
JP6392352B2 (ja) 2013-12-19 2018-09-19 ノバルティス アーゲー リーシュマニア症などの寄生虫病を処置するための原生動物のプロテアソーム阻害剤としての[1,2,4]トリアゾロ[1,5−a]ピリミジン誘導体
CN104557691B (zh) * 2014-12-11 2017-10-24 中国农业大学 一种3‑胺酰双酰肼衍生物及其制备方法和应用
US9950992B2 (en) * 2016-03-14 2018-04-24 West Virginia University Water soluble haloanilide calcium-release calcium channel inhibitory compounds and methods to control bone erosion and inflammation associated with arthritides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL254871A (enExample) * 1959-08-14
US3062813A (en) * 1960-05-13 1962-11-06 Pennsalt Chemicals Corp Novel synthesis of sulfonamides
GB1075166A (en) * 1965-06-01 1967-07-12 Monsanto Chemicals Fluorinated aromatic diamides
ZA98825B (en) * 1997-02-27 1998-10-19 Guilford Pharm Inc Method of using neurotrophic carbamates and ureas
WO2001017953A1 (en) * 1999-09-08 2001-03-15 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008093674A1 (ja) * 2007-01-29 2008-08-07 Santen Pharmaceutical Co., Ltd. キナーゼ阻害活性を有する新規チアジアゾール誘導体
WO2008093677A1 (ja) * 2007-01-29 2008-08-07 Santen Pharmaceutical Co., Ltd. 血管新生阻害活性を有する新規オキサジアゾール誘導体およびチアジアゾール誘導体
JP2008266294A (ja) * 2007-01-29 2008-11-06 Santen Pharmaceut Co Ltd 血管新生阻害活性を有する新規オキサジアゾール誘導体およびチアジアゾール誘導体
JPWO2013111798A1 (ja) * 2012-01-27 2015-05-11 国立大学法人富山大学 セリンラセマーゼ阻害剤

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