JP2004523490A - 二置換カルボサイクリックサイクロフィリン結合化合物とその用途 - Google Patents
二置換カルボサイクリックサイクロフィリン結合化合物とその用途 Download PDFInfo
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- JP2004523490A JP2004523490A JP2002546496A JP2002546496A JP2004523490A JP 2004523490 A JP2004523490 A JP 2004523490A JP 2002546496 A JP2002546496 A JP 2002546496A JP 2002546496 A JP2002546496 A JP 2002546496A JP 2004523490 A JP2004523490 A JP 2004523490A
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- dichlorophenyl
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- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
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- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
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- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
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- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
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- C07C333/16—Salts of dithiocarbamic acids
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- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
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- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07C2601/00—Systems containing only non-condensed rings
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- C07C2601/14—The ring being saturated
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- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
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- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25307400P | 2000-11-28 | 2000-11-28 | |
| US29196601P | 2001-05-21 | 2001-05-21 | |
| PCT/US2001/044449 WO2002044126A2 (en) | 2000-11-28 | 2001-11-28 | Bisubstituted carbocyclic cyclophilin binding compounds and theirus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004523490A true JP2004523490A (ja) | 2004-08-05 |
| JP2004523490A5 JP2004523490A5 (enExample) | 2005-12-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002546496A Pending JP2004523490A (ja) | 2000-11-28 | 2001-11-28 | 二置換カルボサイクリックサイクロフィリン結合化合物とその用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20020127605A1 (enExample) |
| EP (1) | EP1339668A2 (enExample) |
| JP (1) | JP2004523490A (enExample) |
| AU (1) | AU2002225767A1 (enExample) |
| CA (1) | CA2430409A1 (enExample) |
| MX (1) | MXPA03004821A (enExample) |
| WO (1) | WO2002044126A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008093677A1 (ja) * | 2007-01-29 | 2008-08-07 | Santen Pharmaceutical Co., Ltd. | 血管新生阻害活性を有する新規オキサジアゾール誘導体およびチアジアゾール誘導体 |
| JPWO2013111798A1 (ja) * | 2012-01-27 | 2015-05-11 | 国立大学法人富山大学 | セリンラセマーゼ阻害剤 |
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| DE10121003A1 (de) | 2001-04-28 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| MXPA02010231A (es) * | 2001-11-27 | 2004-12-13 | Warner Lambert Co | Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas. |
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| US20040192738A1 (en) * | 2003-03-18 | 2004-09-30 | Aventis Pharma Deutschland Gmbh | 2-(Butyl-1-sulfonylamino)-N-[1(R)-(6-methoxypyridin-3-yl)propyl] benzamide, its use as a medicament, and pharmaceutical preparations comprising it |
| US20070213374A1 (en) * | 2003-07-07 | 2007-09-13 | Merck Patent Gmbh | Malonamide Derivatives |
| TW200510305A (en) | 2003-07-25 | 2005-03-16 | Wyeth Corp | Process for the preparation of CPLA2 inhibitors |
| JP4667384B2 (ja) | 2003-10-07 | 2011-04-13 | レノビス, インコーポレイテッド | イオンチャネルリガンドとしてのアミド誘導体および薬学的組成物、ならびにこれらを使用する方法 |
| CA2971928C (en) | 2004-01-23 | 2019-01-08 | Cornell Research Foundation, Inc. | Methods for reducing oxidative damage |
| US20080287546A1 (en) * | 2005-01-21 | 2008-11-20 | Ute Muh | Quorum Sensing Modulators |
| US7576099B2 (en) | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| WO2006110276A2 (en) * | 2005-04-08 | 2006-10-19 | Cropsolution, Inc. | Acylated thiosemicarbazides as herbicides |
| DE602007010821D1 (de) * | 2006-10-24 | 2011-01-05 | Congenia S R L | Phenyl-substituierte maleimide als medikamente zur hemmung von degenerativen gewebeschäden durch hemmung von mpt |
| US8273900B2 (en) | 2008-08-07 | 2012-09-25 | Novartis Ag | Organic compounds |
| US9079880B2 (en) | 2010-07-07 | 2015-07-14 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| US8697911B2 (en) | 2010-07-07 | 2014-04-15 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| WO2012054367A1 (en) | 2010-10-19 | 2012-04-26 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| WO2013066836A1 (en) * | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| KR20140135835A (ko) | 2012-03-20 | 2014-11-26 | 아다메드 에스피. 제트 오.오. | Cns 질환의 치료를 위한 벤질아민의 설폰아미드 유도체 |
| WO2014151729A1 (en) | 2013-03-15 | 2014-09-25 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| AU2014233520B2 (en) * | 2013-03-15 | 2019-02-21 | The Regents Of The University Of California | Modulators of the eIF2alpha pathway |
| WO2014151630A2 (en) | 2013-03-15 | 2014-09-25 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| US9296754B2 (en) | 2013-03-15 | 2016-03-29 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| ES2968371T3 (es) | 2013-10-10 | 2024-05-09 | Eastern Virginia Medical School | Derivados de 4-((2-hidroxi-3-metoxibencil)amino) bencenosulfonamida como inhibidores de la 12-lipoxigenasa |
| HRP20182021T1 (hr) | 2013-12-19 | 2019-01-25 | Novartis Ag | Derivati [1,2,4]triazolo[1,5-a]pirimidina kao inhibitori proteazoma protozoe za liječenje parazitskih bolesti poput lišmenijaze |
| CN104557691B (zh) * | 2014-12-11 | 2017-10-24 | 中国农业大学 | 一种3‑胺酰双酰肼衍生物及其制备方法和应用 |
| US9950992B2 (en) * | 2016-03-14 | 2018-04-24 | West Virginia University | Water soluble haloanilide calcium-release calcium channel inhibitory compounds and methods to control bone erosion and inflammation associated with arthritides |
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| NL254871A (enExample) * | 1959-08-14 | |||
| US3062813A (en) * | 1960-05-13 | 1962-11-06 | Pennsalt Chemicals Corp | Novel synthesis of sulfonamides |
| GB1075166A (en) * | 1965-06-01 | 1967-07-12 | Monsanto Chemicals | Fluorinated aromatic diamides |
| ZA98825B (en) * | 1997-02-27 | 1998-10-19 | Guilford Pharm Inc | Method of using neurotrophic carbamates and ureas |
| WO2001017953A1 (en) * | 1999-09-08 | 2001-03-15 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
-
2001
- 2001-11-28 WO PCT/US2001/044449 patent/WO2002044126A2/en not_active Ceased
- 2001-11-28 CA CA002430409A patent/CA2430409A1/en not_active Abandoned
- 2001-11-28 AU AU2002225767A patent/AU2002225767A1/en not_active Abandoned
- 2001-11-28 US US09/994,927 patent/US20020127605A1/en not_active Abandoned
- 2001-11-28 JP JP2002546496A patent/JP2004523490A/ja active Pending
- 2001-11-28 MX MXPA03004821A patent/MXPA03004821A/es unknown
- 2001-11-28 EP EP01995251A patent/EP1339668A2/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008093677A1 (ja) * | 2007-01-29 | 2008-08-07 | Santen Pharmaceutical Co., Ltd. | 血管新生阻害活性を有する新規オキサジアゾール誘導体およびチアジアゾール誘導体 |
| WO2008093674A1 (ja) * | 2007-01-29 | 2008-08-07 | Santen Pharmaceutical Co., Ltd. | キナーゼ阻害活性を有する新規チアジアゾール誘導体 |
| JP2008266294A (ja) * | 2007-01-29 | 2008-11-06 | Santen Pharmaceut Co Ltd | 血管新生阻害活性を有する新規オキサジアゾール誘導体およびチアジアゾール誘導体 |
| JPWO2013111798A1 (ja) * | 2012-01-27 | 2015-05-11 | 国立大学法人富山大学 | セリンラセマーゼ阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20020127605A1 (en) | 2002-09-12 |
| WO2002044126A3 (en) | 2002-09-26 |
| EP1339668A2 (en) | 2003-09-03 |
| WO2002044126A2 (en) | 2002-06-06 |
| CA2430409A1 (en) | 2002-06-06 |
| MXPA03004821A (es) | 2004-03-26 |
| AU2002225767A1 (en) | 2002-06-11 |
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