JP2004522528A - 体腔用幾何学的停留装置 - Google Patents
体腔用幾何学的停留装置 Download PDFInfo
- Publication number
- JP2004522528A JP2004522528A JP2002562420A JP2002562420A JP2004522528A JP 2004522528 A JP2004522528 A JP 2004522528A JP 2002562420 A JP2002562420 A JP 2002562420A JP 2002562420 A JP2002562420 A JP 2002562420A JP 2004522528 A JP2004522528 A JP 2004522528A
- Authority
- JP
- Japan
- Prior art keywords
- wing
- region
- generally
- shaped
- wings
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000004873 anchoring Methods 0.000 title 1
- 239000000463 material Substances 0.000 claims abstract description 57
- 229920001610 polycaprolactone Polymers 0.000 claims abstract description 44
- 241000124008 Mammalia Species 0.000 claims abstract description 23
- 230000000717 retained effect Effects 0.000 claims abstract description 10
- 239000013543 active substance Substances 0.000 claims abstract description 8
- 229940079593 drug Drugs 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims abstract description 4
- 241000894007 species Species 0.000 claims abstract description 4
- 239000000126 substance Substances 0.000 claims abstract description 3
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 58
- 239000000583 progesterone congener Substances 0.000 claims description 29
- 241001465754 Metazoa Species 0.000 claims description 17
- 239000011159 matrix material Substances 0.000 claims description 17
- 229920000858 Cyclodextrin Polymers 0.000 claims description 16
- 230000014759 maintenance of location Effects 0.000 claims description 16
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 16
- 210000001215 vagina Anatomy 0.000 claims description 14
- 239000004677 Nylon Substances 0.000 claims description 11
- 229920001778 nylon Polymers 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 239000000186 progesterone Substances 0.000 claims description 10
- 229960003387 progesterone Drugs 0.000 claims description 10
- 229920000642 polymer Polymers 0.000 claims description 9
- 230000012173 estrus Effects 0.000 claims description 6
- 230000007704 transition Effects 0.000 claims description 6
- 230000004962 physiological condition Effects 0.000 claims description 5
- 102000009151 Luteinizing Hormone Human genes 0.000 claims description 3
- 108010073521 Luteinizing Hormone Proteins 0.000 claims description 3
- 239000012190 activator Substances 0.000 claims description 3
- 229940040129 luteinizing hormone Drugs 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 claims description 3
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 3
- 238000012377 drug delivery Methods 0.000 claims description 2
- 230000005489 elastic deformation Effects 0.000 claims description 2
- 238000000465 moulding Methods 0.000 claims description 2
- 230000001766 physiological effect Effects 0.000 claims description 2
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims 4
- 239000012858 resilient material Substances 0.000 claims 1
- 238000003780 insertion Methods 0.000 description 40
- 230000037431 insertion Effects 0.000 description 40
- 241000283690 Bos taurus Species 0.000 description 12
- 239000000047 product Substances 0.000 description 9
- 150000004676 glycans Chemical class 0.000 description 6
- 229920001282 polysaccharide Polymers 0.000 description 6
- 239000005017 polysaccharide Substances 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 229920002379 silicone rubber Polymers 0.000 description 4
- 239000004945 silicone rubber Substances 0.000 description 4
- 241000283707 Capra Species 0.000 description 2
- 241000282994 Cervidae Species 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 244000144980 herd Species 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 2
- 229960005375 lutein Drugs 0.000 description 2
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 2
- 235000012680 lutein Nutrition 0.000 description 2
- 239000001656 lutein Substances 0.000 description 2
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 238000000944 Soxhlet extraction Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000004442 gravimetric analysis Methods 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000009027 insemination Effects 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ509894A NZ509894A (en) | 2001-02-09 | 2001-02-09 | A "T" or "Y" shaped intravaginal device suitable for delivery of pharmaceuticals such as progesterone |
| PCT/NZ2002/000011 WO2002062415A1 (en) | 2001-02-09 | 2002-02-01 | Geometry retainable devices for body cavities |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004522528A true JP2004522528A (ja) | 2004-07-29 |
| JP2004522528A5 JP2004522528A5 (enExample) | 2005-12-22 |
Family
ID=19928345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002562420A Abandoned JP2004522528A (ja) | 2001-02-09 | 2002-02-01 | 体腔用幾何学的停留装置 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040142012A1 (enExample) |
| EP (1) | EP1363696A1 (enExample) |
| JP (1) | JP2004522528A (enExample) |
| KR (1) | KR20030083712A (enExample) |
| AU (1) | AU2002235050B2 (enExample) |
| BR (1) | BR0207497A (enExample) |
| NZ (1) | NZ509894A (enExample) |
| WO (1) | WO2002062415A1 (enExample) |
| ZA (1) | ZA200306042B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019502520A (ja) * | 2016-01-04 | 2019-01-31 | ジュロックス ピーティーワイ リミテッドＪｕｒｏｘ Ｐｔｙ Ｌｔｄ | 薬剤放出デバイス及び使用 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ593497A (en) * | 2011-06-16 | 2013-01-25 | Kahne Ltd | Animal digestion monitoring system with bolus having a transmitter and designed to be retained in the dorsal sac of the rumen |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | 天然の併用ホルモン補充療法剤及び療法 |
| ES2956708T3 (es) | 2015-07-09 | 2023-12-26 | Ulti Pharmaceuticals Ltd | Un dispositivo de administración de fármacos |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2079158B (en) * | 1980-06-09 | 1985-01-09 | Ahi Operations Ltd | Intra-vaginal devices |
| NZ200564A (en) * | 1982-05-10 | 1987-03-06 | Ahi Operations Ltd | Device for slowly releasing chemicals into body cavities of animals |
| NZ207341A (en) * | 1984-03-01 | 1988-02-29 | Harvey Alex Ind Ltd | Device containing chemical impregnants for insertion into a body cavity of an animal |
| AU664365B2 (en) * | 1991-04-02 | 1995-11-16 | Access Pharmaceuticals Australia Pty Limited | Oral delivery systems for microparticles |
| FI97944C (fi) * | 1994-07-05 | 1997-03-25 | Leiras Oy | Vaikuttavaa ainetta luovuttava laite |
| AU723217B2 (en) * | 1997-05-28 | 2000-08-24 | Interag | Intra-vaginal device for pigs |
| NZ330726A (en) | 1998-06-18 | 2000-10-27 | Dec Res | Intra-vaginal delivery unit or composition containing a cyclodextrin which improves absorbtion of 17-beta oestradiol or oestradiol benzoate |
| NZ331391A (en) | 1998-08-14 | 2000-12-22 | Dec Res | Dispensing apparatus comprising a formulation, a pair of electrodes and a housing means for agent and electrodes |
-
2001
- 2001-02-09 NZ NZ509894A patent/NZ509894A/xx not_active IP Right Cessation
-
2002
- 2002-02-01 JP JP2002562420A patent/JP2004522528A/ja not_active Abandoned
- 2002-02-01 EP EP02701817A patent/EP1363696A1/en not_active Withdrawn
- 2002-02-01 WO PCT/NZ2002/000011 patent/WO2002062415A1/en not_active Ceased
- 2002-02-01 KR KR10-2003-7010516A patent/KR20030083712A/ko not_active Withdrawn
- 2002-02-01 US US10/470,735 patent/US20040142012A1/en not_active Abandoned
- 2002-02-01 BR BR0207497-4A patent/BR0207497A/pt not_active IP Right Cessation
- 2002-02-01 AU AU2002235050A patent/AU2002235050B2/en not_active Expired
-
2003
- 2003-08-05 ZA ZA200306042A patent/ZA200306042B/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019502520A (ja) * | 2016-01-04 | 2019-01-31 | ジュロックス ピーティーワイ リミテッドＪｕｒｏｘ Ｐｔｙ Ｌｔｄ | 薬剤放出デバイス及び使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002062415A1 (en) | 2002-08-15 |
| AU2002235050B2 (en) | 2007-02-15 |
| ZA200306042B (en) | 2004-11-05 |
| EP1363696A1 (en) | 2003-11-26 |
| US20040142012A1 (en) | 2004-07-22 |
| NZ509894A (en) | 2002-11-26 |
| KR20030083712A (ko) | 2003-10-30 |
| BR0207497A (pt) | 2004-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050131 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050131 |
|
| A762 | Written abandonment of application |
Free format text: JAPANESE INTERMEDIATE CODE: A762 Effective date: 20070313 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20070313 |