JP2004521076A5 - - Google Patents

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Publication number
JP2004521076A5
JP2004521076A5 JP2002522926A JP2002522926A JP2004521076A5 JP 2004521076 A5 JP2004521076 A5 JP 2004521076A5 JP 2002522926 A JP2002522926 A JP 2002522926A JP 2002522926 A JP2002522926 A JP 2002522926A JP 2004521076 A5 JP2004521076 A5 JP 2004521076A5
Authority
JP
Japan
Prior art keywords
thrombomodulin
analog
seq
modified
linked glycosylation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2002522926A
Other languages
English (en)
Other versions
JP2004521076A (ja
Filing date
Publication date
Priority claimed from US09/938,405 external-priority patent/US20020111296A1/en
Application filed filed Critical
Publication of JP2004521076A publication Critical patent/JP2004521076A/ja
Publication of JP2004521076A5 publication Critical patent/JP2004521076A5/ja
Withdrawn legal-status Critical Current

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Description

【特許請求の範囲】
【請求項1】 脊髄損傷を治療するための医薬を製造するための、抗酸化性であり、かつ388位でメチオニンがロイシンに置換されている可溶性組換えトロンボモジュリン類似体の治療的有効量の使用、その際、類似体は天然トロンボモジュリン(配列番号2)に従って番号付けされている
【請求項】 トロンボモジュリン類似体が、天然トロンボモジュリン(配列番号2)のO−結合グリコシル化領域の糖残基で修飾されている、請求項1に記載の使用
【請求項】 トロンボモジュリン類似体が、O−結合グリコシル化領域がコンドロイチン硫酸を有しない程度に修飾されている、請求項1または2に記載の使用
【請求項4】 類似体がプロテアーゼ分解に対する耐性を有している、請求項1から3までのいずれか1項に記載の使用
【請求項5】 トロンボモジュリン類似体(Solulin TM)が、以下の位置:
アミノ酸1〜3の除去、
M388L
R456G
H457Q
S474Aおよび
P490での終結
で修飾された天然トロンボモジュリン(配列番号2)のアミノ酸配列を有する、請求項1から4までのいずれか1項に記載の使用
【請求項6】 哺乳類がヒトである、請求項1から5までのいずれか1項に記載の使用
JP2002522926A 2000-08-31 2001-08-31 シグナルコード障害の回復に使用するためのトロンボモジュリン類似体 Withdrawn JP2004521076A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22971400P 2000-08-31 2000-08-31
US09/938,405 US20020111296A1 (en) 2000-08-31 2001-08-23 Thrombomodulin analogs for use in recovery of spinal cord injury
PCT/US2001/041930 WO2002017953A2 (en) 2000-08-31 2001-08-31 Thrombomodulin analogs for use in recovery of signal cord injury

Publications (2)

Publication Number Publication Date
JP2004521076A JP2004521076A (ja) 2004-07-15
JP2004521076A5 true JP2004521076A5 (ja) 2008-09-11

Family

ID=26923554

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002522926A Withdrawn JP2004521076A (ja) 2000-08-31 2001-08-31 シグナルコード障害の回復に使用するためのトロンボモジュリン類似体

Country Status (14)

Country Link
US (3) US20020111296A1 (ja)
EP (1) EP1365788B1 (ja)
JP (1) JP2004521076A (ja)
AT (1) ATE361755T1 (ja)
AU (2) AU2001293229B2 (ja)
CA (1) CA2420900A1 (ja)
DE (1) DE60128399T2 (ja)
DK (1) DK1365788T3 (ja)
ES (1) ES2287161T3 (ja)
HK (1) HK1062398A1 (ja)
IL (2) IL154600A0 (ja)
NO (1) NO20030919L (ja)
PT (1) PT1365788E (ja)
WO (1) WO2002017953A2 (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006005362A1 (en) * 2004-07-13 2006-01-19 Paion Deutschland Gmbh Production of mammalian proteins in plant cells
US8293710B2 (en) * 2005-01-03 2012-10-23 Blue Blood Biotech Corp. Method for treating wounds using an EGF-like domain of thrombomodulin
US20060148695A1 (en) * 2005-01-03 2006-07-06 National Cheng Kung University Novel angiogenic composition and use thereof
EP1912660A1 (en) * 2005-08-11 2008-04-23 Medigenes Co., Ltd. Pharmaceutical composition for the treatment of nerve damage comprising blood plasma or serum
AR067345A1 (es) * 2007-07-10 2009-10-07 Paion Deutschland Gmbh Uso de trombomodulina para la preparacion de un medicamento trombolitico
EP2014296A1 (en) * 2007-07-10 2009-01-14 PAION Deutschland GmbH Novel strategies for increasing the reperfusion in obstructed blood vessel
WO2010006634A1 (en) * 2008-07-16 2010-01-21 Paion Deutschland Gmbh Prevention and treatment of radiation injury
WO2010006635A1 (en) * 2008-07-16 2010-01-21 Paion Deutschland Gmbh Treatment of inflammatory bowel disease
IN2014DN10075A (ja) 2012-05-31 2015-08-21 Univ Kinki
US11497795B2 (en) 2018-09-28 2022-11-15 Asahi Kasei Pharma Corporation Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
US5466668A (en) * 1989-04-28 1995-11-14 Schering Aktiengesellschaft Superior thrombomodulin analogs for pharmaceutical use
JP3789147B2 (ja) * 1995-04-11 2006-06-21 旭化成ファーマ株式会社 脊髄損傷後の神経障害に対する治療剤

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