JP2004518704A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004518704A5 JP2004518704A5 JP2002563162A JP2002563162A JP2004518704A5 JP 2004518704 A5 JP2004518704 A5 JP 2004518704A5 JP 2002563162 A JP2002563162 A JP 2002563162A JP 2002563162 A JP2002563162 A JP 2002563162A JP 2004518704 A5 JP2004518704 A5 JP 2004518704A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- hydrogen
- sialyl
- compound
- lewis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 description 11
- 239000001257 hydrogen Substances 0.000 description 11
- -1 cycloalkylidene Chemical group 0.000 description 7
- 150000002431 hydrogen Chemical class 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 125000002446 fucosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O)[C@@H](O1)C)* 0.000 description 5
- 125000002519 galactosyl group Chemical group C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 description 5
- 125000002566 glucosaminyl group Chemical group 0.000 description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- NIGUVXFURDGQKZ-UQTBNESHSA-N alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc Chemical class O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O NIGUVXFURDGQKZ-UQTBNESHSA-N 0.000 description 4
- 239000003446 ligand Substances 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 125000005630 sialyl group Chemical group 0.000 description 4
- 0 CC(C(C1O)O)OC(C)C1O* Chemical compound CC(C(C1O)O)OC(C)C1O* 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 150000002016 disaccharides Chemical class 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 150000003904 phospholipids Chemical group 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 150000004043 trisaccharides Chemical class 0.000 description 3
- 102000003800 Selectins Human genes 0.000 description 2
- 108090000184 Selectins Proteins 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 125000001118 alkylidene group Chemical group 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- 125000003968 arylidene group Chemical group [H]C(c)=* 0.000 description 2
- 239000002872 contrast media Substances 0.000 description 2
- 125000002573 ethenylidene group Chemical group [*]=C=C([H])[H] 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 125000003107 substituted aryl group Chemical group 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 150000004044 tetrasaccharides Chemical class 0.000 description 2
- SLKDGVPOSSLUAI-UHFFFAOYSA-N CCCCCCCCCCCCCCCC(OCC(COP(O)(OCCN)=O)OC(CCCCCCCCCCCCCCC)=O)=O Chemical compound CCCCCCCCCCCCCCCC(OCC(COP(O)(OCCN)=O)OC(CCCCCCCCCCCCCCC)=O)=O SLKDGVPOSSLUAI-UHFFFAOYSA-N 0.000 description 1
- YLEIFZAVNWDOBM-ZTNXSLBXSA-N ac1l9hc7 Chemical compound C([C@H]12)C[C@@H](C([C@@H](O)CC3)(C)C)[C@@]43C[C@@]14CC[C@@]1(C)[C@@]2(C)C[C@@H]2O[C@]3(O)[C@H](O)C(C)(C)O[C@@H]3[C@@H](C)[C@H]12 YLEIFZAVNWDOBM-ZTNXSLBXSA-N 0.000 description 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 125000000000 cycloalkoxy group Chemical group 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000002961 echo contrast media Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25023800P | 2000-11-29 | 2000-11-29 | |
| PCT/US2001/044590 WO2002062810A2 (en) | 2000-11-29 | 2001-11-29 | Linkable sialyl lewis x analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004518704A JP2004518704A (ja) | 2004-06-24 |
| JP2004518704A5 true JP2004518704A5 (enExample) | 2006-01-12 |
| JP4262480B2 JP4262480B2 (ja) | 2009-05-13 |
Family
ID=22946912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002563162A Expired - Lifetime JP4262480B2 (ja) | 2000-11-29 | 2001-11-29 | 結合能を有するシアリル・ルイスｘ類似物 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US7422733B2 (enExample) |
| EP (1) | EP1337539A2 (enExample) |
| JP (1) | JP4262480B2 (enExample) |
| AU (1) | AU2002251678A1 (enExample) |
| CA (1) | CA2429781C (enExample) |
| WO (1) | WO2002062810A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5183010B2 (ja) | 2002-05-16 | 2013-04-17 | グリコミメティクス， インコーポレイテッド | セレクチンによって媒介される機能を阻害するための化合物および方法 |
| DE602004011272T2 (de) | 2003-11-19 | 2008-12-24 | Glycomimetics, Inc. | Spezifischer antagonist sowohl für e- als auch p-selektine |
| US7205385B2 (en) * | 2004-11-12 | 2007-04-17 | General Electric Company | Polymerization method for the synthesis of polypeptide imaging agents |
| DK1928892T3 (da) | 2005-08-09 | 2012-01-30 | Glycomimetics Inc | Glycomimetiske inhibitorer af PA-IL-lectin PA-IIL-lectin eller begge lectiner fra pseudomonas |
| GB0517077D0 (en) * | 2005-08-19 | 2005-09-28 | Isis Innovation | Imaging agent |
| PL1934236T3 (pl) | 2005-09-02 | 2013-04-30 | Glycomimetics Inc | Heterobifunkcjonalne inhibitory pan-selektyny |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| WO2007042504A2 (fr) | 2005-10-07 | 2007-04-19 | Guerbet | Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium |
| US8895510B2 (en) | 2008-04-08 | 2014-11-25 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| FR2942227B1 (fr) | 2009-02-13 | 2011-04-15 | Guerbet Sa | Utilisation de tampons pour la complexation de radionucleides |
| CA2760292A1 (en) * | 2009-05-01 | 2010-11-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
| WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
| WO2012061662A1 (en) * | 2010-11-03 | 2012-05-10 | Glycomimetics, Inc. | Glycomimetic-peptidomimetic inhibitors of e-selectins and cxcr4 chemokine receptors |
| WO2012060718A1 (en) * | 2010-11-05 | 2012-05-10 | Sally Diana Poppitt | Preventing or treating metabolic syndrome by administering a trans fatty acid, or a salt, ester or precursor thereof, or sialic acid in free or bound form |
| FR2968999B1 (fr) | 2010-12-20 | 2013-01-04 | Guerbet Sa | Nanoemulsion de chelate pour irm |
| FR2980364B1 (fr) | 2011-09-26 | 2018-08-31 | Guerbet | Nanoemulsions et leur utilisation comme agents de contraste |
| WO2013096926A1 (en) | 2011-12-22 | 2013-06-27 | Glycomimetics, Inc. | E-selectin antagonist compounds, compositions, and methods of use |
| PT2928476T (pt) | 2012-12-07 | 2018-05-10 | Glycomimetics Inc | Compostos, composições e métodos que utilizam antagonistas de e-selectina para mobilização de células hematopoiéticas |
| FR3001154B1 (fr) | 2013-01-23 | 2015-06-26 | Guerbet Sa | Magneto-emulsion vectorisee |
| JP2016539172A (ja) * | 2013-12-06 | 2016-12-15 | ザ ロイヤル インスティチューション フォー ザ アドバンスメント オブ ラーニング／マギル ユニバーシティ | 癌標的化及び抗体作製のための抗ガングリオシド化合物 |
| WO2016089872A1 (en) | 2014-12-03 | 2016-06-09 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
| EP3170832A1 (en) * | 2015-11-17 | 2017-05-24 | Centre National De La Recherche Scientifique | Method of preparation of 6-azido-2,4-diacetamido-2,4,6-trideoxy-d-mannose |
| US11045485B2 (en) | 2016-01-22 | 2021-06-29 | Glycomimetics, Inc. | Glycomimetic inhibitors of PA-IL and PA-IIL lectins |
| US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
| JP2019524791A (ja) | 2016-08-08 | 2019-09-05 | グリコミメティクス， インコーポレイテッド | Ｅ−セレクチンの阻害剤もしくはｃｘｃｒ４の阻害剤との、またはｅ−セレクチンおよびｃｘｃｒ４両方のヘテロ二機能性阻害剤とのｔ細胞チェックポイント阻害剤の組み合わせ |
| US11072625B2 (en) | 2016-10-07 | 2021-07-27 | Glycomimetics, Inc. | Highly potent multimeric e-selectin antagonists |
| WO2018112669A1 (en) | 2016-12-23 | 2018-06-28 | Realist Pharma, Inc. | Ganglioside carbohydrate structures and uses thereof |
| CA3054605A1 (en) | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| US11712446B2 (en) | 2017-11-30 | 2023-08-01 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| BR112020013198A2 (pt) | 2017-12-29 | 2020-12-01 | Glycomimetics, Inc. | inibidores heterobifuncionais de e-selectina e galectina-3 |
| KR20200128025A (ko) | 2018-03-05 | 2020-11-11 | 글리코미메틱스, 인크. | 급성 골수성 백혈병 및 관련 병태의 치료 방법 |
| WO2020007822A1 (en) | 2018-07-02 | 2020-01-09 | Conservatoire National Des Arts Et Metiers (Cnam) | Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1260393A (en) * | 1984-10-16 | 1989-09-26 | Lajos Tarcsay | Liposomes of synthetic lipids |
| US5776093A (en) * | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
| MX174467B (es) * | 1986-01-23 | 1994-05-17 | Squibb & Sons Inc | 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos |
| JPH06510745A (ja) | 1991-06-10 | 1994-12-01 | グライカムド インコーポレイテッド | 修飾シアリルルイスａ化合物 |
| CA2110797C (en) | 1991-06-10 | 2001-02-20 | Andre P. Venot | Modified sialyl lewis x compounds |
| GB9309513D0 (en) | 1993-05-08 | 1993-06-23 | Univ Coventry | Electrochemical method of modifying biomolecules in particular proteins |
| CA2162478A1 (en) * | 1993-05-14 | 1994-11-24 | Shawn A. Defrees | Sialyl lex analogues as inhibitors of cellular adhesion |
| US5608110A (en) * | 1993-06-15 | 1997-03-04 | Bracco International B.V. | Heteroatom-bearing ligands and metal complexes thereof |
| US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
| US6132764A (en) * | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| US6331289B1 (en) * | 1996-10-28 | 2001-12-18 | Nycomed Imaging As | Targeted diagnostic/therapeutic agents having more than one different vectors |
-
2001
- 2001-11-29 AU AU2002251678A patent/AU2002251678A1/en not_active Abandoned
- 2001-11-29 WO PCT/US2001/044590 patent/WO2002062810A2/en not_active Ceased
- 2001-11-29 US US10/432,914 patent/US7422733B2/en not_active Expired - Lifetime
- 2001-11-29 JP JP2002563162A patent/JP4262480B2/ja not_active Expired - Lifetime
- 2001-11-29 EP EP01999154A patent/EP1337539A2/en not_active Withdrawn
- 2001-11-29 CA CA2429781A patent/CA2429781C/en not_active Expired - Lifetime
-
2008
- 2008-08-13 US US12/190,857 patent/US20080300220A1/en not_active Abandoned
-
2011
- 2011-05-26 US US13/116,828 patent/US20110229409A1/en not_active Abandoned
-
2012
- 2012-04-26 US US13/456,747 patent/US20120258043A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004518704A5 (enExample) | ||
| TW319763B (enExample) | ||
| JPH05504125A (ja) | マルチサイト金属キレート化剤 | |
| JP4262480B2 (ja) | 結合能を有するシアリル・ルイスｘ類似物 | |
| US5281704A (en) | Polychelant compounds | |
| US5403572A (en) | Macrocyclic polyaza compounds containing 5 or 6 membered rings, process for producing them and pharmaceutical media containing them | |
| KR100202796B1 (ko) | 착화합물이 결합된캐스케이드중합체,이의착물및콘쥬게이트,이의제조방법,및이들을함유하는약제학적제제 | |
| US4529561A (en) | Method for producing liposomes in selected size range | |
| US5679810A (en) | Linear oligomeric polychelant compounds | |
| US5446145A (en) | Polychelant compounds | |
| JP6883046B2 (ja) | 長寿命ガドリニウムに基づく腫瘍標的化イメージングおよび治療薬 | |
| JPH06507147A (ja) | コントラスト媒体 | |
| JPH05112567A (ja) | ６員環を有する巨大環式テトラアザ化合物、その製法及びこれを含有する薬剤 | |
| JPH0665174A (ja) | ジエチレントリアミンペンタ酢酸−モノアミド及びその錯体及び錯塩、その製法、これを含有するｎｍｒ−、レントゲン−及び放射線−診断剤並びに放射線−又は射線療法剤及びその薬剤の製法 | |
| JP2004506645A5 (enExample) | ||
| JP2000510838A (ja) | 造影剤 | |
| JP2009029810A (ja) | 生物学的薬剤の体内分布を改変させるための組成物および方法 | |
| TWI228512B (en) | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation | |
| US6303101B1 (en) | Bismuth compounds | |
| US20020164288A1 (en) | Fullerene (C60) -based X-ray contrast agent for diagnostic imaging | |
| US6117412A (en) | Non-cluster type bismuth compounds | |
| US20220048935A1 (en) | Radioactive Phospholipid Metal Chelates for Cancer Imaging and Therapy | |
| JPWO2006003731A1 (ja) | 高分子ミセル型ｍｒｉ造影剤 | |
| JPH07502277A (ja) | 二環式ポリアザ大環状カルボン酸錯体、複合体、その製造及び造影剤としての用途 | |
| JPH11504002A (ja) | 診断医薬品及び治療医薬品としての使用のためのヒドロキシアルキルホスフィン化合物並びにその製造方法 |