JP2004515218A - プロモータへ隣接する遺伝子から保護抗原を発現する呼吸器系合胞体ウイルスワクチン - Google Patents
プロモータへ隣接する遺伝子から保護抗原を発現する呼吸器系合胞体ウイルスワクチン Download PDFInfo
- Publication number
- JP2004515218A JP2004515218A JP2002505815A JP2002505815A JP2004515218A JP 2004515218 A JP2004515218 A JP 2004515218A JP 2002505815 A JP2002505815 A JP 2002505815A JP 2002505815 A JP2002505815 A JP 2002505815A JP 2004515218 A JP2004515218 A JP 2004515218A
- Authority
- JP
- Japan
- Prior art keywords
- rsv
- gene
- genome
- antigenome
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18541—Use of virus, viral particle or viral elements as a vector
- C12N2760/18543—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18561—Methods of inactivation or attenuation
- C12N2760/18562—Methods of inactivation or attenuation by genetic engineering
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21370800P | 2000-06-23 | 2000-06-23 | |
| PCT/US2001/020107 WO2002000693A2 (en) | 2000-06-23 | 2001-06-22 | Respiratory syncytial virus vaccines expressing protective antigens from promotor-proximal genes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004515218A true JP2004515218A (ja) | 2004-05-27 |
| JP2004515218A5 JP2004515218A5 (enExample) | 2008-08-21 |
Family
ID=22796187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002505815A Pending JP2004515218A (ja) | 2000-06-23 | 2001-06-22 | プロモータへ隣接する遺伝子から保護抗原を発現する呼吸器系合胞体ウイルスワクチン |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1294858B1 (enExample) |
| JP (1) | JP2004515218A (enExample) |
| KR (1) | KR100899030B1 (enExample) |
| CN (1) | CN1468301A (enExample) |
| AT (1) | ATE416251T1 (enExample) |
| AU (3) | AU6870901A (enExample) |
| BR (1) | BRPI0112276B8 (enExample) |
| CA (1) | CA2413786A1 (enExample) |
| DE (1) | DE60136811D1 (enExample) |
| ES (1) | ES2317914T3 (enExample) |
| IL (1) | IL153530A0 (enExample) |
| MX (1) | MXPA02012818A (enExample) |
| WO (1) | WO2002000693A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009544322A (ja) * | 2006-07-27 | 2009-12-17 | リゴサイト ファーマシューティカルズ インコーポレイテッド | キメラウイルス様粒子 |
| US8920812B2 (en) | 2009-11-03 | 2014-12-30 | Takeda Vaccines, Inc. | Chimeric RSV-F polypeptide and lentivirus or alpha-retrovirus Gag-based VLPS |
| JP2018537103A (ja) * | 2015-12-11 | 2018-12-20 | ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンテッド バイ ザ セクレタリー、デパートメント オブ ヘルス アンド ヒューマン サービシーズThe U.S.A.As Represented By The Secretary,Department Of Health And Human Services | Ns1およびns2遺伝子シフトを含む組換えrsウイルス株 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003530073A (ja) * | 1999-07-09 | 2003-10-14 | アメリカ合衆国 | 弱毒化されたヒト−ウシキメラ呼吸器合胞体ウィルスワクチンの製造 |
| WO2008094197A2 (en) | 2006-07-27 | 2008-08-07 | Ligocyte Pharmaceuticals, Inc. | Chimeric influenza virus-like particles |
| CN105200069A (zh) * | 2015-10-16 | 2015-12-30 | 北京交通大学 | 基于rna聚合酶ⅰ的rsv微型复制基因组及其应用 |
| CN110229219B (zh) * | 2019-06-21 | 2021-03-30 | 中国科学院武汉病毒研究所 | 一种新型的呼吸道合胞病毒疫苗抗原的制备方法及其用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998002530A1 (en) * | 1996-07-15 | 1998-01-22 | The Government Of The United States Of America, As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences |
-
2001
- 2001-06-22 EP EP01946696A patent/EP1294858B1/en not_active Expired - Lifetime
- 2001-06-22 BR BR0112276-2 patent/BRPI0112276B8/pt not_active IP Right Cessation
- 2001-06-22 AU AU6870901A patent/AU6870901A/xx active Pending
- 2001-06-22 KR KR1020027017577A patent/KR100899030B1/ko not_active Expired - Fee Related
- 2001-06-22 JP JP2002505815A patent/JP2004515218A/ja active Pending
- 2001-06-22 IL IL15353001A patent/IL153530A0/xx not_active IP Right Cessation
- 2001-06-22 AU AU2001268709A patent/AU2001268709B2/en not_active Ceased
- 2001-06-22 DE DE60136811T patent/DE60136811D1/de not_active Expired - Lifetime
- 2001-06-22 CA CA002413786A patent/CA2413786A1/en not_active Abandoned
- 2001-06-22 WO PCT/US2001/020107 patent/WO2002000693A2/en not_active Ceased
- 2001-06-22 MX MXPA02012818A patent/MXPA02012818A/es active IP Right Grant
- 2001-06-22 ES ES01946696T patent/ES2317914T3/es not_active Expired - Lifetime
- 2001-06-22 CN CNA018143628A patent/CN1468301A/zh active Pending
- 2001-06-22 AT AT01946696T patent/ATE416251T1/de not_active IP Right Cessation
-
2006
- 2006-12-22 AU AU2006252238A patent/AU2006252238A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998002530A1 (en) * | 1996-07-15 | 1998-01-22 | The Government Of The United States Of America, As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009544322A (ja) * | 2006-07-27 | 2009-12-17 | リゴサイト ファーマシューティカルズ インコーポレイテッド | キメラウイルス様粒子 |
| JP2015015954A (ja) * | 2006-07-27 | 2015-01-29 | タケダ ヴァクシーンズ, インコーポレイテッド | キメラウイルス様粒子 |
| US8920812B2 (en) | 2009-11-03 | 2014-12-30 | Takeda Vaccines, Inc. | Chimeric RSV-F polypeptide and lentivirus or alpha-retrovirus Gag-based VLPS |
| JP2018537103A (ja) * | 2015-12-11 | 2018-12-20 | ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンテッド バイ ザ セクレタリー、デパートメント オブ ヘルス アンド ヒューマン サービシーズThe U.S.A.As Represented By The Secretary,Department Of Health And Human Services | Ns1およびns2遺伝子シフトを含む組換えrsウイルス株 |
| JP7063808B2 (ja) | 2015-12-11 | 2022-05-09 | ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンテッド バイ ザ セクレタリー、デパートメント オブ ヘルス アンド ヒューマン サービシーズ | Ns1およびns2遺伝子シフトを含む組換えrsウイルス株 |
| JP7063808B6 (ja) | 2015-12-11 | 2022-06-07 | ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンテッド バイ ザ セクレタリー、デパートメント オブ ヘルス アンド ヒューマン サービシーズ | Ns1およびns2遺伝子シフトを含む組換えrsウイルス株 |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0112276B1 (pt) | 2019-12-31 |
| ATE416251T1 (de) | 2008-12-15 |
| ES2317914T3 (es) | 2009-05-01 |
| CA2413786A1 (en) | 2002-01-03 |
| CN1468301A (zh) | 2004-01-14 |
| IL153530A0 (en) | 2003-07-06 |
| DE60136811D1 (de) | 2009-01-15 |
| EP1294858B1 (en) | 2008-12-03 |
| KR100899030B1 (ko) | 2009-05-21 |
| AU6870901A (en) | 2002-01-08 |
| KR20030045685A (ko) | 2003-06-11 |
| WO2002000693A3 (en) | 2002-09-26 |
| BRPI0112276B8 (pt) | 2021-05-25 |
| MXPA02012818A (es) | 2003-05-14 |
| WO2002000693A2 (en) | 2002-01-03 |
| AU2006252238A1 (en) | 2007-01-25 |
| EP1294858A2 (en) | 2003-03-26 |
| AU2001268709B2 (en) | 2006-09-28 |
| BR0112276A (pt) | 2004-02-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100905450B1 (ko) | 약독화된 인간-소 키메릭 호흡기 신시티움 바이러스백신의 제조 방법 | |
| EP2112220A2 (en) | Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences | |
| US7846455B2 (en) | Attenuated chimeric respiratory syncytial virus | |
| CN100491530C (zh) | 从克隆的核苷酸序列制备减毒嵌合呼吸道合胞病毒疫苗 | |
| US6923971B2 (en) | Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes | |
| US7744902B2 (en) | Respiratory syncytial virus vaccines expressing protective antigens from promotor-proximal genes | |
| WO2001004321A1 (en) | Production of attenuated respiratory syncytial virus vaccines involving modification of m2 orf2 | |
| KR100899030B1 (ko) | 프로모터 인접 유전자로부터 보호적 항원을 발현하는호흡기 신시티움 바이러스 백신 | |
| US7662397B2 (en) | Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes | |
| AU2001268709A1 (en) | Respiratory syncytial virus vaccines expressing protective antigens from promotor-proximal genes | |
| US7820182B2 (en) | Production of attenuated, human-bovine chimeric respiratory syncytial viruses for use in immunogenic compositions | |
| AU2005201040A1 (en) | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080623 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080623 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110222 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110520 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110527 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120403 |